ABCA5 (ATP binding cassette subfamily A member 5) - Rat Genome Database

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Gene: ABCA5 (ATP binding cassette subfamily A member 5) Chlorocebus sabaeus
Analyze
Symbol: ABCA5
Name: ATP binding cassette subfamily A member 5
RGD ID: 18540737
Description: ENCODES a protein that exhibits ABC-type transporter activity (inferred); ATP binding (inferred); ATP hydrolysis activity (inferred); INVOLVED IN cholesterol efflux (ortholog); cholesterol homeostasis (ortholog); cholesterol metabolic process (ortholog); PARTICIPATES IN transport pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Generalized Hypertrichosis Terminalis, with or without Gingival Hyperplasia (ortholog); genetic disease (ortholog); FOUND IN lysosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ATP-binding cassette sub-family A member 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11652,278,563 - 52,373,218 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1652,278,573 - 52,362,273 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607723,173,583 - 23,258,733 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
late endosome  (IEA)
lysosome  (ISO)
membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ABCA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11652,278,563 - 52,373,218 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1652,278,573 - 52,362,273 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607723,173,583 - 23,258,733 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ABCA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381769,244,311 - 69,327,133 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1769,244,311 - 69,327,244 (-)EnsemblGRCh38hg38GRCh38
GRCh371767,240,452 - 67,323,274 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361764,754,386 - 64,834,885 (-)NCBINCBI36Build 36hg18NCBI36
Build 341764,754,386 - 64,834,885NCBI
Celera1763,812,102 - 63,894,875 (-)NCBICelera
Cytogenetic Map17q24.3NCBI
HuRef1762,625,936 - 62,708,949 (-)NCBIHuRef
CHM1_11767,305,073 - 67,387,811 (-)NCBICHM1_1
T2T-CHM13v2.01770,120,918 - 70,203,761 (-)NCBIT2T-CHM13v2.0
Abca5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911110,160,195 - 110,228,542 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11110,160,195 - 110,228,542 (-)EnsemblGRCm39 Ensembl
GRCm3811110,269,369 - 110,337,723 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11110,269,369 - 110,337,716 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711110,130,683 - 110,199,030 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611110,088,340 - 110,153,765 (-)NCBIMGSCv36mm8
Celera11122,007,376 - 122,077,299 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1173.53NCBI
Abca5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81095,739,610 - 95,808,633 (-)NCBIGRCr8
mRatBN7.21095,240,159 - 95,309,195 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1095,240,154 - 95,308,976 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10100,294,252 - 100,362,644 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01099,757,272 - 99,825,665 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01095,165,548 - 95,233,940 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01098,573,226 - 98,645,028 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1098,576,039 - 98,644,938 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01098,279,926 - 98,351,693 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41099,724,778 - 99,793,593 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11099,739,147 - 99,807,963 (-)NCBI
Celera1093,891,432 - 93,960,222 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
Abca5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554783,519,368 - 3,586,811 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554783,526,376 - 3,586,811 (+)NCBIChiLan1.0ChiLan1.0
ABCA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21985,266,810 - 85,348,381 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11790,087,682 - 90,169,309 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01763,172,670 - 63,255,587 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11768,560,610 - 68,642,471 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1768,563,702 - 68,629,791 (-)Ensemblpanpan1.1panPan2
ABCA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1915,708,070 - 15,781,100 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl915,420,835 - 15,783,045 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha916,600,274 - 16,672,802 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0917,369,465 - 17,442,894 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl917,369,925 - 17,442,845 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1916,313,793 - 16,386,862 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0911,147,500 - 11,219,940 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0911,146,365 - 11,219,543 (+)NCBIUU_Cfam_GSD_1.0
Abca5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560210,632,645 - 10,730,283 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365418,463,436 - 8,539,942 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365418,467,035 - 8,549,893 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1211,067,500 - 11,152,688 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11211,018,692 - 11,152,916 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21211,331,441 - 11,338,746 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Abca5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248704,153,594 - 4,218,132 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248704,150,287 - 4,224,448 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 6 33
Low 30 20 27
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000002404   ⟹   ENSCSAP00000000717
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1652,278,573 - 52,362,273 (+)Ensembl
RefSeq Acc Id: XM_008011976   ⟹   XP_008010167
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11652,278,563 - 52,357,758 (+)NCBI
Vero_WHO_p1.0NW_02366607723,173,588 - 23,258,733 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037993241   ⟹   XP_037849169
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607723,173,587 - 23,258,733 (+)NCBI
RefSeq Acc Id: XM_037993242   ⟹   XP_037849170
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607723,173,588 - 23,258,733 (+)NCBI
RefSeq Acc Id: XR_005238724
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607723,173,583 - 23,255,234 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008010167 (Get FASTA)   NCBI Sequence Viewer  
  XP_037849169 (Get FASTA)   NCBI Sequence Viewer  
  XP_037849170 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000000717.1
Reference Protein Sequences
RefSeq Acc Id: XP_008010167   ⟸   XM_008011976
- Peptide Label: isoform X2
- UniProtKB: A0A0D9QWH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000000717   ⟸   ENSCSAT00000002404
RefSeq Acc Id: XP_037849169   ⟸   XM_037993241
- Peptide Label: isoform X1
- UniProtKB: A0A0D9QWH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037849170   ⟸   XM_037993242
- Peptide Label: isoform X2
- UniProtKB: A0A0D9QWH8 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000004374 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000002404.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  ABC2_TM UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/TrEMBL
  ABCA UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene ABCA5 ENTREZGENE
PANTHER PTHR19229 UniProtKB/TrEMBL
  PTHR19229:SF100 UniProtKB/TrEMBL
Pfam ABC2_membrane_3 UniProtKB/TrEMBL
  ABC_tran UniProtKB/TrEMBL
PROSITE ABC_TRANSPORTER_1 UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0D9QWH8 ENTREZGENE, UniProtKB/TrEMBL