VPS37C (VPS37C subunit of ESCRT-I) - Rat Genome Database

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Gene: VPS37C (VPS37C subunit of ESCRT-I) Chlorocebus sabaeus
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Symbol: VPS37C
Name: VPS37C subunit of ESCRT-I
RGD ID: 18395548
Description: ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); INVOLVED IN catabolic process (inferred); multivesicular body assembly (inferred); protein targeting to membrane (inferred); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); leukocyte adhesion deficiency 3 (ortholog); FOUND IN ESCRT I complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: vacuolar protein sorting-associated protein 37C; VPS37C, ESCRT-I subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1112,686,887 - 12,717,335 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl112,686,708 - 12,717,365 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038110,050,915 - 110,081,430 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
VPS37C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1112,686,887 - 12,717,335 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl112,686,708 - 12,717,365 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038110,050,915 - 110,081,430 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
VPS37C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,130,257 - 61,161,426 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,130,257 - 61,161,615 (-)EnsemblGRCh38hg38GRCh38
GRCh371160,897,729 - 60,928,898 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361160,654,304 - 60,685,492 (-)NCBINCBI36Build 36hg18NCBI36
Celera1158,257,905 - 58,289,087 (-)NCBICelera
Cytogenetic Map11q12.2NCBI
HuRef1157,241,628 - 57,272,809 (-)NCBIHuRef
CHM1_11160,761,998 - 60,793,179 (-)NCBICHM1_1
T2T-CHM13v2.01161,081,750 - 61,112,918 (-)NCBIT2T-CHM13v2.0
Vps37c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391910,666,095 - 10,691,992 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1910,666,099 - 10,691,991 (+)EnsemblGRCm39 Ensembl
GRCm381910,688,735 - 10,714,628 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1910,688,735 - 10,714,627 (+)EnsemblGRCm38mm10GRCm38
MGSCv371910,763,305 - 10,788,909 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361910,755,860 - 10,781,464 (+)NCBIMGSCv36mm8
Celera1911,387,159 - 11,414,512 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map197.16NCBI
Vps37c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,760,675 - 216,787,198 (+)NCBIGRCr8
mRatBN7.21207,336,694 - 207,362,295 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1207,336,731 - 207,362,289 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1215,715,355 - 215,740,904 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,770,930 - 222,796,483 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,465,930 - 215,491,482 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01226,742,267 - 226,774,109 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1226,742,343 - 226,767,868 (+)EnsemblRnor6.0rn6Rnor6.0
Celera1204,829,674 - 204,861,514 (+)NCBICelera
Cytogenetic Map1q43NCBI
Vps37c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555115,672,977 - 5,676,335 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555115,672,053 - 5,684,660 (-)NCBIChiLan1.0ChiLan1.0
VPS37C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2962,296,966 - 62,333,742 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11163,340,763 - 63,377,359 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01156,390,882 - 56,422,143 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11159,828,856 - 59,859,379 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1159,828,856 - 59,844,854 (-)Ensemblpanpan1.1panPan2
VPS37C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11855,204,918 - 55,212,902 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1855,205,469 - 55,212,505 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1853,757,368 - 53,786,133 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01856,232,821 - 56,261,541 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1856,232,879 - 56,261,533 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11855,290,683 - 55,319,414 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01854,912,010 - 54,940,776 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01855,793,111 - 55,821,878 (+)NCBIUU_Cfam_GSD_1.0
Vps37c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494711,711,636 - 11,737,077 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365811,843,281 - 1,850,937 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365811,843,330 - 1,850,895 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VPS37C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl210,632,927 - 10,643,539 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1210,614,198 - 10,643,545 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2210,167,657 - 10,175,719 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Vps37c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624926383,580 - 396,489 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624926383,725 - 395,894 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 27 20
Low 9 18 40
Below cutoff 2

Sequence


RefSeq Acc Id: ENSCSAT00000004334   ⟹   ENSCSAP00000002588
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl112,686,708 - 12,717,365 (+)Ensembl
RefSeq Acc Id: XM_007996440   ⟹   XP_007994631
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1112,690,143 - 12,717,333 (+)NCBI
Vero_WHO_p1.0NW_023666038110,054,221 - 110,081,430 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007996448   ⟹   XP_007994639
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1112,690,190 - 12,717,333 (+)NCBI
Vero_WHO_p1.0NW_023666038110,054,274 - 110,081,430 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007996458   ⟹   XP_007994649
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1112,686,887 - 12,717,335 (+)NCBI
Vero_WHO_p1.0NW_023666038110,050,915 - 110,081,430 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007996468   ⟹   XP_007994659
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1112,707,012 - 12,717,333 (+)NCBI
Vero_WHO_p1.0NW_023666038110,070,673 - 110,081,430 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007996476   ⟹   XP_007994667
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1112,708,754 - 12,717,333 (+)NCBI
Vero_WHO_p1.0NW_023666038110,072,948 - 110,081,430 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037999251   ⟹   XP_037855179
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666038110,051,091 - 110,081,430 (+)NCBI
RefSeq Acc Id: XM_037999252   ⟹   XP_037855180
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666038110,051,202 - 110,081,430 (+)NCBI
RefSeq Acc Id: XP_007994649   ⟸   XM_007996458
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R1U9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007994631   ⟸   XM_007996440
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R1U9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007994639   ⟸   XM_007996448
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R1U9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007994659   ⟸   XM_007996468
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R1U9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007994667   ⟸   XM_007996476
- Peptide Label: isoform X3
- UniProtKB: A0A0D9R1U9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000002588   ⟸   ENSCSAT00000004334
RefSeq Acc Id: XP_037855179   ⟸   XM_037999251
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R1U9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037855180   ⟸   XM_037999252
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R1U9 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000006298 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000004334.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.660 UniProtKB/TrEMBL
InterPro ESCRT_assembly_dom UniProtKB/TrEMBL
  Helix_hairpin_bin_sf UniProtKB/TrEMBL
  Mod_r UniProtKB/TrEMBL
KEGG Report csab:103234543 UniProtKB/TrEMBL
NCBI Gene VPS37C ENTREZGENE
PANTHER VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37 UniProtKB/TrEMBL
  VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37C UniProtKB/TrEMBL
Pfam Mod_r UniProtKB/TrEMBL
PROSITE VPS37_C UniProtKB/TrEMBL
Superfamily-SCOP SSF140111 UniProtKB/TrEMBL
UniProt A0A0D9R1U9 ENTREZGENE, UniProtKB/TrEMBL