CHAC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2) - Rat Genome Database

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Gene: CHAC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2) Chlorocebus sabaeus
Analyze
Symbol: CHAC2
Name: ChaC glutathione specific gamma-glutamylcyclotransferase 2
RGD ID: 18389710
Description: ENCODES a protein that exhibits gamma-glutamylcyclotransferase activity (inferred); glutathione specific gamma-glutamylcyclotransferase activity (inferred); lyase activity (inferred); INVOLVED IN glutathione catabolic process (inferred); ASSOCIATED WITH genetic disease (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cation transport regulator-like protein 2; ChaC cation transport regulator homolog 2; glutathione-specific gamma-glutamylcyclotransferase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11453,205,940 - 53,214,439 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1453,203,361 - 53,213,885 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604558,493,585 - 58,501,099 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CHAC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11453,205,940 - 53,214,439 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1453,203,361 - 53,213,885 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604558,493,585 - 58,501,099 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CHAC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38253,767,783 - 53,775,196 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl253,767,804 - 53,775,196 (+)EnsemblGRCh38hg38GRCh38
GRCh37253,994,920 - 54,002,333 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36253,848,433 - 53,855,791 (+)NCBINCBI36Build 36hg18NCBI36
Celera253,835,783 - 53,843,141 (+)NCBICelera
Cytogenetic Map2p16.2NCBI
HuRef253,729,267 - 53,736,626 (+)NCBIHuRef
CHM1_1253,925,914 - 53,933,272 (+)NCBICHM1_1
T2T-CHM13v2.0253,763,988 - 53,771,398 (+)NCBIT2T-CHM13v2.0
Chac2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391130,926,707 - 30,936,365 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1130,926,707 - 30,936,350 (-)EnsemblGRCm39 Ensembl
GRCm381130,976,707 - 30,986,365 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1130,976,707 - 30,986,350 (-)EnsemblGRCm38mm10GRCm38
MGSCv371130,876,709 - 30,886,365 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361130,876,724 - 30,886,334 (-)NCBIMGSCv36mm8
Celera1133,385,672 - 33,395,218 (-)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1118.2NCBI
Chac2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814108,921,669 - 108,929,215 (-)NCBIGRCr8
mRatBN7.214104,720,754 - 104,728,305 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl14104,720,758 - 104,728,301 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14109,032,788 - 109,040,227 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014110,259,770 - 110,267,198 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014106,732,201 - 106,739,629 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014115,383,906 - 115,391,757 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14115,383,910 - 115,391,652 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014115,005,083 - 115,047,440 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414112,082,173 - 112,122,592 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.114112,141,673 - 112,148,939 (-)NCBI
Celera14103,558,180 - 103,565,612 (-)NCBICelera
Cytogenetic Map14q22NCBI
Chac2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544119,502,383 - 19,509,736 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544119,502,389 - 19,509,736 (+)NCBIChiLan1.0ChiLan1.0
CHAC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21272,583,066 - 72,591,548 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A72,587,032 - 72,594,557 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A53,911,057 - 53,918,620 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A54,823,066 - 54,830,474 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A54,823,067 - 54,830,474 (+)Ensemblpanpan1.1panPan2
CHAC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11054,790,670 - 54,799,823 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1054,790,942 - 54,798,955 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1054,742,510 - 54,751,696 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01055,789,281 - 55,798,477 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1055,789,595 - 55,797,618 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11055,482,583 - 55,491,741 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01055,768,555 - 55,777,742 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01056,055,614 - 56,064,806 (+)NCBIUU_Cfam_GSD_1.0
Chac2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629228,236,736 - 28,246,775 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936491324,524 - 336,601 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936491324,540 - 336,619 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHAC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl387,405,978 - 87,416,260 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1387,405,937 - 87,417,268 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2392,565,352 - 92,575,558 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Chac2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248337,937,183 - 7,945,755 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248337,937,152 - 7,946,815 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 36 20 60
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000011885   ⟹   ENSCSAP00000009945
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1453,203,361 - 53,213,885 (-)Ensembl
RefSeq Acc Id: XM_007970646   ⟹   XP_007968837
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11453,205,940 - 53,214,439 (-)NCBI
Vero_WHO_p1.0NW_02366604558,493,586 - 58,501,099 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007970647   ⟹   XP_007968838
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11453,205,940 - 53,214,438 (-)NCBI
Vero_WHO_p1.0NW_02366604558,493,585 - 58,501,099 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038006928   ⟹   XP_037862856
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604558,493,610 - 58,501,099 (+)NCBI
RefSeq Acc Id: XM_038006929   ⟹   XP_037862857
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604558,493,689 - 58,501,099 (+)NCBI
RefSeq Acc Id: XM_038006930   ⟹   XP_037862858
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604558,493,685 - 58,501,099 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_007968837   ⟸   XM_007970646
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RMV6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007968838   ⟸   XM_007970647
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCSAP00000009945   ⟸   ENSCSAT00000011885
RefSeq Acc Id: XP_037862856   ⟸   XM_038006928
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037862858   ⟸   XM_038006930
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037862857   ⟸   XM_038006929
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013789 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011885.1 UniProtKB/TrEMBL
Gene3D-CATH Gamma-glutamyl cyclotransferase-like UniProtKB/TrEMBL
InterPro ChaC UniProtKB/TrEMBL
  GGCT-like UniProtKB/TrEMBL
  GGCT-like_sf UniProtKB/TrEMBL
KEGG Report csab:103220269 UniProtKB/TrEMBL
NCBI Gene CHAC2 ENTREZGENE
PANTHER GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2 UniProtKB/TrEMBL
  PTHR12192 UniProtKB/TrEMBL
Pfam ChaC UniProtKB/TrEMBL
Superfamily-SCOP SSF110857 UniProtKB/TrEMBL
UniProt A0A0D9RMV6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-03-25 CHAC2  ChaC glutathione specific gamma-glutamylcyclotransferase 2  CHAC2  ChaC cation transport regulator homolog 2  Symbol and/or name change 5135510 APPROVED