DVL2 (dishevelled segment polarity protein 2) - Rat Genome Database

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Gene: DVL2 (dishevelled segment polarity protein 2) Chlorocebus sabaeus
Analyze
Symbol: DVL2
Name: dishevelled segment polarity protein 2
RGD ID: 18423930
Description: ENCODES a protein that exhibits frizzled binding (inferred); identical protein binding (inferred); obsolete protein self-association (inferred); INVOLVED IN canonical Wnt signaling pathway (ortholog); cochlea morphogenesis (ortholog); convergent extension involved in neural plate elongation (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH common variable immunodeficiency (ortholog); congenital myasthenic syndrome 2A (ortholog); dextro-looped transposition of the great arteries (ortholog); FOUND IN aggresome (inferred); apical part of cell (inferred); clathrin-coated vesicle (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: segment polarity protein dishevelled homolog DVL-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,599,056 - 6,608,613 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,599,579 - 6,608,544 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605914,802,139 - 14,811,719 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DVL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,599,056 - 6,608,613 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,599,579 - 6,608,544 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605914,802,139 - 14,811,719 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
DVL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,225,342 - 7,234,517 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,225,342 - 7,234,517 (-)EnsemblGRCh38hg38GRCh38
GRCh37177,128,661 - 7,137,836 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,069,385 - 7,078,587 (-)NCBINCBI36Build 36hg18NCBI36
Build 34177,069,384 - 7,078,587NCBI
Celera177,153,295 - 7,162,512 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,020,651 - 7,029,658 (-)NCBIHuRef
CHM1_1177,137,409 - 7,146,611 (-)NCBICHM1_1
T2T-CHM13v2.0177,126,253 - 7,135,444 (-)NCBIT2T-CHM13v2.0
Dvl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,891,418 - 69,900,935 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,891,421 - 69,903,127 (+)EnsemblGRCm39 Ensembl
GRCm381170,000,592 - 70,010,109 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,000,595 - 70,012,301 (+)EnsemblGRCm38mm10GRCm38
MGSCv371169,814,128 - 69,823,611 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,816,821 - 69,826,304 (+)NCBIMGSCv36mm8
Celera1177,548,436 - 77,558,061 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.96NCBI
Dvl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,222,245 - 55,231,506 (+)NCBIGRCr8
mRatBN7.21054,723,356 - 54,732,823 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,723,411 - 54,732,820 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01056,609,810 - 56,619,269 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,610,051 - 56,619,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,354,931 - 56,364,388 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1053,877,195 - 53,886,407 (+)NCBICelera
Cytogenetic Map10q24NCBI
Dvl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,675,912 - 9,683,996 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,675,912 - 9,683,996 (+)NCBIChiLan1.0ChiLan1.0
DVL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21914,818,013 - 14,827,230 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11716,784,020 - 16,793,224 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,255,241 - 7,264,452 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,242,493 - 7,251,572 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,242,493 - 7,251,571 (-)Ensemblpanpan1.1panPan2
DVL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,194,326 - 32,201,922 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,194,313 - 32,201,857 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,332,631 - 32,340,205 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,299,943 - 32,307,523 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,299,946 - 32,307,706 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,265,249 - 32,272,821 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,224,284 - 32,231,849 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,401,214 - 32,408,791 (-)NCBIUU_Cfam_GSD_1.0
Dvl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,046,111 - 47,054,173 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936595520,548 - 528,371 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936595520,299 - 528,361 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DVL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,581,688 - 52,590,285 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,581,687 - 52,590,266 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23139,857,220 - 139,865,809 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Dvl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247869,844,157 - 9,851,301 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247869,843,580 - 9,851,538 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 35
Low 20 25
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000010014   ⟹   ENSCSAP00000008116
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl166,599,579 - 6,608,544 (-)Ensembl
RefSeq Acc Id: XM_008010096   ⟹   XP_008008287
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1166,599,056 - 6,608,613 (-)NCBI
Vero_WHO_p1.0NW_02366605914,802,139 - 14,811,719 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008008287 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000008116.1
Reference Protein Sequences
RefSeq Acc Id: XP_008008287   ⟸   XM_008010096
- UniProtKB: A0A0D9RHM7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000008116   ⟸   ENSCSAT00000010014


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000011919 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000010014.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
  2.40.240.130 UniProtKB/TrEMBL
InterPro DEP_dom UniProtKB/TrEMBL
  Dishevelled_C-dom UniProtKB/TrEMBL
  Dishevelled_fam UniProtKB/TrEMBL
  Dishevelled_protein_dom UniProtKB/TrEMBL
  DIX UniProtKB/TrEMBL
  DIX_dom_sf UniProtKB/TrEMBL
  Dsh/Dvl-rel UniProtKB/TrEMBL
  DVL2 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene DVL2 ENTREZGENE
PANTHER PTHR10878 UniProtKB/TrEMBL
  PTHR10878:SF8 UniProtKB/TrEMBL
Pfam DEP UniProtKB/TrEMBL
  Dishevelled UniProtKB/TrEMBL
  DIX UniProtKB/TrEMBL
  Dsh_C UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
PRINTS DISHEVELLED UniProtKB/TrEMBL
  DISHEVELLED2 UniProtKB/TrEMBL
PROSITE DEP UniProtKB/TrEMBL
  DIX UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
SMART DAX UniProtKB/TrEMBL
  DEP UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A0D9RHM7 ENTREZGENE, UniProtKB/TrEMBL