DENND1B (DENN domain containing 1B) - Rat Genome Database

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Gene: DENND1B (DENN domain containing 1B) Chlorocebus sabaeus
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Symbol: DENND1B
Name: DENN domain containing 1B
RGD ID: 18385762
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); phosphatidylinositol phosphate binding (inferred); small GTPase binding (inferred); INVOLVED IN endocytic recycling (inferred); endocytosis (inferred); positive regulation of T-helper 2 cell cytokine production (inferred); ASSOCIATED WITH COVID-19 (ortholog); Crohn's disease (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN cytoplasmic vesicle (inferred); cytosol (inferred); nuclear speck (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DENN domain-containing protein 1B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12531,633,876 - 31,908,207 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2531,640,823 - 31,907,365 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605532,538,275 - 32,815,444 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
DENND1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12531,633,876 - 31,908,207 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2531,640,823 - 31,907,365 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605532,538,275 - 32,815,444 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
DENND1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381197,504,748 - 197,782,150 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1197,504,748 - 197,775,696 (-)EnsemblGRCh38hg38GRCh38
GRCh371197,473,878 - 197,744,610 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361195,788,008 - 196,010,947 (-)NCBINCBI36Build 36hg18NCBI36
Build 341194,253,041 - 194,475,979NCBI
Celera1170,644,089 - 170,867,541 (-)NCBICelera
Cytogenetic Map1q31.3NCBI
HuRef1168,632,607 - 168,900,462 (-)NCBIHuRef
CHM1_11198,896,297 - 199,166,967 (-)NCBICHM1_1
T2T-CHM13v2.01196,766,532 - 197,041,541 (-)NCBIT2T-CHM13v2.0
Dennd1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391138,891,447 - 139,103,781 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1138,891,173 - 139,106,698 (+)EnsemblGRCm39 Ensembl
GRCm381138,963,709 - 139,176,043 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1138,963,435 - 139,178,960 (+)EnsemblGRCm38mm10GRCm38
MGSCv371140,860,286 - 141,072,620 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361140,780,197 - 140,880,129 (+)NCBIMGSCv36mm8
MGSCv361139,836,601 - 139,937,379 (+)NCBIMGSCv36mm8
Celera1141,601,415 - 141,811,483 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map160.84NCBI
Dennd1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81353,096,717 - 53,324,372 (+)NCBIGRCr8
mRatBN7.21350,545,324 - 50,772,922 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1350,545,836 - 50,770,601 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01356,015,813 - 56,242,041 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1356,015,901 - 56,236,677 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01361,038,636 - 61,263,533 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41352,298,620 - 52,525,392 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11352,452,059 - 52,539,199 (+)NCBI
Celera1350,826,848 - 51,045,893 (+)NCBICelera
Cytogenetic Map13q13NCBI
Dennd1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540634,027,046 - 34,241,737 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540634,021,508 - 34,241,735 (-)NCBIChiLan1.0ChiLan1.0
DENND1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2151,618,074 - 51,869,474 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1151,578,395 - 51,838,287 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01173,102,371 - 173,365,024 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11177,415,682 - 177,676,293 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1177,420,565 - 177,676,293 (-)Ensemblpanpan1.1panPan2
DENND1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.175,008,249 - 5,267,392 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl74,999,430 - 5,262,630 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha74,691,222 - 4,886,756 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.074,822,617 - 4,957,348 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl74,693,827 - 4,951,586 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.174,632,039 - 4,899,335 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.074,732,615 - 4,999,970 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.074,764,682 - 5,032,009 (+)NCBIUU_Cfam_GSD_1.0
Dennd1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934476,887,099 - 77,113,632 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365676,134,179 - 6,348,086 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365676,131,433 - 6,353,003 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DENND1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1020,395,481 - 20,635,748 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11020,391,507 - 20,635,808 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21025,082,454 - 25,194,513 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Dennd1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247982,622,379 - 2,838,775 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247982,621,604 - 2,844,370 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 10 28
Low 36 10 32
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000011725   ⟹   ENSCSAP00000009785
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2531,640,823 - 31,907,365 (+)Ensembl
RefSeq Acc Id: XM_007989064   ⟹   XP_007987255
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12531,640,058 - 31,908,207 (+)NCBI
Vero_WHO_p1.0NW_02366605532,538,275 - 32,815,444 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007989067   ⟹   XP_007987258
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12531,640,784 - 31,908,207 (+)NCBI
Vero_WHO_p1.0NW_02366605532,538,633 - 32,815,444 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007989069   ⟹   XP_007987260
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12531,640,934 - 31,908,207 (+)NCBI
Vero_WHO_p1.0NW_02366605532,539,052 - 32,815,444 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007989071   ⟹   XP_007987262
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12531,640,386 - 31,908,207 (+)NCBI
Vero_WHO_p1.0NW_02366605532,538,490 - 32,815,444 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007989072   ⟹   XP_007987263
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12531,640,641 - 31,908,207 (+)NCBI
Vero_WHO_p1.0NW_02366605532,538,631 - 32,815,444 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037985770   ⟹   XP_037841698
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605532,538,278 - 32,815,444 (+)NCBI
RefSeq Acc Id: XM_037985771   ⟹   XP_037841699
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605532,538,277 - 32,776,591 (+)NCBI
RefSeq Acc Id: XP_007987255   ⟸   XM_007989064
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RME6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007987262   ⟸   XM_007989071
- Peptide Label: isoform X5
- UniProtKB: A0A0D9RME6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007987263   ⟸   XM_007989072
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RME6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007987258   ⟸   XM_007989067
- Peptide Label: isoform X4
- UniProtKB: A0A0D9RME6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007987260   ⟸   XM_007989069
- Peptide Label: isoform X5
- UniProtKB: A0A0D9RME6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000009785   ⟸   ENSCSAT00000011725
RefSeq Acc Id: XP_037841699   ⟸   XM_037985771
- Peptide Label: isoform X6
RefSeq Acc Id: XP_037841698   ⟸   XM_037985770
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RME6 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013627 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011725.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.450.200 UniProtKB/TrEMBL
  3.40.50.11500 UniProtKB/TrEMBL
  6.10.140.1000 UniProtKB/TrEMBL
InterPro cDENN_dom UniProtKB/TrEMBL
  dDENN_dom UniProtKB/TrEMBL
  DENN_C UniProtKB/TrEMBL
  DENND1A/B/C UniProtKB/TrEMBL
  Tripartite_DENN UniProtKB/TrEMBL
  uDENN_dom UniProtKB/TrEMBL
NCBI Gene DENND1B ENTREZGENE
PANTHER DENN DOMAIN-CONTAINING PROTEIN 1B UniProtKB/TrEMBL
  PTHR13196 UniProtKB/TrEMBL
Pfam dDENN UniProtKB/TrEMBL
  DENN UniProtKB/TrEMBL
  uDENN UniProtKB/TrEMBL
PROSITE DENN UniProtKB/TrEMBL
SMART dDENN UniProtKB/TrEMBL
  DENN UniProtKB/TrEMBL
  uDENN UniProtKB/TrEMBL
UniProt A0A0D9RME6 ENTREZGENE, UniProtKB/TrEMBL