GDF3 (growth differentiation factor 3)

Gene: GDF3 (growth differentiation factor 3) Chlorocebus sabaeus

Analyze

Symbol:

GDF3

Name:

growth differentiation factor 3

RGD ID:

18463417

Description:

ENCODES a protein that exhibits cytokine activity (inferred); growth factor activity (inferred); protein kinase binding (inferred); INVOLVED IN endoderm development (ortholog); formation of anatomical boundary (ortholog); in utero embryonic development (ortholog); ASSOCIATED WITH Camptocormia (ortholog); congenital heart disease (ortholog); developmental and epileptic encephalopathy 21 (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

growth/differentiation factor 3

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	7,727,818 - 7,733,514 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	7,727,913 - 7,733,075 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	470,438 - 475,790 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Camptocormia (ISO)

congenital heart disease (ISO)

developmental and epileptic encephalopathy 21 (ISO)

Edema (ISO)

genetic disease (ISO)

Germ Cell and Embryonal Neoplasms (ISO)

Hyperphosphatemic Familial Tumoral Calcinosis 1 (ISO)

isolated microphthalmia 7 (ISO)

Isolated Microphthalmia with Coloboma 6 (ISO)

Klippel-Feil syndrome 3 (ISO)

lymphoproliferative syndrome 2 (ISO)

peroxisome biogenesis disorder 2B (ISO)

scoliosis (ISO)

Temtamy syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

endoderm development (ISO)

eye development (IEA)

formation of anatomical boundary (ISO)

in utero embryonic development (ISO)

mesoderm development (ISO)

negative regulation of BMP signaling pathway (IEA)

negative regulation of epidermal cell differentiation (IEA)

negative regulation of myoblast differentiation (ISO)

notochord development (ISO)

positive regulation of fat cell differentiation (ISO)

primitive streak formation (ISO)

regulation of cell fate commitment (IEA)

response to dietary excess (ISO)

signal transduction (IEA,ISO)

skeletal system development (IEA)

somite rostral/caudal axis specification (ISO)

Cellular Component

cytoplasm (IEA)

extracellular region (IEA)

extracellular space (IEA)

Molecular Function

cytokine activity (IEA)

growth factor activity (IEA)

protein binding (ISO)

protein kinase binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

GDF3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	7,727,818 - 7,733,514 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	7,727,913 - 7,733,075 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	470,438 - 475,790 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

GDF3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	7,689,784 - 7,695,775 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	7,689,784 - 7,695,775 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	7,842,380 - 7,848,371 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	7,733,648 - 7,739,627 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	7,733,647 - 7,739,627	NCBI
Celera	12	9,419,392 - 9,425,368 (-)	NCBI		Celera
Cytogenetic Map	12	p13.31	NCBI
HuRef	12	7,656,489 - 7,662,465 (-)	NCBI		HuRef
CHM1_1	12	7,839,618 - 7,847,334 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	7,704,552 - 7,710,540 (-)	NCBI		T2T-CHM13v2.0

Gdf3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	122,582,362 - 122,587,046 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	122,582,362 - 122,587,046 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	122,605,403 - 122,610,087 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	122,605,403 - 122,610,087 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	122,555,421 - 122,560,089 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	122,571,022 - 122,575,690 (-)	NCBI		MGSCv36	mm8
Celera	6	124,400,537 - 124,405,205 (-)	NCBI		Celera
Cytogenetic Map	6	F1	NCBI
cM Map	6	57.7	NCBI

Gdf3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	157,503,547 - 157,507,923 (-)	NCBI		GRCr8
mRatBN7.2	4	155,831,572 - 155,835,953 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	155,830,909 - 155,835,937 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	162,096,256 - 162,100,528 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	157,879,466 - 157,883,738 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	156,524,567 - 156,528,834 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	155,417,667 - 155,422,014 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	155,417,004 - 155,421,998 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	222,441,866 - 222,445,551 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	159,064,054 - 159,067,854 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	144,650,730 - 144,655,147 (-)	NCBI		Celera
Cytogenetic Map	4	q42	NCBI

Gdf3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955413	6,493,734 - 6,516,315 (-)	NCBI	ChiLan1.0	ChiLan1.0

GDF3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	13,248,001 - 13,262,305 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	13,244,760 - 13,259,063 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	7,813,288 - 7,819,418 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	7,972,941 - 7,979,654 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	7,972,907 - 7,979,815 (-)	Ensembl	panpan1.1		panPan2

GDF3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	37,125,845 - 37,129,567 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	37,125,928 - 37,129,484 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	9,486,781 - 9,490,505 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	37,475,220 - 37,478,894 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	37,475,303 - 37,478,814 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	37,356,251 - 37,359,922 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	37,391,174 - 37,394,862 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	8,972,861 - 8,976,557 (+)	NCBI		UU_Cfam_GSD_1.0

Gdf3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	98,790,269 - 98,799,229 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004937847	7,456 - 16,783 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004937847	8,179 - 16,783 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GDF3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	62,835,880 - 62,841,884 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	62,835,926 - 62,841,827 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	65,666,056 - 65,672,100 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Gdf3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624860	4,968,624 - 4,970,362 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium
Low	10	12	7
Below cutoff	25	5	13

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007967480	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000007894 ⟹ ENSCSAP00000006055

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	11	7,727,913 - 7,733,075 (-)	Ensembl

RefSeq Acc Id:

XM_007967480 ⟹ XP_007965671

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	11	7,727,818 - 7,733,514 (-)	NCBI
Vero_WHO_p1.0	NW_023666063	470,438 - 475,790 (+)	NCBI

Sequence:

show sequence

CTGCATTCAAAGCCATCATGTGCCTCATGCGACCCTCTGCATTGGTCTGTGCAGATGATGAATG
ATAAGTCTATGAATTATTCACTGCTCTGTTCCTAGCACCTATCTCAGCACCTTGCACATAATAG
ATGCTTAGTAACTGTTTGTTAAATGAATAAATGCATGTCTCCTTTTCACTCTGTCTACTGCTGA
CAACCTCACATTGTTGTAGAGTTTATGTCCATGCATTGGTAATCTTTATTCTGTGAACTTTTTC
CTGGAAGAGTAGAGCAAGAGAAGAGAAAAAAAAAATTCCGTCTTCACATCCAATGGCCTTTGAG
GAGCTGGGAAGAGAGCAATTCACACTTGATTATCTTACAACAGATAAATTAGCAGCCCCTGAAT
TGTTGGGCAGTCTGGCAGTGGAGCTCTCCCTGGCCTGATAGCCACTCTAGAGGCCATGCTTCGA
TTCTTGCCAGATTTGGCTTTCAGCTTCCTGTTAACTCTGGCTTTGGGCCAGGCAGTCCAATTTC
AAGAATATGTCTTTCTCCAATTTATGGGCTTAGATAAGGCGCCTTCACCCCAGAAGTTCCAACC
TGTGCCTTATATCTTGAAGAAAATCTTCCAGGATCGCGAGGCAGCAGTGACCACTGGGGTCTCC
CGAGACTCATGCTACGTAAAGGAGCTGGGCGTCCGTGGGAATGTACTTCGCTTTCTCCCAGACC
AAGGTTTCTTTCTTTACCCAAAGAAATTTTCCCAAGCTTCCTCCTGCCTGCAAAAGCTGCTCTA
CTTTAACCTGTCTGCCATCAAAGAAAGAGAACAGTTGACACTGGCCCAGCTGGGCCTGGACTTG
GGGCCCAATTCTTACTATTACCTGGGACCAGAGCTGGAACTGGCTCTGTTCCTGGTTCAAGAGC
CTCATGTGTGGGGCCAGACCACCCCTAAGCCAGGTAAAATGTTTATGTTGCGGTCAGTCCCATG
GCCACAAGGTGCTGTTGACTTCAACCTGCTGGATGTAGCTAAGGACTGGAATGACAACCCCCAG
AAAAACTTTGGGTTATTCCTGGAGATACTGGTCAAAGCAGACAGAGACTCTGGGGTGAATTTTC
AGCCTGAGGACACCTGTGCCAGACTGAGACGCTCCCTTCATGCTTCCCTGCTGGTGGTGGCCCT
CAACCCTGATGAGTGCCACCCTTCTCGGAAAAGGAGAGCAGCCATCCCTGTCCCCAAGGTTTCT
TGTAAGAACCTCTGCCACCGTCACCAGCTATTCATTAACTTCCAGGACCTGGGTTGGCACAAGT
GGATCATTGCCCCCAAGGGGTTCATGGCAAATTACTGCCACGGAGAGTGTCCCTTCTCACTGAC
CATCTCTCTTAACAGCTCCAATTATGCTTTCATGCAAGCCCTGATGCATGCAGTTGACCCAGAG
ATCCCCCAGGCTGTGTGTGTCCCCACCAAGCTGTCTCCCATTTCCATGCTCTACCAGGACAATA
ATGACAATGTCATTCTACGACATTATGAAGACATGGTAGTCGATGAATGTGGGTGTGGGTAGGA
TGTCAGAAATGGGAATAGAAGGAGTGTTCTTAGGATAAATCTTCTAATAAAACTACCTATCTGG
TTTATGACCACTTAGATCGGAAATGTCAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007965671	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000006055.1

RefSeq Acc Id:	XP_007965671 ⟸ XM_007967480
- UniProtKB:	A0A0D9RBR6 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000006055 ⟸ ENSCSAT00000007894

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000009810	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000007894.1	UniProtKB/TrEMBL
Gene3D-CATH	2.10.90.10	UniProtKB/TrEMBL
	2.60.120.970	UniProtKB/TrEMBL
InterPro	Cystine-knot_cytokine	UniProtKB/TrEMBL
	TGF-b_C	UniProtKB/TrEMBL
	TGF-beta-rel	UniProtKB/TrEMBL
	TGFb_CS	UniProtKB/TrEMBL
KEGG Report	csab:103218510	UniProtKB/TrEMBL
NCBI Gene	GDF3	ENTREZGENE
PANTHER	GROWTH/DIFFERENTIATION FACTOR 3	UniProtKB/TrEMBL
	PTHR11848	UniProtKB/TrEMBL
Pfam	TGF_beta	UniProtKB/TrEMBL
PRINTS	INHIBINA	UniProtKB/TrEMBL
PROSITE	TGF_BETA_1	UniProtKB/TrEMBL
	TGF_BETA_2	UniProtKB/TrEMBL
SMART	TGFB	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57501	UniProtKB/TrEMBL
UniProt	A0A0D9RBR6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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