DUOX2 (dual oxidase 2) - Rat Genome Database

Name: DUOX2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: DUOX2 (dual oxidase 2) Chlorocebus sabaeus

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Symbol:

DUOX2

Name:

dual oxidase 2

RGD ID:

18374361

Description:

ENCODES a protein that exhibits calcium ion binding (inferred); heme binding (inferred); metal ion binding (inferred); INVOLVED IN adenohypophysis morphogenesis (ortholog); bone mineralization (ortholog); cytokine-mediated signaling pathway (ortholog); PARTICIPATES IN thyroid hormone biosynthetic pathway; ASSOCIATED WITH AGAT deficiency (ortholog); Bloom syndrome (ortholog); cholera (ortholog); FOUND IN apical part of cell (ortholog); cell leading edge (ortholog); cell surface (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DUOX2 (dual oxidase 2)	NCBI	Ortholog
Mus musculus (house mouse):	Duox2 (dual oxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Duox2 (dual oxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Duox2 (dual oxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DUOX2 (dual oxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DUOX2 (dual oxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Duox2 (dual oxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DUOX2 (dual oxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Duox2 (dual oxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	38,090,053 - 38,110,781 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	38,090,648 - 38,109,636 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	102,947,646 - 102,968,937 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

AGAT deficiency (ISO)

Bloom syndrome (ISO)

cholera (ISO)

colorectal cancer (ISO)

congenital hypothyroidism (ISO)

Crohn's disease (ISO)

familial thyroid dyshormonogenesis (ISO)

genetic disease (ISO)

Helicobacter Infections (ISO)

Idiopathic Basal Ganglia Calcification 1 (ISO)

influenza A (ISO)

Meckel Syndrome 11 (ISO)

thyroid dyshormonogenesis 6 (ISO)

ulcerative colitis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenohypophysis morphogenesis (IEA,ISO)

bone mineralization (IEA,ISO)

cellular oxidant detoxification (IEA)

cytokine-mediated signaling pathway (ISO)

defense response (IEA)

fertilization (IEA,ISO)

hormone biosynthetic process (IEA)

hormone metabolic process (IEA,ISO)

hydrogen peroxide biosynthetic process (ISO)

inner ear development (IEA,ISO)

multicellular organism growth (IEA,ISO)

positive regulation of cell motility (ISO)

positive regulation of wound healing (ISO)

response to cAMP (ISO)

response to oxidative stress (IEA)

response to virus (ISO)

superoxide anion generation (IEA)

thyroid gland development (IEA,ISO)

thyroid hormone generation (IEA)

thyroid hormone metabolic process (IEA,ISO)

Cellular Component

apical part of cell (ISO)

apical plasma membrane (IEA)

cell leading edge (ISO)

cell surface (ISO)

cytosol (ISO)

endoplasmic reticulum (ISO)

membrane (IEA)

NADPH oxidase complex (IEA)

plasma membrane (IEA)

Molecular Function

calcium ion binding (IEA)

heme binding (IEA)

metal ion binding (IEA)

NAD(P)H oxidase H2O2-forming activity (IEA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor (IEA)

peroxidase activity (IEA)

protein binding (ISO)

superoxide-generating NAD(P)H oxidase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

thyroid hormone biosynthetic pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

DUOX2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	38,090,053 - 38,110,781 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	38,090,648 - 38,109,636 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	102,947,646 - 102,968,937 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

DUOX2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	45,092,650 - 45,114,172 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	45,092,650 - 45,114,172 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	45,384,848 - 45,406,370 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	43,172,144 - 43,193,651 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	43,172,144 - 43,193,651	NCBI
Celera	15	22,276,281 - 22,297,794 (-)	NCBI		Celera
Cytogenetic Map	15	q21.1	NCBI
HuRef	15	22,209,058 - 22,230,571 (-)	NCBI		HuRef
CHM1_1	15	45,503,163 - 45,524,692 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	42,900,666 - 42,922,193 (-)	NCBI		T2T-CHM13v2.0

Duox2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	122,109,727 - 122,129,221 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	122,109,728 - 122,128,930 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	122,279,246 - 122,298,740 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	122,279,247 - 122,298,449 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	122,106,173 - 122,123,901 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	121,971,878 - 121,989,606 (-)	NCBI		MGSCv36	mm8
Celera	2	123,430,543 - 123,448,297 (-)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI
cM Map	2	60.61	NCBI

Duox2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	129,680,543 - 129,698,886 (-)	NCBI		GRCr8
mRatBN7.2	3	109,223,809 - 109,247,023 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	109,226,924 - 109,245,902 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	112,900,635 - 112,918,867 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	121,496,154 - 121,514,388 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	119,156,528 - 119,174,762 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	114,218,187 - 114,237,808 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	114,218,193 - 114,235,933 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	120,757,633 - 120,776,304 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	109,059,360 - 109,077,106 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	108,964,932 - 108,982,679 (-)	NCBI
Celera	3	108,124,745 - 108,142,508 (-)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

Duox2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	8,271,164 - 8,287,096 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	8,270,657 - 8,288,201 (+)	NCBI	ChiLan1.0	ChiLan1.0

DUOX2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	34,333,405 - 34,353,780 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	38,511,302 - 38,531,933 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	24,040,513 - 24,061,758 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	42,393,643 - 42,414,281 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	42,395,135 - 42,414,281 (-)	Ensembl	panpan1.1		panPan2

DUOX2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	11,521,833 - 11,541,719 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	11,521,845 - 11,541,716 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	11,578,140 - 11,598,867 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	11,658,603 - 11,679,500 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	11,658,612 - 11,678,512 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	11,564,842 - 11,585,734 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	11,687,574 - 11,708,297 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	11,806,853 - 11,827,575 (-)	NCBI		UU_Cfam_GSD_1.0

Duox2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	89,964,100 - 89,983,254 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	7,813,128 - 7,831,258 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	7,812,163 - 7,831,258 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DUOX2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	126,620,510 - 126,641,406 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	126,620,468 - 126,641,406 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	141,221,502 - 141,241,329 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Duox2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	14,122,608 - 14,138,121 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624731	14,121,855 - 14,139,344 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
32	31	17	29	29	20	19

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008016762	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008016763	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008016764	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038009937	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000007738 ⟹ ENSCSAP00000005906

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	26	38,090,648 - 38,109,636 (+)	Ensembl

RefSeq Acc Id:

XM_038009937 ⟹ XP_037865865

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666048	102,947,646 - 102,968,937 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_037865865	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000005906.1

Ensembl Acc Id:

ENSCSAP00000005906 ⟸ ENSCSAT00000007738

RefSeq Acc Id:	XP_037865865 ⟸ XM_038009937
- UniProtKB:	A0A0D9RBB7 (UniProtKB/TrEMBL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000009867	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000007738.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.640.10	UniProtKB/TrEMBL
	3.40.50.80	UniProtKB/TrEMBL
	EF-hand	UniProtKB/TrEMBL
	Translation factors	UniProtKB/TrEMBL
InterPro	DUOX_peroxidase	UniProtKB/TrEMBL
	EF-hand-dom_pair	UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/TrEMBL
	FAD-bd_8	UniProtKB/TrEMBL
	FAD-bd_FR_type	UniProtKB/TrEMBL
	Fe3_Rdtase_TM_dom	UniProtKB/TrEMBL
	Fe_red_NAD-bd_6	UniProtKB/TrEMBL
	FNR_nucleotide-bd	UniProtKB/TrEMBL
	Haem_peroxidase_animal	UniProtKB/TrEMBL
	Haem_peroxidase_sf	UniProtKB/TrEMBL
	Haem_peroxidase_sf_animal	UniProtKB/TrEMBL
	RBOH/FRE	UniProtKB/TrEMBL
	Riboflavin_synthase-like_b-brl	UniProtKB/TrEMBL
NCBI Gene	DUOX2	ENTREZGENE
PANTHER	NADPH OXIDASE	UniProtKB/TrEMBL
	PTHR11972:SF67	UniProtKB/TrEMBL
Pfam	An_peroxidase	UniProtKB/TrEMBL
	EF-hand_1	UniProtKB/TrEMBL
	EF-hand_8	UniProtKB/TrEMBL
	FAD_binding_8	UniProtKB/TrEMBL
	Ferric_reduct	UniProtKB/TrEMBL
	NAD_binding_6	UniProtKB/TrEMBL
PRINTS	ANPEROXIDASE	UniProtKB/TrEMBL
PROSITE	EF_HAND_1	UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/TrEMBL
	FAD_FR	UniProtKB/TrEMBL
	PEROXIDASE_3	UniProtKB/TrEMBL
SMART	EFh	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47473	UniProtKB/TrEMBL
	SSF48113	UniProtKB/TrEMBL
	SSF52343	UniProtKB/TrEMBL
	SSF63380	UniProtKB/TrEMBL
UniProt	A0A0D9RBB7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB