ERBB4 (erb-b2 receptor tyrosine kinase 4) - Rat Genome Database

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Pathways
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Gene: ERBB4 (erb-b2 receptor tyrosine kinase 4) Chlorocebus sabaeus
Analyze
Symbol: ERBB4
Name: erb-b2 receptor tyrosine kinase 4
RGD ID: 18555014
Description: ENCODES a protein that exhibits epidermal growth factor receptor activity (ortholog); epidermal growth factor receptor binding (ortholog); GABA receptor binding (ortholog); INVOLVED IN cardiac muscle tissue regeneration (ortholog); cell fate commitment (ortholog); cell migration (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH amblyopia (ortholog); amyotrophic lateral sclerosis (ortholog); amyotrophic lateral sclerosis type 10 (ortholog); FOUND IN basolateral plasma membrane (ortholog); caveola (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: receptor tyrosine-protein kinase erbB-4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11097,099,090 - 98,281,697 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040101,138,707 - 102,297,290 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac muscle tissue regeneration  (ISO)
cell fate commitment  (ISO)
cell migration  (ISO)
cell surface receptor protein tyrosine kinase signaling pathway  (ISO)
cell surface receptor signaling pathway  (ISO)
cell surface receptor signaling pathway via JAK-STAT  (ISO)
cellular response to acetylcholine  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to L-glutamate  (ISO)
cellular response to mechanical stimulus  (ISO)
central nervous system morphogenesis  (ISO)
embryonic pattern specification  (ISO)
ERBB2-ERBB4 signaling pathway  (ISO)
ERBB4 signaling pathway  (ISO)
ERBB4-ERBB4 signaling pathway  (ISO)
establishment of planar polarity involved in nephron morphogenesis  (ISO)
heart development  (ISO)
lactation  (ISO)
mammary gland alveolus development  (ISO)
mammary gland development  (ISO)
mammary gland epithelial cell differentiation  (ISO)
mitochondrial fragmentation involved in apoptotic process  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of muscle cell apoptotic process  (ISO)
nervous system development  (ISO)
neural crest cell migration  (ISO)
neurotransmitter receptor localization to postsynaptic specialization membrane  (ISO)
olfactory bulb interneuron differentiation  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of glucose import  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of phospholipid biosynthetic process  (ISO)
positive regulation of protein localization to cell surface  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of synaptic transmission, GABAergic  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
regulation of cell migration  (ISO)
response to hydrogen peroxide  (ISO)
response to muscle activity  (ISO)
response to nutrient levels  (ISO)
response to progesterone  (ISO)
response to vitamin D  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (ISO)
surfactant homeostasis  (ISO)
synapse assembly  (ISO)
synapse maturation  (ISO)
telencephalon development  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ERBB4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11097,099,090 - 98,281,697 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040101,138,707 - 102,297,290 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ERBB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382211,375,717 - 212,538,802 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2211,375,717 - 212,538,841 (-)EnsemblGRCh38hg38GRCh38
GRCh372212,240,442 - 213,403,526 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362211,948,687 - 213,111,597 (-)NCBINCBI36Build 36hg18NCBI36
Build 342212,072,320 - 213,228,793NCBI
Celera2206,008,419 - 207,168,130 (-)NCBICelera
Cytogenetic Map2q34NCBI
HuRef2204,087,816 - 205,252,852 (-)NCBIHuRef
CHM1_12212,246,189 - 213,409,602 (-)NCBICHM1_1
T2T-CHM13v2.02211,856,201 - 213,019,445 (-)NCBIT2T-CHM13v2.0
Erbb4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39168,071,063 - 69,147,756 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl168,071,345 - 69,147,218 (-)EnsemblGRCm39 Ensembl
GRCm38168,031,884 - 69,108,576 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl168,032,186 - 69,108,059 (-)EnsemblGRCm38mm10GRCm38
MGSCv37168,086,540 - 69,154,633 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36167,973,174 - 69,041,267 (-)NCBIMGSCv36mm8
Celera168,604,658 - 69,678,621 (-)NCBICelera
Cytogenetic Map1C3NCBI
cM Map133.8NCBI
Erbb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8976,973,386 - 78,045,633 (-)NCBIGRCr8
mRatBN7.2969,523,733 - 70,596,743 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl969,531,481 - 70,596,595 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx978,025,868 - 79,086,390 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0983,154,766 - 84,215,249 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0981,560,145 - 82,620,859 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0975,021,790 - 76,178,936 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl975,021,790 - 75,528,644 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0974,804,287 - 75,310,350 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4966,843,898 - 67,967,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1966,990,879 - 68,114,952 (-)NCBI
Celera967,006,553 - 68,064,842 (-)NCBICelera
Cytogenetic Map9q32-q33NCBI
Erbb4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554573,177,991 - 4,228,558 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554573,177,905 - 4,236,152 (+)NCBIChiLan1.0ChiLan1.0
ERBB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213113,991,295 - 115,165,716 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B114,006,258 - 115,180,343 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B98,625,630 - 99,795,371 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B217,107,266 - 218,272,621 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B217,069,644 - 218,272,006 (-)Ensemblpanpan1.1panPan2
ERBB4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13719,029,647 - 20,134,576 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3719,037,217 - 20,134,426 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3719,902,993 - 21,014,297 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03718,975,969 - 20,127,356 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3718,980,387 - 20,127,189 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13718,924,908 - 20,033,426 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03718,881,529 - 19,982,057 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03718,890,858 - 19,999,263 (-)NCBIUU_Cfam_GSD_1.0
Erbb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303167,518,016 - 168,559,414 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365864,066,498 - 5,100,035 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365864,065,767 - 5,100,690 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERBB4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15113,974,437 - 115,096,565 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115113,966,573 - 115,096,984 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215125,910,709 - 126,652,753 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Erbb4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247653,613,379 - 4,734,585 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247653,612,781 - 4,742,219 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_007966140   ⟹   XP_007964331
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11097,099,090 - 98,281,697 (-)NCBI
Vero_WHO_p1.0NW_023666040101,138,707 - 102,297,290 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007966143   ⟹   XP_007964334
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11097,099,090 - 98,281,691 (-)NCBI
Vero_WHO_p1.0NW_023666040101,138,707 - 102,297,290 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007966144   ⟹   XP_007964335
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11097,099,090 - 98,281,691 (-)NCBI
Vero_WHO_p1.0NW_023666040101,138,707 - 102,297,290 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007966145   ⟹   XP_007964336
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11097,099,090 - 98,281,691 (-)NCBI
Vero_WHO_p1.0NW_023666040101,138,707 - 102,297,290 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007964331 (Get FASTA)   NCBI Sequence Viewer  
  XP_007964334 (Get FASTA)   NCBI Sequence Viewer  
  XP_007964335 (Get FASTA)   NCBI Sequence Viewer  
  XP_007964336 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_007964331   ⟸   XM_007966140
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007964335   ⟸   XM_007966144
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007964336   ⟸   XM_007966145
- Peptide Label: isoform X4
RefSeq Acc Id: XP_007964334   ⟸   XM_007966143
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
NCBI Gene ERBB4 ENTREZGENE