NR0B1 (nuclear receptor subfamily 0 group B member 1)

Gene: NR0B1 (nuclear receptor subfamily 0 group B member 1) Chlorocebus sabaeus

Analyze

Symbol:

NR0B1

Name:

nuclear receptor subfamily 0 group B member 1

RGD ID:

18412022

Description:

ENCODES a protein that exhibits AF-2 domain binding (ortholog); DNA hairpin binding (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN adrenal gland development (ortholog); endodermal cell differentiation (ortholog); gonad development (ortholog); ASSOCIATED WITH 46,XY sex reversal 2 (ortholog); autistic disorder (ortholog); Duchenne muscular dystrophy (ortholog); FOUND IN centriolar satellite (ortholog); intracellular membrane-bounded organelle (ortholog); membrane (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	28,707,698 - 28,713,158 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	28,707,699 - 28,712,708 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666056	30,693,186 - 30,698,838 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

46,XY sex reversal 2 (ISO)

autistic disorder (ISO)

Duchenne muscular dystrophy (ISO)

genetic disease (ISO)

hypogonadism (ISO)

Isolated Mineralocorticoid Deficiency (ISO)

Neurodevelopmental Disorders (ISO)

oligospermia (ISO)

ornithine carbamoyltransferase deficiency (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

X-linked adrenal hypoplasia congenita (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adrenal gland development (IEA,ISO)

endodermal cell differentiation (ISO)

gonad development (ISO)

Leydig cell differentiation (ISO)

male gonad development (IEA,ISO)

male sex determination (ISO)

negative regulation of DNA-binding transcription factor activity (ISO)

negative regulation of DNA-templated transcription (IEA,ISO)

negative regulation of intracellular steroid hormone receptor signaling pathway (ISO)

negative regulation of steroid biosynthetic process (ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

protein localization (ISO)

response to benzoic acid (ISO)

response to immobilization stress (ISO)

response to organic substance (ISO)

response to peptide hormone (ISO)

response to retinoic acid (ISO)

Sertoli cell differentiation (ISO)

sex determination (ISO)

spermatogenesis (IEA,ISO)

Cellular Component

centriolar satellite (ISO)

cytoplasm (IEA)

intracellular membrane-bounded organelle (ISO)

membrane (ISO)

nuclear speck (ISO)

nucleoplasm (IEA)

nucleus (IEA)

ribosome (ISO)

Molecular Function

AF-2 domain binding (ISO)

DNA hairpin binding (ISO)

double-stranded DNA binding (ISO)

nuclear receptor binding (ISO)

protein binding (ISO)

protein domain specific binding (ISO)

protein homodimerization activity (ISO)

RNA binding (ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (ISO)

sequence-specific DNA binding (ISO)

transcription corepressor activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

NR0B1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	28,707,698 - 28,713,158 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	28,707,699 - 28,712,708 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666056	30,693,186 - 30,698,838 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

NR0B1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	30,304,206 - 30,309,390 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	30,304,206 - 30,309,390 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	30,322,323 - 30,327,507 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	30,232,506 - 30,237,413 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	30,082,242 - 30,087,149	NCBI
Celera	X	34,444,104 - 34,449,076 (-)	NCBI		Celera
Cytogenetic Map	X	p21.2	NCBI
HuRef	X	28,059,200 - 28,064,172 (-)	NCBI		HuRef
CHM1_1	X	30,353,361 - 30,358,333 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	29,896,466 - 29,901,652 (-)	NCBI		T2T-CHM13v2.0

Nr0b1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	85,235,381 - 85,239,553 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	85,235,370 - 85,239,553 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	86,191,775 - 86,195,947 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	86,191,764 - 86,195,947 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	83,437,114 - 83,441,283 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	82,444,494 - 82,448,663 (+)	NCBI		MGSCv36	mm8
Celera	X	77,386,142 - 77,390,314 (+)	NCBI		Celera
Cytogenetic Map	X	C1	NCBI
cM Map	X	39.67	NCBI

Nr0b1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	54,707,658 - 54,711,786 (+)	NCBI		GRCr8
mRatBN7.2	X	50,756,886 - 50,761,014 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	50,756,886 - 50,761,011 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	52,086,588 - 52,090,716 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	55,587,000 - 55,591,128 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	53,217,986 - 53,222,114 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	54,734,385 - 54,738,513 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	54,734,385 - 54,738,513 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	54,937,819 - 54,941,947 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	73,006,294 - 73,010,422 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	73,079,585 - 73,083,711 (+)	NCBI
Celera	X	51,292,676 - 51,296,804 (+)	NCBI		Celera
Cytogenetic Map	X	q21	NCBI

Nr0b1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955531	567,173 - 572,331 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955531	567,491 - 572,329 (+)	NCBI	ChiLan1.0	ChiLan1.0

NR0B1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	32,097,705 - 32,102,856 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	32,100,823 - 32,106,018 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	22,903,403 - 22,908,527 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	30,459,527 - 30,464,652 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	30,459,527 - 30,464,652 (-)	Ensembl	panpan1.1		panPan2

NR0B1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	25,396,527 - 25,401,587 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	25,396,527 - 25,401,715 (-)	NCBI	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	30,371,048 - 30,375,977 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	25,418,991 - 25,424,263 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	X	25,467,201 - 25,472,041 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	25,464,894 - 25,469,724 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	25,560,779 - 25,565,608 (-)	NCBI		UU_Cfam_GSD_1.0

Nr0b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	18,343,850 - 18,347,995 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936553	6,436,371 - 6,440,141 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936553	6,436,371 - 6,440,141 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NR0B1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	26,117,874 - 26,122,951 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	26,117,874 - 26,122,951 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	28,384,122 - 28,389,200 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	X	p24	NCBI

Nr0b1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624762	25,764,452 - 25,769,487 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624762	25,759,976 - 25,769,543 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	26		25
Low	10	10	23
Below cutoff		7	12

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007991346	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000012370 ⟹ ENSCSAP00000010409

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	X	28,707,699 - 28,712,708 (-)	Ensembl

RefSeq Acc Id:

XM_007991346 ⟹ XP_007989537

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	X	28,707,698 - 28,713,158 (-)	NCBI
Vero_WHO_p1.0	NW_023666056	30,693,186 - 30,698,838 (-)	NCBI

Sequence:

show sequence

ATGTTTGTCTATGTTCTGTATTTTTCAAGGTCTCAGAAAATGAGACCTCTCTATCCATATACAA
ATATGAGTCTCACAAACTGTGATAATTTAATGAAAGTTTACAAAGAGCATAGAAGTAGATGTTT
CCTCTTTTCCCCTACCCTCCCAATAAAGGGAACAAATTAGATGCGAGGGTTCAATGGAAAGAGT
TGCAACAGCATCCAGGCGCTCGCTCTCCTCCGGTCTTCCTGAGAGACAGGGAAAGGGGTAATGA
GAGGAAGGAGGGAAGTGTCCAGGAGCTCCCACGCTGCTGTTCCTCTTCCATTTTCAGCTTTTAA
AGAACACCCGCCCCTTCGAACCACCGAGGTCATGGGCGAATACACCGGAGCGCAGCACCGCGCC
CCCCCTGCCCGCCTCCGCGCCCTTGCCCAGACCGAGGCGGCCGACGCGCCTGCGTGCGCGCTAG
GTATAAATAGGTCCCAGGAGGCAGCCACTGGGCAGAACCGGGCTGCGGGAGCCGCGGGCCATGG
CGGGCGAGAACCACCAGTGGCAGGGCAGCATCCTCTACAACATGCTTATGAGCGCGAAGCAAAC
GCGCGCGGCTCCTGAGGCTCCAGAGACGCGGCTGGTGGATCAGTGCTGGGGCTGTTCGTGCGGC
GATGAGCCCGGGGTGGGCAGAGAGGGGCTGCTGGGCGGGCGGAACGTGTCGCTCCTGTACCGCT
GCTGCTTTTGCGGTAAAGACCACCCACGGCAGGGCAGCATCCTCTACAGCATGCTCACGAGCGC
AAAGCAAACGTACGCGGCACCGAAGGCGCCCGAGGCGACGCTGGGTCCGTGCTGGGGCTGTTCG
TGCGGCTCTGATCCCGGGGTGGGCAGAGCGGGGCTTCCGGGTGGGCGGCCCGTGGCACTCCTGT
ACCGCTGCTGCTTTTGTGGTGAAGACCACCCGCGGCAGGGCAGCATCCTCTACAGCTTGCTCAC
TAGCGCAAAGCAAACGCACGTGGCTCCGGCAGCGCCCGAGGCACGGCCAGTGGGCGCGTGGTGG
GACCGCTCCTACTTCGCGCAGAGGCCAGGGGGTAGAGAGGCGCTAGCAGGCGGGCGGGCCATGG
GGCTTCTGTACCGCTGCTGCTTTTGCGGTGAAGACCACCCGCAGCAGGGCAGCACCCTCTACTG
CATGCCCACGAGCACAAATCAAGTGCAGGCGGTTCCGGAGGAGCGGCCGAGGGCCCCCTGGTGG
GACACCTCCTCTGGTGCGCTGCGGCCAGTGGCGCTCAAGAGTCCACAGGTGGTCTGCGAGGCAG
CCTCAGCTGGCCTGTTGAAGACGCTGCGCTTCGTCAAGTACTTGCCCTGCTTCCAGGTGCTGCC
CCTGGACCAGCAGCTGGTGCTGGTGCGCAACTGCTGGGCGTCCCTGCTCATGCTTGAGCTGGCC
CAGGACCGCTTGCAGTTCGAGACTGTAGAAGTCTCGGAGCCCAGCATGCTGCAGAAGATCCTCA
CCACCAGGCGGCGGGAGACCGGGGGCGACGAGCCACTGCCCGTGTCCATGCTGCAGCCCCATTT
GGCACCGCCGGCGGAGGCCAGGAAGGTGCCCTCCGCCTCCCAGGTCCAAGCCATCAAGTGCTTT
CTTTCCAAGTGCTGGAGTCTGAACATCAGTACCAAGGAGTACGCCTACCTCAAGGGGACCGTGC
TCTTTAACCCGGACGTGCCGGGCCTGCAGTGCGTGAAGTACATTCAGGGACTCCAGTGGGGAAC
TCAGCAGATACTCAGTGAACACGCCAGGATGACGCACCAAGGGCCCCATGACAGATTCATCGAA
CTGAATAGTACCCTTTTCCTGCTGAGATTCATCAATGCCAATGTCATTGCTGAACTGTTCTTCA
GGCCCATCATTGGCACAGTCAGCATGGATGATATGATGCTGGAAATGCTTTGTACAAAGTTGTA
AAGGCCTGTGGGCCACACAAATGCAGTACTGCAGTTCACCATGAGGGAAGAATAAAGAGCTGTG
GGCAAAAGAGTGTAAAATATTTTAAAATAAACTTTCTTATTATTTTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007989537	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000010409
	ENSCSAP00000010409.1

RefSeq Acc Id:	XP_007989537 ⟸ XM_007991346
- UniProtKB:	A0A0D9RP70 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000010409 ⟸ ENSCSAT00000012370

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000014272	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000012370.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.565.10	UniProtKB/TrEMBL
InterPro	NHR-like_dom_sf	UniProtKB/TrEMBL
	NR0B1	UniProtKB/TrEMBL
	Nucl_hrmn_rcpt_lig-bd	UniProtKB/TrEMBL
	Nuclear_hrmn_rcpt	UniProtKB/TrEMBL
	Nuclear_receptor_repeat	UniProtKB/TrEMBL
KEGG Report	csab:103231762	UniProtKB/TrEMBL
NCBI Gene	NR0B1	ENTREZGENE
PANTHER	NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B MEMBER 1	UniProtKB/TrEMBL
	PTHR24081	UniProtKB/TrEMBL
Pfam	Hormone_recep	UniProtKB/TrEMBL
	NR_Repeat	UniProtKB/TrEMBL
PRINTS	STRDHORMONER	UniProtKB/TrEMBL
PROSITE	NR_LBD	UniProtKB/TrEMBL
SMART	HOLI	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48508	UniProtKB/TrEMBL
UniProt	A0A0D9RP70	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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