VAMP3 (vesicle associated membrane protein 3)

Gene: VAMP3 (vesicle associated membrane protein 3) Chlorocebus sabaeus

Analyze

Symbol:

VAMP3

Name:

vesicle associated membrane protein 3

RGD ID:

18580393

Description:

ENCODES a protein that exhibits SNARE binding (ortholog); syntaxin-1 binding (ortholog); INVOLVED IN calcium-ion regulated exocytosis (ortholog); cellular response to type II interferon (ortholog); establishment of localization in cell (ortholog); PARTICIPATES IN autophagy pathway; ASSOCIATED WITH chromosome 1p36 deletion syndrome (ortholog); genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN apical plasma membrane (ortholog); clathrin-coated vesicle membrane (ortholog); intracellular vesicle (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

vesicle-associated membrane protein 3

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	123,973,672 - 123,984,230 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	123,971,992 - 123,984,187 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	28,008,620 - 28,019,197 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 1p36 deletion syndrome (ISO)

genetic disease (ISO)

Neurodevelopmental Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium-ion regulated exocytosis (IEA,ISO)

cellular response to type II interferon (IEA,ISO)

establishment of localization in cell (IEA,ISO)

Golgi to plasma membrane protein transport (IEA,ISO)

mucus secretion (ISO)

negative regulation of secretion by cell (IEA)

positive regulation of immunoglobulin production (ISO)

positive regulation of receptor recycling (IEA)

protein-containing complex assembly (ISO)

regulation of histamine secretion by mast cell (ISO)

retrograde transport, endosome to Golgi (IEA)

SNARE complex assembly (IEA)

substrate adhesion-dependent cell spreading (IEA)

vesicle fusion (IEA)

vesicle-mediated transport (IEA)

Cellular Component

apical plasma membrane (ISO)

cell surface (IEA)

clathrin-coated vesicle (IEA)

clathrin-coated vesicle membrane (ISO)

cytoplasmic vesicle (IEA)

cytosol (IEA)

early endosome (IEA)

early endosome membrane (IEA)

intracellular membrane-bounded organelle (IEA)

intracellular vesicle (ISO)

membrane (IEA)

perinuclear region of cytoplasm (IEA)

phagocytic vesicle (IEA)

plasma membrane (IEA)

recycling endosome (IEA,ISO)

recycling endosome membrane (IEA)

secretory granule (IEA)

SNARE complex (IEA,ISO)

synapse (IEA)

synaptic vesicle membrane (ISO)

Molecular Function

protein binding (ISO)

SNAP receptor activity (IEA)

SNARE binding (ISO)

syntaxin-1 binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

autophagy pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

VAMP3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	123,973,672 - 123,984,230 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	123,971,992 - 123,984,187 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	28,008,620 - 28,019,197 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

VAMP3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	7,771,296 - 7,781,432 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	7,771,296 - 7,781,432 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	7,831,356 - 7,841,492 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	7,753,916 - 7,764,079 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	7,765,594 - 7,775,757	NCBI
Celera	1	6,939,057 - 6,949,218 (+)	NCBI		Celera
Cytogenetic Map	1	p36.23	NCBI
HuRef	1	6,979,774 - 6,989,939 (+)	NCBI		HuRef
CHM1_1	1	7,819,031 - 7,829,192 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	7,302,342 - 7,312,478 (+)	NCBI		T2T-CHM13v2.0

Vamp3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	151,131,762 - 151,142,410 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	151,131,757 - 151,142,420 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	151,047,305 - 151,057,953 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	151,047,300 - 151,057,963 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	150,421,414 - 150,432,062 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	149,891,105 - 149,901,753 (-)	NCBI		MGSCv36	mm8
Celera	4	153,323,081 - 153,333,830 (-)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI
cM Map	4	81.53	NCBI

Vamp3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	166,780,927 - 166,791,522 (-)	NCBI		GRCr8
mRatBN7.2	5	161,498,109 - 161,508,704 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	161,498,109 - 161,508,751 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	164,214,807 - 164,225,406 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	166,031,426 - 166,042,030 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	165,993,451 - 166,004,050 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	168,126,157 - 168,136,628 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	168,126,157 - 168,136,666 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	171,703,252 - 171,713,723 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	168,190,569 - 168,201,165 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	168,200,756 - 168,386,085 (-)	NCBI
Celera	5	159,750,283 - 159,760,878 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Vamp3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	5,103,106 - 5,112,176 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955486	5,103,228 - 5,112,157 (-)	NCBI	ChiLan1.0	ChiLan1.0

VAMP3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	220,444,847 - 220,455,016 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	219,085,975 - 219,096,144 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	6,534,115 - 6,544,275 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	7,782,810 - 7,792,958 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

VAMP3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	61,430,711 - 61,440,626 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	61,430,740 - 61,439,063 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	61,439,454 - 61,449,379 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	61,647,556 - 61,657,492 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	61,647,531 - 61,657,492 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	61,646,808 - 61,656,746 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	61,511,261 - 61,521,200 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	61,914,945 - 61,924,879 (+)	NCBI		UU_Cfam_GSD_1.0

Vamp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	31,793,913 - 31,802,660 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936623	2,280,534 - 2,287,898 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

VAMP3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	6	68,473,921 - 68,482,438 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Vamp3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	4,009,991 - 4,019,728 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624818	4,010,130 - 4,019,695 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	36	3	34
Low		17	26
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007980701	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007980702	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000017781 ⟹ ENSCSAP00000017253

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	20	123,971,992 - 123,984,187 (-)	Ensembl

RefSeq Acc Id:

XM_007980702 ⟹ XP_007978893

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	20	123,973,672 - 123,984,230 (-)	NCBI
Vero_WHO_p1.0	NW_023666054	28,008,620 - 28,019,197 (-)	NCBI

Sequence:

show sequence

GGCCCTGCCTAGTGACGTCTTTGCCCGGAGCCGCGCCGTTCCGCCCATCTCCTTGGCCTCCGGT
CCCTACTTCGCTGCTCTGCTGACCCTCGCTCGCCGCCGCCGCCGCCGCCGCCGCAGCTGCCAAA
ATGTCTACAGGTCCAACTGCTGCCGCTGGCAGTAATCGAAGACTTCAGCAGACACAAAATCAAG
TAGATGAGGTGGTGGACATAATGCGAGTTAACGTGGACAAGGTTCTGGAAAGAGACCAGAAGCT
CTCTGAGTTAGACGACCGTGCAGATGCACTGCAGGCAGGCGCTTCTCAATTTGAAACGAGCGCA
GCCAAGTTGAAGAGGAAATATTGGTGGAAGAATTGCAAGATGTGGGCAATCGGGATTACTGTTC
TGGTTATCTTCATCATCATCATCATCGTGTGGGTTGTCTCTTCATGAAGAACCAGCGGAACTCA
AAACTGCTGTTCAAGAAACCTCTTCAAGACTTTTGACTTAGAACCTGCTATATTATCAAGCTTA
CCTACTGTTATCTCTAAAATGTTTTTTTGTGTGTGTGTTAGTTAAAAGTTGAATTTCTAGGAAA
CGTGCCTTTGTTTTTTAATATGCACTCCAAATTAGAAGTAAGGCCAGCCCCGTCCACATTTTGC
ACAGTGCCTTTACAGATTTACGTATGGGCTGATGAAGAGGCCTTCTTAAGTTCCAGAGTGCTAT
AATCTAGATGTAATGTTGTCACTAATTAATTGCCATTGCTCCCAGTTAGTTACCCTTGTCATTC
GGCATTATTTTCAGAACCACATTTTAAAACTTTGGGTAATCAGATTTCCAACTTGTGCCTTCCA
GAAAAAAACACTACTGCCTAACACAAATCTGTGATAACAACAGGCTGTGCCTTATTTTGATAAT
TTTCTGATTCCCTAGAAGAGAACCCTCTACTTTTTGTAAGCACTACTGACTCTCGCTGTATTTA
AGATAAGATGCTGGTGAAGAGCTTTTGCTCTTGCATTAGATTTGAAGATGTTTACTTTGTTGTT
ATTGTTATGTATCACTTGCTAAAAATGTTGTTTAATCATAAATAACCTCCTTTAAAAAAATTTT
ATAGAACTATGGCTATGACCAAAGCTTCTATTTTGCCAAAAAGTTAAATGCCGATAAAATGGCC
TTAAGTGTATTCCTGATAGTTAAATTCAGAAACCTGCCAAATGGAACTCAAGGTGCCCCTTCAG
AATTAAAATCATTACATTGTGTATGAAACTTGTACATCTTAACAGGCCTTTCTTCCTTTTGAAA
GGCTGTAGACAGTGTGGCTCCTCTTCTGATTCAGTATTCTGCATGGGGGTTAGGGAAGGTGTGA
GGTAGACTCTGACCGTCTCATTCCTATGGACAGAAGAGTTTTACCCAGCAGTTGGCAGATTATC
AGCTGTGGACTCCAACATGTTTCTGATAATTATGCAAGCAACAATTCTGTAGCCTCAAGTAAGA
CCACCTGTGAACTTGATCATTATCTGGCCCAAATATGAAGATAAACGATAACTTTTTGGAGTTT
GTTTCCTATTTGTAGTCACATCTGCTTCCTAAATCAGTTTTCTAAATTATGCCTGCAATTAGGC
ATTGGTCAGGGGTGAACGAACGACTCTTTTCACAGAGAGTAGCCAACCAGAGACCTTTGCTTTG
ATACCATCAACTGCAGAGAATGCTGTTGGTGGGAATGCTGGAAGTAGCTGTTGTCGCCAAAGAA
ACTTTGTCATCGGAGAAACTTTTCTTCTATACATGAGACTCAACATCACAGCTTAAAGATGGGA
ATTCAGATATGAAAGAAAACAGGCAAGGAGGCACTGAGGGAGAAAGACACAGACTTTATTGCTC
TGTGGCTCATTGTTACTGGAATATTCTAAAACTCTTGTTCACATGCTATTAAGACTTATAAAGC
AGCAACAGCTGAGGCGCACCAGGACACAACTTCCATTTCTTTAACATCTGTTCCCTTAACATCG
CTGAAACGATTTACTTTTGAAGACATGCCTTGCAGTGTGGCTAGCTGTGAGAAGCAAGCAGCTG
GCAGTGTTAGGACACTAGCCCACCTTCAGCGCAGGATCTCTGGCCGGGTGTGACTCTGAAACCT
TGGTGCTCGCCCCTTGGCCACAGAGCTCAGACCCATGTAACCCACTGGCTCCTGCATTAACCCA
GAAATACCTCGCTTGTCTCTGTGCACTTAGCTGGGAACTTACCCACTGTAGTGACCTAAATAAA
GTGTTTATAAACATGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007978893	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000017253
	ENSCSAP00000017253.1

RefSeq Acc Id:	XP_007978893 ⟸ XM_007980702
- UniProtKB:	A0A0D9S8R4 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000017253 ⟸ ENSCSAT00000017781

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000000753	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000017781.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.110	UniProtKB/TrEMBL
InterPro	Synaptobrevin	UniProtKB/TrEMBL
	Synaptobrevin/VAMP	UniProtKB/TrEMBL
	V_SNARE_CC	UniProtKB/TrEMBL
NCBI Gene	VAMP3	ENTREZGENE
PANTHER	PTHR45701	UniProtKB/TrEMBL
	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3	UniProtKB/TrEMBL
Pfam	Synaptobrevin	UniProtKB/TrEMBL
PIRSF	Synaptobrevin_euk	UniProtKB/TrEMBL
PRINTS	SYNAPTOBREVN	UniProtKB/TrEMBL
PROSITE	SYNAPTOBREVIN	UniProtKB/TrEMBL
	V_SNARE	UniProtKB/TrEMBL
Superfamily-SCOP	SNARE fusion complex	UniProtKB/TrEMBL
UniProt	A0A0D9S8R4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

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Imported Disease Annotations - ClinVar

RGD Manual Annotations