THOC3 (THO complex 3) - Rat Genome Database

Name: THOC3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: THOC3 (THO complex 3) Chlorocebus sabaeus

Analyze

Symbol:

THOC3

Name:

THO complex 3 (Ensembl:THO complex subunit 3)

RGD ID:

18523646

Description:

INVOLVED IN mRNA export from nucleus (inferred); ASSOCIATED WITH Ehlers-Danlos syndrome dermatosparaxis type (ortholog); genetic disease (ortholog); Sotos syndrome (ortholog); FOUND IN chromosome, telomeric region (inferred); THO complex part of transcription export complex (inferred); transcription export complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

THO complex subunit 3

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	THOC3 (THO complex subunit 3)	NCBI	Ortholog
Mus musculus (house mouse):	Thoc3 (THO complex 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Thoc3 (THO complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Thoc3 (THO complex 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	THOC3 (THO complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	THOC3 (THO complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Thoc3 (THO complex 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	THOC3 (THO complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Thoc3 (THO complex 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	78,106,835 - 78,115,342 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	78,106,635 - 78,115,269 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	473,479 - 482,230 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Ehlers-Danlos syndrome dermatosparaxis type (ISO)

genetic disease (ISO)

Sotos syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mRNA export from nucleus (IEA)

Cellular Component

chromosome, telomeric region (IEA)

THO complex part of transcription export complex (IEA)

transcription export complex (IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

THOC3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	78,106,835 - 78,115,342 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	78,106,635 - 78,115,269 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	473,479 - 482,230 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

THOC3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	175,959,531 - 175,968,315 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	175,917,873 - 176,034,680 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	175,386,534 - 175,395,318 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	175,319,140 - 175,328,151 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	177,235,132 - 177,243,873	NCBI
Celera	5	122,313,128 - 122,314,601 (+)	NCBI		Celera
Cytogenetic Map	5	q35.2	NCBI
HuRef	5	172,063,942 - 172,065,852 (+)	NCBI		HuRef
CHM1_1	5	174,819,332 - 174,828,116 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	176,503,198 - 176,512,029 (-)	NCBI		T2T-CHM13v2.0

Thoc3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	54,606,650 - 54,616,653 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	54,606,650 - 54,616,662 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	54,458,837 - 54,468,840 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	54,458,837 - 54,468,849 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	54,560,198 - 54,570,201 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	54,469,140 - 54,478,441 (-)	NCBI		MGSCv36	mm8
Celera	13	55,524,317 - 55,534,319 (-)	NCBI		Celera
Cytogenetic Map	13	B1	NCBI
cM Map	13	28.69	NCBI

Thoc3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	10,148,281 - 10,157,472 (+)	NCBI		GRCr8
mRatBN7.2	17	10,143,184 - 10,152,375 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	10,143,139 - 10,152,370 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	10,157,081 - 10,166,261 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	11,690,656 - 11,699,832 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	10,153,524 - 10,162,704 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	10,676,943 - 10,686,134 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	10,676,943 - 10,686,134 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	12,803,773 - 12,812,964 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	16,233,851 - 16,243,042 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	16,217,971 - 16,242,379 (+)	NCBI
Celera	17	10,215,590 - 10,224,767 (+)	NCBI		Celera
Cytogenetic Map	17	p14	NCBI

Thoc3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	28,467,540 - 28,480,613 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	28,467,540 - 28,480,613 (-)	NCBI	ChiLan1.0	ChiLan1.0

THOC3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	171,048,030 - 171,101,061 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	169,187,568 - 169,240,599 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	171,310,321 - 171,319,192 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	178,205,744 - 178,214,684 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	178,205,744 - 178,214,684 (-)	Ensembl	panpan1.1		panPan2

THOC3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	37,130,944 - 37,151,479 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	37,057,940 - 37,199,448 (+)	NCBI	CanFam3.1		canFam3	CanFam3.1
CanFam3.1 Ensembl	4	37,057,940 - 37,199,448 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	4	37,497,845 - 37,518,160 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	37,425,038 - 37,666,348 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	37,323,077 - 37,343,388 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	37,511,047 - 37,531,365 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	38,020,440 - 38,040,769 (+)	NCBI		UU_Cfam_GSD_1.0

Thoc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	121,399,735 - 121,411,954 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936597	433,865 - 436,852 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

THOC3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	81,658,788 - 81,670,127 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	81,658,736 - 81,670,996 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	83,306,568 - 83,318,259 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Thoc3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	14,005,501 - 14,023,617 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	14,005,563 - 14,022,516 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	36	7	40
Low		13	20
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008015357	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000007532 ⟹ ENSCSAP00000005705

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	23	78,106,635 - 78,115,269 (-)	Ensembl

RefSeq Acc Id:

XM_008015357 ⟹ XP_008013548

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	23	78,106,835 - 78,115,342 (-)	NCBI
Vero_WHO_p1.0	NW_023666034	473,479 - 482,230 (+)	NCBI

Sequence:

show sequence

AGCCGTCGCTCTTCCGGGCGCATGCGTGCGGCAGCGGCGCCAGGACTGATTGCACCCTTGCGGC
TGCTGGCGTGTTGTGAGCTGGGAGTTCGGCATGGCGGTGCCCCCTGCAGCCATGGGGCCCTCGG
CATTGGGCCAGAGCGGCCCCGGCTCGATGGCCCCGTGGTGCTCAGTGAGCAGCGGCCCGTCGCG
CTACGTGCTTGGGATGCAGGAGCTGTTCCGGGGCCACAGCAAGACACGCGAGTTCCTGGCTCAC
AGCGCCAAGGTGCACTCGGTGGCCTGGAGTTGCGACGGGCGTCGCCTAGCCTCGGGGTCCTTCG
ACAAGACGGCCAGTGTCTTCTTGCTGGAGAAGGACCGGTTGGTCAAGGAAAACAATTATCGGGG
ACATGGGGATAGTGTGGACCAGCTTTGTTGGCATCCAAGTAATCCTGACCTATTCGTTACCGCG
TCCGGAGATAAAACCATTCGCATCTGGGATGTCAGGACTACAAAATGCATTGCCACTGTGAACA
CTAAAGGGGAGAACATTAATATCTGCTGGAGTCCTGATGGGCAGACCATTGCTGTAGGCAACAA
AGATGATGTGGTGACCTTTATTGATGCCAAGACACACCGTTCCAAAGCAGAAGAGCAGTTCAAG
TTCGAGGTCAACGAAATCTCCTGGAACAATGACAACAACATGTTCTTCCTGACAAATGGCAATG
GTTGTATCAACATCCTCAGCTACCCAGAATTGAAGCCTGTGCAGTCCATCAACGCCCATCCTTC
CAACTGCATCTGTATCAAGTTTGACCCAATGGGGAAGTACTTTGCCACAGGAAGTGCAGATGCT
TTGGTTAGCCTCTGGGATGTGGATGAGTTAGTGTGTGTTCGGTGCTTTTCCAGGCTGGATTGGC
CTGTAAGGACCCTCAGTTTCAGCCATGATGGGAAAATGCTGGCATCAGCATCAGAAGACCATTT
TATTGACATTGCTGAAGTGGAGACAGGGGACAAACTATGGGAGGTACAGTGTGAGTCTCCGACC
TTCACAGTGGCGTGGCACCCCAAAAGGCCTCTGCTGGCATTTGCCTGTGATGACAAAGACGGCA
AATATGACAGCAGCCGGGAAGCCGGAACTGTGAAGCTCTTTGGGCTTCCTAATGATTCTTGAGA
GGAGATTATAGGGAGAGGAGGCCCTGGCAGAGGTCTTCCTTCATGTGGTTAGTTTGGTTTGTTC
TCTTGGAGTTGGTGGGCACCCTAAATATTTGTAAATTGGTATAAATTGTAAATGTCTATGGTCA
GGCTGCCCATTCCAGTTCTTCTGCTTTTTCTGTGTATTAGCTCTTTCCATTCTTTGCCCCCAGT
GTGAGTTAACTCGTGTGGACTCTGCAGTGTAGGTAGTGACCCCAGCATACCTTGTCCTCTGGAC
CTCCTGTCTTCTCTGCTTTTGGGTACATGGTAGACTTTGTGGCGTTTGATACAACTTGGACAAT
ACTTAGTTTGGAGGGAGGGGAATGGAAAGGTATGGAAAATTTTTTAAATAATTAAAAATATATA
TATATAATTTTGAGAATTGAGCATTTAATAAACTGACTTTTTTTATTATGGCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008013548	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000005705
	ENSCSAP00000005705.1

RefSeq Acc Id:	XP_008013548 ⟸ XM_008015357
- UniProtKB:	A0A0D9RAR6 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000005705 ⟸ ENSCSAT00000007532

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000009454	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000007532.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	Apc4_WD40_dom	UniProtKB/TrEMBL
	G-protein_beta_WD-40_rep	UniProtKB/TrEMBL
	PD40	UniProtKB/TrEMBL
	Tex1/THOC3	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
KEGG Report	csab:103245021	UniProtKB/TrEMBL
NCBI Gene	THOC3	ENTREZGENE
PANTHER	PTHR22839	UniProtKB/TrEMBL
	THO COMPLEX SUBUNIT 3	UniProtKB/TrEMBL
Pfam	ANAPC4_WD40	UniProtKB/TrEMBL
	PD40	UniProtKB/TrEMBL
	WD40	UniProtKB/TrEMBL
PRINTS	GPROTEINBRPT	UniProtKB/TrEMBL
PROSITE	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50978	UniProtKB/TrEMBL
UniProt	A0A0D9RAR6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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