ACAA2 (acetyl-CoA acyltransferase 2)

Gene: ACAA2 (acetyl-CoA acyltransferase 2) Chlorocebus sabaeus

Analyze

Symbol:

ACAA2

Name:

acetyl-CoA acyltransferase 2

RGD ID:

18430629

Description:

ENCODES a protein that exhibits acetyl-CoA C-acetyltransferase activity (ortholog); acetyl-CoA C-acyltransferase activity (ortholog); fatty acyl-CoA hydrolase activity (ortholog); INVOLVED IN acetyl-CoA metabolic process (ortholog); cellular response to hypoxia (ortholog); fatty acid beta-oxidation (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN mitochondrial matrix (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

3-ketoacyl-CoA thiolase, mitochondrial

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	31,152,067 - 31,181,020 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	31,152,074 - 31,181,706 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	5,299,842 - 5,328,903 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adult respiratory distress syndrome (ISO)

genetic disease (ISO)

intellectual disability (ISO)

osteoarthritis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acetyl-CoA metabolic process (ISO)

cellular response to hypoxia (ISO)

fatty acid beta-oxidation (ISO)

negative regulation of mitochondrial membrane permeability involved in apoptotic process (ISO)

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (ISO)

Cellular Component

mitochondrial matrix (ISO)

mitochondrion (IEA)

Molecular Function

acetyl-CoA C-acetyltransferase activity (ISO)

acetyl-CoA C-acyltransferase activity (IEA,ISO)

acyltransferase activity (IEA)

acyltransferase activity, transferring groups other than amino-acyl groups (IEA)

fatty acyl-CoA hydrolase activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway (ISO)

3-hydroxyacyl-CoA dehydrogenase deficiency pathway (ISO)

3-hydroxyisobutyric aciduria pathway (ISO)

3-methylcrotonyl CoA carboxylase 1 deficiency pathway (ISO)

3-methylglutaconic aciduria type 1 pathway (ISO)

3-methylglutaconic aciduria type 3 pathway (ISO)

carnitine palmitoyltransferase I deficiency pathway (ISO)

ethylmalonic encephalopathy pathway (ISO)

fatty acid beta degradation pathway (ISO)

fatty acid elongation pathway (ISO)

fatty acid metabolic pathway (ISO)

glutaric aciduria type I pathway (ISO)

isobutyryl-CoA dehydrogenase deficiency pathway (ISO)

isovaleric acidemia pathway (ISO)

maple syrup urine disease pathway (ISO)

medium chain acyl-CoA dehydrogenase deficiency pathway (ISO)

methylmalonate semialdehyde dehydrogenase deficiency pathway (ISO)

methylmalonic acidemia pathway (ISO)

propionic acidemia pathway (ISO)

short-chain acyl-CoA dehydrogenase deficiency pathway (ISO)

trifunctional protein deficiency pathway (ISO)

valine, leucine and isoleucine degradation pathway (ISO)

very long-chain acyl-CoA dehydrogenase deficiency pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

ACAA2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	31,152,067 - 31,181,020 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	31,152,074 - 31,181,706 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	5,299,842 - 5,328,903 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

ACAA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	49,782,164 - 49,813,533 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	49,782,164 - 49,813,953 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	47,308,534 - 47,339,903 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	45,563,873 - 45,593,900 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	45,563,872 - 45,593,900	NCBI
Celera	18	44,166,539 - 44,196,918 (-)	NCBI		Celera
Cytogenetic Map	18	q21.1	NCBI
HuRef	18	44,164,298 - 44,194,528 (-)	NCBI		HuRef
CHM1_1	18	47,305,498 - 47,335,866 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	18	49,981,292 - 50,015,307 (-)	NCBI		T2T-CHM13v2.0

Acaa2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	74,912,283 - 74,939,278 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	74,912,268 - 74,939,279 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	74,779,212 - 74,806,207 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	74,779,197 - 74,806,208 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	74,938,866 - 74,965,861 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	74,904,577 - 74,931,572 (+)	NCBI		MGSCv36	mm8
Celera	18	76,003,491 - 76,030,308 (+)	NCBI		Celera
Cytogenetic Map	18	E2	NCBI
cM Map	18	50.76	NCBI

Acaa2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	70,620,310 - 70,648,417 (+)	NCBI		GRCr8
mRatBN7.2	18	68,345,136 - 68,373,246 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	68,345,012 - 68,373,249 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	70,453,198 - 70,481,430 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	71,122,661 - 71,150,827 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	68,979,238 - 69,007,466 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	70,733,872 - 70,762,395 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	70,733,872 - 70,762,395 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	69,873,084 - 69,901,836 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	71,587,259 - 71,632,610 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	71,660,459 - 71,705,811 (+)	NCBI
Celera	18	66,521,595 - 66,549,734 (+)	NCBI		Celera
Cytogenetic Map	18	q12.2	NCBI

Acaa2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	34,857,317 - 34,885,169 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	34,857,317 - 34,885,169 (-)	NCBI	ChiLan1.0	ChiLan1.0

ACAA2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	67,310,784 - 67,341,328 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	53,003,387 - 53,033,936 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	43,164,504 - 43,195,038 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	46,512,374 - 46,542,737 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	46,512,374 - 46,542,737 (-)	Ensembl	panpan1.1		panPan2

ACAA2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	79,028,636 - 79,057,720 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	78,425,399 - 78,464,609 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	79,086,363 - 79,125,478 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	79,086,417 - 79,125,474 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	78,802,328 - 78,841,679 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	78,830,801 - 78,869,895 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	79,116,676 - 79,155,898 (+)	NCBI		UU_Cfam_GSD_1.0

Acaa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	38,003,267 - 38,029,972 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936497	13,242,644 - 13,269,532 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936497	13,242,644 - 13,269,007 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACAA2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	99,284,140 - 99,311,321 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	99,284,467 - 99,310,759 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	108,842,950 - 108,869,736 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Acaa2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624778	13,307,094 - 13,336,120 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624778	13,307,236 - 13,336,347 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	36	9	32
Low		11	28
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007974053	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000016151 ⟹ ENSCSAP00000014072

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	18	31,152,074 - 31,181,706 (+)	Ensembl

RefSeq Acc Id:

XM_007974053 ⟹ XP_007972244

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	18	31,152,067 - 31,181,020 (+)	NCBI
Vero_WHO_p1.0	NW_023666050	5,299,842 - 5,328,903 (+)	NCBI

Sequence:

show sequence

GGCGGCCGCCCGCGCGCCAAGTCCCTCAGGCCTGGGCTCCTGCCAAGTGTTTAGGGTTCTGGCG
GAGACAAAGGGGAACAGTCATTGCCTGTCGGGGCTGGGATATGATGGGTGAGAGGTGTCAAACC
AGATTCTCTCGGTTTGGAAACGGAGAAAATCTAAAAACGAGGACGTGAGGAAAGAGTACGCCCT
CAAGACGCATAGTCGTCTACCCGAGCCCCGACCCCCGGGCTCCCTCGGGCTAGGGTGAGGCGGG
CAGCCACGCGTGGGGTAGGATCATCTTACGCTGGGGCCCTGCCAGGCAGCCCCGGGAAGTAGGT
GAAAGGGCAGGGGCGTGGCTCCCGGGGCGCCACCCACGCTCTTGAAATCTGGGTGACTGCAAGT
GGCCGCTCTGCGTCCCCCAGACCAGAGACCCGCGCCGCCGACGACCCAGCCGCAGCCATGGCTC
TGCTCCGAGGTGTGTTTGTCGTTGCTGCTAAGCGAACGCCCTTTGGAGCTTATGGAGGTCTTCT
GAAAGACTTCACTGCTACTGACTTGTCTGAATTTGCCGCCAAGGCTGCCTTGTCTGCTGGCAAA
GTTTCACCTGAAACTGTTGACAGTGTGATTATAGGCAATGTCGTGCAGAGTTCTTCAAATGCTA
TATATTTGGCAAGGCATGTGGGTTTGCGTGTGGGAGTCCCAAAGGAGACCCCAGCTCTCACGAT
TAATAGGCTCTGTGGTTCTGGTTTCCAGTCCATTGTAAATGGATGTCAGGAAATTTGTGTTAAA
GACGCTGAAGTTGTTTTATGTGGAGGAACCGAAAGCATGAGCCAAGCTCCCTACTGTGTCAGAA
ATGTGCGTTTTGGAACCAAGCTTGGATCAGATATCAAGCTGGAGGATTCTTTATGGGCGGGATT
AACAGATCAGCATGTCCAGCTCCCCATGGCAATGACTGCAGAGAATCTTGCTGTAAAACACAAA
ATAAGCAGAGAAGAATGTGACAAATATGCCCTGCAGTCACAGCAGAGATGGAAAGCTGCTAATG
ATGCTGGCTACTTTAATGATGAAATGGCACCAATTGAAGTGAAGACAAAGAAAGGAAAACAGAC
AATGCAGGTAGACGAGCACGCTCGGCCCCAAACCACCCTGGAACAGTTACAGAAACTTCCTCCA
GTATTCAAGAAAGATGGAACTGTCACTGCAGGGAATGCATCGGGGATAGCTGATGGTGCTGGAG
CTGTTATCATAGCTAGTGAAGATGCTGTTAAGAAGCATAACTTCACACCACTGGCAAGAATTGT
GGGCTACTTTGTATCTGGATGTGATCCCTCTATCATGGGTATTGGTCCTGTCCCTGCTATCAGT
GGAGCACTGAAGAAAGCAGGACTGAGTCTTAAGGACATGGATTTGGTAGAGGTCAATGAAGCTT
TTGCTCCCCAGTACTTGGCTGTTGAGAAGAGTTTGGATCTTGACATAAGTAAAACCAATGTGAA
TGGAGGATCCATTGCTTTGGGTCATCCACTGGGAGGATCTGGATCAAGAATTACTGCACACCTG
GTTCATGAATTAAGGCGTCGAGGTGGAAAATATGCCGTTGGATCAGCTTGCATTGGAGGTGGCC
AAGGTATTGCTGTCATCATTCAGAGCACAGCCTGAAGAGACCAGTGAGCTCACCGTGACCCACT
CTTACTCTGCTTGGCCAGGCCACAGTAAAACAAGTGACCTTCAGAGCCGCTGCCACAACTGGCC
ATGCCCTGCCATTGAAACAGCGATTGCATTTGATCAAGCCATGGTGACACAAAAATACATTGAT
CATGAATAGGAGCCCATGCTAGAAGTACATTCTCTCAGATTTGTACCAGTGAAGTATGATTTTT
GAACTAAAGAAGACATTAAAAGAAATTGTATTCTTGCCAAGTAACCACCACTTCTGCCTTAGGT
AATATGATTATAAGGAAATCGAATAAATGTTGCCTTAACTTCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007972244	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000014072
	ENSCSAP00000014072.1

RefSeq Acc Id:	XP_007972244 ⟸ XM_007974053
- UniProtKB:	A0A0D9RZN3 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000014072 ⟸ ENSCSAT00000016151

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000018054	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000016151.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.47.10	UniProtKB/TrEMBL
InterPro	Thiolase	UniProtKB/TrEMBL
	Thiolase-like	UniProtKB/TrEMBL
	Thiolase_acyl_enz_int_AS	UniProtKB/TrEMBL
	Thiolase_AS	UniProtKB/TrEMBL
	Thiolase_C	UniProtKB/TrEMBL
	Thiolase_CS	UniProtKB/TrEMBL
	Thiolase_N	UniProtKB/TrEMBL
KEGG Report	csab:103222430	UniProtKB/TrEMBL
NCBI Gene	ACAA2	ENTREZGENE
PANTHER	3-KETOACYL-COA THIOLASE, MITOCHONDRIAL	UniProtKB/TrEMBL
	ACETYL-COA C-ACYLTRANSFERASE	UniProtKB/TrEMBL
Pfam	Thiolase_C	UniProtKB/TrEMBL
	Thiolase_N	UniProtKB/TrEMBL
PIRSF	Ac-CoA_Ac_transf	UniProtKB/TrEMBL
PROSITE	THIOLASE_1	UniProtKB/TrEMBL
	THIOLASE_2	UniProtKB/TrEMBL
	THIOLASE_3	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53901	UniProtKB/TrEMBL
UniProt	A0A0D9RZN3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB