AACS (acetoacetyl-CoA synthetase) - Rat Genome Database

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Gene: AACS (acetoacetyl-CoA synthetase) Chlorocebus sabaeus
Analyze
Symbol: AACS
Name: acetoacetyl-CoA synthetase
RGD ID: 18372988
Description: ENCODES a protein that exhibits acetoacetate-CoA ligase activity (ortholog); butyrate-CoA ligase activity (ortholog); INVOLVED IN adipose tissue development (ortholog); cellular response to cholesterol (ortholog); cellular response to glucose stimulus (ortholog); PARTICIPATES IN ketone bodies metabolic pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); genetic disease (ortholog); obesity (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111120,422,138 - 120,502,200 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11120,422,232 - 120,502,271 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037124,780,182 - 124,860,163 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AACS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111120,422,138 - 120,502,200 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11120,422,232 - 120,502,271 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037124,780,182 - 124,860,163 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
AACS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812125,065,435 - 125,143,316 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12125,065,434 - 125,143,333 (+)EnsemblGRCh38hg38GRCh38
GRCh3712125,549,981 - 125,627,862 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612124,115,878 - 124,193,824 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412124,074,886 - 124,152,745NCBI
Celera12125,154,148 - 125,231,815 (+)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12122,513,724 - 122,591,469 (+)NCBIHuRef
CHM1_112125,371,190 - 125,449,292 (+)NCBICHM1_1
T2T-CHM13v2.012125,073,284 - 125,151,299 (+)NCBIT2T-CHM13v2.0
Aacs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395125,552,937 - 125,594,469 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5125,552,878 - 125,594,474 (+)EnsemblGRCm39 Ensembl
GRCm385125,475,873 - 125,517,405 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5125,475,814 - 125,517,410 (+)EnsemblGRCm38mm10GRCm38
MGSCv375125,956,243 - 125,997,773 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365125,765,334 - 125,806,864 (+)NCBIMGSCv36mm8
Celera5122,498,146 - 122,541,335 (+)NCBICelera
Cytogenetic Map5G1.1NCBI
cM Map564.24NCBI
Aacs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,774,471 - 36,817,835 (-)NCBIGRCr8
mRatBN7.21231,113,098 - 31,156,411 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,113,098 - 31,160,954 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1232,283,912 - 32,327,181 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01232,895,349 - 32,938,612 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01231,947,268 - 31,990,536 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01236,512,393 - 36,555,694 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1236,512,393 - 36,555,694 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01238,381,585 - 38,425,026 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41232,206,863 - 32,250,583 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11232,070,250 - 32,113,971 (-)NCBI
Celera1232,807,686 - 32,851,029 (-)NCBICelera
Cytogenetic Map12q14NCBI
Aacs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554824,666,615 - 4,694,021 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554824,663,818 - 4,694,170 (-)NCBIChiLan1.0ChiLan1.0
AACS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210133,153,932 - 133,230,750 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112133,150,310 - 133,227,128 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012122,660,621 - 122,737,421 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112126,942,340 - 127,019,374 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12126,942,340 - 127,019,372 (+)Ensemblpanpan1.1panPan2
AACS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1264,852,582 - 4,903,329 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl264,452,371 - 4,961,436 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,012,574 - 5,070,383 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0265,095,131 - 5,152,920 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl264,689,932 - 5,152,920 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1265,033,494 - 5,091,252 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0265,122,600 - 5,180,458 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0265,076,523 - 5,134,395 (-)NCBIUU_Cfam_GSD_1.0
Aacs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118159,105,954 - 159,147,676 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936558327,407 - 373,683 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936558327,822 - 373,474 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AACS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1428,109,869 - 28,169,253 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11428,109,845 - 28,169,261 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21429,816,562 - 29,871,927 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Aacs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474724,108,968 - 24,145,836 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474724,108,770 - 24,145,836 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 11 58
Low 9 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000016563   ⟹   ENSCSAP00000016069
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl11120,422,232 - 120,502,271 (+)Ensembl
RefSeq Acc Id: XM_008005188   ⟹   XP_008003379
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111120,422,138 - 120,502,200 (+)NCBI
Vero_WHO_p1.0NW_023666037124,780,183 - 124,860,163 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008005189   ⟹   XP_008003380
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111120,422,138 - 120,501,151 (+)NCBI
Vero_WHO_p1.0NW_023666037124,780,182 - 124,860,163 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008003379 (Get FASTA)   NCBI Sequence Viewer  
  XP_008003380 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000016069
  ENSCSAP00000016069.1
Reference Protein Sequences
RefSeq Acc Id: XP_008003379   ⟸   XM_008005188
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S5D0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008003380   ⟸   XM_008005189
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCSAP00000016069   ⟸   ENSCSAT00000016563


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000001967 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000016563.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.300.30 UniProtKB/TrEMBL
  3.40.50.12780 UniProtKB/TrEMBL
InterPro Acac_CoA_synth UniProtKB/TrEMBL
  ACAS_N UniProtKB/TrEMBL
  AMP-bd_C_sf UniProtKB/TrEMBL
  AMP-binding_CS UniProtKB/TrEMBL
  AMP-dep_Synth/Lig UniProtKB/TrEMBL
  AMP-dep_Synthh-like_sf UniProtKB/TrEMBL
KEGG Report csab:103239357 UniProtKB/TrEMBL
NCBI Gene AACS ENTREZGENE
PANTHER ACETOACETYL-COA SYNTHETASE UniProtKB/TrEMBL
  ACETOACETYL-COA SYNTHETASE UniProtKB/TrEMBL
Pfam ACAS_N UniProtKB/TrEMBL
  AMP-binding UniProtKB/TrEMBL
PROSITE AMP_BINDING UniProtKB/TrEMBL
Superfamily-SCOP Acetyl-CoA synthetase-like UniProtKB/TrEMBL
UniProt A0A0D9S5D0 ENTREZGENE, UniProtKB/TrEMBL