SLC38A4 (solute carrier family 38 member 4) - Rat Genome Database

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Gene: SLC38A4 (solute carrier family 38 member 4) Chlorocebus sabaeus
Analyze
Symbol: SLC38A4
Name: solute carrier family 38 member 4
RGD ID: 18400575
Description: ENCODES a protein that exhibits alanine:sodium symporter activity (ortholog); amino acid transmembrane transporter activity (ortholog); amino acid:sodium symporter activity (ortholog); INVOLVED IN L-alanine import across plasma membrane (ortholog); L-alanine transmembrane transport (ortholog); L-arginine transmembrane transport (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH genetic disease (ortholog); FOUND IN microvillus membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sodium-coupled neutral amino acid transporter 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11142,965,744 - 43,035,055 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1142,963,599 - 43,005,300 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037203,383,860 - 203,451,736 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SLC38A4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11142,965,744 - 43,035,055 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1142,963,599 - 43,005,300 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037203,383,860 - 203,451,736 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SLC38A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381246,764,761 - 46,832,431 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1246,764,761 - 46,832,408 (-)EnsemblGRCh38hg38GRCh38
GRCh371247,158,544 - 47,219,780 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361245,444,811 - 45,506,006 (-)NCBINCBI36Build 36hg18NCBI36
Build 341245,444,810 - 45,506,002NCBI
Celera1245,955,607 - 46,016,842 (-)NCBICelera
Cytogenetic Map12q13.11NCBI
HuRef1244,189,482 - 44,250,721 (-)NCBIHuRef
CHM1_11247,123,562 - 47,184,747 (-)NCBICHM1_1
T2T-CHM13v2.01246,724,005 - 46,791,701 (-)NCBIT2T-CHM13v2.0
Slc38a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391596,892,701 - 96,953,837 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1596,892,701 - 96,953,837 (-)EnsemblGRCm39 Ensembl
GRCm381596,994,816 - 97,055,956 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1596,994,820 - 97,055,956 (-)EnsemblGRCm38mm10GRCm38
MGSCv371596,825,254 - 96,886,387 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361596,822,857 - 96,883,990 (-)NCBIMGSCv36mm8
Celera1599,130,658 - 99,191,913 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1552.77NCBI
Slc38a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87130,022,039 - 130,082,169 (-)NCBIGRCr8
mRatBN7.27128,142,866 - 128,203,000 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7128,144,807 - 128,202,995 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7129,943,266 - 130,001,005 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07132,168,810 - 132,226,543 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07132,084,330 - 132,142,464 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07138,459,576 - 138,512,952 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7138,459,504 - 138,512,952 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07138,083,492 - 138,121,200 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47135,693,013 - 135,750,703 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17135,769,452 - 135,827,140 (-)NCBI
Celera7124,640,023 - 124,696,672 (-)NCBICelera
Cytogenetic Map7q35NCBI
Slc38a4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555005,858,642 - 5,925,589 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555005,859,566 - 5,925,084 (-)NCBIChiLan1.0ChiLan1.0
SLC38A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21047,340,869 - 47,402,191 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11247,370,440 - 47,398,051 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01241,906,527 - 41,967,859 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11242,770,576 - 42,838,283 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1242,799,172 - 42,838,283 (+)Ensemblpanpan1.1panPan2
SLC38A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,685,955 - 7,756,222 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,685,660 - 7,770,363 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2738,550,951 - 38,635,574 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0277,816,502 - 7,885,592 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl277,846,744 - 7,968,256 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1277,676,712 - 7,760,967 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0277,719,068 - 7,803,637 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02738,793,742 - 38,877,856 (-)NCBIUU_Cfam_GSD_1.0
Slc38a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494568,235,611 - 68,299,109 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365124,865,769 - 4,929,166 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365124,867,276 - 4,929,175 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC38A4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl577,411,613 - 77,482,013 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1577,411,610 - 77,489,542 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2580,391,346 - 80,496,817 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Slc38a4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248165,450,908 - 5,530,772 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248165,451,464 - 5,529,453 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 20 11 20
Below cutoff 9 7 20

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000004759   ⟹   ENSCSAP00000003006
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1142,963,599 - 43,005,300 (-)Ensembl
RefSeq Acc Id: XM_008002971   ⟹   XP_008001162
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11142,965,744 - 43,026,960 (-)NCBI
Vero_WHO_p1.0NW_023666037203,390,354 - 203,451,736 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008002975   ⟹   XP_008001166
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11142,965,744 - 43,027,042 (-)NCBI
Vero_WHO_p1.0NW_023666037203,390,353 - 203,450,253 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037997231   ⟹   XP_037853159
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037203,383,860 - 203,451,736 (+)NCBI
RefSeq Acc Id: XM_037997232   ⟹   XP_037853160
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037203,390,344 - 203,445,908 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008001162 (Get FASTA)   NCBI Sequence Viewer  
  XP_008001166 (Get FASTA)   NCBI Sequence Viewer  
  XP_037853159 (Get FASTA)   NCBI Sequence Viewer  
  XP_037853160 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000003006
  ENSCSAP00000003006.1
Reference Protein Sequences
RefSeq Acc Id: XP_008001166   ⟸   XM_008002975
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R317 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008001162   ⟸   XM_008002971
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R317 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000003006   ⟸   ENSCSAT00000004759
RefSeq Acc Id: XP_037853159   ⟸   XM_037997231
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R317 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037853160   ⟸   XM_037997232
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000006718 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000004759.1 UniProtKB/TrEMBL
InterPro AA_transpt_TM UniProtKB/TrEMBL
KEGG Report csab:103238198 UniProtKB/TrEMBL
NCBI Gene SLC38A4 ENTREZGENE
PANTHER AMINO ACID TRANSPORTER UniProtKB/TrEMBL
  SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 4 UniProtKB/TrEMBL
Pfam Aa_trans UniProtKB/TrEMBL
UniProt A0A0D9R317 ENTREZGENE, UniProtKB/TrEMBL