HINT1 (histidine triad nucleotide binding protein 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: HINT1 (histidine triad nucleotide binding protein 1) Chlorocebus sabaeus
Analyze
Symbol: HINT1
Name: histidine triad nucleotide binding protein 1
RGD ID: 18389314
Description: ENCODES a protein that exhibits adenosine 5'-monophosphoramidase activity (ortholog); deSUMOylase activity (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); positive regulation of calcium-mediated signaling (ortholog); protein desumoylation (ortholog); ASSOCIATED WITH axonal neuropathy (ortholog); Charcot-Marie-Tooth disease (ortholog); familial adenomatous polyposis 1 (ortholog); FOUND IN cytosol (ortholog); histone deacetylase complex (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: histidine triad nucleotide-binding protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12334,019,009 - 34,025,006 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2334,014,501 - 34,025,323 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603443,941,290 - 43,947,437 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
HINT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12334,019,009 - 34,025,006 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2334,014,501 - 34,025,323 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603443,941,290 - 43,947,437 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
HINT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385131,159,027 - 131,165,256 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5131,155,383 - 131,224,468 (-)EnsemblGRCh38hg38GRCh38
GRCh375130,494,720 - 130,500,949 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365130,522,776 - 130,528,935 (-)NCBINCBI36Build 36hg18NCBI36
Celera5126,625,253 - 126,631,412 (-)NCBICelera
Cytogenetic Map5q23.3NCBI
HuRef5125,686,002 - 125,692,067 (-)NCBIHuRef
CHM1_15129,927,969 - 129,934,034 (-)NCBICHM1_1
T2T-CHM13v2.05131,678,018 - 131,684,247 (-)NCBIT2T-CHM13v2.0
Hint1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391154,757,209 - 54,761,332 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1154,757,209 - 54,761,327 (+)EnsemblGRCm39 Ensembl
GRCm381154,866,383 - 54,870,506 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1154,866,383 - 54,870,501 (+)EnsemblGRCm38mm10GRCm38
MGSCv371154,679,940 - 54,683,998 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361154,709,861 - 54,713,919 (+)NCBIMGSCv36mm8
Celera1159,453,774 - 59,457,833 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.13NCBI
Hint1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81039,490,225 - 39,493,970 (+)NCBIGRCr8
mRatBN7.21038,989,516 - 38,993,259 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl492,100,973 - 92,101,568 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1043,678,169 - 43,681,916 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,168,260 - 43,172,007 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01038,671,971 - 38,675,718 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,208,236 - 40,211,981 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,208,223 - 40,211,975 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01039,980,504 - 39,984,249 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,271,895 - 40,275,640 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1038,327,662 - 38,331,407 (+)NCBICelera
Cytogenetic Map10q22NCBI
Hint1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554082,674,109 - 2,678,528 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554082,673,950 - 2,678,528 (-)NCBIChiLan1.0ChiLan1.0
HINT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24126,483,128 - 126,489,392 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15124,622,692 - 124,628,778 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05126,587,934 - 126,594,032 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15132,755,766 - 132,761,823 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5132,755,766 - 132,761,823 (-)Ensemblpanpan1.1panPan2
HINT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11119,551,057 - 19,555,390 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1118,349,051 - 18,353,388 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01120,329,881 - 20,334,193 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1120,329,885 - 20,334,199 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11119,058,222 - 19,062,564 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01118,904,366 - 18,908,698 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01119,503,840 - 19,508,157 (-)NCBIUU_Cfam_GSD_1.0
Hint1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213116,840,774 - 116,846,653 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366473,843,544 - 3,849,428 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HINT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2133,467,151 - 133,475,454 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12133,469,765 - 133,475,813 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22138,701,204 - 138,705,746 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Hint1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473340,896,588 - 40,902,828 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473340,896,566 - 40,902,835 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 9 60
Low 11
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000012098   ⟹   ENSCSAP00000010145
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2334,014,501 - 34,025,323 (-)Ensembl
RefSeq Acc Id: XM_008014321   ⟹   XP_008012512
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12334,019,009 - 34,025,006 (-)NCBI
Vero_WHO_p1.0NW_02366603443,941,290 - 43,947,437 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005243882
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603443,941,682 - 43,947,135 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008012512 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000010145
  ENSCSAP00000010145.1
Reference Protein Sequences
RefSeq Acc Id: XP_008012512   ⟸   XM_008014321
- UniProtKB: A0A0D9RNF6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000010145   ⟸   ENSCSAT00000012098


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000014000 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000012098.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.428.10 UniProtKB/TrEMBL
InterPro Histidine_triad_CS UniProtKB/TrEMBL
  Histidine_triad_HIT UniProtKB/TrEMBL
  HIT-like UniProtKB/TrEMBL
  HIT-like_sf UniProtKB/TrEMBL
KEGG Report csab:103244488 UniProtKB/TrEMBL
NCBI Gene HINT1 ENTREZGENE
PANTHER HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1 UniProtKB/TrEMBL
  PTHR23089 UniProtKB/TrEMBL
Pfam HIT UniProtKB/TrEMBL
PRINTS HISTRIAD UniProtKB/TrEMBL
PROSITE HIT_1 UniProtKB/TrEMBL
  HIT_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF54197 UniProtKB/TrEMBL
UniProt A0A0D9RNF6 ENTREZGENE, UniProtKB/TrEMBL