GDF5 (growth differentiation factor 5) - Rat Genome Database

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Gene: GDF5 (growth differentiation factor 5) Chlorocebus sabaeus
Analyze
Symbol: GDF5
Name: growth differentiation factor 5
RGD ID: 18438252
Description: ENCODES a protein that exhibits signaling receptor binding (ortholog); INVOLVED IN cell surface receptor protein serine/threonine kinase signaling pathway (ortholog); chondrocyte differentiation (ortholog); embryonic limb morphogenesis (ortholog); ASSOCIATED WITH acromesomelic dysplasia (ortholog); acromesomelic dysplasia, Grebe type (ortholog); acromesomelic dysplasia, Hunter-Thompson type (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: growth/differentiation factor 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1256,340,371 - 56,346,378 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl256,340,933 - 56,345,053 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660872,491,489 - 2,496,692 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GDF5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1256,340,371 - 56,346,378 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl256,340,933 - 56,345,053 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660872,491,489 - 2,496,692 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
GDF5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382035,433,347 - 35,454,749 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2035,433,347 - 35,454,746 (-)EnsemblGRCh38hg38GRCh38
GRCh372034,021,145 - 34,042,571 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362033,484,563 - 33,489,441 (-)NCBINCBI36Build 36hg18NCBI36
Build 342033,484,562 - 33,489,441NCBI
Celera2030,769,772 - 30,774,651 (-)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2030,798,624 - 30,803,509 (-)NCBIHuRef
CHM1_12033,922,579 - 33,927,457 (-)NCBICHM1_1
T2T-CHM13v2.02037,154,208 - 37,175,640 (-)NCBIT2T-CHM13v2.0
Gdf5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392155,782,943 - 155,787,204 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2155,782,943 - 155,787,287 (-)EnsemblGRCm39 Ensembl
GRCm382155,941,023 - 155,945,367 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2155,941,023 - 155,945,367 (-)EnsemblGRCm38mm10GRCm38
MGSCv372155,766,759 - 155,771,100 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362155,632,468 - 155,636,808 (-)NCBIMGSCv36mm8
Celera2161,874,286 - 161,878,600 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map277.26NCBI
Gdf5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,914,401 - 164,918,593 (-)NCBIGRCr8
mRatBN7.23144,454,316 - 144,458,508 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3144,454,338 - 144,458,612 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3148,319,762 - 148,323,943 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,937,031 - 156,941,212 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,676,561 - 154,680,742 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03151,482,672 - 151,487,129 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,483,249 - 151,486,693 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03157,849,749 - 157,853,231 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3143,176,803 - 143,181,254 (-)NCBICelera
Cytogenetic Map3q42NCBI
Gdf5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542225,992,081 - 25,997,122 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542225,992,081 - 25,997,122 (+)NCBIChiLan1.0ChiLan1.0
GDF5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22141,166,285 - 41,174,274 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12041,159,388 - 41,167,377 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02031,761,199 - 31,766,229 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12032,882,094 - 32,903,044 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2032,882,094 - 32,886,899 (-)Ensemblpanpan1.1panPan2
GDF5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12424,395,699 - 24,400,302 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2424,395,263 - 24,399,928 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2424,041,515 - 24,046,000 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02425,088,106 - 25,092,591 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2425,088,006 - 25,092,220 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12424,374,851 - 24,379,335 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02424,469,869 - 24,474,354 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02424,908,900 - 24,913,385 (-)NCBIUU_Cfam_GSD_1.0
Gdf5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640173,399,611 - 173,406,429 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365615,343,038 - 5,347,721 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365615,343,038 - 5,347,721 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDF5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1738,792,187 - 38,797,005 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11738,792,854 - 38,796,806 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21743,913,724 - 43,917,676 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Gdf5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248423,959,617 - 3,963,020 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248423,958,814 - 3,963,713 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007963220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCSAT00000008514   ⟹   ENSCSAP00000006660
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl256,340,933 - 56,345,053 (-)Ensembl
RefSeq Acc Id: XM_007963220   ⟹   XP_007961411
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1256,340,371 - 56,346,378 (-)NCBI
Vero_WHO_p1.0NW_0236660872,491,489 - 2,496,692 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007961411 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000006660
  ENSCSAP00000006660.1
RefSeq Acc Id: XP_007961411   ⟸   XM_007963220
- UniProtKB: A0A0D9RDH1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000006660   ⟸   ENSCSAT00000008514


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010427 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008514.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
  2.60.120.970 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/TrEMBL
  TGFb_CS UniProtKB/TrEMBL
KEGG Report csab:103216071 UniProtKB/TrEMBL
NCBI Gene GDF5 ENTREZGENE
PANTHER GROWTH/DIFFERENTIATION FACTOR 5 UniProtKB/TrEMBL
  PTHR11848 UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/TrEMBL
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A0D9RDH1 ENTREZGENE, UniProtKB/TrEMBL