ADO (2-aminoethanethiol dioxygenase) - Rat Genome Database

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Pathways
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Gene: ADO (2-aminoethanethiol dioxygenase) Chlorocebus sabaeus
Analyze
Symbol: ADO
Name: 2-aminoethanethiol dioxygenase
RGD ID: 18571486
Description: ENCODES a protein that exhibits cysteamine dioxygenase activity (inferred); iron ion binding (inferred); metal ion binding (inferred); INVOLVED IN cellular response to hypoxia (inferred); PARTICIPATES IN taurine and hypotaurine metabolic pathway; ASSOCIATED WITH Autosomal Dominant Intellectual Developmental Disorder 70 (ortholog); genetic disease (ortholog); FOUND IN mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1968,483,110 - 68,486,866 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl968,485,720 - 68,486,532 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604829,367,071 - 29,371,016 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1968,483,110 - 68,486,866 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl968,485,720 - 68,486,532 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604829,367,071 - 29,371,016 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ADO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381062,804,720 - 62,808,479 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1062,804,720 - 62,808,479 (+)EnsemblGRCh38hg38GRCh38
GRCh371064,564,480 - 64,568,239 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361064,234,522 - 64,238,245 (+)NCBINCBI36Build 36hg18NCBI36
Build 341064,234,651 - 64,238,244NCBI
Celera1057,831,785 - 57,835,508 (+)NCBICelera
Cytogenetic Map10q21.3NCBI
HuRef1058,556,298 - 58,560,021 (+)NCBIHuRef
CHM1_11064,846,508 - 64,850,231 (+)NCBICHM1_1
T2T-CHM13v2.01063,662,863 - 63,666,622 (+)NCBIT2T-CHM13v2.0
Ado
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391067,380,341 - 67,384,785 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1067,380,341 - 67,384,898 (-)EnsemblGRCm39 Ensembl
GRCm381067,544,511 - 67,548,955 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1067,544,511 - 67,549,068 (-)EnsemblGRCm38mm10GRCm38
MGSCv371067,007,259 - 67,011,703 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361066,940,488 - 66,944,299 (-)NCBIMGSCv36mm8
Celera1068,635,994 - 68,640,438 (-)NCBICelera
Cytogenetic Map10B5.1NCBI
cM Map1034.96NCBI
Ado
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82021,043,694 - 21,044,862 (+)NCBIGRCr8
mRatBN7.22021,044,815 - 21,045,983 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2021,044,555 - 21,049,235 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2021,768,994 - 21,770,162 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02021,122,055 - 21,123,223 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02021,599,535 - 21,600,703 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02022,447,996 - 22,449,176 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2022,447,994 - 22,449,176 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02024,545,375 - 24,546,303 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42021,877,141 - 21,878,612 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12021,835,054 - 21,892,516 (+)NCBI
Celera2022,406,218 - 22,407,386 (+)NCBICelera
Cytogenetic Map20p11NCBI
Ado
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542516,049,284 - 16,050,096 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542516,049,194 - 16,052,275 (+)NCBIChiLan1.0ChiLan1.0
ADO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2874,987,624 - 74,994,534 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11074,996,097 - 74,999,868 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01059,312,788 - 59,316,554 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11061,641,371 - 61,644,848 (+)NCBIpanpan1.1PanPan1.1panPan2
ADO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1414,698,582 - 14,702,635 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl414,698,616 - 14,699,428 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha414,915,996 - 14,920,120 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0414,962,585 - 14,966,710 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl414,962,691 - 14,963,503 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1414,945,248 - 14,949,371 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0415,070,279 - 15,074,404 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0415,425,875 - 15,430,000 (+)NCBIUU_Cfam_GSD_1.0
Ado
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721366,391,222 - 66,394,926 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367531,965,840 - 1,969,554 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1466,277,947 - 66,278,759 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11466,277,224 - 66,281,964 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21471,509,996 - 71,514,349 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Ado
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624791965,433 - 966,245 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624791962,840 - 966,603 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 21 36
Low 15 20 24
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007963324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000018526   ⟹   ENSCSAP00000017978
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl968,485,720 - 68,486,532 (-)Ensembl
RefSeq Acc Id: XM_007963324   ⟹   XP_007961515
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1968,483,110 - 68,486,866 (-)NCBI
Vero_WHO_p1.0NW_02366604829,367,071 - 29,371,016 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007961515 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000017978
  ENSCSAP00000017978.1
Reference Protein Sequences
RefSeq Acc Id: XP_007961515   ⟸   XM_007963324
- UniProtKB: A0A0D9SAT9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000017978   ⟸   ENSCSAT00000018526


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000018436 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000018526.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/TrEMBL
InterPro PCO/ADO UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
  RmlC_Cupin_sf UniProtKB/TrEMBL
KEGG Report csab:103216129 UniProtKB/TrEMBL
NCBI Gene ADO ENTREZGENE
PANTHER 2-AMINOETHANETHIOL DIOXYGENASE UniProtKB/TrEMBL
  PTHR22966 UniProtKB/TrEMBL
Pfam PCO_ADO UniProtKB/TrEMBL
Superfamily-SCOP SSF51182 UniProtKB/TrEMBL
UniProt A0A0D9SAT9 ENTREZGENE, UniProtKB/TrEMBL