DFFB (DNA fragmentation factor subunit beta)

Gene: DFFB (DNA fragmentation factor subunit beta) Chlorocebus sabaeus

Analyze

Symbol:

DFFB

Name:

DNA fragmentation factor subunit beta

RGD ID:

18579248

Description:

ENCODES a protein that exhibits disordered domain specific binding (ortholog); DNA binding (ortholog); DNA nuclease activity (ortholog); INVOLVED IN apoptotic chromosome condensation (ortholog); apoptotic DNA fragmentation (ortholog); DNA catabolic process (ortholog); ASSOCIATED WITH chromosome 1p36 deletion syndrome (ortholog); Chromosome Breakage (ortholog); genetic disease (ortholog); FOUND IN chromatin (ortholog); cytosol (ortholog); nucleolus (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	127,800,351 - 127,823,512 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666054	31,993,772 - 32,025,522 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 1p36 deletion syndrome (ISO)

Chromosome Breakage (ISO)

genetic disease (ISO)

megacolon (ISO)

Neurodevelopmental Disorders (ISO)

transient cerebral ischemia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic chromosome condensation (ISO)

apoptotic DNA fragmentation (ISO)

DNA catabolic process (ISO)

negative regulation of apoptotic DNA fragmentation (ISO)

Cellular Component

chromatin (ISO)

cytosol (ISO)

nucleolus (ISO)

nucleoplasm (ISO)

nucleus (ISO)

protein-containing complex (ISO)

Molecular Function

disordered domain specific binding (ISO)

DNA binding (ISO)

DNA nuclease activity (ISO)

enzyme binding (ISO)

identical protein binding (ISO)

nuclease activity (ISO)

protein binding (ISO)

protein domain specific binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

DFFB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	127,800,351 - 127,823,512 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666054	31,993,772 - 32,025,522 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

DFFB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	3,857,476 - 3,885,429 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	3,857,267 - 3,885,429 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	3,774,040 - 3,801,993 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	3,763,705 - 3,791,853 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	3,797,001 - 3,825,149	NCBI
Celera	1	3,028,085 - 3,056,136 (+)	NCBI		Celera
Cytogenetic Map	1	p36.32	NCBI
HuRef	1	3,069,403 - 3,097,689 (+)	NCBI		HuRef
CHM1_1	1	3,760,848 - 3,789,006 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	3,369,074 - 3,397,333 (+)	NCBI		T2T-CHM13v2.0

Dffb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	154,048,904 - 154,059,578 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	154,048,906 - 154,059,583 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	153,964,447 - 153,975,121 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	153,964,449 - 153,975,126 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	153,338,558 - 153,349,190 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	152,808,255 - 152,818,926 (-)	NCBI		MGSCv36	mm8
Celera	4	156,252,603 - 156,263,261 (-)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI
cM Map	4	83.78	NCBI

Dffb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	169,804,873 - 169,817,157 (-)	NCBI		GRCr8
mRatBN7.2	5	164,522,446 - 164,534,733 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	164,522,463 - 164,534,628 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	167,227,348 - 167,238,664 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	169,048,756 - 169,060,074 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	169,011,205 - 169,022,522 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	171,250,559 - 171,261,875 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	171,249,633 - 171,262,119 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	174,742,181 - 174,753,497 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	170,750,718 - 170,762,034 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	170,761,212 - 170,772,529 (-)	NCBI
Celera	5	162,735,202 - 162,746,518 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Dffb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	7,838,273 - 7,850,180 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955486	7,836,013 - 7,849,875 (-)	NCBI	ChiLan1.0	ChiLan1.0

DFFB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	224,411,057 - 224,450,359 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	223,052,777 - 223,094,130 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	2,529,733 - 2,559,490 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	3,649,723 - 3,676,896 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	3,649,729 - 3,676,896 (+)	Ensembl	panpan1.1		panPan2

DFFB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	58,340,183 - 58,355,353 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	58,339,634 - 58,354,326 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	58,350,476 - 58,365,648 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	58,547,681 - 58,562,856 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	58,547,687 - 58,562,863 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	58,555,388 - 58,570,554 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	58,424,285 - 58,439,461 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	58,814,557 - 58,829,729 (+)	NCBI		UU_Cfam_GSD_1.0

Dffb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	29,369,795 - 29,385,848 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936737	81,078 - 96,151 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936737	79,789 - 96,140 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DFFB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	65,310,864 - 65,323,806 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	65,310,868 - 65,323,816 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	60,157,486 - 60,164,636 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Dffb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	6,700,050 - 6,712,450 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624818	6,700,120 - 6,712,449 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007980841	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007980842	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037985138	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037985139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037985140	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037985141	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037985142	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037985143	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_007980842 ⟹ XP_007979033

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	20	127,806,093 - 127,823,512 (-)	NCBI
Vero_WHO_p1.0	NW_023666054	32,004,953 - 32,025,522 (-)	NCBI

Sequence:

show sequence

CTGTGCCAGCTTGCAGAGCTCACCAGGTGCAGACCCCTGCGGCCAGGGCGAGGACGGATCTCAG
CAGCCAGCCAGCGGGTGCCGCCGCCCGCGGGACCCAGAGGCCTTGAGCACATCTGCAATGCTCC
AGAAGCCCAAGAGCGTGAAGCTGCGGGCCCTGCGCAGCCCGAGGAAGTTCGGCGTGGCTGGCCG
GAGCTGCCAGGAGGTGCTGCGCAAGGGCTGTCTCCGCTTCCAGCTCCCTGAGCGCGGTTCCCGG
CTGTGCCTGTACGAGGATGGCACGGAGCTCACCGAAGACTACTTCCCCAGCGTTCCCGACAACG
CCGAGCTGGTGCTGCTCACCTCGGGCCAGGCCTGGCAGGGCTATGTGAGTGACATCGGGCGCTT
CCTCAGTGCATTTCACGAGCCGCACGCGGGGCTCATCCAGGCCGCCCAGCAGCTGCTGTGTGAT
GAGCAGGCCCCGCAGAGGCAGAGGCTGCTGGCCGACCTCCTGCACAATGTCAGCCAGAACATTG
CAGCTGAGACCCGGGCTGAGGACCCGCCGTGGTTTGAAGGCTTGGAGTCCCGATTTCAGAATAA
GTCTGGCTATCTGAGATACAGCTGTGAGAGCCGGATCCGGAGTTACCTGAGAGAGGTGAGCTCC
TACCCCTCCTTGGTGGGTGCGGAGGCTCAGGAGGAATTCCTGCGGGTCCTCAGCTCCATGTGCC
AGAAGCTCCGGTCCGTGCAGTACAATGGCAGCTACTTCGACAGAGGAGCCAAGGGCGGCGGCCG
TCTCTGCACGCCGGAAGGCTGGTTCTCCTGCCAGGGTCCCTTTGACATGGACAGCTGCTTATCA
AGACACTCCATCAACCCCTACAGTAACAGGGAGAGCAGGATCCTCTTCAGCACCTGGAACCTGG
ATCACATAGACGGAGTCTTGCTCTGTGGCCCAGGCTAAGTGCAGTG

hide sequence

RefSeq Acc Id:

XM_037985138 ⟹ XP_037841066

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666054	31,993,772 - 32,025,522 (-)	NCBI

RefSeq Acc Id:

XM_037985139 ⟹ XP_037841067

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666054	31,993,772 - 32,025,522 (-)	NCBI

RefSeq Acc Id:

XM_037985140 ⟹ XP_037841068

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666054	31,993,961 - 32,025,522 (-)	NCBI

RefSeq Acc Id:

XM_037985141 ⟹ XP_037841069

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666054	31,993,772 - 32,025,522 (-)	NCBI

RefSeq Acc Id:

XM_037985142 ⟹ XP_037841070

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666054	32,004,953 - 32,025,522 (-)	NCBI

RefSeq Acc Id:

XM_037985143 ⟹ XP_037841071

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666054	31,993,772 - 32,025,522 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_007979033	(Get FASTA)	NCBI Sequence Viewer
	XP_037841066	(Get FASTA)	NCBI Sequence Viewer
	XP_037841067	(Get FASTA)	NCBI Sequence Viewer
	XP_037841068	(Get FASTA)	NCBI Sequence Viewer
	XP_037841069	(Get FASTA)	NCBI Sequence Viewer
	XP_037841070	(Get FASTA)	NCBI Sequence Viewer
	XP_037841071	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_007979033 ⟸ XM_007980842
- Peptide Label:	isoform X7

RefSeq Acc Id:	XP_037841071 ⟸ XM_037985143
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_037841067 ⟸ XM_037985139
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_037841069 ⟸ XM_037985141
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_037841066 ⟸ XM_037985138
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_037841068 ⟸ XM_037985140
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_037841070 ⟸ XM_037985142
- Peptide Label:	isoform X5

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	DFFB	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD