TTK (TTK protein kinase) - Rat Genome Database

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Gene: TTK (TTK protein kinase) Chlorocebus sabaeus
Analyze
Symbol: TTK
Name: TTK protein kinase
RGD ID: 18540174
Description: ENCODES a protein that exhibits ATP binding (inferred); identical protein binding (inferred); kinase activity (inferred); INVOLVED IN peptidyl-serine phosphorylation (ortholog); peptidyl-threonine phosphorylation (ortholog); peptidyl-tyrosine phosphorylation (ortholog); ASSOCIATED WITH COVID-19 (ortholog); hepatocellular carcinoma (ortholog); maple syrup urine disease (ortholog); FOUND IN cytoplasm (inferred); kinetochore (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dual specificity protein kinase TTK
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1134,738,849 - 4,779,563 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl134,738,959 - 4,780,627 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040180,959,238 - 181,026,938 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
kinetochore  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TTK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1134,738,849 - 4,779,563 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl134,738,959 - 4,780,627 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040180,959,238 - 181,026,938 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TTK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38680,004,649 - 80,042,527 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl680,003,887 - 80,042,527 (+)EnsemblGRCh38hg38GRCh38
GRCh37680,714,366 - 80,752,244 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36680,771,078 - 80,808,958 (+)NCBINCBI36Build 36hg18NCBI36
Build 34680,771,077 - 80,808,956NCBI
Celera681,132,293 - 81,170,226 (+)NCBICelera
Cytogenetic Map6q14.1NCBI
HuRef677,937,044 - 77,974,979 (+)NCBIHuRef
CHM1_1680,811,776 - 80,849,705 (+)NCBICHM1_1
T2T-CHM13v2.0681,213,044 - 81,250,924 (+)NCBIT2T-CHM13v2.0
Ttk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39983,716,704 - 83,754,442 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl983,716,742 - 83,754,442 (+)EnsemblGRCm39 Ensembl
GRCm38983,834,651 - 83,872,390 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl983,834,689 - 83,872,389 (+)EnsemblGRCm38mm10GRCm38
MGSCv37983,728,296 - 83,765,997 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36983,631,459 - 83,669,102 (+)NCBIMGSCv36mm8
Celera980,934,680 - 80,972,688 (+)NCBICelera
Cytogenetic Map9E2NCBI
cM Map945.61NCBI
Ttk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8893,632,678 - 93,672,664 (+)NCBIGRCr8
mRatBN7.2884,754,329 - 84,792,653 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl884,754,315 - 84,792,651 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx890,359,283 - 90,404,092 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0888,583,852 - 88,622,109 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0886,456,985 - 86,494,976 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0891,368,065 - 91,405,995 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl891,368,111 - 91,405,993 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0890,886,724 - 90,924,327 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4888,906,665 - 88,944,613 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera884,402,963 - 84,441,218 (+)NCBICelera
Cytogenetic Map8q31NCBI
Ttk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555027,824,194 - 7,866,879 (+)NCBIChiLan1.0ChiLan1.0
TTK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25100,089,805 - 100,129,839 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1697,969,110 - 98,010,196 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0677,887,382 - 77,925,737 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1681,158,143 - 81,196,478 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl681,158,143 - 81,196,478 (+)Ensemblpanpan1.1panPan2
TTK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11240,915,733 - 40,959,423 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1240,915,439 - 40,957,279 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1240,787,409 - 40,829,802 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01241,678,975 - 41,721,444 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1241,679,025 - 41,720,658 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11240,992,362 - 41,034,814 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01240,969,244 - 41,011,626 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01241,120,015 - 41,162,453 (+)NCBIUU_Cfam_GSD_1.0
Ttk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494676,256,203 - 76,303,738 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493651010,176,968 - 10,213,483 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,076,583 - 86,125,718 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,076,576 - 86,125,334 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2196,781,685 - 96,828,277 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Ttk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248196,631,697 - 6,682,181 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TTK
921 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000015507   ⟹   ENSCSAP00000013446
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl134,738,959 - 4,780,627 (+)Ensembl
RefSeq Acc Id: XM_038002189   ⟹   XP_037858117
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666040180,959,238 - 180,999,201 (+)NCBI
RefSeq Acc Id: XM_038002190   ⟹   XP_037858118
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666040180,959,238 - 180,998,843 (+)NCBI
RefSeq Acc Id: XM_038002191   ⟹   XP_037858119
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666040180,959,238 - 180,999,201 (+)NCBI
RefSeq Acc Id: XM_038002192   ⟹   XP_037858120
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666040180,959,238 - 180,999,201 (+)NCBI
RefSeq Acc Id: XM_038002193   ⟹   XP_037858121
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666040180,959,238 - 181,026,938 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037858117 (Get FASTA)   NCBI Sequence Viewer  
  XP_037858118 (Get FASTA)   NCBI Sequence Viewer  
  XP_037858119 (Get FASTA)   NCBI Sequence Viewer  
  XP_037858120 (Get FASTA)   NCBI Sequence Viewer  
  XP_037858121 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000013446.1
Ensembl Acc Id: ENSCSAP00000013446   ⟸   ENSCSAT00000015507
RefSeq Acc Id: XP_037858121   ⟸   XM_038002193
- Peptide Label: isoform X4
- UniProtKB: A0A0D9RXV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037858117   ⟸   XM_038002189
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RXV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037858120   ⟸   XM_038002192
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RXV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037858119   ⟸   XM_038002191
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RXV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037858118   ⟸   XM_038002190
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RXV7 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000017414 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015507.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kin_Mps1_fam UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/TrEMBL
KEGG Report csab:103239980 UniProtKB/TrEMBL
NCBI Gene TTK ENTREZGENE
PANTHER MIXED LINEAGE PROTEIN KINASE UniProtKB/TrEMBL
  PTHR22974:SF21 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9RXV7 ENTREZGENE, UniProtKB/TrEMBL