MPIG6B (megakaryocyte and platelet inhibitory receptor G6b)

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Gene: MPIG6B (megakaryocyte and platelet inhibitory receptor G6b) Chlorocebus sabaeus

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Symbol:

MPIG6B

Name:

megakaryocyte and platelet inhibitory receptor G6b

RGD ID:

18482804

Description:

INVOLVED IN blood coagulation (ortholog); integrin-mediated signaling pathway (ortholog); megakaryocyte development (ortholog); ASSOCIATED WITH genetic disease (ortholog); hemorrhagic disease (ortholog); proteasome-associated autoinflammatory syndrome 1 (ortholog); FOUND IN cytosol (inferred); endoplasmic reticulum (inferred); Golgi apparatus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

C17H6orf25; protein G6b

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	40,297,946 - 40,300,442 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	40,298,473 - 40,300,174 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	31,635,311 - 31,637,978 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

hemorrhagic disease (ISO)

proteasome-associated autoinflammatory syndrome 1 (ISO)

Thrombocytopenia, Anemia, and Myelofibrosis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood coagulation (IEA,ISO)

erythrocyte differentiation (IEA)

integrin-mediated signaling pathway (IEA,ISO)

megakaryocyte development (IEA,ISO)

megakaryocyte differentiation (IEA)

negative regulation of signal transduction (IEA)

platelet formation (IEA,ISO)

Cellular Component

cytosol (IEA)

endoplasmic reticulum (IEA)

Golgi apparatus (IEA)

membrane (IEA)

nucleoplasm (IEA)

plasma membrane (IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

MPIG6B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	40,297,946 - 40,300,442 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	40,298,473 - 40,300,174 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	31,635,311 - 31,637,978 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

MPIG6B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	31,720,296 - 31,726,714 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	31,718,594 - 31,726,714 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	31,691,150 - 31,694,491 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	31,799,140 - 31,800,830 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	31,799,139 - 31,800,830	NCBI
Celera	6	33,289,386 - 33,291,076 (+)	NCBI		Celera
Cytogenetic Map	6	p21.33	NCBI
HuRef	6	31,477,345 - 31,480,711 (+)	NCBI		HuRef
CHM1_1	6	31,693,238 - 31,696,604 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	31,573,330 - 31,579,747 (+)	NCBI		T2T-CHM13v2.0

Mpig6b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	35,281,669 - 35,285,761 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	35,281,669 - 35,285,160 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	35,062,693 - 35,066,848 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	35,062,693 - 35,066,184 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	35,199,638 - 35,203,129 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	34,670,749 - 34,674,240 (-)	NCBI		MGSCv36	mm8
Celera	17	38,159,378 - 38,162,865 (-)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	18.59	NCBI

Mpig6b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	3,761,832 - 3,765,679 (+)	NCBI		GRCr8
mRatBN7.2	20	3,757,396 - 3,761,024 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	3,757,536 - 3,760,735 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	4,457,050 - 4,458,874 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	3,819,104 - 3,820,928 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	4,356,987 - 4,358,821 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	5,054,419 - 5,056,655 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	5,054,583 - 5,056,488 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	7,127,351 - 7,129,889 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	3,821,900 - 3,823,719 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	3,822,126 - 3,823,945 (+)	NCBI
Celera	20	4,266,685 - 4,268,492 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

Mpig6b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	262,161 - 266,148 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	259,780 - 264,549 (+)	NCBI	ChiLan1.0	ChiLan1.0

MPIG6B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	46,199,303 - 46,204,157 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	42,160,792 - 42,165,658 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	31,384,220 - 31,388,071 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	32,273,438 - 32,276,772 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	32,273,438 - 32,276,772 (+)	Ensembl	panpan1.1		panPan2

MPIG6B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	1,202,297 - 1,205,867 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	1,202,721 - 1,204,655 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	1,338,859 - 1,342,403 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	1,347,686 - 1,351,229 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	1,348,111 - 1,364,292 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	1,206,963 - 1,210,498 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	1,274,384 - 1,277,726 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	1,341,825 - 1,345,366 (+)	NCBI		UU_Cfam_GSD_1.0

Mpig6b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	35,749,973 - 35,753,635 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936727	1,809,407 - 1,811,058 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936727	1,808,317 - 1,811,058 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MPIG6B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	23,834,930 - 23,838,593 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	23,834,650 - 23,836,784 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Mpig6b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	24,487,765 - 24,489,315 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	24,486,241 - 24,491,771 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
68	35	20	35	35	53	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007973110	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007973111	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007973112	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007973113	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC244030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACDXN010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000006729 ⟹ ENSCSAP00000004926

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	17	40,298,473 - 40,300,174 (-)	Ensembl

RefSeq Acc Id:

XM_007973110 ⟹ XP_007971301

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	17	40,297,946 - 40,300,442 (-)	NCBI
Vero_WHO_p1.0	NW_023666044	31,635,311 - 31,637,978 (+)	NCBI

Sequence:

show sequence

GGAATTACAGGCGCGCCTGAAAAGTTAAGCAGGCAAAAGCGTTTGTGTAAATGGCCCGAGCACA
CATTTTAAGTGAGCACCATCTGAGGACTCTGAGTTTGCCTGCGAGGATTCCCAAAGGGATCTGG
GCAGTTGGTGGCCCCGCCCCCTCTCTTATCGGAGCCCCCCAGCCCCTCCGTTCTCCTCACCCCC
AACTTCCCTCCGGTCCCCCGCCAACCCGCCCCACGCCGCTGATTCGCTCGCAGCTTCTCCTCAC
CACATCCCAACCATGGCTGTGTTTCTGCAGCTGCTACCGCTGCTGCTCTTGAGGGCCCAAGGGA
ACCAAGGGGCTTCTCTGGACGGCCGCCCTGGGGACCGGGTGAATCTCTCTTGCGTAGGAGTCTC
TCACCCCATCCGCTGGGTCTGGGCGCCCAGCTTTCCGGCCTGCAAGGGCCTCTCCAAAGGACGC
CGACCGATCCTGTGGGCCTCTTCGAGCGGGACCCCCACCGTGCCTCCCCTCCAGCCTTTTGTAG
GCCGCCTTCGCTCCCTGGACTCTAGTATCCGGCGGCTGGAGCTCCTCTTGAGCGCGGGGGACTC
GGGCACCTTTTTCTGCAAGGGCCGCCACGAGGACGAGAGCCGTACAGTGCTTCACGTGCTGGGG
GACAGGACCTATTGCAAGACTCCTGGGCCTACCCATGGGTCCGTGTATCCCCAGCTCCTGATCC
CGCTGCTGGGCGCTGGGCTGGTGCTGGGACTGGGAGCTTTGGGCCTGGTCTGGTGGCTGCACAG
GCGCCTGCCCCCGCAACCGATTCGACCACTCCCTAGATTTGCTCCACTTGTGAAAACCGAGCCC
CAGAGGCCAGTAAAGGAGGAAGAGCCCAAGATTCCAGGGGACCTGGACCAGGAACCGAGCCTGC
TCTATGCGGATCTGGACCATCTAGCCCTCAGCAGGCCCCGCCGACTGTCCACAGTGGACCCTGC
TGATGCCTCCACCATCTATGCGGTTGTAGTTTGAAGGGAAGCCCTTACTCCAAACCTCCCAAAC
TAGGGGATCCCAGCTACCCATAATCCCTCTCCCCTCCTTGGTCCTCACCTGGAAGAGGAAGGCA
CCACGGTATGGAAATAAGTGCTAGACTGGGAGTCGGGAGACCTGGGCTCTAGGCTGTCTCTGCC
ACTGATCTTACTCCTACACTTACTCACATCTCTCCTATAACCTCCATGTCTCCCTCAACACCGG
TGTCCTCTCTATATCCAATCAAGCCCTAGCTCCTATCTCACGACATCAAAAGTCCCAGACAGTT
GCCTTATCTCTTCCCTTCCCTTCACAGTCAAACTTTGGAACCAGGGGCATACACCTGCCTTTTT
CATTTTCTTCTCCTTCACTTTATCCCCACTGCTCATCTGTTGAAATTGCTTATCTGCTCTCCAT
AAGATTGCAGGTAACGTCCTAATAGCCACACCCAGTAGACATTTTTAGTATTCATCTGGTTTGG
TCTCTGATTACTCCATTCCTTTTTTTTTTTTTTTTTTTTTGAGATA

hide sequence

RefSeq Acc Id:

XM_007973111 ⟹ XP_007971302

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	17	40,297,946 - 40,300,442 (-)	NCBI
Vero_WHO_p1.0	NW_023666044	31,635,311 - 31,637,978 (+)	NCBI

Sequence:

show sequence

GGAATTACAGGCGCGCCTGAAAAGTTAAGCAGGCAAAAGCGTTTGTGTAAATGGCCCGAGCACA
CATTTTAAGTGAGCACCATCTGAGGACTCTGAGTTTGCCTGCGAGGATTCCCAAAGGGATCTGG
GCAGTTGGTGGCCCCGCCCCCTCTCTTATCGGAGCCCCCCAGCCCCTCCGTTCTCCTCACCCCC
AACTTCCCTCCGGTCCCCCGCCAACCCGCCCCACGCCGCTGATTCGCTCGCAGCTTCTCCTCAC
CACATCCCAACCATGGCTGTGTTTCTGCAGCTGCTACCGCTGCTGCTCTTGAGGGCCCAAGGGA
ACCAAGGGGCTTCTCTGGACGGCCGCCCTGGGGACCGGGTGAATCTCTCTTGCGTAGGAGTCTC
TCACCCCATCCGCTGGGTCTGGGCGCCCAGCTTTCCGGCCTGCAAGGGCCTCTCCAAAGGACGC
CGACCGATCCTGTGGGCCTCTTCGAGCGGGACCCCCACCGTGCCTCCCCTCCAGCCTTTTGTAG
GCCGCCTTCGCTCCCTGGACTCTAGTATCCGGCGGCTGGAGCTCCTCTTGAGCGCGGGGGACTC
GGGCACCTTTTTCTGCAAGGGCCGCCACGAGGACGAGAGCCGTACAGTGCTTCACGTGCTGGGG
GACAGGACCTATTGCAAGACTCCTGGGCCTACCCATGGGTCCGTGTATCCCCAGCTCCTGATCC
CGCTGCTGGGCGCTGGGCTGGTGCTGGGACTGGGAGCTTTGGGCCTGGTCTGGTGGCTGCACAG
GCGCCTGCCCCCGCAACCGATTCGACCACTCCCTAGATTTGCTCTGTCCCCCCCACATAGCTCC
ACTTGTGAAAACCGAGCCCCAGAGGCCAGTAAAGGAGGAAGAGCCCAAGATTCCAGGGGACCTG
GACCAGGAACCGAGCCTGCTCTATGCGGATCTGGACCATCTAGCCCTCAGCAGGCCCCGCCGAC
TGTCCACAGTGGACCCTGCTGATGCCTCCACCATCTATGCGGTTGTAGTTTGAAGGGAAGCCCT
TACTCCAAACCTCCCAAACTAGGGGATCCCAGCTACCCATAATCCCTCTCCCCTCCTTGGTCCT
CACCTGGAAGAGGAAGGCACCACGGTATGGAAATAAGTGCTAGACTGGGAGTCGGGAGACCTGG
GCTCTAGGCTGTCTCTGCCACTGATCTTACTCCTACACTTACTCACATCTCTCCTATAACCTCC
ATGTCTCCCTCAACACCGGTGTCCTCTCTATATCCAATCAAGCCCTAGCTCCTATCTCACGACA
TCAAAAGTCCCAGACAGTTGCCTTATCTCTTCCCTTCCCTTCACAGTCAAACTTTGGAACCAGG
GGCATACACCTGCCTTTTTCATTTTCTTCTCCTTCACTTTATCCCCACTGCTCATCTGTTGAAA
TTGCTTATCTGCTCTCCATAAGATTGCAGGTAACGTCCTAATAGCCACACCCAGTAGACATTTT
TAGTATTCATCTGGTTTGGTCTCTGATTACTCCATTCCTTTTTTTTTTTTTTTTTTTTTGAGAT
A

hide sequence

Protein Sequences


Protein RefSeqs	XP_007971301	(Get FASTA)	NCBI Sequence Viewer
	XP_007971302	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000004926
	ENSCSAP00000004926.1

RefSeq Acc Id:	XP_007971301 ⟸ XM_007973110
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9R8I7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_007971302 ⟸ XM_007973111
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSCSAP00000004926 ⟸ ENSCSAT00000006729

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000008668	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000006729.1	UniProtKB/TrEMBL
InterPro	G6B	UniProtKB/TrEMBL
	G6B_V-set	UniProtKB/TrEMBL
	Ig-like_dom	UniProtKB/TrEMBL
KEGG Report	csab:103221753	UniProtKB/TrEMBL
NCBI Gene	MPIG6B	ENTREZGENE
PANTHER	MEGAKARYOCYTE AND PLATELET INHIBITORY RECEPTOR G6B	UniProtKB/TrEMBL
	PTHR37347	UniProtKB/TrEMBL
Pfam	G6B	UniProtKB/TrEMBL
PROSITE	IG_LIKE	UniProtKB/TrEMBL
UniProt	A0A0D9R8I7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM