LZTS3 (leucine zipper tumor suppressor family member 3) - Rat Genome Database

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Gene: LZTS3 (leucine zipper tumor suppressor family member 3) Chlorocebus sabaeus
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Symbol: LZTS3
Name: leucine zipper tumor suppressor family member 3
RGD ID: 18504354
Description: ENCODES a protein that exhibits obsolete protein self-association (ortholog); PDZ domain binding (ortholog); INVOLVED IN protein homooligomerization (ortholog); regulation of postsynapse assembly (ortholog); ASSOCIATED WITH Huntington's disease-like 1 (ortholog); Inosine Triphosphatase Deficiency (ortholog); pantothenate kinase-associated neurodegeneration (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog); synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leucine zipper putative tumor suppressor 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1233,835,361 - 33,845,948 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl233,835,012 - 33,839,895 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607110,667,679 - 10,679,140 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
LZTS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1233,835,361 - 33,845,948 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl233,835,012 - 33,839,895 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607110,667,679 - 10,679,140 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LZTS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38203,162,617 - 3,173,549 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl203,162,617 - 3,173,549 (-)EnsemblGRCh38hg38GRCh38
GRCh37203,143,263 - 3,154,195 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,091,273 - 3,097,207 (-)NCBINCBI36Build 36hg18NCBI36
Build 34203,091,272 - 3,097,207NCBI
Celera203,205,231 - 3,211,165 (-)NCBICelera
Cytogenetic Map20p13NCBI
HuRef203,091,031 - 3,097,003 (-)NCBIHuRef
CHM1_1203,143,306 - 3,149,240 (-)NCBICHM1_1
T2T-CHM13v2.0203,193,522 - 3,204,462 (-)NCBIT2T-CHM13v2.0
Lzts3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392130,474,685 - 130,484,764 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2130,474,759 - 130,484,723 (-)EnsemblGRCm39 Ensembl
GRCm382130,632,765 - 130,642,866 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2130,632,839 - 130,642,803 (-)EnsemblGRCm38mm10GRCm38
MGSCv372130,458,575 - 130,468,539 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362130,324,213 - 130,334,285 (-)NCBIMGSCv36mm8
Celera2131,857,390 - 131,867,607 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.24NCBI
Lzts3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83138,303,378 - 138,313,645 (-)NCBIGRCr8
mRatBN7.23117,850,286 - 117,861,132 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3117,851,702 - 117,860,081 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3121,744,582 - 121,754,799 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03130,342,131 - 130,352,346 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03128,000,716 - 128,010,934 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03123,174,444 - 123,185,649 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,175,860 - 123,179,644 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03129,672,572 - 129,683,734 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,264,579 - 118,268,363 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13118,170,151 - 118,173,254 (-)NCBI
Celera3116,662,570 - 116,666,354 (-)NCBICelera
Cytogenetic Map3q36NCBI
Lzts3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541514,065,338 - 14,072,617 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541514,065,338 - 14,075,718 (-)NCBIChiLan1.0ChiLan1.0
LZTS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2214,129,943 - 4,140,949 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1204,126,762 - 4,137,774 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0203,248,955 - 3,259,932 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1203,011,611 - 3,022,582 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl203,011,611 - 3,022,573 (-)Ensemblpanpan1.1panPan2
LZTS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12418,111,188 - 18,122,246 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2418,117,723 - 18,120,428 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2417,940,272 - 17,950,683 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02418,530,804 - 18,541,218 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2418,531,201 - 18,541,054 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12418,124,487 - 18,134,901 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02418,237,097 - 18,247,509 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02418,564,415 - 18,574,829 (+)NCBIUU_Cfam_GSD_1.0
Lzts3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640167,106,923 - 167,116,423 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648515,538,337 - 15,548,148 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648515,538,302 - 15,547,778 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LZTS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1732,508,706 - 32,518,522 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11732,507,512 - 32,518,524 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,877,505 - 36,888,515 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Lzts3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247414,268,869 - 4,281,653 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247414,271,584 - 4,282,082 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 13 53
Low 23 14 7
Below cutoff 6

Sequence


RefSeq Acc Id: ENSCSAT00000011389   ⟹   ENSCSAP00000009460
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl233,835,012 - 33,839,895 (-)Ensembl
RefSeq Acc Id: XM_008019328   ⟹   XP_008017519
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1233,835,361 - 33,845,948 (-)NCBI
Vero_WHO_p1.0NW_02366607110,668,413 - 10,679,140 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008019333   ⟹   XP_008017524
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1233,835,361 - 33,840,628 (-)NCBI
Vero_WHO_p1.0NW_02366607110,668,402 - 10,679,140 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008019341   ⟹   XP_008017532
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1233,835,361 - 33,840,591 (-)NCBI
Vero_WHO_p1.0NW_02366607110,668,415 - 10,679,140 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008019346   ⟹   XP_008017537
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1233,835,361 - 33,840,591 (-)NCBI
Vero_WHO_p1.0NW_02366607110,668,458 - 10,679,140 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037990660   ⟹   XP_037846588
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607110,667,679 - 10,679,140 (+)NCBI
RefSeq Acc Id: XP_008017519   ⟸   XM_008019328
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RLH1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008017524   ⟸   XM_008019333
- Peptide Label: isoform X1
RefSeq Acc Id: XP_008017537   ⟸   XM_008019346
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RLH1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008017532   ⟸   XM_008019341
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RLH1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000009460   ⟸   ENSCSAT00000011389
RefSeq Acc Id: XP_037846588   ⟸   XM_037990660
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013291 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011389.1 UniProtKB/TrEMBL
InterPro LZTS UniProtKB/TrEMBL
KEGG Report csab:103247226 UniProtKB/TrEMBL
NCBI Gene LZTS3 ENTREZGENE
PANTHER PTHR19354 UniProtKB/TrEMBL
  PTHR19354:SF6 UniProtKB/TrEMBL
Pfam Fez1 UniProtKB/TrEMBL
UniProt A0A0D9RLH1 ENTREZGENE, UniProtKB/TrEMBL