GNPDA2 (glucosamine-6-phosphate deaminase 2)

Gene: GNPDA2 (glucosamine-6-phosphate deaminase 2) Chlorocebus sabaeus

Analyze

Symbol:

GNPDA2

Name:

glucosamine-6-phosphate deaminase 2

RGD ID:

18473019

Description:

ENCODES a protein that exhibits glucosamine-6-phosphate deaminase activity (inferred); hydrolase activity (inferred); identical protein binding (inferred); INVOLVED IN carbohydrate metabolic process (inferred); glucosamine catabolic process (inferred); N-acetylglucosamine catabolic process (inferred); ASSOCIATED WITH Body Weight (ortholog); genetic disease (ortholog); obesity (ortholog); FOUND IN cytoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

glucosamine-6-phosphate isomerase 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	5,562,894 - 5,587,459 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	5,562,916 - 5,586,543 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	51,710,663 - 51,735,473 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Body Weight (ISO)

genetic disease (ISO)

obesity (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carbohydrate metabolic process (IEA)

glucosamine catabolic process (IEA)

N-acetylglucosamine catabolic process (IEA)

N-acetylglucosamine metabolic process (IEA)

N-acetylneuraminate catabolic process (IEA)

UDP-N-acetylglucosamine biosynthetic process (IEA)

Cellular Component

cytoplasm (IEA)

Molecular Function

glucosamine-6-phosphate deaminase activity (IEA)

hydrolase activity (IEA)

identical protein binding (IEA)

isomerase activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

GNPDA2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	5,562,894 - 5,587,459 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	5,562,916 - 5,586,543 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	51,710,663 - 51,735,473 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

GNPDA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	44,701,795 - 44,726,556 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	44,682,200 - 44,726,588 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	44,703,812 - 44,728,573 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	44,398,925 - 44,423,369 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	44,545,096 - 44,569,540	NCBI
Celera	4	45,152,192 - 45,176,638 (-)	NCBI		Celera
Cytogenetic Map	4	p12	NCBI
HuRef	4	44,025,436 - 44,050,279 (-)	NCBI		HuRef
CHM1_1	4	44,702,923 - 44,727,736 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	44,668,716 - 44,693,480 (-)	NCBI		T2T-CHM13v2.0

Gnpda2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	69,732,344 - 69,749,684 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	69,730,451 - 69,749,683 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	69,574,998 - 69,592,332 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	69,573,108 - 69,592,340 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	69,966,240 - 69,983,524 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	69,852,245 - 69,871,420 (-)	NCBI		MGSCv36	mm8
Celera	5	66,858,645 - 66,875,974 (-)	NCBI		Celera
Cytogenetic Map	5	C3.1	NCBI
cM Map	5	37.13	NCBI

Gnpda2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	38,874,611 - 38,892,688 (+)	NCBI		GRCr8
mRatBN7.2	14	38,520,663 - 38,538,713 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	38,520,705 - 38,538,713 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	38,896,548 - 38,914,550 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	40,196,580 - 40,214,582 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	38,677,427 - 38,695,429 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	62,628,102 - 62,646,158 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	62,628,111 - 62,646,110 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	62,730,787 - 62,749,053 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	41,048,839 - 41,067,584 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	41,051,193 - 41,069,954 (+)	NCBI
Celera	14	37,719,177 - 37,737,184 (+)	NCBI		Celera
Cytogenetic Map	14	p11	NCBI

Gnpda2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955443	3,338,300 - 3,360,561 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955443	3,338,300 - 3,360,561 (+)	NCBI	ChiLan1.0	ChiLan1.0

GNPDA2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	44,878,721 - 44,923,195 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	45,065,371 - 45,109,845 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	39,011,732 - 39,056,234 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	44,861,252 - 44,905,733 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	44,881,220 - 44,905,733 (-)	Ensembl	panpan1.1		panPan2

GNPDA2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	41,207,192 - 41,228,573 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	41,207,897 - 41,232,404 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	41,160,250 - 41,185,478 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	41,814,500 - 41,839,486 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	41,801,109 - 41,839,600 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	41,494,001 - 41,518,794 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	41,538,927 - 41,563,984 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	41,931,427 - 41,956,525 (-)	NCBI		UU_Cfam_GSD_1.0

LOC101968793
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	34,874,360 - 34,958,967 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936482	11,339,682 - 11,362,150 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0 Ensembl	NW_004936482	11,397,322 - 11,423,885 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936482	11,382,358 - 11,423,823 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GNPDA2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	35,193,659 - 35,216,206 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	35,192,509 - 35,219,527 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	36,899,569 - 36,925,403 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Gnpda2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624761	22,261,869 - 22,286,147 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624761	22,261,838 - 22,286,180 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	36	5	60
Low		15
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008017504	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008017505	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008017506	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038008580	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038008581	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038008582	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000015222 ⟹ ENSCSAP00000013167

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	27	5,562,916 - 5,586,543 (+)	Ensembl

RefSeq Acc Id:

XM_008017506 ⟹ XP_008015697

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	27	5,562,894 - 5,587,459 (+)	NCBI
Vero_WHO_p1.0	NW_023666047	51,710,663 - 51,735,473 (+)	NCBI

Sequence:

show sequence

CAGCGCCTGCCGGCCGCGCCGCGGTTCCTTCCTGCGCCTTTATCTGCATCCGGGTCCGTGGGAT
TCGCGCTCCACTGGTCCGCCGGGGTCGCTCGCGGGTGGTTGGGTGTTGCTTGTTCCCGCTGTTC
CAGCGTCGGAAGAGCCATTGGGTCTGCCGGGAGTACACCTTTAGGATGCTATAAAAAACTAATA
GAATATCATAAGAATGGACACCTTTCTTTTAAATATGTGAAGACCTTTAATATGGATGAATATG
TAGGACTTCCGAGAAATCATCCTGAAAGCTACCATTCTTATATGTGGAATAACTTTTTTAAGCA
TATTGATATAGATCCTAATAATGCACATATCCTTGATGGGAATGCTGCAGATTTACAAGCAGAA
TGTGATGCTTTTGAAAAGAAAATAAAGGAAGCTGGAGGAATAGATCTTTTTGTTGGAGGAATTG
GTCCAGATGGTCATATCGCTTTCAATGAGCCTGGATCCAGTTTAGTATCAAGGACAAGATTAAA
GACTCTAGCAATGGATACCATCTTGGCAAATGCCAAATATTTTGATGGAGATTTATCAAAAGTG
CCAACTATGGCTCTAACTGTTGGTGTGGGGACAGTGATGGATGCTAGAGAAGTAATGATCCTCA
TAACAGGGGCACACAAGGCATTTGCCCTGTACAAAGCAATAGAAGAAGGAGTCAATCACATGTG
GACTGTTTCCGCTTTCCAGCAGCATCCCCGAACTATTTTTGTATGTGATGAAGATGCTACTTTA
GAATTAAGAGTTAAAACTGTGAAATACTTTAAAGGTCTAATGCATGTGCACAATAAACTTGTGG
ATCCACTATTCAGTATGAAAGATGGAAATTGAAGGAGAATGGAGCAAAATTCTGCTTGAATGAA
CAGAGCACTTTTTACTAAGTAGTAGATGAATTTTCAGCTATGCAATATGATAAAACATGGGAAA
TTTTGAAGACTGTCATTTTTTCATTTGAGTATCTATGTTAAACATTCCATAATTTGAATATTTA
TATCTTGTACTTGGGTTTAAGAGAAGTAGCTGGCTCTCAAGATTGGCTGTTATAAAGTATTGAA
GTCACATAGCCACTTATAAACAGCATAGAAATGTCTGCCCGTTTAAAAAGTCATTTTAAAGGTA
GAGTGTACACATCAGGTGCCATTTGTGATATGACTCCAGTGGCATATATTTCATTTTTTAATGA
CATGACACTCCAAACCTTTCAGATCAAACTGTCATTGCAGACCTTCACTTTTGGAATGCGATCT
TCATATTTTCTGTGCATCACACACATGCTTTTCTGCACGTGGTTGCCTTAGTCATCTTCCTACA
GCACTATCTAGACATCAAAAATTGTGCTATATATCGTTGGTAAAGGAAATTTGAAGAGATGACA
GTGCCTAAAAGTAGTTTACATCCTTTCAGAAAGTATGTGTAAGTGCATGTTTTTTGTGCACCAC
CTTCTATAGCACTTTTTTACAAATATCTTATTTTTAACGACTTGGGTTCATGTCCCTAACATAA
GTATCTTGACAATTATGAGCTTTATACCTAGCAATCCACTTCAGGAAATTATTTTGGAGAATAT
TTTCTGATTATTGTTAAACTTAATATACGACTAGCTTTATTCCTTATGTCTAAAATAATATGAA
CTATATATAAAAGGAATTACTGTAAACTACATTGCCATAGCAATTTACATAAAAGTATATTGTT
TTCTATCTTTAACTCAAATAAAGCGTGTAATAAATAAGTTATCTAAATTTTA

hide sequence

RefSeq Acc Id:

XM_038008580 ⟹ XP_037864508

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666047	51,714,999 - 51,735,473 (+)	NCBI

RefSeq Acc Id:

XM_038008581 ⟹ XP_037864509

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666047	51,716,227 - 51,735,473 (+)	NCBI

RefSeq Acc Id:

XM_038008582 ⟹ XP_037864510

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666047	51,714,999 - 51,729,585 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_008015697	(Get FASTA)	NCBI Sequence Viewer
	XP_037864508	(Get FASTA)	NCBI Sequence Viewer
	XP_037864509	(Get FASTA)	NCBI Sequence Viewer
	XP_037864510	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000013167.1

RefSeq Acc Id:	XP_008015697 ⟸ XM_008017506
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSCSAP00000013167 ⟸ ENSCSAT00000015222

RefSeq Acc Id:	XP_037864508 ⟸ XM_038008580
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_037864510 ⟸ XM_038008582
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_037864509 ⟸ XM_038008581
- Peptide Label:	isoform X2

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000017128	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000015222.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1360	UniProtKB/TrEMBL
InterPro	Glc/Gal-6P_isomerase	UniProtKB/TrEMBL
	Glucosamine6P_isomerase	UniProtKB/TrEMBL
	Glucosamine6P_isomerase_CS	UniProtKB/TrEMBL
	NagB/RpiA_transferase-like	UniProtKB/TrEMBL
KEGG Report	csab:103246154	UniProtKB/TrEMBL
NCBI Gene	GNPDA2	ENTREZGENE
PANTHER	GLUCOSAMINE-6-PHOSPHATE ISOMERASE 2	UniProtKB/TrEMBL
	PTHR11280	UniProtKB/TrEMBL
Pfam	Glucosamine_iso	UniProtKB/TrEMBL
PROSITE	GLC_GALNAC_ISOMERASE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF100950	UniProtKB/TrEMBL
UniProt	A0A0D9RX28_CHLSB	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD