DLG3 (discs large MAGUK scaffold protein 3) - Rat Genome Database

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Gene: DLG3 (discs large MAGUK scaffold protein 3) Chlorocebus sabaeus
Analyze
Symbol: DLG3
Name: discs large MAGUK scaffold protein 3
RGD ID: 18496599
Description: ENCODES a protein that exhibits ionotropic glutamate receptor binding (ortholog); PDZ domain binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN establishment of planar polarity (ortholog); establishment or maintenance of epithelial cell apical/basal polarity (ortholog); ASSOCIATED WITH autistic disorder (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN dendritic shaft (ortholog); glutamatergic synapse (ortholog); growth cone (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: disks large homolog 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X60,290,280 - 60,346,954 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX60,290,630 - 60,346,953 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660652,134,119 - 2,191,196 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DLG3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X60,290,280 - 60,346,954 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX60,290,630 - 60,346,953 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660652,134,119 - 2,191,196 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
DLG3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X70,444,835 - 70,505,490 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX70,444,835 - 70,505,490 (+)EnsemblGRCh38hg38GRCh38
GRCh37X69,664,685 - 69,725,340 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X69,581,449 - 69,642,062 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X69,447,839 - 69,505,554NCBI
CeleraX70,018,031 - 70,078,673 (+)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX63,486,322 - 63,547,144 (+)NCBIHuRef
CHM1_1X69,558,605 - 69,619,214 (+)NCBICHM1_1
T2T-CHM13v2.0X68,878,160 - 68,938,810 (+)NCBIT2T-CHM13v2.0
Dlg3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X99,811,200 - 99,862,016 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX99,811,328 - 99,862,016 (+)EnsemblGRCm39 Ensembl
GRCm38X100,767,411 - 100,818,410 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX100,767,722 - 100,818,410 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X97,963,062 - 98,013,749 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X96,970,466 - 97,021,127 (+)NCBIMGSCv36mm8
CeleraX87,686,891 - 87,737,556 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX43.72NCBI
Dlg3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X69,899,694 - 69,951,928 (+)NCBIGRCr8
mRatBN7.2X65,859,653 - 65,911,887 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX65,860,172 - 65,910,322 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX67,343,327 - 67,394,012 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X70,843,724 - 70,894,417 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,404,631 - 68,455,321 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X70,596,246 - 70,648,529 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX70,596,576 - 70,648,532 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X71,468,290 - 71,520,286 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X88,777,585 - 88,828,504 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X88,851,017 - 88,901,937 (+)NCBI
CeleraX66,218,231 - 66,268,819 (+)NCBICelera
Cytogenetic MapXq22NCBI
Dlg3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554759,992,215 - 10,056,348 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554759,992,888 - 10,056,197 (+)NCBIChiLan1.0ChiLan1.0
DLG3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X70,121,582 - 70,181,058 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X70,125,184 - 70,184,660 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X59,712,755 - 59,773,372 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X69,771,482 - 69,831,376 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX69,771,477 - 69,831,369 (+)Ensemblpanpan1.1panPan2
DLG3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X54,886,700 - 54,941,502 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX54,886,389 - 54,939,675 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX45,713,141 - 45,768,580 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X55,853,333 - 55,908,759 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX55,853,116 - 55,908,756 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X53,822,238 - 53,877,672 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X55,153,323 - 55,208,774 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X55,080,264 - 55,135,709 (+)NCBIUU_Cfam_GSD_1.0
Dlg3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X47,220,157 - 47,276,307 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936762982,258 - 1,038,492 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936762982,331 - 1,038,486 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLG3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX56,472,307 - 56,527,983 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X56,471,941 - 56,531,481 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X63,666,759 - 63,724,414 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Dlg3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624903409,709 - 473,659 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624903409,721 - 473,422 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 20 60
Low 16 20
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000009687   ⟹   ENSCSAP00000007801
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 EnsemblX60,290,630 - 60,346,953 (+)Ensembl
RefSeq Acc Id: XM_007991991   ⟹   XP_007990182
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1X60,290,563 - 60,346,954 (+)NCBI
Vero_WHO_p1.0NW_0236660652,134,119 - 2,191,196 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007991992   ⟹   XP_007990183
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1X60,290,564 - 60,346,954 (+)NCBI
Vero_WHO_p1.0NW_0236660652,134,120 - 2,191,196 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007991993   ⟹   XP_007990184
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1X60,290,563 - 60,346,954 (+)NCBI
Vero_WHO_p1.0NW_0236660652,134,119 - 2,191,196 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007991994   ⟹   XP_007990185
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1X60,290,563 - 60,346,954 (+)NCBI
Vero_WHO_p1.0NW_0236660652,134,119 - 2,191,196 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007991995   ⟹   XP_007990186
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1X60,290,280 - 60,346,952 (+)NCBI
Vero_WHO_p1.0NW_0236660652,134,120 - 2,191,196 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007991996   ⟹   XP_007990187
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1X60,290,355 - 60,346,952 (+)NCBI
Vero_WHO_p1.0NW_0236660652,134,119 - 2,191,196 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007991997   ⟹   XP_007990188
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1X60,297,490 - 60,346,954 (+)NCBI
Vero_WHO_p1.0NW_0236660652,141,435 - 2,191,196 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007991998   ⟹   XP_007990189
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1X60,300,523 - 60,346,952 (+)NCBI
Vero_WHO_p1.0NW_0236660652,144,395 - 2,191,196 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007991999   ⟹   XP_007990190
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1X60,297,869 - 60,346,954 (+)NCBI
Vero_WHO_p1.0NW_0236660652,141,753 - 2,191,196 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037988899   ⟹   XP_037844827
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660652,144,395 - 2,191,196 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_007990186   ⟸   XM_007991995
- Peptide Label: isoform X6
- UniProtKB: A0A0D9RGR2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007990187   ⟸   XM_007991996
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RGR2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007990182   ⟸   XM_007991991
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RGR2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007990184   ⟸   XM_007991993
- Peptide Label: isoform X4
- UniProtKB: A0A0D9RGR2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007990185   ⟸   XM_007991994
- Peptide Label: isoform X5
- UniProtKB: A0A0D9RGR2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007990183   ⟸   XM_007991992
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RGR2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007990188   ⟸   XM_007991997
- Peptide Label: isoform X7
RefSeq Acc Id: XP_007990190   ⟸   XM_007991999
- Peptide Label: isoform X8
RefSeq Acc Id: XP_007990189   ⟸   XM_007991998
- Peptide Label: isoform X8
RefSeq Acc Id: ENSCSAP00000007801   ⟸   ENSCSAT00000009687
RefSeq Acc Id: XP_037844827   ⟸   XM_037988899
- Peptide Label: isoform X9


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000011603 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000009687.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  Guanylate Kinase phosphate binding domain UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro DLG1-like UniProtKB/TrEMBL
  DLG3_SH3 UniProtKB/TrEMBL
  GK/Ca_channel_bsu UniProtKB/TrEMBL
  Guanylate_kin-like_dom UniProtKB/TrEMBL
  Guanylate_kinase_CS UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_assoc UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene DLG3 ENTREZGENE
PANTHER DISCS LARGE UniProtKB/TrEMBL
  DISKS LARGE HOMOLOG 3 UniProtKB/TrEMBL
Pfam Guanylate_kin UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_assoc UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PIRSF MAGUK_DLGH UniProtKB/TrEMBL
PROSITE GUANYLATE_KINASE_1 UniProtKB/TrEMBL
  GUANYLATE_KINASE_2 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART GuKc UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A0D9RGR2 ENTREZGENE, UniProtKB/TrEMBL