UPF3A (UPF3A regulator of nonsense mediated mRNA decay) - Rat Genome Database

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Gene: UPF3A (UPF3A regulator of nonsense mediated mRNA decay) Chlorocebus sabaeus
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Symbol: UPF3A
Name: UPF3A regulator of nonsense mediated mRNA decay
RGD ID: 18578541
Description: ENCODES a protein that exhibits mRNA binding (inferred); nucleic acid binding (inferred); telomeric DNA binding (inferred); INVOLVED IN in utero embryonic development (ortholog); nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (ortholog); positive regulation of mRNA cis splicing, via spliceosome (ortholog); ASSOCIATED WITH factor X deficiency (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); exon-exon junction complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: regulator of nonsense transcripts 3A; UPF3 regulator of nonsense transcripts homolog A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1392,066,229 - 92,089,868 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl392,066,248 - 92,088,976 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604649,360,990 - 49,384,490 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
UPF3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1392,066,229 - 92,089,868 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl392,066,248 - 92,088,976 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604649,360,990 - 49,384,490 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
UPF3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813114,281,601 - 114,305,817 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13114,281,601 - 114,305,817 (+)EnsemblGRCh38hg38GRCh38
GRCh3713115,047,076 - 115,071,292 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613114,065,180 - 114,089,385 (+)NCBINCBI36Build 36hg18NCBI36
Build 3413114,065,179 - 114,089,383NCBI
Celera1395,719,450 - 95,743,911 (+)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1395,309,726 - 95,333,660 (+)NCBIHuRef
CHM1_113115,015,732 - 115,039,962 (+)NCBICHM1_1
T2T-CHM13v2.013113,490,661 - 113,514,877 (+)NCBIT2T-CHM13v2.0
Upf3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39813,834,636 - 13,848,723 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl813,835,615 - 13,849,193 (+)EnsemblGRCm39 Ensembl
GRCm38813,785,055 - 13,798,723 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl813,785,615 - 13,799,193 (+)EnsemblGRCm38mm10GRCm38
MGSCv37813,785,615 - 13,798,538 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36813,785,609 - 13,799,165 (+)NCBIMGSCv36mm8
Celera813,951,656 - 13,964,579 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map86.38NCBI
Upf3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81682,459,651 - 82,470,686 (-)NCBIGRCr8
mRatBN7.21675,757,442 - 75,768,478 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1675,757,441 - 75,769,345 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,038,094 - 81,049,129 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01684,491,624 - 84,502,061 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01679,741,309 - 79,752,356 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01681,521,084 - 81,532,512 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,521,073 - 81,532,520 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01681,009,176 - 81,020,604 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41680,612,505 - 80,623,540 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11680,612,769 - 80,623,805 (-)NCBI
Celera1673,566,324 - 73,577,359 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
Upf3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540425,556 - 36,730 (-)NCBIChiLan1.0ChiLan1.0
UPF3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214115,777,762 - 115,802,131 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113114,458,047 - 114,482,606 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01395,349,449 - 95,373,984 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113114,416,454 - 114,439,586 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13114,415,784 - 114,438,692 (+)Ensemblpanpan1.1panPan2
UPF3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12261,320,575 - 61,373,082 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2261,320,451 - 61,345,839 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2261,032,216 - 61,084,507 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02262,007,564 - 62,059,865 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12261,445,161 - 61,478,456 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02261,453,315 - 61,503,788 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02261,480,547 - 61,514,061 (+)NCBIUU_Cfam_GSD_1.0
Upf3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945196,196,490 - 196,210,608 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004937030243,104 - 258,355 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UPF3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1179,118,603 - 79,136,222 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11179,117,708 - 79,137,083 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Upf3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624793136,642 - 151,692 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624793134,607 - 151,730 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 1 60
Low 19
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000015478   ⟹   ENSCSAP00000013417
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl392,066,248 - 92,088,976 (+)Ensembl
RefSeq Acc Id: XM_007961031   ⟹   XP_007959222
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1392,066,229 - 92,089,867 (+)NCBI
Vero_WHO_p1.0NW_02366604649,360,990 - 49,384,490 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007961033   ⟹   XP_007959224
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1392,066,229 - 92,089,867 (+)NCBI
Vero_WHO_p1.0NW_02366604649,360,990 - 49,384,490 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038007937   ⟹   XP_037863865
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604649,360,990 - 49,384,490 (+)NCBI
RefSeq Acc Id: XM_038007938   ⟹   XP_037863866
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604649,361,018 - 49,384,490 (+)NCBI
RefSeq Acc Id: XM_038007939   ⟹   XP_037863867
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604649,360,990 - 49,384,490 (+)NCBI
Protein Sequences
Protein RefSeqs XP_007959222 (Get FASTA)   NCBI Sequence Viewer  
  XP_007959224 (Get FASTA)   NCBI Sequence Viewer  
  XP_037863865 (Get FASTA)   NCBI Sequence Viewer  
  XP_037863866 (Get FASTA)   NCBI Sequence Viewer  
  XP_037863867 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000013417.1
RefSeq Acc Id: XP_007959222   ⟸   XM_007961031
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RXS8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007959224   ⟸   XM_007961033
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RXS8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000013417   ⟸   ENSCSAT00000015478
RefSeq Acc Id: XP_037863865   ⟸   XM_038007937
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037863867   ⟸   XM_038007939
- Peptide Label: isoform X5
RefSeq Acc Id: XP_037863866   ⟸   XM_038007938
- Peptide Label: isoform X4


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000017388 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015478.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  Upf3 UniProtKB/TrEMBL
  UPF3_dom UniProtKB/TrEMBL
NCBI Gene UPF3A ENTREZGENE
PANTHER PTHR13112 UniProtKB/TrEMBL
  PTHR13112:SF2 UniProtKB/TrEMBL
Pfam Smg4_UPF3 UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A0D9RXS8 ENTREZGENE, UniProtKB/TrEMBL