PARP8 (poly(ADP-ribose) polymerase family member 8) - Rat Genome Database

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Gene: PARP8 (poly(ADP-ribose) polymerase family member 8) Chlorocebus sabaeus
Analyze
Symbol: PARP8
Name: poly(ADP-ribose) polymerase family member 8
RGD ID: 18416087
Description: ENCODES a protein that exhibits glycosyltransferase activity (inferred); kinase binding (inferred); NAD+ ADP-ribosyltransferase activity (inferred); INVOLVED IN endoplasmic reticulum unfolded protein response (inferred); protein auto-ADP-ribosylation (inferred); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN endoplasmic reticulum tubular network (inferred); membrane (inferred); nuclear envelope (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: poly [ADP-ribose] polymerase 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1446,963,640 - 47,146,195 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl446,965,400 - 47,146,270 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660824,039,205 - 4,227,138 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PARP8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1446,963,640 - 47,146,195 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl446,965,400 - 47,146,270 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660824,039,205 - 4,227,138 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PARP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38550,665,931 - 50,846,519 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl550,665,899 - 50,846,519 (+)EnsemblGRCh38hg38GRCh38
GRCh37549,961,765 - 50,142,353 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36549,998,570 - 50,173,933 (+)NCBINCBI36Build 36hg18NCBI36
Build 34549,998,569 - 50,173,933NCBI
Celera546,908,424 - 47,088,865 (+)NCBICelera
Cytogenetic Map5q11.1NCBI
HuRef546,926,307 - 47,106,926 (+)NCBIHuRef
CHM1_1549,964,864 - 50,145,462 (+)NCBICHM1_1
T2T-CHM13v2.0551,485,094 - 51,665,708 (+)NCBIT2T-CHM13v2.0
Parp8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913116,987,378 - 117,162,549 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13116,991,356 - 117,162,073 (-)EnsemblGRCm39 Ensembl
GRCm3813116,850,842 - 117,026,019 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13116,854,820 - 117,025,537 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713117,643,631 - 117,814,323 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613117,974,105 - 118,144,797 (-)NCBIMGSCv36mm8
Celera13121,257,786 - 121,440,921 (-)NCBICelera
Cytogenetic Map13D2.3NCBI
cM Map1365.32NCBI
Parp8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8250,408,404 - 50,581,513 (-)NCBIGRCr8
mRatBN7.2248,679,405 - 48,848,700 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl248,679,436 - 48,849,253 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0249,086,949 - 49,455,848 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl249,087,226 - 49,170,025 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0267,463,833 - 67,571,508 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4248,669,640 - 48,856,151 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera244,404,542 - 44,573,987 (-)NCBICelera
Cytogenetic Map2q14NCBI
Parp8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544616,332,893 - 16,516,717 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544616,332,614 - 16,516,719 (-)NCBIChiLan1.0ChiLan1.0
PARP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2463,086,627 - 63,274,791 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1561,240,253 - 61,428,422 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0563,175,182 - 63,363,346 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1564,789,584 - 64,975,287 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl564,789,584 - 64,975,283 (-)Ensemblpanpan1.1panPan2
PARP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1464,107,927 - 64,280,399 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl464,109,711 - 64,279,337 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha463,867,185 - 64,039,936 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0464,605,277 - 64,777,929 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl464,605,277 - 64,776,813 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1464,370,032 - 64,542,480 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0464,491,470 - 64,664,936 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0465,031,028 - 65,203,625 (-)NCBIUU_Cfam_GSD_1.0
Parp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213207,359,909 - 207,528,633 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648016,296,401 - 16,465,506 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648016,297,110 - 16,465,178 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PARP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1630,305,738 - 30,486,414 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11630,304,800 - 30,486,416 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21631,879,379 - 32,055,658 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Parp8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247598,699,664 - 8,880,253 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247598,694,148 - 8,880,450 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 17 16 42
Low 19 4 18
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000014818   ⟹   ENSCSAP00000012779
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl446,965,400 - 47,146,270 (+)Ensembl
RefSeq Acc Id: XM_007972032   ⟹   XP_007970223
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1446,965,438 - 47,146,195 (+)NCBI
Vero_WHO_p1.0NW_0236660824,039,205 - 4,226,642 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007972040   ⟹   XP_007970231
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1446,963,640 - 47,146,195 (+)NCBI
Vero_WHO_p1.0NW_0236660824,039,205 - 4,227,138 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007972048   ⟹   XP_007970239
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1446,966,502 - 47,146,195 (+)NCBI
Vero_WHO_p1.0NW_0236660824,039,205 - 4,225,689 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037994648   ⟹   XP_037850576
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660824,055,799 - 4,225,691 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007970223 (Get FASTA)   NCBI Sequence Viewer  
  XP_007970231 (Get FASTA)   NCBI Sequence Viewer  
  XP_007970239 (Get FASTA)   NCBI Sequence Viewer  
  XP_037850576 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000012779
  ENSCSAP00000012779.1
Reference Protein Sequences
RefSeq Acc Id: XP_007970231   ⟸   XM_007972040
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007970223   ⟸   XM_007972032
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RVZ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007970239   ⟸   XM_007972048
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCSAP00000012779   ⟸   ENSCSAT00000014818
RefSeq Acc Id: XP_037850576   ⟸   XM_037994648
- Peptide Label: isoform X4


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000016722 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000014818.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.228.10 UniProtKB/TrEMBL
InterPro Poly(ADP-ribose)pol_cat_dom UniProtKB/TrEMBL
KEGG Report csab:103221205 UniProtKB/TrEMBL
NCBI Gene PARP8 ENTREZGENE
PANTHER POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP UniProtKB/TrEMBL
  PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP8 UniProtKB/TrEMBL
Pfam PARP UniProtKB/TrEMBL
PROSITE PARP_CATALYTIC UniProtKB/TrEMBL
Superfamily-SCOP ADP-ribosylation UniProtKB/TrEMBL
UniProt A0A0D9RVZ0 ENTREZGENE, UniProtKB/TrEMBL