TBX18 (T-box transcription factor 18) - Rat Genome Database

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Gene: TBX18 (T-box transcription factor 18) Chlorocebus sabaeus
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Symbol: TBX18
Name: T-box transcription factor 18
RGD ID: 18415611
Description: ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); protein homodimerization activity (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); anterior/posterior axis specification (ortholog); cell differentiation (ortholog); ASSOCIATED WITH CAKUT (ortholog); CAKUT2 (ortholog); chronic kidney disease (ortholog); FOUND IN nucleoplasm (ortholog); RNA polymerase II transcription repressor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: T-box 18; T-box transcription factor TBX18
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1139,407,384 - 9,441,157 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl139,411,004 - 9,439,642 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040185,588,730 - 185,620,701 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TBX18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1139,407,384 - 9,441,157 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl139,411,004 - 9,439,642 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040185,588,730 - 185,620,701 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TBX18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38684,732,496 - 84,764,598 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl684,687,351 - 84,764,598 (-)EnsemblGRCh38hg38GRCh38
GRCh37685,442,214 - 85,474,316 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36685,500,876 - 85,530,618 (-)NCBINCBI36Build 36hg18NCBI36
Build 34685,510,715 - 85,529,036NCBI
Celera685,871,383 - 85,901,128 (-)NCBICelera
Cytogenetic Map6q14.3NCBI
HuRef682,665,241 - 82,696,981 (-)NCBIHuRef
CHM1_1685,539,567 - 85,571,307 (-)NCBICHM1_1
T2T-CHM13v2.0685,949,735 - 85,981,843 (-)NCBIT2T-CHM13v2.0
Tbx18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39987,584,853 - 87,613,313 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl987,584,853 - 87,613,313 (-)EnsemblGRCm39 Ensembl
GRCm38987,702,800 - 87,731,260 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl987,702,800 - 87,731,260 (-)EnsemblGRCm38mm10GRCm38
MGSCv37987,597,635 - 87,626,095 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36987,502,145 - 87,529,206 (-)NCBIMGSCv36mm8
Celera984,762,550 - 84,791,101 (-)NCBICelera
Cytogenetic Map9E3.1NCBI
cM Map947.06NCBI
Tbx18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8897,531,960 - 97,559,988 (-)NCBIGRCr8
mRatBN7.2888,652,054 - 88,680,081 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl888,652,054 - 88,680,058 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx894,313,052 - 94,341,076 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0892,512,256 - 92,540,280 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0890,358,693 - 90,386,745 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0895,359,354 - 95,387,363 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl895,359,354 - 95,387,363 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0894,860,116 - 94,888,125 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4892,984,336 - 93,012,343 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1892,982,189 - 93,031,958 (-)NCBI
Celera888,229,534 - 88,257,537 (-)NCBICelera
Cytogenetic Map8q31NCBI
Tbx18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541112,194,550 - 12,232,374 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541112,194,560 - 12,232,374 (-)NCBIChiLan1.0ChiLan1.0
TBX18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25104,826,534 - 104,858,674 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16102,721,222 - 102,753,498 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0682,621,987 - 82,654,137 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1685,906,500 - 85,938,356 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl685,862,810 - 85,938,799 (-)Ensemblpanpan1.1panPan2
TBX18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11244,901,076 - 44,929,730 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1244,873,119 - 44,929,205 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1244,715,143 - 44,743,697 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01245,667,650 - 45,696,229 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1245,642,129 - 45,695,798 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11245,001,870 - 45,030,386 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01244,937,063 - 44,965,596 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01245,119,019 - 45,147,578 (-)NCBIUU_Cfam_GSD_1.0
Tbx18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494680,074,742 - 80,104,499 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365106,366,846 - 6,393,882 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365106,366,450 - 6,396,056 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBX18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl153,838,189 - 53,867,254 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1153,836,939 - 53,867,460 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2160,192,672 - 60,223,150 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Tbx18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247999,694,374 - 9,719,385 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247999,694,167 - 9,721,468 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 19 11 35
Below cutoff 16 6 24

Sequence


RefSeq Acc Id: ENSCSAT00000015468   ⟹   ENSCSAP00000013408
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl139,411,004 - 9,439,642 (-)Ensembl
RefSeq Acc Id: XM_008006514   ⟹   XP_008004705
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1139,407,561 - 9,441,157 (-)NCBI
Vero_WHO_p1.0NW_023666040185,588,730 - 185,620,701 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008004705 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000013408
  ENSCSAP00000013408.1
RefSeq Acc Id: XP_008004705   ⟸   XM_008006514
- UniProtKB: A0A0D9RXR9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000013408   ⟸   ENSCSAT00000015468


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000017375 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015468.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.820 UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  T-box_DNA-bd UniProtKB/TrEMBL
  T-box_sf UniProtKB/TrEMBL
  TF_T-box UniProtKB/TrEMBL
  TF_T-box_CS UniProtKB/TrEMBL
KEGG Report csab:103240031 UniProtKB/TrEMBL
NCBI Gene TBX18 ENTREZGENE
PANTHER PTHR11267 UniProtKB/TrEMBL
  T-BOX TRANSCRIPTION FACTOR TBX18 UniProtKB/TrEMBL
Pfam T-box UniProtKB/TrEMBL
PRINTS TBOX UniProtKB/TrEMBL
PROSITE TBOX_1 UniProtKB/TrEMBL
  TBOX_2 UniProtKB/TrEMBL
  TBOX_3 UniProtKB/TrEMBL
SMART TBOX UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/TrEMBL
UniProt A0A0D9RXR9 ENTREZGENE, UniProtKB/TrEMBL