GDF15 (growth differentiation factor 15) - Rat Genome Database

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Gene: GDF15 (growth differentiation factor 15) Chlorocebus sabaeus
Analyze
Symbol: GDF15
Name: growth differentiation factor 15
RGD ID: 18452538
Description: ENCODES a protein that exhibits hormone activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN cellular response to chemical stress (ortholog); energy homeostasis (ortholog); GDF15-GFRAL signaling pathway (ortholog); ASSOCIATED WITH anemia (ortholog); Cachexia (ortholog); congestive heart failure (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); Golgi apparatus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: growth/differentiation factor 15
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,853,397 - 16,861,924 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,852,971 - 16,861,964 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660742,479,299 - 2,485,699 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GDF15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,853,397 - 16,861,924 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,852,971 - 16,861,964 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660742,479,299 - 2,485,699 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
GDF15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,386,158 - 18,389,176 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,374,731 - 18,389,176 (+)EnsemblGRCh38hg38GRCh38
GRCh371918,496,968 - 18,499,986 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,357,968 - 18,360,986 (+)NCBINCBI36Build 36hg18NCBI36
Build 341918,357,984 - 18,360,986NCBI
Celera1918,398,797 - 18,401,815 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1918,062,378 - 18,063,268 (+)NCBIHuRef
CHM1_11918,497,209 - 18,500,231 (+)NCBICHM1_1
T2T-CHM13v2.01918,515,920 - 18,523,324 (+)NCBIT2T-CHM13v2.0
Gdf15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,082,043 - 71,085,106 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,082,043 - 71,085,106 (-)EnsemblGRCm39 Ensembl
GRCm38870,629,393 - 70,632,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,629,393 - 70,632,456 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,153,293 - 73,155,534 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,558,382 - 73,561,082 (-)NCBIMGSCv36mm8
Celera873,186,175 - 73,188,416 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
Gdf15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,838,436 - 18,842,022 (+)NCBIGRCr8
mRatBN7.21618,804,457 - 18,808,043 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,805,239 - 18,808,055 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,847,005 - 18,849,564 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,979,943 - 19,982,528 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,899,963 - 18,902,522 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,555,395 - 20,557,978 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,555,395 - 20,557,978 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,411,167 - 20,413,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,310,882 - 19,313,465 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,310,851 - 19,313,463 (+)NCBI
Celera1618,997,242 - 18,999,829 (+)NCBICelera
Cytogenetic Map16p14NCBI
Gdf15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,123,760 - 3,125,621 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,123,513 - 3,125,642 (-)NCBIChiLan1.0ChiLan1.0
GDF15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22023,235,317 - 23,249,754 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11922,255,036 - 22,258,089 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,864,840 - 17,867,883 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,835,216 - 18,838,470 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,835,216 - 18,838,470 (+)Ensemblpanpan1.1panPan2
GDF15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,633,131 - 44,636,842 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,634,588 - 44,636,821 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,547,490 - 44,551,239 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,119,086 - 45,122,834 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,120,542 - 45,122,775 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,356,357 - 44,360,107 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,766,491 - 44,770,241 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,041,907 - 45,045,657 (-)NCBIUU_Cfam_GSD_1.0
Gdf15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,305,463 - 203,310,650 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365962,854,841 - 2,857,111 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365962,854,620 - 2,857,018 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDF15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,408,904 - 59,411,358 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,409,035 - 59,411,356 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Gdf15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,634,174 - 1,636,242 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,633,927 - 1,636,242 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 16 18 24
Below cutoff 20 2 36

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000003395   ⟹   ENSCSAP00000001674
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl616,852,971 - 16,861,964 (+)Ensembl
RefSeq Acc Id: XM_037992438   ⟹   XP_037848366
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660742,479,299 - 2,485,699 (-)NCBI
Protein Sequences
Protein RefSeqs XP_037848366 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000001674.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000001674   ⟸   ENSCSAT00000003395
RefSeq Acc Id: XP_037848366   ⟸   XM_037992438
- UniProtKB: A0A0D9QZ85 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000005364 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000003395.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/TrEMBL
KEGG Report csab:103234180 UniProtKB/TrEMBL
NCBI Gene GDF15 ENTREZGENE
PANTHER GROWTH/DIFFERENTIATION FACTOR 15 UniProtKB/TrEMBL
  PTHR11848 UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
PROSITE TGF_BETA_2 UniProtKB/TrEMBL
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A0D9QZ85 ENTREZGENE, UniProtKB/TrEMBL