FLRT2 (fibronectin leucine rich transmembrane protein 2) - Rat Genome Database

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Gene: FLRT2 (fibronectin leucine rich transmembrane protein 2) Chlorocebus sabaeus
Analyze
Symbol: FLRT2
Name: fibronectin leucine rich transmembrane protein 2
RGD ID: 18576071
Description: ENCODES a protein that exhibits chemorepellent activity (inferred); fibroblast growth factor receptor binding (inferred); INVOLVED IN axon guidance (ortholog); positive regulation of synapse assembly (ortholog); regulation of neuron migration (ortholog); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic membrane (ortholog); presynaptic membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leucine-rich repeat transmembrane protein FLRT2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12463,169,746 - 63,174,743 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2463,170,210 - 63,172,192 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605350,601,261 - 50,701,130 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FLRT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12463,169,746 - 63,174,743 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2463,170,210 - 63,172,192 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605350,601,261 - 50,701,130 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
FLRT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381485,530,144 - 85,654,428 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1485,530,144 - 85,654,428 (+)EnsemblGRCh38hg38GRCh38
GRCh371485,996,488 - 86,120,772 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361485,066,241 - 85,164,023 (+)NCBINCBI36Build 36hg18NCBI36
Build 341485,157,274 - 85,164,016NCBI
Celera1466,040,840 - 66,138,639 (+)NCBICelera
Cytogenetic Map14q31.3NCBI
HuRef1466,165,769 - 66,263,573 (+)NCBIHuRef
CHM1_11485,934,262 - 86,032,186 (+)NCBICHM1_1
T2T-CHM13v2.01479,742,250 - 79,868,256 (+)NCBIT2T-CHM13v2.0
Flrt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391295,658,780 - 95,751,989 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1295,659,000 - 95,751,989 (+)EnsemblGRCm39 Ensembl
GRCm381295,692,006 - 95,785,215 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1295,692,226 - 95,785,215 (+)EnsemblGRCm38mm10GRCm38
MGSCv371296,930,436 - 97,023,425 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361296,088,085 - 96,176,856 (+)NCBIMGSCv36mm8
Celera1296,935,203 - 97,028,175 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1246.44NCBI
Flrt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86120,507,998 - 120,603,133 (+)NCBIGRCr8
mRatBN7.26114,777,547 - 114,872,688 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6114,777,599 - 114,872,785 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6114,942,341 - 115,033,832 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06115,241,032 - 115,330,613 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06114,575,936 - 114,665,510 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06119,518,459 - 119,613,534 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6119,519,714 - 119,609,296 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06128,739,108 - 128,832,871 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46119,569,366 - 119,658,949 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16119,648,546 - 119,665,217 (+)NCBI
Celera6112,434,783 - 112,524,482 (+)NCBICelera
Cytogenetic Map6q31NCBI
Flrt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554388,565,319 - 8,656,186 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554388,565,319 - 8,656,195 (+)NCBIChiLan1.0ChiLan1.0
FLRT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21586,647,366 - 86,747,309 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11485,861,376 - 85,972,952 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01466,114,208 - 66,738,948 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11485,482,218 - 85,579,867 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1485,572,250 - 85,574,232 (+)Ensemblpanpan1.1panPan2
FLRT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1857,234,748 - 57,334,598 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl857,326,238 - 57,328,220 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha856,811,905 - 56,911,952 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0857,490,477 - 57,590,816 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl857,490,620 - 57,587,420 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1857,184,414 - 57,280,451 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0857,218,309 - 57,318,324 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0857,560,012 - 57,660,315 (+)NCBIUU_Cfam_GSD_1.0
Flrt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864018,611,370 - 18,696,033 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648813,373,030 - 13,457,300 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648813,372,889 - 13,457,586 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLRT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7107,812,613 - 107,913,618 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17107,812,354 - 107,913,006 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27114,356,715 - 114,364,377 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Flrt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473416,587,357 - 16,676,063 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473416,587,367 - 16,674,998 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 22 49
Low 14 11 11
Below cutoff 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000019666   ⟹   ENSCSAP00000019075
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2463,170,210 - 63,172,192 (+)Ensembl
RefSeq Acc Id: XM_037984350   ⟹   XP_037840278
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605350,601,261 - 50,701,130 (+)NCBI
RefSeq Acc Id: XM_037984351   ⟹   XP_037840279
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605350,603,686 - 50,701,130 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037840278 (Get FASTA)   NCBI Sequence Viewer  
  XP_037840279 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000019075.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000019075   ⟸   ENSCSAT00000019666
RefSeq Acc Id: XP_037840278   ⟸   XM_037984350
- UniProtKB: A0A0D9SDY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037840279   ⟸   XM_037984351
- UniProtKB: A0A0D9SDY6 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000019576 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000019666.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  LRRNT UniProtKB/TrEMBL
KEGG Report csab:103229469 UniProtKB/TrEMBL
NCBI Gene FLRT2 ENTREZGENE
PANTHER AGAP008170-PA UniProtKB/TrEMBL
  LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN FLRT2 UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  LRRNT UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
UniProt A0A0D9SDY6 ENTREZGENE, UniProtKB/TrEMBL