SAFB (scaffold attachment factor B) - Rat Genome Database

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Gene: SAFB (scaffold attachment factor B) Chlorocebus sabaeus
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Symbol: SAFB
Name: scaffold attachment factor B
RGD ID: 18528074
Description: ENCODES a protein that exhibits chromatin binding (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN hormone metabolic process (ortholog); intracellular estrogen receptor signaling pathway (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN midbody (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: scaffold attachment factor B1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.165,281,171 - 5,326,049 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl65,281,232 - 5,328,511 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660812,779,415 - 2,824,606 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
midbody  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SAFB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.165,281,171 - 5,326,049 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl65,281,232 - 5,328,511 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660812,779,415 - 2,824,606 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SAFB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38195,623,083 - 5,668,478 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl195,623,035 - 5,668,478 (+)EnsemblGRCh38hg38GRCh38
GRCh37195,623,094 - 5,668,489 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36195,574,164 - 5,619,489 (+)NCBINCBI36Build 36hg18NCBI36
Build 34195,574,163 - 5,619,488NCBI
Celera195,560,521 - 5,605,843 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef195,384,164 - 5,429,603 (+)NCBIHuRef
CHM1_1195,622,638 - 5,668,071 (+)NCBICHM1_1
T2T-CHM13v2.0195,609,766 - 5,655,162 (+)NCBIT2T-CHM13v2.0
Safb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391756,891,982 - 56,913,294 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1756,891,825 - 56,913,294 (+)EnsemblGRCm39 Ensembl
GRCm381756,584,982 - 56,606,294 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,584,825 - 56,606,294 (+)EnsemblGRCm38mm10GRCm38
MGSCv371756,724,405 - 56,745,717 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,269,818 - 56,291,413 (+)NCBIMGSCv36mm8
Celera1760,929,194 - 60,950,493 (+)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.4NCBI
Safb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,504,657 - 1,525,545 (+)NCBIGRCr8
mRatBN7.291,417,449 - 1,438,408 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,417,525 - 1,438,644 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx91,850,960 - 1,871,831 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,201,129 - 7,222,017 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,156,164 - 6,177,036 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,450,216 - 10,471,174 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,450,205 - 10,471,176 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,447,161 - 9,468,030 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera97,075,428 - 7,096,066 (-)NCBICelera
Cytogenetic Map9q11NCBI
Safb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554953,743,858 - 3,774,913 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554953,743,673 - 3,775,073 (-)NCBIChiLan1.0ChiLan1.0
SAFB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22010,019,474 - 10,064,975 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1199,245,664 - 9,291,164 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0194,640,267 - 4,685,643 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1195,575,592 - 5,620,513 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl195,575,592 - 5,620,513 (+)Ensemblpanpan1.1panPan2
SAFB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12054,346,273 - 54,381,078 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2054,346,353 - 54,381,363 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2054,072,813 - 54,107,740 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02055,001,804 - 55,036,977 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2055,001,804 - 55,037,252 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12054,064,174 - 54,099,109 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02054,544,742 - 54,579,637 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,741,968 - 54,777,221 (-)NCBIUU_Cfam_GSD_1.0
Safb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,581,094 - 214,610,314 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365883,225,752 - 3,253,678 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365883,225,315 - 3,253,689 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SAFB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl273,300,632 - 73,334,494 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1273,300,624 - 73,334,494 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2273,822,604 - 73,905,016 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Safb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248284,525,536 - 4,557,715 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248284,526,708 - 4,557,458 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 10 60
Low 10
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000008033   ⟹   ENSCSAP00000006191
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl65,281,232 - 5,328,511 (+)Ensembl
RefSeq Acc Id: XM_007994927   ⟹   XP_007993118
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.165,281,171 - 5,326,049 (+)NCBI
Vero_WHO_p1.0NW_0236660812,779,415 - 2,824,606 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007994928   ⟹   XP_007993119
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.165,281,171 - 5,326,049 (+)NCBI
Vero_WHO_p1.0NW_0236660812,779,415 - 2,824,606 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007994929   ⟹   XP_007993120
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.165,281,171 - 5,326,049 (+)NCBI
Vero_WHO_p1.0NW_0236660812,779,415 - 2,824,606 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007994930   ⟹   XP_007993121
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.165,281,219 - 5,326,049 (+)NCBI
Vero_WHO_p1.0NW_0236660812,779,415 - 2,824,606 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037994581   ⟹   XP_037850509
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660812,779,415 - 2,821,229 (-)NCBI
RefSeq Acc Id: XP_007993118   ⟸   XM_007994927
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007993120   ⟸   XM_007994929
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007993119   ⟸   XM_007994928
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RC52 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007993121   ⟸   XM_007994930
- Peptide Label: isoform X4
RefSeq Acc Id: ENSCSAP00000006191   ⟸   ENSCSAT00000008033
RefSeq Acc Id: XP_037850509   ⟸   XM_037994581
- Peptide Label: isoform X5


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000009949 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008033.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.720.30 UniProtKB/TrEMBL
  3.30.70.330 UniProtKB/TrEMBL
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
  SAFB1 UniProtKB/TrEMBL
  SAP_dom UniProtKB/TrEMBL
  SAP_dom_sf UniProtKB/TrEMBL
NCBI Gene SAFB ENTREZGENE
PANTHER PTHR15683:SF6 UniProtKB/TrEMBL
  SCAFFOLD ATTACHMENT FACTOR B-RELATED UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/TrEMBL
  SAP UniProtKB/TrEMBL
PROSITE RRM UniProtKB/TrEMBL
  SAP UniProtKB/TrEMBL
SMART RRM UniProtKB/TrEMBL
  SAP UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
  SSF68906 UniProtKB/TrEMBL
UniProt A0A0D9RC52 ENTREZGENE, UniProtKB/TrEMBL