CXCL11 (C-X-C motif chemokine ligand 11)

Gene: CXCL11 (C-X-C motif chemokine ligand 11) Chlorocebus sabaeus

Analyze

Symbol:

CXCL11

Name:

C-X-C motif chemokine ligand 11

RGD ID:

18585891

Description:

ENCODES a protein that exhibits chemokine activity (ortholog); CXCR3 chemokine receptor binding (ortholog); heparin binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); chemokine-mediated signaling pathway (ortholog); ASSOCIATED WITH bacterial pneumonia (ortholog); bronchiolitis obliterans (ortholog); celiac disease (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

C-X-C motif chemokine 11

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	24,540,401 - 24,543,456 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	24,541,767 - 24,542,832 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	2,882,698 - 2,885,219 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

bacterial pneumonia (ISO)

bronchiolitis obliterans (ISO)

celiac disease (ISO)

chronic obstructive pulmonary disease (ISO)

COVID-19 (ISO)

extrinsic allergic alveolitis (ISO)

genetic disease (ISO)

graft-versus-host disease (ISO)

hepatocellular carcinoma (ISO)

inhalation anthrax (ISO)

interstitial cystitis (ISO)

pancreatic ductal carcinoma (ISO)

progressive myoclonus epilepsy (ISO)

pulmonary sarcoidosis (ISO)

severe acute respiratory syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (ISO)

antimicrobial humoral immune response mediated by antimicrobial peptide (ISO)

cell chemotaxis (IEA)

chemokine-mediated signaling pathway (ISO)

chemotaxis (IEA)

defense response (IEA)

immune response (IEA,ISO)

inflammatory response (IEA)

positive regulation of release of sequestered calcium ion into cytosol (ISO)

regulation of cell population proliferation (ISO)

signal transduction (IEA)

T cell chemotaxis (ISO)

Cellular Component

extracellular region (IEA)

extracellular space (IEA)

Molecular Function

chemokine activity (IEA,ISO)

CXCR3 chemokine receptor binding (ISO)

cytokine activity (IEA)

heparin binding (ISO)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CXCL11
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	24,540,401 - 24,543,456 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	24,541,767 - 24,542,832 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	2,882,698 - 2,885,219 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

CXCL11
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	76,033,682 - 76,036,070 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	76,033,682 - 76,041,415 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	76,954,835 - 76,957,223 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	77,173,859 - 77,176,257 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	77,312,020 - 77,314,412	NCBI
Celera	4	74,255,322 - 74,257,722 (-)	NCBI		Celera
Cytogenetic Map	4	q21.1	NCBI
HuRef	4	72,707,280 - 72,709,795 (-)	NCBI		HuRef
CHM1_1	4	76,931,383 - 76,933,900 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	79,374,343 - 79,376,731 (-)	NCBI		T2T-CHM13v2.0

Cxcl11
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	92,507,403 - 92,511,155 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	92,507,403 - 92,513,344 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	92,359,544 - 92,363,296 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	92,359,544 - 92,365,485 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	92,788,570 - 92,792,303 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	93,434,744 - 93,438,477 (-)	NCBI		MGSCv36	mm8
Celera	5	90,503,193 - 90,506,930 (-)	NCBI		Celera
Cytogenetic Map	5	E2	NCBI
cM Map	5	46.61	NCBI

Cxcl11
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	15,973,728 - 15,976,503 (+)	NCBI		GRCr8
mRatBN7.2	14	15,689,432 - 15,692,207 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	15,689,424 - 15,692,271 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	15,697,639 - 15,700,419 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	17,016,484 - 17,019,264 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	15,711,911 - 15,714,691 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	17,195,395 - 17,198,170 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	17,195,014 - 17,198,291 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	17,111,527 - 17,114,302 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	17,250,648 - 17,253,423 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	17,250,647 - 17,253,423 (+)	NCBI
Celera	14	15,083,879 - 15,086,654 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

Cxcl11
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955433	766,272 - 771,231 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955433	769,449 - 771,137 (-)	NCBI	ChiLan1.0	ChiLan1.0

CXCL11
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	54,037,310 - 54,039,639 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	54,227,065 - 54,229,394 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	48,169,954 - 48,172,455 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	54,007,818 - 54,010,343 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	54,007,818 - 54,010,336 (+)	Ensembl	panpan1.1		panPan2

CXCL11
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	631,084 - 636,997 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	631,478 - 632,868 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1 Ensembl	32	631,478 - 632,868 (-)	NCBI	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	32	655,797 - 662,280 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	32	655,531 - 661,573 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	609,837 - 615,880 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	39,553,718 - 39,589,852 (+)	NCBI		UU_Cfam_GSD_1.0

Cxcl11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	11,433,511 - 11,435,471 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936676	71,667 - 73,738 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936676	72,383 - 73,697 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CXCL11
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	71,713,803 - 71,725,674 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	71,713,790 - 71,725,669 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	75,909,581 - 75,921,427 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Cxcl11
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624757	14,952,851 - 14,954,905 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624757	14,952,966 - 14,954,343 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium
Low	11	12	6
Below cutoff	19	5	19

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007998939	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037988916	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000002678 ⟹ ENSCSAP00000000977

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	7	24,541,767 - 24,542,832 (-)	Ensembl

RefSeq Acc Id:

XM_007998939 ⟹ XP_007997130

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	7	24,540,401 - 24,543,456 (-)	NCBI
Vero_WHO_p1.0	NW_023666037	2,882,698 - 2,885,219 (-)	NCBI

Sequence:

show sequence

CTGTAATAAAAGCTTCGCAGAATAAAATAATTATAAAATAAAATAATAAAATTAAATTAAATTT
AAAAATAAAATAAAGCAAAACAAAATAAATAAAATATATAAAGTAAAAATTGTTGAAAATGCAA
AACAATATGGACATAAATACAGAAGCACAGGGAAACTTCTTTAGGCACTCATTTCAGGCAAAAA
TATGAAAAGGTCATCTGGTGTCAAATAACATAGGCCTTATCTATCATAAGAGTTTGAACTGGAA
AGAAACAGTTAGATGATAAAGAAAAAGCTTCTCAGAATATTCTTTTGTATAGTTATGTGAAGGA
TGAAGGGTGGGTGAAAGGACCAAAAACAGAAACACAGTCTTCCTGAATGAATGACAATCAGAAT
TCCGCTGCCCACCACAATTAAACAGATTTCTAGGAAAAGCTACCTTAAAAAGGCTGGTTACCAT
CTGGGTTTACACAGTGCTTTCACATTCTTATCACTTTCAACACTACTACAAATAGGAAGGGACA
GTAGCATTTAGAAGAGAACAAAACAGAAACTCTTGGAAGCAAGAAAGGTGCATGACTCAAAGAG
GGAAATTCCTGTGCCATAAAAGGATTGCGGGTGTACAAAATGCTGTATATATACCAATTGTCAA
TTTCCTTTCATGTTCAGCATTTCTACTCCTTCCAAGAAGAGTAGCAAAGCTGAAGTAGCAGCAG
CAGCAGCAGCAGCAGTAGCAGCAACCACAGCAGCAGCAAAAAACAAACATGAGTGTGAAGGGCA
TGGCTATAGCCTTAGCTATGATATTGTGTGCTACGGTTGTTCAAGGTTTCCCTATGTTCAAAAG
AGGACGCTGTCTTTGCATAGGCCCTGGAGTAAAAGCAGTGAAAGTGGCAGATATTGAGAAAGCC
TCCATAATTTACCCAAGTAACAACTGTGACAAAATAGAAGTGATTATTACCCTGAAAGAAAATA
AAGGACAACGATGCCTAAATCCCAAATCGAAGCAAGCAAGACTTATAATCAAAAAAGTTGAAAG
AAAGAATTTTTAAAAATATCAAATCATATGAAGTCCTGGAAAAGAGGATTTGAAAAACTTAGAA
CAAGTTAAACTGTGACTACTGAAATGACAAGAATTCTGCAGTAGGAAACTGAGACTTTTCTATA
GGTTTGTGACTTTCAACTTTTGTACAGTTATGTGAAGGATGAAAGGTGGGTGAAAGGACCAAAA
ATAGAAACACAGTCTTCCTGAATGAATGACAATCAGAATTCCGCTGCCCAACGTAGTCCAACAA
TTAAATGGATTTCTAGGAAAAGCTACCTTAACAAAGGCTCCTTACCACTGGAGTTTACAAAGTG
CTTTCACACTGTTACTTGTTGTATTATACATTCATGCATTTCTAGGCTAGAGAACCTTCTAGAT
TTGATGCTTATAACTATTCTGTTGTTACTATGAGAACATTTCTGTCTCTAGAAGTCATCTCTCT
GTATTGATCTTTATGCTACGTTACTATCTGTGGTTACAGTGGAAACATTGACATTACTGGAGTC
AAGCCCTTATGAGTCAAAAGCATCTATGTGTAGTAAAACATTCCTCAAATGTTTTTTCATGCAA
ATACACATTTCTTTCTCCAAATATCATGTAGCACATCAGTATATAGGGAAACATTCTTATGCAT
CATTTGGTTTGTTTTATAACCAATTCATGAAATGTAATTCATAAAATGTACTATGAAAAAATTA
TACGCTGTGGGATACTGGCAAAAGTGCACATATTTCATAACCAAATTAGTAGCACTGGTCTTCA
TTTGATGTTTTTCAACTGTTTTTCATTGAGATGTTTTAAAGCAATTAGGATATGTGTGTTTACT
GTACTTTGTGTTTTTATCCATTTGTATAAATGATAGCAATATCTTGGACACATTTGAAATATAA
AACGTTTTTGTCTACCAAAGAAAAATGTTGAAAAATAAGCAAATGTATATCTGGCAATCACCTT
CAGTTTTCGTAATTCTGTCTCTTAGAAAAACACGTAATCTAATAAATTTCTTTGTTGATGCCTA
TATACTATAAAATTTGGGTATACTCAAGACTAGTTTAAAGAATCAAAGTCATTTTTTTCTCTAA
TAAACTACCACAACCTTTCTTTTTT

hide sequence

RefSeq Acc Id:

XM_037988916 ⟹ XP_037844844

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666037	2,883,758 - 2,885,219 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_007997130	(Get FASTA)	NCBI Sequence Viewer
	XP_037844844	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000000977
	ENSCSAP00000000977.1

RefSeq Acc Id:	XP_007997130 ⟸ XM_007998939
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9QX88 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000000977 ⟸ ENSCSAT00000002678

RefSeq Acc Id:	XP_037844844 ⟸ XM_037988916
- Peptide Label:	isoform X2

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000004644	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000002678.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.50.40	UniProtKB/TrEMBL
InterPro	Chemokine_CXC	UniProtKB/TrEMBL
	Chemokine_CXC_CS	UniProtKB/TrEMBL
	Chemokine_IL8-like_dom	UniProtKB/TrEMBL
	CXC_Chemokine_domain	UniProtKB/TrEMBL
	Interleukin_8-like_sf	UniProtKB/TrEMBL
NCBI Gene	CXCL11	ENTREZGENE
Pfam	IL8	UniProtKB/TrEMBL
PRINTS	INTERLEUKIN8	UniProtKB/TrEMBL
	SMALLCYTKCXC	UniProtKB/TrEMBL
PROSITE	SMALL_CYTOKINES_CXC	UniProtKB/TrEMBL
SMART	SCY	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54117	UniProtKB/TrEMBL
UniProt	A0A0D9QX88	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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