LOC103223672 (low affinity immunoglobulin gamma Fc region receptor II-b) - Rat Genome Database

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Gene: LOC103223672 (low affinity immunoglobulin gamma Fc region receptor II-b) Chlorocebus sabaeus
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Symbol: LOC103223672
Name: low affinity immunoglobulin gamma Fc region receptor II-b
RGD ID: 18474225
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); IgG binding (ortholog); immunoglobulin binding (ortholog); INVOLVED IN antigen processing and presentation of exogenous peptide antigen via MHC class II (ortholog); B cell proliferation (ortholog); cell surface receptor signaling pathway (ortholog); PARTICIPATES IN clathrin-mediated endocytosis pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); asthma (ortholog); atherosclerosis (ortholog); FOUND IN cell body (ortholog); cell surface (ortholog); dendritic spine (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Fc fragment of IgG receptor IIb; FCGR2B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,398,425 - 2,413,328 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660381,453,854 - 1,469,432 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibody-dependent cellular cytotoxicity  (IEA)
antigen processing and presentation of exogenous peptide antigen via MHC class II  (ISO)
B cell proliferation  (ISO)
cell surface receptor signaling pathway  (IEA,ISO)
cellular response to amyloid-beta  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to molecule of bacterial origin  (ISO)
cerebellum development  (ISO)
defense response  (ISO)
dendrite development  (ISO)
endocytic recycling  (ISO)
establishment of localization in cell  (ISO)
Fc receptor-mediated immune complex endocytosis  (ISO)
Fc-gamma receptor signaling pathway  (IEA)
immune complex clearance  (ISO)
immune effector process  (ISO)
immunoglobulin mediated immune response  (ISO)
mast cell activation  (ISO)
negative regulation of acute inflammatory response to antigenic stimulus  (ISO)
negative regulation of B cell proliferation  (ISO)
negative regulation of B cell receptor signaling pathway  (ISO)
negative regulation of humoral immune response mediated by circulating immunoglobulin  (ISO)
negative regulation of immune response  (ISO)
negative regulation of immunoglobulin production  (ISO)
negative regulation of inflammatory response to antigenic stimulus  (ISO)
negative regulation of interleukin-10 production  (ISO)
negative regulation of neutrophil apoptotic process  (ISO)
negative regulation of phagocytosis  (ISO)
negative regulation of type I hypersensitivity  (ISO)
phagocytosis  (ISO)
phagocytosis, engulfment  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of phagocytosis  (IEA,ISO)
positive regulation of response to endoplasmic reticulum stress  (ISO)
positive regulation of tumor necrosis factor production  (IEA)
receptor-mediated endocytosis  (ISO)
regulation of dendritic spine maintenance  (ISO)
regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
response to bacterium  (ISO)
response to estradiol  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
LOC103223672
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,398,425 - 2,413,328 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660381,453,854 - 1,469,432 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
FCGR2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,647,243 - 161,678,654 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,663,143 - 161,678,654 (+)EnsemblGRCh38hg38GRCh38
GRCh371161,617,033 - 161,648,444 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,899,564 - 159,914,575 (+)NCBINCBI36Build 36hg18NCBI36
Build 341158,364,610 - 158,379,618NCBI
Celera1134,746,188 - 134,751,893 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,877,468 - 132,892,993 (+)NCBIHuRef
CHM1_11163,054,757 - 163,070,270 (+)NCBICHM1_1
T2T-CHM13v2.01160,991,589 - 161,022,983 (+)NCBIT2T-CHM13v2.0
Fcgr2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81385,725,897 - 85,740,517 (-)NCBIGRCr8
mRatBN7.21383,191,253 - 83,207,778 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,193,163 - 83,207,778 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1385,812,894 - 85,827,509 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,106,375 - 87,120,989 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,344,287 - 84,358,917 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,329,298 - 89,343,916 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,327,794 - 89,433,815 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01393,968,425 - 93,983,043 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41386,809,011 - 86,823,599NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1382,845,906 - 82,860,494 (-)NCBICelera
Cytogenetic Map13q24NCBI
Fcgr2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546214,639,396 - 14,653,801 (-)NCBIChiLan1.0ChiLan1.0
FCGR2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,107,912 - 88,123,421 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1187,776,270 - 87,791,796 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01137,074,342 - 137,090,962 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,882,104 - 140,890,036 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,882,043 - 140,890,637 (+)Ensemblpanpan1.1panPan2
FCGR2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13820,980,777 - 20,994,403 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,032,683 - 21,053,133 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,063,938 - 21,084,394 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,063,938 - 21,077,559 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,035,622 - 21,062,414 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,388,877 - 21,409,738 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03821,664,830 - 21,685,450 (-)NCBIUU_Cfam_GSD_1.0
Fcgr2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,560,625 - 7,575,166 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493713180,014 - 96,114 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FCGR2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1488,873,762 - 88,892,964 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2496,889,007 - 96,908,224 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Fcgr2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462482697,605 - 112,101 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
75 36 20 36 36 59 20

Sequence


RefSeq Acc Id: XM_007976382   ⟹   XP_007974573
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1202,398,425 - 2,413,311 (-)NCBI
Vero_WHO_p1.0NW_0236660381,453,854 - 1,469,432 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007976383   ⟹   XP_007974574
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1202,398,425 - 2,413,328 (-)NCBI
Vero_WHO_p1.0NW_0236660381,453,854 - 1,469,432 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007974573 (Get FASTA)   NCBI Sequence Viewer  
  XP_007974574 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000015353
  ENSCSAP00000015353.1
RefSeq Acc Id: XP_007974574   ⟸   XM_007976383
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S3B4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007974573   ⟸   XM_007976382
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S3B4 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000002694 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000000709.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_Fc_receptor UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
NCBI Gene FCGR2B ENTREZGENE
PANTHER IMMUNOGLOBULIN FC RECEPTOR UniProtKB/TrEMBL
  LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR II-B-RELATED UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A0D9S3B4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-08 LOC103223672  low affinity immunoglobulin gamma Fc region receptor II-b  FCGR2B  Fc fragment of IgG receptor IIb  Symbol and/or name change 5135510 APPROVED