ICOSLG (inducible T cell costimulator ligand) - Rat Genome Database

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Gene: ICOSLG (inducible T cell costimulator ligand) Chlorocebus sabaeus
Analyze
Symbol: ICOSLG
Name: inducible T cell costimulator ligand
RGD ID: 18389321
Description: ENCODES a protein that exhibits identical protein binding (inferred); signaling receptor binding (inferred); INVOLVED IN positive regulation of interleukin-4 production (ortholog); ASSOCIATED WITH autistic disorder (ortholog); autoimmune polyendocrine syndrome type 1 (ortholog); cataract 9 multiple types (ortholog); FOUND IN external side of plasma membrane (inferred); intracellular membrane-bounded organelle (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ICOS ligand
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1287,974,651 - 87,986,867 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl287,973,786 - 87,986,639 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605416,086,384 - 16,100,434 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
ICOSLG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1287,974,651 - 87,986,867 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl287,973,786 - 87,986,639 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605416,086,384 - 16,100,434 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ICOSLG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382144,216,981 - 44,240,943 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2144,215,382 - 44,241,446 (-)EnsemblGRCh38hg38GRCh38
GRCh372145,642,874 - 45,660,826 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362144,471,149 - 44,485,262 (-)NCBINCBI36Build 36hg18NCBI36
Build 342144,471,151 - 44,485,262NCBI
Celera2130,751,996 - 30,766,092 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2131,016,759 - 31,030,941 (-)NCBIHuRef
CHM1_12145,207,363 - 45,221,476 (-)NCBICHM1_1
T2T-CHM13v2.02142,571,002 - 42,595,008 (-)NCBIT2T-CHM13v2.0
Icosl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391077,904,921 - 77,915,359 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1077,905,136 - 77,919,747 (+)EnsemblGRCm39 Ensembl
GRCm381078,069,368 - 78,079,525 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1078,069,302 - 78,083,913 (+)EnsemblGRCm38mm10GRCm38
MGSCv371077,532,113 - 77,542,270 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361077,472,497 - 77,482,654 (+)NCBIMGSCv36mm8
Celera1079,108,390 - 79,118,547 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Icoslg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,600,078 - 10,610,385 (-)NCBIGRCr8
mRatBN7.22010,600,420 - 10,610,718 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2010,600,420 - 10,610,703 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02011,330,000 - 11,340,307 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,329,992 - 11,340,296 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02013,500,200 - 13,510,518 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42010,930,797 - 10,954,666 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2012,106,187 - 12,116,495 (-)NCBICelera
Cytogenetic Map20p12NCBI
Icoslg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540741,189,974 - 41,198,254 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540741,190,875 - 41,197,521 (+)NCBIChiLan1.0ChiLan1.0
ICOSLG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22240,221,886 - 40,249,640 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12135,071,404 - 35,099,737 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02130,474,655 - 30,499,302 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12143,770,310 - 43,793,410 (-)NCBIpanpan1.1PanPan1.1panPan2
ICOSLG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13138,084,861 - 38,094,743 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3137,242,305 - 37,252,241 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03137,632,500 - 37,642,445 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3137,632,501 - 37,642,512 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13137,499,628 - 37,509,566 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03137,483,631 - 37,493,563 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03137,978,199 - 37,988,166 (-)NCBIUU_Cfam_GSD_1.0
Icoslg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497137,294,671 - 37,303,213 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936500164,603 - 173,155 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936500164,659 - 173,144 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ICOSLG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.113207,106,202 - 207,115,886 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213216,984,895 - 216,994,580 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Icoslg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474529,880,992 - 29,888,717 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474529,880,943 - 29,888,635 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 9 5
Low 36 11 55
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000005927   ⟹   ENSCSAP00000004143
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl287,973,786 - 87,986,639 (-)Ensembl
RefSeq Acc Id: XM_007969748   ⟹   XP_007967939
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1287,974,651 - 87,986,866 (-)NCBI
Vero_WHO_p1.0NW_02366605416,086,384 - 16,100,434 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037984891   ⟹   XP_037840819
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605416,086,384 - 16,100,394 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007967939 (Get FASTA)   NCBI Sequence Viewer  
  XP_037840819 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000004143.1
Reference Protein Sequences
RefSeq Acc Id: XP_007967939   ⟸   XM_007969748
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R6A4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037840819   ⟸   XM_037984891
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R6A4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000004143   ⟸   ENSCSAT00000005927


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000007876 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000005927.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro CD80_C2-set UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
NCBI Gene ICOSLG ENTREZGENE
PANTHER BUTYROPHILIN UniProtKB/TrEMBL
  ICOS LIGAND UniProtKB/TrEMBL
Pfam C2-set_2 UniProtKB/TrEMBL
  V-set UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A0D9R6A4 ENTREZGENE, UniProtKB/TrEMBL