GMDS (GDP-mannose 4,6-dehydratase)

Gene: GMDS (GDP-mannose 4,6-dehydratase) Chlorocebus sabaeus

Analyze

Symbol:

GMDS

Name:

GDP-mannose 4,6-dehydratase

RGD ID:

18471307

Description:

ENCODES a protein that exhibits GDP-mannose 4,6-dehydratase activity (ortholog); identical protein binding (ortholog); NADP+ binding (ortholog); INVOLVED IN 'de novo' GDP-L-fucose biosynthetic process (ortholog); GDP-mannose metabolic process (ortholog); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; ASSOCIATED WITH aniridia (ortholog); genetic disease (ortholog); open-angle glaucoma (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

GDP-mannose 4,6 dehydratase

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	69,899,089 - 70,523,126 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666044	1,566,497 - 2,196,283 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

aniridia (ISO)

genetic disease (ISO)

open-angle glaucoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

'de novo' GDP-L-fucose biosynthetic process (ISO)

GDP-mannose metabolic process (ISO)

Molecular Function

GDP-mannose 4,6-dehydratase activity (ISO)

identical protein binding (ISO)

NADP+ binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

fructose and mannose metabolic pathway (ISO)

fructosuria pathway (ISO)

hereditary fructose intolerance syndrome pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

GMDS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	69,899,089 - 70,523,126 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666044	1,566,497 - 2,196,283 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

GMDS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	1,623,806 - 2,245,605 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	1,623,806 - 2,245,605 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	1,624,041 - 2,245,839 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	1,569,040 - 2,190,845 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	1,569,040 - 2,190,845	NCBI
Celera	6	2,852,269 - 3,473,926 (-)	NCBI		Celera
Cytogenetic Map	6	p25.3	NCBI
HuRef	6	1,493,473 - 2,117,107 (-)	NCBI		HuRef
CHM1_1	6	1,625,952 - 2,247,981 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	1,486,810 - 2,109,239 (-)	NCBI		T2T-CHM13v2.0

Gmds
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	32,003,566 - 32,522,744 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	32,003,562 - 32,522,723 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	31,819,583 - 32,338,762 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	31,819,579 - 32,338,740 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	31,911,455 - 32,430,413 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	31,827,051 - 32,346,009 (-)	NCBI		MGSCv36	mm8
Celera	13	32,029,445 - 32,552,254 (-)	NCBI		Celera
Cytogenetic Map	13	A3.2	NCBI
cM Map	13	13.52	NCBI

Gmds
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	32,304,029 - 32,830,708 (+)	NCBI		GRCr8
mRatBN7.2	17	32,095,315 - 32,621,975 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	32,095,386 - 32,621,961 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	31,943,309 - 32,469,749 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	33,547,114 - 34,073,564 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	31,939,117 - 32,465,571 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	33,408,722 - 33,938,086 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	33,408,722 - 33,938,085 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	35,298,853 - 35,824,292 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	38,461,733 - 39,016,771 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	17	31,657,264 - 32,181,220 (+)	NCBI		Celera
Cytogenetic Map	17	p12	NCBI

Gmds
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955465	11,145,837 - 11,563,352 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955465	11,133,513 - 11,562,562 (+)	NCBI	ChiLan1.0	ChiLan1.0

GMDS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	16,178,749 - 16,875,792 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	12,234,431 - 12,866,878 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	1,443,129 - 2,071,856 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	1,559,444 - 2,178,324 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	1,556,227 - 2,178,330 (-)	Ensembl	panpan1.1		panPan2

GMDS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	35	2,108,459 - 2,519,902 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	35	2,151,528 - 2,519,513 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	35	2,079,228 - 2,654,331 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	35	2,025,524 - 2,554,965 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	35	2,000,500 - 2,575,207 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	35	2,021,716 - 2,596,616 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	35	3,357,422 - 3,932,361 (-)	NCBI		UU_Cfam_GSD_1.0

Gmds
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	23,253,265 - 23,867,993 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936633	2,752,443 - 3,367,443 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936633	2,752,677 - 3,367,408 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GMDS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	752,592 - 1,285,550 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	849,088 - 1,285,563 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	1,047,471 - 1,386,586 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Gmds
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624756	22,504,499 - 23,051,938 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624756	22,504,483 - 23,051,215 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007973861	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007973862	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_007973861 ⟹ XP_007972052

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	17	69,899,208 - 70,523,126 (+)	NCBI
Vero_WHO_p1.0	NW_023666044	1,566,497 - 2,196,200 (-)	NCBI

Sequence:

show sequence

CGCCGCACACACCCGCGTTCCTGCCGGCGCCGCGCCTGCCCTCTGCCGCGCTCCGCCCTGCCGC
CGACCGCACGCCCGCCGCGGGACATGGCACACGCACCGGCACGCTGCTCCAGCGCCCGGGGCTC
CGGGGACGGCGAGATGGGCAAGCCCAGGAACGTGGCGCTCATCACCGGCATCACGGGCCAGGGT
GAAAACATTGCTTTTTGTGTGACTCACATTGTAGTAGAAGGCACTCTGAGGAAAGAAGATCAAC
ACTTTCATACCCCTTCAGGAACTGATTGTCCTGCTGAAGAACCAAGACAAAAATCGAACATCCC
TACTGATGGTTCCTACCTGGCTGAGTTCCTGCTGGAGAAAGGCTATGAGGTCCATGGAATTGTA
CGGCGGTCCAGTTCATTTAATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCTCACA
TTGAAGGAAACATGAAGTTGCACTATGGCGATCTCACTGACAGTACCTGCCTTGTGAAGATCAT
TAATGAAGTAAAGCCCACGGAGATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTTCCTTT
GACCTCGCTGAGTACACTGCAGATGTTGATGGAGTTGGCACTCTACGACTTCTAGATGCAGTTA
AGACTTGTGGCCTTATCAACTCTGTGAAGTTCTACCAAGCCTCAACAAGTGAACTTTATGGGAA
AGTGCAGGAAATACCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGGGCAGCA
AAACTCTATGCCTATTGGATTGTGGTGAACTTCCGTGAGGCGTATAATCTCTTTGCGGTGAATG
GCATTCTGTTCAATCATGAGAGTCCCAGAAGAGGAGCTAATTTCGTTACTCGAAAAATTAGCCG
GTCAGTAGCTAAGATTTACCTTGGACAACTGGAATGTTTCAGTTTGGGAAATCTGGATGCCAAA
CGAGATTGGGGCCATGCCAAGGACTATGTGGAGGCTATGTGGTTGATGTTGCAGAATGATGAGC
CGGAGGACTTCGTCATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTCGAGAAATCATT
CATGCACATTGGAAAAACCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAA
GAGACCGGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGGACTTTC
TGCAGGGCGACTGCACCAAAGCGAAACAGAAGCTGAACTGGAAGCCCCGGGTCGCTTTCGATGA
GCTGGTGAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGACGAACCCCAATGCCTGAGCA
CGGCCGCGGAGCCCGCCCGACCCGCCCTCCGGCTGCGATCCCGCAGAGGCACCGTGGGGATGGG
GAGGGGCGTGCCAGTCTGCGGGTCCCTGTGGCCCCTGCTGCCACCGCGCTGTCCCGGCCGCAGG
AGCCGGCCGCCCCGCCGAGTTTTGTAGCAGCCGGGATGTGACCCTCCAGGGTTTGGGCCGCTTC
GCTTTTGTCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATGTTTTAATCATACTCACTTT
ACTTGAAATTATGTTGTCAGACAACAAATTGTGGGGCCTTCAAATTGTTTTTCTCTTTTCATAT
TAAAAATGGTCTTTCTGTGAACTAACA

hide sequence

RefSeq Acc Id:

XM_007973862 ⟹ XP_007972053

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	17	69,899,089 - 70,523,126 (+)	NCBI
Vero_WHO_p1.0	NW_023666044	1,566,497 - 2,196,283 (-)	NCBI

Sequence:

show sequence

GCCGGCTCGTCCCGCCCCCGGCCCTCCCCGCGCGGCCTCCCGTGCGCCCCTGTCAGACTGTGGC
GGCCGGTCGCGCGGTGCGCTCTCTCTCCCTGCCCGCAGCCTGGAGAGGCGCTTCGCGCCGCACA
CACCCGCGTTCCTGCCGGCGCCGCGCCTGCCCTCTGCCGCGCTCCGCCCTGCCGCCGACCGCAC
GCCCGCCGCGGGACATGGCACACGCACCGGCACGCTGCTCCAGCGCCCGGGGCTCCGGGGACGG
CGAGATGGGCAAGCCCAGGAACGTGGCGCTCATCACCGGCATCACGGGCCAGGATGGTTCCTAC
CTGGCTGAGTTCCTGCTGGAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCAT
TTAATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCTCACATTGAAGGAAACATGAA
GTTGCACTATGGCGATCTCACTGACAGTACCTGCCTTGTGAAGATCATTAATGAAGTAAAGCCC
ACGGAGATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTTCCTTTGACCTCGCTGAGTACA
CTGCAGATGTTGATGGAGTTGGCACTCTACGACTTCTAGATGCAGTTAAGACTTGTGGCCTTAT
CAACTCTGTGAAGTTCTACCAAGCCTCAACAAGTGAACTTTATGGGAAAGTGCAGGAAATACCC
CAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGGGCAGCAAAACTCTATGCCTATT
GGATTGTGGTGAACTTCCGTGAGGCGTATAATCTCTTTGCGGTGAATGGCATTCTGTTCAATCA
TGAGAGTCCCAGAAGAGGAGCTAATTTCGTTACTCGAAAAATTAGCCGGTCAGTAGCTAAGATT
TACCTTGGACAACTGGAATGTTTCAGTTTGGGAAATCTGGATGCCAAACGAGATTGGGGCCATG
CCAAGGACTATGTGGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTCAT
AGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTCGAGAAATCATTCATGCACATTGGAAAA
ACCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTC
ACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCAC
CAAAGCGAAACAGAAGCTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGGTGAGGGAGATG
GTGCACGCCGACGTGGAGCTCATGAGGACGAACCCCAATGCCTGAGCACGGCCGCGGAGCCCGC
CCGACCCGCCCTCCGGCTGCGATCCCGCAGAGGCACCGTGGGGATGGGGAGGGGCGTGCCAGTC
TGCGGGTCCCTGTGGCCCCTGCTGCCACCGCGCTGTCCCGGCCGCAGGAGCCGGCCGCCCCGCC
GAGTTTTGTAGCAGCCGGGATGTGACCCTCCAGGGTTTGGGCCGCTTCGCTTTTGTCGAAGCCT
CCTCTGAATGGCTTTGTGAAATCAAGATGTTTTAATCATACTCACTTTACTTGAAATTATGTTG
TCAGACAACAAATTGTGGGGCCTTCAAATTGTTTTTCTCTTTTCATATTAAAAATGGTCTTTCT
GTGAACTAACA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007972052	(Get FASTA)	NCBI Sequence Viewer
	XP_007972053	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_007972053 ⟸ XM_007973862
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_007972052 ⟸ XM_007973861
- Peptide Label:	isoform X1

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	GMDS	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB