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Gene: TOP2B (DNA topoisomerase II beta) Chlorocebus sabaeus

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Symbol:

TOP2B

Name:

DNA topoisomerase II beta

RGD ID:

18484410

Description:

ENCODES a protein that exhibits ribonucleoprotein complex binding (ortholog); INVOLVED IN axonogenesis (ortholog); cellular response to ATP (ortholog); cellular response to hydrogen peroxide (ortholog); PARTICIPATES IN doxorubicin pharmacodynamics pathway; doxorubicin response pathway; etoposide pharmacodynamics pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); B-Cell Immunodeficiency, Distal Limb Anomalies, and Urogenital Malformations (ortholog); congenital disorder of deglycosylation (ortholog); FOUND IN chromosome (ortholog); nucleolus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA topoisomerase 2-beta; topoisomerase (DNA) II beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	70,266,267 - 70,332,079 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	70,266,601 - 70,332,824 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	43,404,940 - 43,471,152 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

B-Cell Immunodeficiency, Distal Limb Anomalies, and Urogenital Malformations (ISO)

congenital disorder of deglycosylation (ISO)

genetic disease (ISO)

myeloid leukemia (ISO)

Neurodevelopmental Disorders (ISO)

prostate carcinoma in situ (ISO)

syndromic microphthalmia 12 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axonogenesis (IEA,ISO)

B cell differentiation (IEA)

cellular response to ATP (ISO)

cellular response to hydrogen peroxide (ISO)

cellular senescence (ISO)

DNA topological change (IEA)

forebrain development (IEA,ISO)

neuron migration (IEA,ISO)

positive regulation of double-strand break repair via nonhomologous end joining (ISO)

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate (IEA)

resolution of meiotic recombination intermediates (IEA)

sister chromatid segregation (IEA)

Cellular Component

chromosome (ISO)

cytosol (IEA)

heterochromatin (IEA)

nucleolus (IEA,ISO)

nucleoplasm (IEA)

nucleus (IEA)

Molecular Function

ATP binding (IEA)

chromatin binding (IEA)

DNA binding (IEA)

DNA negative supercoiling activity (IEA)

DNA topoisomerase activity (IEA)

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity (IEA)

metal ion binding (IEA)

protein binding (ISO)

ribonucleoprotein complex binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

doxorubicin pharmacodynamics pathway (ISO)

doxorubicin response pathway (ISO)

etoposide pharmacodynamics pathway (ISO)

etoposide pharmacokinetics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

TOP2B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	70,266,267 - 70,332,079 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	70,266,601 - 70,332,824 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	43,404,940 - 43,471,152 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

TOP2B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	25,597,905 - 25,664,907 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	25,597,978 - 25,664,909 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	25,639,396 - 25,706,398 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	25,614,479 - 25,680,792 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	25,614,478 - 25,680,792	NCBI
Celera	3	25,576,353 - 25,642,666 (-)	NCBI		Celera
Cytogenetic Map	3	p24.2	NCBI
HuRef	3	25,584,872 - 25,651,422 (-)	NCBI		HuRef
CHM1_1	3	25,589,386 - 25,655,854 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	25,600,752 - 25,667,754 (-)	NCBI		T2T-CHM13v2.0

Top2b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	6,038,976 - 6,104,585 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	6,034,301 - 6,104,584 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	16,365,206 - 16,430,787 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	16,365,179 - 16,435,462 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	17,197,720 - 17,263,301 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	15,158,473 - 15,224,054 (+)	NCBI		MGSCv36	mm8
Celera	14	12,058,636 - 12,125,106 (+)	NCBI		Celera
Cytogenetic Map	14	A1	NCBI
cM Map	14	7.08	NCBI

Top2b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	11,482,089 - 11,542,464 (-)	NCBI		GRCr8
mRatBN7.2	15	9,051,340 - 9,111,721 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	9,051,341 - 9,112,085 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	11,194,159 - 11,253,909 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	12,106,947 - 12,166,695 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	10,407,427 - 10,467,175 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	10,262,972 - 10,319,741 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	10,262,651 - 10,320,233 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	14,308,369 - 14,366,373 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	15	9,095,127 - 9,153,091 (-)	NCBI		Celera
Cytogenetic Map	15	p16	NCBI

Top2b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955430	17,457,603 - 17,507,012 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955430	17,457,603 - 17,523,115 (-)	NCBI	ChiLan1.0	ChiLan1.0

TOP2B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	25,558,594 - 25,625,391 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	25,563,361 - 25,630,147 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	25,499,239 - 25,566,029 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	25,830,424 - 25,877,870 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	25,828,879 - 25,896,912 (-)	Ensembl	panpan1.1		panPan2

TOP2B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	18,159,521 - 18,206,413 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	18,146,095 - 18,206,287 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	18,145,151 - 18,204,187 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	18,450,639 - 18,509,671 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	18,462,741 - 18,509,662 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	18,269,373 - 18,328,309 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	18,372,171 - 18,431,166 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	18,486,061 - 18,545,078 (+)	NCBI		UU_Cfam_GSD_1.0

Top2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	184,007,995 - 184,050,993 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936473	17,143,894 - 17,189,605 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936473	17,146,576 - 17,189,589 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TOP2B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	12,507,138 - 12,575,583 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	12,507,738 - 12,575,042 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	14,119,707 - 14,187,251 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Top2b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624788	3,493,188 - 3,590,138 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008009296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008009297	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000007809 ⟹ ENSCSAP00000005976

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	15	70,266,601 - 70,332,824 (-)	Ensembl

RefSeq Acc Id:

XM_008009296 ⟹ XP_008007487

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	15	70,266,267 - 70,332,079 (-)	NCBI
Vero_WHO_p1.0	NW_023666041	43,404,940 - 43,471,152 (-)	NCBI

Sequence:

show sequence

CCACGCTAGGCCCGGGCGACGCGGACGCCGCGCCTCGAGTTTGAGGGCAGCCGGCGGCGCGGCC
TCCTCAGCGGGCTCGGCTAGACGTCCGCTCCGAGTGTTCGCGATGGGGCGCGGGGGTCGGCGCG
GCTAGGAGTGCGGCGAGTGGAGCGGTGGGTGCGGAGCGGCGGGGCCTAGCGGCCCGCAGGGAGG
CGGGAGCGGCGGCTGCGGCCTCGGGGCCTGTGAGCTGGAGGCACTCGCCATGGCCAAGTCGGGT
GGCTGCGGCGCGGGAGCCGGCGTGGGCGGCGGCAACGGTGCACTGACCTGGGTGACTCTTTTTG
ATCAGAACAATGCTGCAAAAAAAGAAGAGTCAGAAACTGCCAACAAAAATGATTCTTCAAAGAA
GTTGTCTGTTGAGAGAGTGTATCAGAAGAAGACACAACTTGAACACATTCTTCTTCGTCCTGAT
ACATATATTGGGTCAGTGGAGCCATTGACGCAGTTCATGTGGGTGTATGATGAAGATGTAGGAA
TGAATTGCAGAGAGGTTACCTTTGTGCCAGGTTTATACAAGATCTTTGATGAAATTTTGGTTAA
TGCTGCTGACAATAAACAGAGGGATAAGAACATGACTTGTATTAAAGTTTCTATTGATCCTGAA
TCTAATATTATAAGCATTTGGAATAATGGAAAAGGCATTCCAGTAGTAGAACACAAGGTAGAGA
AAGTTTATGTTCCTGCTTTAATTTTTGGACAGCTTTTAACATCCAGTAACTATGATGATGATGA
GAAAAAAGTTACAGGTGGTCGTAATGGTTATGGTGCAAAACTTTGTAATATTTTCAGTACAAAG
TTTACAGTAGAAACAGCTTGCAAAGAATACAAACACAGTTTTAAGCAGACATGGATGAATAATA
TGATGAAGACTTCTGAAGCCAAAATTAAACATTTTGATGGTGAAGATTACACATGCATAACATT
CCAACCAGATCTGTCCAAATTTAAAATGGAAAAACTTGACAAGGATATTGTGGCCCTCATGACC
AGAAGGGCATATGATTTGGCTGGTTCATGTAAAGGGGTCAAGGTCATGTTTAATGGAAAGAAAT
TGCCTGTAAATGGATTTCGCAGTTATGTAGATCTTTATGTGAAAGACAAATTGGATGAAACTGG
GGTGGCCCTGAAAGTTATTCATGAGCTTGCAAATGAAAGATGGGATGTTTGTCTCACATTGAGT
GAAAAAGGATTCCAGCAGATCAGCTTTGTAAATAGTATTGCGACTACAAAAGGTGGACGGCACG
TGGATTATGTGGTAGATCAAGTTGTTGGTAAACTGATTGAAGTGGTTAAGAAAAAGAACAAAGC
TGGTGTATCAGTGAAACCATTTCAAGTAAAAAACCATATATGGGTTTTTATTAATTGCCTTATT
GAAAATCCAACTTTTGATTCTCAGACTAAGGAAAACATGACTCTGCAGCCCAAAAGTTTTGGGT
CTAAATGCCAGCTGTCAGAAAAATTTTTTAAAGCAGCCTCTAATTGTGGCATTGTAGAAAGTAT
CCTAAACTGGGTGAAATTTAAGGCTCAGACTCAGCTGAATAAGAAGTGTTCATCAGTAAAATAC
AGTAAAATCAAAGGTATTCCCAAACTGGATGACGCTAATGATGCTGGTGGCAAACATTCCCTGG
AGTGTACACTGATATTAACAGAGGGAGACTCTGCCAAATCACTGGCTGTGTCTGGATTAGGTGT
GATTGGACGAGACAGATACGGAGTTTTTCCACTCAGGGGCAAAATTCTTAACGTACGGGAAGCT
TCTCATAAACAGATCATGGAAAATGCTGAAATAAATAATATTATTAAAATAGTTGGTCTACAAT
ATAAGAAAAGTTACGATGATGCAGAATCTCTGAAAACCTTACGCTATGGAAAGATTATGATTAT
GACCGATCAGGATCAAGATGGTTCTCACATAAAAGGCCTGCTTATTAATTTCATCCATCACAAT
TGGCCATCGCTTTTGAAGCATGGTTTTCTTGAAGAGTTCATTACTCCTATTGTAAAGGCAAGCA
AAAATAAGCAGGAACTTTCCTTCTACAGTATTCCTGAATTTGATGAGTGGAAAAAACATATAGA
AAACCAGAAAGCCTGGAAAATCAAGTACTATAAAGGATTGGGTACTAGTACAGCTAAAGAAGCA
AAGGAATATTTTGCTGATATGGAAAGGCATCGCATCTTGTTTAGATACGCTGGTCCTGAAGATG
ATGCTGCCATTACCTTGGCATTCAGTAAGAAGAAGATTGATGACAGAAAAGAATGGTTAACAAA
TTTTATGGAAGACCGGAGACAGCGTAGGCTACATGGCTTACCAGAGCAATTTTTATATGGTACT
GCAACAAAGCATTTGACTTATAATGATTTCATCAACAAGGAATTGATTCTCTTCTCAAACTCAG
ACAATGAAAGATCTATACCATCTCTTGTTGATGGCTTTAAACCTGGCCAGCGGAAAGTTTTATT
TACCTGTTTCAAGAGGAATGATAAACGTGAAGTAAAAGTTGCCCAGTTGGCTGGATCTGTTGCT
GAGATGTCGGCTTATCATCATGGAGAACAAGCATTGATGATGACTATTGTGAATTTGGCTCAGA
ACTTTGTGGGAAGTAACAACATTAACTTGCTTCAGCCTATTGGTCAGTTTGGAACTCGGCTTCA
TGGTGGCAAAGATGCTGCAAGCCCTCGTTATATTTTCACAATGTTAAGCTCTTTAGCAAGGCTA
CTTTTTCCTGCCGTGGATGACAACCTGCTTAAGTTCCTTTATGATGATAATCAACGTGTAGAGC
CTGAGTGGTATATTCCCATAATTCCCATGGTTTTAATAAATGGTGCTGAGGGCATTGGTACTGG
ATGGGCTTGTAAACTACCCAACTATGATGCTAGGGAAATTGTGAACAATGTCAGACGAATGCTA
GATGGCTTGGATCCTCATCCCATGCTTCCAAACTACAAAAACTTTAAAGGGACGATTCAAGAAC
TTGGTCAAAACCAGTATGCAGTCAGTGGTGAAATATTTGTAGTGGACAGAAACACAGTAGAAAT
TACAGAGCTTCCAGTTAGAACTTGGACACAGGTATACAAAGAACAGGTTTTAGAACCTATGCTA
AATGGAACAGATAAAACACCAGCATTAATTTCTGATTATAAAGAATATCATACTGACACAACTG
TGAAATTTGTGGTGAAAATGACTGAAGAGAAACTAGCACAAGCAGAAGCTGCTGGACTGCATAA
AGTTTTTAAACTTCAAACTACTCTTACTTGTAATTCCATGGTACTCTTTGATCATATGGGATGT
CTGAAGAAATATGAAACTGTGCAAGACATTCTGAAAGAATTCTTTGATTTACGATTAAGTTATT
ATGGTTTACGTAAGGAGTGGCTTGTGGGAATGCTGGGAGCAGAATCTACAAAGCTTAACAATCA
AGCCCGTTTCATTTTAGAGAAGATACAAGGGAAAATTACTATAGAGAATAGGTCAAAGAAAGAT
TTGATTCAAATGTTAGTCCAGAGAGGTTATGAATCTGACCCAGTGAAAGCCTGGAAAGAAGCAC
AAGAAAAGGCAGCAGAAGAGGATGAAACACAAAACCAGCATGATGATAGTTCCTCCGATTCAGG
AACTCCTTCAGGCCCAGATTTTAATTATATTTTAAATATGTCTCTGTGGTCTCTTACTAAAGAA
AAAGTTGAAGAACTGATTAAACAGAGAGATGCAAAAGGGCGAGAGGTTAATGATCTTAAAAGAA
AATCTCCTTCAGATCTTTGGAAAGAAGATTTAGCAGCGTTTGTTGAAGAACTGGATAAAGTGGA
AGCTCAAGAACGAGAAGATATTCTGGCTGGAATGTCTGGAAAAGCAATTAAAGGTAAAGTTGGC
AAACCTAAGGTGAAGAAACTCCAATTGGAAGAGACAATGCCCTCACCTTATGGCAGAAGAGTAA
TTCCTGAAATTACAGCTATGAAGGCAGATGCCAGCAAAAAGTTGCTGAAGAAGAAGAAGGGTGA
TCTTGATACTGCAGCAGTAAAAGTGGAATTTGATGAAGAATTCAGTGGAGTGCCAGTAGAAGGT
GTAGGAGAAGAGGCATTGATTCCGTCAGCTCCTATAAATAAAGGCCCCAAACCCAAAAGGGAGA
AGAAGGAGCCTGGTACCAGAGTGAGAAAAACACCCACATCATCTGGTAAACCTAGTGCAAAGAA
AGTGAAGAAACGGAATCCTTGGTCAGATGATGAATCCAAGTCAGAAAGTGACTTGGAAGAAACA
GAACCTGTGGTTATTCCAAGAGATTCTTTGCTTAGGAGAGCAGCCGCTGAAAGACCTAAATACA
CATTTGATTTCTCAGAAGAAGAGGATGATGATGCTGATGATGATGATGATGACAATAATGATTT
AGAGGAATTGAAAGTTAAAACATCTCCCATAACAAATGATGGGGAAGATGAATTTGTTCCTTCA
GATGGGTTAGATAAAGATGAATATACATTTTCACCAGGCAAATCAAAAGCCACTCCAGAAAAAT
CTTTGCATGACAAAAAAAGTCAGGATTTTGGAAATCTCTTTTCATTTCCTTCATATTCTCAGAA
GTCAGAAGATGATTCAGCTAAATTTGACAGTAATGAAGAAGATTCTGCTTCTGTTTTTTCACCA
TCATTTGGTCTGAAACAGATAGATAAAGTTCCAAGTAAAACAGTAGCTGCTAAAAAGGGAAAAC
CGTCTTCAGATACAGCCCCTAAGCCCAAGAGAGCCCCCAAACAGAAGAAAGTAGTAGAGGCTGT
AAACTCGGACTCAGATTCAGAATTTGGCATTCCAAAGAAGACTACAACACCAAAAGGTAAAGGC
CGAGGGGCAAAGAAAAGGAAAGCATCTGGCTCTGAAAATGAAGGCGACTATAACCCTGGCAGGA
AAACATCCAAAACAGCAAGCAAGAAACCGAAGAAAACATCCTTTGATCAGGATTCAGATGTGGA
CATCTTCCCCTCAGACTTCCCTTCTGAGCCACCTTCTCTGCCACGAACCGGTCGGGCTAGGAAA
GAAGTAAAATATTTTGCAGAGTCTGATGAAGAAGAAGATGATGTTGATTTTGCAATGTTTAATT
AAGTGCCCAAAGAGCACAAACAAACATTTTTCAACAAATACCTTGTGTTGTCCTTTTGTCTTTT
CTGTCTCAGACTTTTGTACATCTGGCTTATTTTAATGTGATGATGTAATTGATGATGGATTTTT
ATTATTGTGGTAGGCCTTTTAACATTTTGTTCTTACACATACAGTTTTATGCTCTTTTTTACTC
ATTGAAATGTCACGTACTGTCTGTCTGATTGGCTTGTAGAATTGTTATAGACTGCCGTGCATTA
GCACAGATTTTAACTGTCATGGTTACAAACTACAGACCTGCTTTTTGAAATGAAATTTAAACAT
TAAAAATGGAACTGTG

hide sequence

RefSeq Acc Id:

XM_008009297 ⟹ XP_008007488

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	15	70,266,267 - 70,332,079 (-)	NCBI
Vero_WHO_p1.0	NW_023666041	43,404,940 - 43,471,152 (-)	NCBI

Sequence:

show sequence

CCACGCTAGGCCCGGGCGACGCGGACGCCGCGCCTCGAGTTTGAGGGCAGCCGGCGGCGCGGCC
TCCTCAGCGGGCTCGGCTAGACGTCCGCTCCGAGTGTTCGCGATGGGGCGCGGGGGTCGGCGCG
GCTAGGAGTGCGGCGAGTGGAGCGGTGGGTGCGGAGCGGCGGGGCCTAGCGGCCCGCAGGGAGG
CGGGAGCGGCGGCTGCGGCCTCGGGGCCTGTGAGCTGGAGGCACTCGCCATGGCCAAGTCGGGT
GGCTGCGGCGCGGGAGCCGGCGTGGGCGGCGGCAACGGTGCACTGACCTGGGTGAACAATGCTG
CAAAAAAAGAAGAGTCAGAAACTGCCAACAAAAATGATTCTTCAAAGAAGTTGTCTGTTGAGAG
AGTGTATCAGAAGAAGACACAACTTGAACACATTCTTCTTCGTCCTGATACATATATTGGGTCA
GTGGAGCCATTGACGCAGTTCATGTGGGTGTATGATGAAGATGTAGGAATGAATTGCAGAGAGG
TTACCTTTGTGCCAGGTTTATACAAGATCTTTGATGAAATTTTGGTTAATGCTGCTGACAATAA
ACAGAGGGATAAGAACATGACTTGTATTAAAGTTTCTATTGATCCTGAATCTAATATTATAAGC
ATTTGGAATAATGGAAAAGGCATTCCAGTAGTAGAACACAAGGTAGAGAAAGTTTATGTTCCTG
CTTTAATTTTTGGACAGCTTTTAACATCCAGTAACTATGATGATGATGAGAAAAAAGTTACAGG
TGGTCGTAATGGTTATGGTGCAAAACTTTGTAATATTTTCAGTACAAAGTTTACAGTAGAAACA
GCTTGCAAAGAATACAAACACAGTTTTAAGCAGACATGGATGAATAATATGATGAAGACTTCTG
AAGCCAAAATTAAACATTTTGATGGTGAAGATTACACATGCATAACATTCCAACCAGATCTGTC
CAAATTTAAAATGGAAAAACTTGACAAGGATATTGTGGCCCTCATGACCAGAAGGGCATATGAT
TTGGCTGGTTCATGTAAAGGGGTCAAGGTCATGTTTAATGGAAAGAAATTGCCTGTAAATGGAT
TTCGCAGTTATGTAGATCTTTATGTGAAAGACAAATTGGATGAAACTGGGGTGGCCCTGAAAGT
TATTCATGAGCTTGCAAATGAAAGATGGGATGTTTGTCTCACATTGAGTGAAAAAGGATTCCAG
CAGATCAGCTTTGTAAATAGTATTGCGACTACAAAAGGTGGACGGCACGTGGATTATGTGGTAG
ATCAAGTTGTTGGTAAACTGATTGAAGTGGTTAAGAAAAAGAACAAAGCTGGTGTATCAGTGAA
ACCATTTCAAGTAAAAAACCATATATGGGTTTTTATTAATTGCCTTATTGAAAATCCAACTTTT
GATTCTCAGACTAAGGAAAACATGACTCTGCAGCCCAAAAGTTTTGGGTCTAAATGCCAGCTGT
CAGAAAAATTTTTTAAAGCAGCCTCTAATTGTGGCATTGTAGAAAGTATCCTAAACTGGGTGAA
ATTTAAGGCTCAGACTCAGCTGAATAAGAAGTGTTCATCAGTAAAATACAGTAAAATCAAAGGT
ATTCCCAAACTGGATGACGCTAATGATGCTGGTGGCAAACATTCCCTGGAGTGTACACTGATAT
TAACAGAGGGAGACTCTGCCAAATCACTGGCTGTGTCTGGATTAGGTGTGATTGGACGAGACAG
ATACGGAGTTTTTCCACTCAGGGGCAAAATTCTTAACGTACGGGAAGCTTCTCATAAACAGATC
ATGGAAAATGCTGAAATAAATAATATTATTAAAATAGTTGGTCTACAATATAAGAAAAGTTACG
ATGATGCAGAATCTCTGAAAACCTTACGCTATGGAAAGATTATGATTATGACCGATCAGGATCA
AGATGGTTCTCACATAAAAGGCCTGCTTATTAATTTCATCCATCACAATTGGCCATCGCTTTTG
AAGCATGGTTTTCTTGAAGAGTTCATTACTCCTATTGTAAAGGCAAGCAAAAATAAGCAGGAAC
TTTCCTTCTACAGTATTCCTGAATTTGATGAGTGGAAAAAACATATAGAAAACCAGAAAGCCTG
GAAAATCAAGTACTATAAAGGATTGGGTACTAGTACAGCTAAAGAAGCAAAGGAATATTTTGCT
GATATGGAAAGGCATCGCATCTTGTTTAGATACGCTGGTCCTGAAGATGATGCTGCCATTACCT
TGGCATTCAGTAAGAAGAAGATTGATGACAGAAAAGAATGGTTAACAAATTTTATGGAAGACCG
GAGACAGCGTAGGCTACATGGCTTACCAGAGCAATTTTTATATGGTACTGCAACAAAGCATTTG
ACTTATAATGATTTCATCAACAAGGAATTGATTCTCTTCTCAAACTCAGACAATGAAAGATCTA
TACCATCTCTTGTTGATGGCTTTAAACCTGGCCAGCGGAAAGTTTTATTTACCTGTTTCAAGAG
GAATGATAAACGTGAAGTAAAAGTTGCCCAGTTGGCTGGATCTGTTGCTGAGATGTCGGCTTAT
CATCATGGAGAACAAGCATTGATGATGACTATTGTGAATTTGGCTCAGAACTTTGTGGGAAGTA
ACAACATTAACTTGCTTCAGCCTATTGGTCAGTTTGGAACTCGGCTTCATGGTGGCAAAGATGC
TGCAAGCCCTCGTTATATTTTCACAATGTTAAGCTCTTTAGCAAGGCTACTTTTTCCTGCCGTG
GATGACAACCTGCTTAAGTTCCTTTATGATGATAATCAACGTGTAGAGCCTGAGTGGTATATTC
CCATAATTCCCATGGTTTTAATAAATGGTGCTGAGGGCATTGGTACTGGATGGGCTTGTAAACT
ACCCAACTATGATGCTAGGGAAATTGTGAACAATGTCAGACGAATGCTAGATGGCTTGGATCCT
CATCCCATGCTTCCAAACTACAAAAACTTTAAAGGGACGATTCAAGAACTTGGTCAAAACCAGT
ATGCAGTCAGTGGTGAAATATTTGTAGTGGACAGAAACACAGTAGAAATTACAGAGCTTCCAGT
TAGAACTTGGACACAGGTATACAAAGAACAGGTTTTAGAACCTATGCTAAATGGAACAGATAAA
ACACCAGCATTAATTTCTGATTATAAAGAATATCATACTGACACAACTGTGAAATTTGTGGTGA
AAATGACTGAAGAGAAACTAGCACAAGCAGAAGCTGCTGGACTGCATAAAGTTTTTAAACTTCA
AACTACTCTTACTTGTAATTCCATGGTACTCTTTGATCATATGGGATGTCTGAAGAAATATGAA
ACTGTGCAAGACATTCTGAAAGAATTCTTTGATTTACGATTAAGTTATTATGGTTTACGTAAGG
AGTGGCTTGTGGGAATGCTGGGAGCAGAATCTACAAAGCTTAACAATCAAGCCCGTTTCATTTT
AGAGAAGATACAAGGGAAAATTACTATAGAGAATAGGTCAAAGAAAGATTTGATTCAAATGTTA
GTCCAGAGAGGTTATGAATCTGACCCAGTGAAAGCCTGGAAAGAAGCACAAGAAAAGGCAGCAG
AAGAGGATGAAACACAAAACCAGCATGATGATAGTTCCTCCGATTCAGGAACTCCTTCAGGCCC
AGATTTTAATTATATTTTAAATATGTCTCTGTGGTCTCTTACTAAAGAAAAAGTTGAAGAACTG
ATTAAACAGAGAGATGCAAAAGGGCGAGAGGTTAATGATCTTAAAAGAAAATCTCCTTCAGATC
TTTGGAAAGAAGATTTAGCAGCGTTTGTTGAAGAACTGGATAAAGTGGAAGCTCAAGAACGAGA
AGATATTCTGGCTGGAATGTCTGGAAAAGCAATTAAAGGTAAAGTTGGCAAACCTAAGGTGAAG
AAACTCCAATTGGAAGAGACAATGCCCTCACCTTATGGCAGAAGAGTAATTCCTGAAATTACAG
CTATGAAGGCAGATGCCAGCAAAAAGTTGCTGAAGAAGAAGAAGGGTGATCTTGATACTGCAGC
AGTAAAAGTGGAATTTGATGAAGAATTCAGTGGAGTGCCAGTAGAAGGTGTAGGAGAAGAGGCA
TTGATTCCGTCAGCTCCTATAAATAAAGGCCCCAAACCCAAAAGGGAGAAGAAGGAGCCTGGTA
CCAGAGTGAGAAAAACACCCACATCATCTGGTAAACCTAGTGCAAAGAAAGTGAAGAAACGGAA
TCCTTGGTCAGATGATGAATCCAAGTCAGAAAGTGACTTGGAAGAAACAGAACCTGTGGTTATT
CCAAGAGATTCTTTGCTTAGGAGAGCAGCCGCTGAAAGACCTAAATACACATTTGATTTCTCAG
AAGAAGAGGATGATGATGCTGATGATGATGATGATGACAATAATGATTTAGAGGAATTGAAAGT
TAAAACATCTCCCATAACAAATGATGGGGAAGATGAATTTGTTCCTTCAGATGGGTTAGATAAA
GATGAATATACATTTTCACCAGGCAAATCAAAAGCCACTCCAGAAAAATCTTTGCATGACAAAA
AAAGTCAGGATTTTGGAAATCTCTTTTCATTTCCTTCATATTCTCAGAAGTCAGAAGATGATTC
AGCTAAATTTGACAGTAATGAAGAAGATTCTGCTTCTGTTTTTTCACCATCATTTGGTCTGAAA
CAGATAGATAAAGTTCCAAGTAAAACAGTAGCTGCTAAAAAGGGAAAACCGTCTTCAGATACAG
CCCCTAAGCCCAAGAGAGCCCCCAAACAGAAGAAAGTAGTAGAGGCTGTAAACTCGGACTCAGA
TTCAGAATTTGGCATTCCAAAGAAGACTACAACACCAAAAGGTAAAGGCCGAGGGGCAAAGAAA
AGGAAAGCATCTGGCTCTGAAAATGAAGGCGACTATAACCCTGGCAGGAAAACATCCAAAACAG
CAAGCAAGAAACCGAAGAAAACATCCTTTGATCAGGATTCAGATGTGGACATCTTCCCCTCAGA
CTTCCCTTCTGAGCCACCTTCTCTGCCACGAACCGGTCGGGCTAGGAAAGAAGTAAAATATTTT
GCAGAGTCTGATGAAGAAGAAGATGATGTTGATTTTGCAATGTTTAATTAAGTGCCCAAAGAGC
ACAAACAAACATTTTTCAACAAATACCTTGTGTTGTCCTTTTGTCTTTTCTGTCTCAGACTTTT
GTACATCTGGCTTATTTTAATGTGATGATGTAATTGATGATGGATTTTTATTATTGTGGTAGGC
CTTTTAACATTTTGTTCTTACACATACAGTTTTATGCTCTTTTTTACTCATTGAAATGTCACGT
ACTGTCTGTCTGATTGGCTTGTAGAATTGTTATAGACTGCCGTGCATTAGCACAGATTTTAACT
GTCATGGTTACAAACTACAGACCTGCTTTTTGAAATGAAATTTAAACATTAAAAATGGAACTGT
G

hide sequence

Protein Sequences


Protein RefSeqs	XP_008007487	(Get FASTA)	NCBI Sequence Viewer
	XP_008007488	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000005976
	ENSCSAP00000005976.1

RefSeq Acc Id:	XP_008007488 ⟸ XM_008009297
- Peptide Label:	isoform X2
- UniProtKB:	A0A0D9RBI7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_008007487 ⟸ XM_008009296
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSCSAP00000005976 ⟸ ENSCSAT00000007809

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000009724	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000007809.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.268.10	UniProtKB/TrEMBL
	3.30.1360.40	UniProtKB/TrEMBL
	3.30.1490.30	UniProtKB/TrEMBL
	3.30.230.10	UniProtKB/TrEMBL
	3.30.565.10	UniProtKB/TrEMBL
	3.40.50.670	UniProtKB/TrEMBL
	3.90.199.10	UniProtKB/TrEMBL
InterPro	DNA_Topoisomerase_II	UniProtKB/TrEMBL
	DTHCT	UniProtKB/TrEMBL
	HATPase_C	UniProtKB/TrEMBL
	HATPase_C_sf	UniProtKB/TrEMBL
	Ribosomal_S5_D2-typ_fold	UniProtKB/TrEMBL
	Ribosomal_S5_D2-typ_fold_subgr	UniProtKB/TrEMBL
	Topo_IIA	UniProtKB/TrEMBL
	Topo_IIA-like_dom_sf	UniProtKB/TrEMBL
	Topo_IIA_A/C	UniProtKB/TrEMBL
	Topo_IIA_A/C_ab	UniProtKB/TrEMBL
	Topo_IIA_A_a_sf	UniProtKB/TrEMBL
	Topo_IIA_B_C	UniProtKB/TrEMBL
	Topo_IIA_bsu_dom2	UniProtKB/TrEMBL
	TopoII_euk	UniProtKB/TrEMBL
	TopoIIA_CS	UniProtKB/TrEMBL
	TOPRIM_C	UniProtKB/TrEMBL
	TOPRIM_domain	UniProtKB/TrEMBL
	TOPRIM_TopoII	UniProtKB/TrEMBL
NCBI Gene	TOP2B	ENTREZGENE
PANTHER	DNA TOPOISOMERASE/GYRASE	UniProtKB/TrEMBL
	PTHR10169:SF36	UniProtKB/TrEMBL
Pfam	DNA_gyraseB	UniProtKB/TrEMBL
	DNA_topoisoIV	UniProtKB/TrEMBL
	DTHCT	UniProtKB/TrEMBL
	HATPase_c	UniProtKB/TrEMBL
	Toprim	UniProtKB/TrEMBL
	TOPRIM_C	UniProtKB/TrEMBL
PRINTS	TOPISMRASEII	UniProtKB/TrEMBL
	TPI2FAMILY	UniProtKB/TrEMBL
PROSITE	TOPOISOMERASE_II	UniProtKB/TrEMBL
	TOPRIM	UniProtKB/TrEMBL
SMART	TOP2c	UniProtKB/TrEMBL
	TOP4c	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54211	UniProtKB/TrEMBL
	SSF55874	UniProtKB/TrEMBL
	SSF56719	UniProtKB/TrEMBL
UniProt	A0A0D9RBI7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB