MPPE1 (metallophosphoesterase 1) - Rat Genome Database

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Gene: MPPE1 (metallophosphoesterase 1) Chlorocebus sabaeus
Analyze
Symbol: MPPE1
Name: metallophosphoesterase 1
RGD ID: 18493426
Description: ENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); phosphoric diester hydrolase activity (inferred); INVOLVED IN endoplasmic reticulum to Golgi vesicle-mediated transport (inferred); GPI anchor biosynthetic process (inferred); ASSOCIATED WITH chromosome 18p deletion syndrome (ortholog); dystonia (ortholog); genetic disease (ortholog); FOUND IN nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11869,484,134 - 69,507,797 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1869,495,055 - 69,511,087 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605044,482,171 - 44,506,942 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MPPE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11869,484,134 - 69,507,797 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1869,495,055 - 69,511,087 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605044,482,171 - 44,506,942 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MPPE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381811,882,622 - 11,908,317 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1811,882,622 - 11,908,366 (-)EnsemblGRCh38hg38GRCh38
GRCh371811,882,621 - 11,908,316 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361811,873,470 - 11,898,641 (-)NCBINCBI36Build 36hg18NCBI36
Celera1811,764,340 - 11,789,530 (-)NCBICelera
Cytogenetic Map18p11.21NCBI
HuRef1811,838,124 - 11,863,296 (-)NCBIHuRef
CHM1_11811,882,962 - 11,908,304 (-)NCBICHM1_1
T2T-CHM13v2.01812,045,331 - 12,071,022 (-)NCBIT2T-CHM13v2.0
Mppe1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391867,358,119 - 67,378,901 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1867,358,114 - 67,378,901 (-)EnsemblGRCm39 Ensembl
GRCm381867,225,043 - 67,245,830 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1867,225,043 - 67,245,830 (-)EnsemblGRCm38mm10GRCm38
MGSCv371867,385,184 - 67,405,484 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361867,350,899 - 67,371,199 (-)NCBIMGSCv36mm8
Celera1868,493,601 - 68,513,781 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1839.9NCBI
Mppe1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81863,033,329 - 63,051,461 (-)NCBIGRCr8
mRatBN7.21860,763,418 - 60,781,553 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1860,763,419 - 60,781,553 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1862,836,092 - 62,854,510 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01863,534,833 - 63,553,257 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01861,384,005 - 61,402,164 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01862,946,952 - 62,966,174 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1862,946,953 - 62,965,538 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01862,133,742 - 62,151,775 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41863,738,125 - 63,756,486 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11863,811,325 - 63,824,805 (-)NCBI
Celera1858,871,180 - 58,889,224 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
Mppe1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554021,172,704 - 1,181,908 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554021,167,711 - 1,182,410 (+)NCBIChiLan1.0ChiLan1.0
MPPE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21726,115,631 - 26,141,007 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11811,808,230 - 11,832,880 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0182,397,423 - 2,423,209 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1184,662,348 - 4,686,832 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl184,662,348 - 4,686,262 (+)Ensemblpanpan1.1panPan2
MPPE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1777,521,348 - 77,544,033 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl777,521,546 - 77,540,405 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha776,923,004 - 76,945,768 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0777,579,113 - 77,601,951 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl777,579,119 - 77,602,017 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1777,276,286 - 77,299,044 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0777,322,870 - 77,345,612 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0777,610,005 - 77,632,807 (-)NCBIUU_Cfam_GSD_1.0
Mppe1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049441,107,676 - 1,142,757 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936626361,270 - 373,629 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936626349,324 - 371,073 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MPPE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl697,324,727 - 97,344,736 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1697,324,652 - 97,344,068 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2690,704,988 - 90,724,645 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Mppe1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477019,505,326 - 19,526,750 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477019,504,774 - 19,526,710 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 20 56
Low 16 20 4
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000015627   ⟹   ENSCSAP00000013560
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1869,495,055 - 69,511,087 (+)Ensembl
RefSeq Acc Id: XM_007974677   ⟹   XP_007972868
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11869,484,286 - 69,507,797 (+)NCBI
Vero_WHO_p1.0NW_02366605044,482,299 - 44,506,942 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007974680   ⟹   XP_007972871
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11869,484,134 - 69,507,797 (+)NCBI
Vero_WHO_p1.0NW_02366605044,482,171 - 44,506,942 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007974681   ⟹   XP_007972872
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11869,487,063 - 69,507,797 (+)NCBI
Vero_WHO_p1.0NW_02366605044,485,086 - 44,506,942 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007974682   ⟹   XP_007972873
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11869,484,286 - 69,507,797 (+)NCBI
Vero_WHO_p1.0NW_02366605044,482,299 - 44,506,942 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037982512   ⟹   XP_037838440
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605044,482,299 - 44,506,942 (+)NCBI
RefSeq Acc Id: XP_007972871   ⟸   XM_007974680
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007972868   ⟸   XM_007974677
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007972873   ⟸   XM_007974682
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RY71 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007972872   ⟸   XM_007974681
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCSAP00000013560   ⟸   ENSCSAT00000015627
RefSeq Acc Id: XP_037838440   ⟸   XM_037982512
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000017532 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015627.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.21.10 UniProtKB/TrEMBL
InterPro Calcineurin-like_PHP_ApaH UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/TrEMBL
  MPP_MPPE1 UniProtKB/TrEMBL
  PGAP5/Cdc1/Ted1 UniProtKB/TrEMBL
NCBI Gene MPPE1 ENTREZGENE
PANTHER METALLOPHOSPHOESTERASE 1 UniProtKB/TrEMBL
  PTHR13315 UniProtKB/TrEMBL
Pfam Metallophos UniProtKB/TrEMBL
Superfamily-SCOP SSF56300 UniProtKB/TrEMBL
UniProt A0A0D9RY71 ENTREZGENE, UniProtKB/TrEMBL