FRRS1L (ferric chelate reductase 1 like)

Gene: FRRS1L (ferric chelate reductase 1 like) Chlorocebus sabaeus

Analyze

Symbol:

FRRS1L

Name:

ferric chelate reductase 1 like

RGD ID:

18537230

Description:

ENCODES a protein that exhibits dynein intermediate chain binding (inferred); protein-containing complex binding (inferred); INVOLVED IN regulation of AMPA glutamate receptor clustering (ortholog); regulation of synaptic transmission, glutamatergic (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 37 (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); postsynapse (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DOMON domain-containing protein FRRS1L

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	30,385,877 - 30,416,302 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	30,385,878 - 30,416,088 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666035	12,268,035 - 12,298,514 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

developmental and epileptic encephalopathy 37 (ISO)

epilepsy (ISO)

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

regulation of AMPA glutamate receptor clustering (IEA,ISO)

regulation of glutamate receptor signaling pathway (IEA)

regulation of postsynaptic membrane neurotransmitter receptor levels (IEA)

regulation of synaptic transmission, glutamatergic (IEA,ISO)

Cellular Component

endoplasmic reticulum membrane (ISO)

membrane (IEA)

postsynapse (ISO)

Molecular Function

dynein intermediate chain binding (IEA)

protein-containing complex binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

FRRS1L
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	30,385,877 - 30,416,302 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	30,385,878 - 30,416,088 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666035	12,268,035 - 12,298,514 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

FRRS1L
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	109,130,293 - 109,167,249 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	109,130,293 - 109,167,249 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	111,892,573 - 111,929,529 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	110,939,402 - 110,969,392 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	9	82,398,790 - 82,428,780 (-)	NCBI		Celera
Cytogenetic Map	9	q31.3	NCBI
HuRef	9	81,499,489 - 81,529,700 (-)	NCBI		HuRef
CHM1_1	9	112,046,053 - 112,076,070 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	121,299,358 - 121,336,331 (-)	NCBI		T2T-CHM13v2.0

Frrs1l
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	56,957,173 - 56,990,408 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	56,957,173 - 56,990,391 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	56,960,136 - 56,990,391 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	56,957,173 - 56,990,391 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	56,973,008 - 57,003,263 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	57,056,871 - 57,084,564 (-)	NCBI		MGSCv36	mm8
Celera	4	56,869,139 - 56,900,419 (-)	NCBI		Celera
Cytogenetic Map	4	B3	NCBI
cM Map	4	31.66	NCBI

Frrs1l
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	76,451,101 - 76,485,319 (-)	NCBI		GRCr8
mRatBN7.2	5	71,655,911 - 71,690,132 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	71,659,284 - 71,690,108 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	5	73,997,958 - 74,029,381 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	74,000,227 - 74,029,238 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	78,152,377 - 78,183,855 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	74,866,398 - 74,896,487 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	74,871,510 - 74,954,497 (-)	NCBI
Celera	5	70,513,180 - 70,544,038 (-)	NCBI		Celera
Cytogenetic Map	5	q24	NCBI

Frrs1l
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	17,825,868 - 17,848,868 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955419	17,825,868 - 17,848,868 (+)	NCBI	ChiLan1.0	ChiLan1.0

FRRS1L
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	30,240,491 - 30,277,394 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	30,242,858 - 30,279,759 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	80,283,385 - 80,320,293 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	108,462,269 - 108,491,968 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

FRRS1L
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	64,281,466 - 64,298,319 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	64,281,892 - 64,292,418 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	62,682,468 - 62,706,912 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	65,415,181 - 65,439,701 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	65,409,937 - 65,439,686 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	63,934,536 - 63,958,849 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	63,956,494 - 63,981,023 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	64,647,321 - 64,671,674 (-)	NCBI		UU_Cfam_GSD_1.0

Frrs1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	179,514,818 - 179,543,255 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936559	3,722,890 - 3,750,919 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936559	3,723,325 - 3,753,209 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FRRS1L
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	250,194,230 - 250,220,716 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	250,187,568 - 250,220,716 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	280,723,135 - 280,750,355 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Frrs1l
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	2,365,096 - 2,387,735 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624758	2,365,246 - 2,392,699 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	5		45
Low	31	15	15
Below cutoff		3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007968477	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007968478	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037983375	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000009673 ⟹ ENSCSAP00000007783

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	12	30,385,878 - 30,416,088 (+)	Ensembl

RefSeq Acc Id:

XM_007968477 ⟹ XP_007966668

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	12	30,385,877 - 30,416,302 (+)	NCBI
Vero_WHO_p1.0	NW_023666035	12,268,035 - 12,298,514 (-)	NCBI

Sequence:

show sequence

GATGCGCAGACCGAGACAGGGAGGCGGGGGTGCGGGAGGCTCCGCGGCTGCGCGGGCGCGTGCT
GGTGGCCTCAGCGGCGGCTCAGTCCCGGCCCGCGCCCGCGGCGCCCCAGCTGCGGCCCGAGCGG
CCTGGCTGCGGGATCTGTGCGCAGCGATGGCGCGGCCGCTCCGGCAGCACCCGAGGGTCTGGAC
GCCGCTGCTCCTGCTGTTGCTGACGGGACCCGCCGCCTGCGCAGCCAGCCCAGCGGACGACGGT
GCGGGCCCGGGGGGCCGGGGACCCCGGGGCCGCGCGCGGGGGGACACGGGCGCCGATGAGGCGG
TGCAGCGCCACGACTCCTCCTATGGCACCTTTGCGGGGGAGTTCTACGACCTGCGCTACCTGTC
GGAGGAGGGTTACCCCTTCCCTACTGCTCCTCCTGTGGATCCATTTGCCAAAATCAAAGTGGAC
GACTGTGGAAAAACTAAGGGATGCTTTAGATATGGCAAACCAGGCTGTAATGCAGAGACCTGTG
ACTACTTCCTCAGCTACCGGATGATAGGGGCTGATGTAGAATTTGAGCTGAGTGCAGACACAGA
TGGTTGGGTAGCAGTTGGATTCTCTTCAGACAAGAAAATGGGTGGTGATGATGTCATGGCCTGC
GTCCATGATGACAATGGCAGGGTCCGCATACAGCACTTCTATAATGTAGGCCAGTGGGCAAAGG
AGATTCAGAGAAACCCTGCCAGAGATGAAGAAGGAGTTTTTGAGAATAATCGCGTCACCTGCAG
ATTTAAACGCCCTGTGAATGTTCCCAGAGATGAAACAATTGTTGATCTGCATTTGAGTTGGTAT
TATCTGTTTGCTTGGGGTCCAGCCATTCAGGGCTCTATCACTCGACATGATATAGACTCACCAC
CAGCTTCAGAGCGTGTTGTCAGTATTTACAAGTATGAAGACATTTTTATGCCATCAGCTGCCTA
TCAAACCTTCTCATCTCCATTTTGTTTGCTTCTGATTGTTGCTCTGACCTTCTACCTATTGATG
GGAACCCCCTAACCACAACTGCAGGGCCAACAGATTACATGGATTGGGAAGTCTTTAGTATAAA
TATATTTTTAAAGAATATCCAGTATAATTTTAGCTTCAATTATTTAAGAAAACAAACCCTCATA
TAATTTCAGCTTTTTGGAAGAAAGAACAAGCTTCTTTTCTAGTCAAAGAAGATTGTTTAATAAT
GACCCTATACTTTTGGAATGTACTTACACCTTTT

hide sequence

RefSeq Acc Id:

XM_007968478 ⟹ XP_007966669

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	12	30,385,878 - 30,416,302 (+)	NCBI
Vero_WHO_p1.0	NW_023666035	12,268,035 - 12,298,469 (-)	NCBI

Sequence:

show sequence

ATGCGCAGACCGAGACAGGGAGGCGGGGGTGCGGGAGGCTCCGCGGCTGCGCGGGCGCGTGCTG
GTGGCCTCAGCGGCGGCTCAGTCCCGGCCCGCGCCCGCGGCGCCCCAGCTGCGGCCCGAGCGGC
CTGGCTGCGGGATCTGTGCGCAGCGATGGCGCGGCCGCTCCGGCAGCACCCGAGGGTCTGGACG
CCGCTGCTCCTGCTGTTGCTGACGGGACCCGCCGCCTGCGCAGCCAGCCCAGCGGACGACGGTT
ACCCCTTCCCTACTGCTCCTCCTGTGGATCCATTTGCCAAAATCAAAGTGGACGACTGTGGAAA
AACTAAGGGATGCTTTAGATATGGCAAACCAGGCTGTAATGCAGAGACCTGTGACTACTTCCTC
AGCTACCGGATGATAGGGGCTGATGTAGAATTTGAGCTGAGTGCAGACACAGATGGTTGGGTAG
CAGTTGGATTCTCTTCAGACAAGAAAATGGGTGGTGATGATGTCATGGCCTGCGTCCATGATGA
CAATGGCAGGGTCCGCATACAGCACTTCTATAATGTAGGCCAGTGGGCAAAGGAGATTCAGAGA
AACCCTGCCAGAGATGAAGAAGGAGTTTTTGAGAATAATCGCGTCACCTGCAGATTTAAACGCC
CTGTGAATGTTCCCAGAGATGAAACAATTGTTGATCTGCATTTGAGTTGGTATTATCTGTTTGC
TTGGGGTCCAGCCATTCAGGGCTCTATCACTCGACATGATATAGACTCACCACCAGCTTCAGAG
CGTGTTGTCAGTATTTACAAGTATGAAGACATTTTTATGCCATCAGCTGCCTATCAAACCTTCT
CATCTCCATTTTGTTTGCTTCTGATTGTTGCTCTGACCTTCTACCTATTGATGGGAACCCCCTA
ACCACAACTGCAGGGCCAACAGATTACATGGATTGGGAAGTCTTTAGTATAAATATATTTTTAA
AGAATATCCAGTATAATTTTAGCTTCAATTATTTAAGAAAACAAACCCTCATATAATTTCAGCT
TTTTGGAAGAAAGAACAAGCTTCTTTTCTAGTCAAAGAAGATTGTTTAATAATGACCCTATACT
TTTGGAATGTACTTACACCTTTT

hide sequence

RefSeq Acc Id:

XM_037983375 ⟹ XP_037839303

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666035	12,268,035 - 12,298,484 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_007966668	(Get FASTA)	NCBI Sequence Viewer
	XP_007966669	(Get FASTA)	NCBI Sequence Viewer
	XP_037839303	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000007783.1

RefSeq Acc Id:	XP_007966668 ⟸ XM_007968477
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9RGP4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_007966669 ⟸ XM_007968478
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSCSAP00000007783 ⟸ ENSCSAT00000009673

RefSeq Acc Id:	XP_037839303 ⟸ XM_037983375
- Peptide Label:	isoform X3

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000011596	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000009673.1	UniProtKB/TrEMBL
InterPro	DOMON_domain	UniProtKB/TrEMBL
	FRRS1L	UniProtKB/TrEMBL
KEGG Report	csab:103219036	UniProtKB/TrEMBL
NCBI Gene	FRRS1L	ENTREZGENE
PANTHER	DOMON DOMAIN-CONTAINING PROTEIN FRRS1L	UniProtKB/TrEMBL
	PTHR46902	UniProtKB/TrEMBL
Pfam	DOMON	UniProtKB/TrEMBL
PROSITE	DOMON	UniProtKB/TrEMBL
SMART	DoH	UniProtKB/TrEMBL
UniProt	A0A0D9RGP4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM