BGLAP (bone gamma-carboxyglutamate protein)

Gene: BGLAP (bone gamma-carboxyglutamate protein) Chlorocebus sabaeus

Analyze

Symbol:

BGLAP

Name:

bone gamma-carboxyglutamate protein

RGD ID:

18369150

Description:

ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); structural constituent of bone (ortholog); transition metal ion binding (ortholog); INVOLVED IN bone development (ortholog); brain development (ortholog); cellular response to BMP stimulus (ortholog); PARTICIPATES IN fibroblast growth factor signaling pathway; ASSOCIATED WITH asthma (ortholog); autosomal dominant hypocalcemia (ortholog); Bone Fractures (ortholog); FOUND IN cell projection (ortholog); collagen-containing extracellular matrix (ortholog); dendrite (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC103223843; osteocalcin

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	7,623,716 - 7,626,353 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	7,623,883 - 7,624,812 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	6,916,245 - 6,918,859 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

asthma (ISO)

autosomal dominant hypocalcemia (ISO)

Bone Fractures (ISO)

calcinosis (ISO)

calcium oxalate nephrolithiasis (ISO)

Charcot-Marie-Tooth disease type 2 (ISO)

congenital hypothyroidism (ISO)

Crohn's disease (ISO)

cystic fibrosis (ISO)

diabetes insipidus (ISO)

Diabetic Nephropathies (ISO)

end stage renal disease (ISO)

Experimental Arthritis (ISO)

Experimental Diabetes Mellitus (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

heart valve disease (ISO)

immunodeficiency 42 (ISO)

Kidney Calculi (ISO)

Knee Osteoarthritis (ISO)

Metabolic Syndrome (ISO)

MHC class II deficiency (ISO)

nephrolithiasis (ISO)

nephrotic syndrome (ISO)

neurofibromatosis 1 (ISO)

osteoarthritis (ISO)

osteoporosis (ISO)

parathyroid carcinoma (ISO)

Parkinson's disease (ISO)

polycystic kidney disease (ISO)

progressive osseous heteroplasia (ISO)

prostate cancer (ISO)

Prostatic Neoplasms (ISO)

rheumatoid arthritis (ISO)

severe congenital neutropenia 3 (ISO)

severe congenital neutropenia 5 (ISO)

Spinal Fractures (ISO)

type 1 diabetes mellitus (ISO)

type 2 diabetes mellitus (ISO)

Vitamin D Deficiency (ISO)

vitamin K deficiency bleeding (ISO)

X-linked dominant hypophosphatemic rickets (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biomineral tissue development (IEA)

bone development (IEA,ISO)

brain development (ISO)

cellular response to BMP stimulus (ISO)

cellular response to growth factor stimulus (ISO)

cellular response to insulin stimulus (ISO)

cellular response to vitamin D (ISO)

cellular response to zinc ion starvation (ISO)

cognition (ISO)

dephosphorylation (ISO)

glucose homeostasis (ISO)

learning or memory (ISO)

negative regulation of bone development (ISO)

ossification (ISO)

osteoblast development (ISO)

osteoblast differentiation (IEA,ISO)

positive regulation of neurotransmitter secretion (ISO)

regulation of bone mineralization (IEA)

regulation of cellular response to insulin stimulus (IEA)

regulation of testosterone biosynthetic process (ISO)

response to activity (ISO)

response to estrogen (ISO)

response to ethanol (ISO)

response to glucocorticoid (ISO)

response to gravity (ISO)

response to hydroxyisoflavone (ISO)

response to inorganic substance (ISO)

response to insulin (ISO)

response to macrophage colony-stimulating factor (ISO)

response to mechanical stimulus (ISO)

response to nutrient levels (ISO)

response to organic cyclic compound (ISO)

response to testosterone (ISO)

response to vitamin D (IEA)

response to vitamin K (IEA,ISO)

response to xenobiotic stimulus (ISO)

response to zinc ion (ISO)

signal transduction (IEA)

stem cell differentiation (ISO)

system development (IEA)

type B pancreatic cell proliferation (ISO)

Cellular Component

cell projection (ISO)

collagen-containing extracellular matrix (ISO)

cytoplasm (IEA)

dendrite (ISO)

extracellular region (IEA,ISO)

extracellular space (ISO)

perikaryon (ISO)

vesicle (ISO)

Molecular Function

calcium ion binding (IEA)

calcium-dependent protein binding (ISO)

hormone activity (IEA)

hydroxyapatite binding (IEA)

metal ion binding (IEA)

protein binding (ISO)

structural constituent of bone (IEA,ISO)

transition metal ion binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

fibroblast growth factor signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

BGLAP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	7,623,716 - 7,626,353 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	7,623,883 - 7,624,812 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	6,916,245 - 6,918,859 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

BGLAP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	156,242,184 - 156,243,317 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	156,242,184 - 156,243,317 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	156,211,975 - 156,213,108 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	154,478,629 - 154,479,736 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	153,025,077 - 153,026,185	NCBI
Celera	1	129,284,933 - 129,286,094 (+)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI
HuRef	1	127,573,050 - 127,574,222 (+)	NCBI		HuRef
CHM1_1	1	157,607,924 - 157,609,096 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	155,380,641 - 155,381,774 (+)	NCBI		T2T-CHM13v2.0

Bglap
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	88,290,802 - 88,291,773 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	88,290,808 - 88,291,771 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	88,383,495 - 88,384,466 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	88,383,501 - 88,384,464 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	88,187,417 - 88,188,386 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	88,469,422 - 88,470,391 (-)	NCBI		MGSCv36	mm8
Celera	3	88,423,135 - 88,424,104 (-)	NCBI		Celera
Cytogenetic Map	3	F1	NCBI
cM Map	3	38.82	NCBI

Bglap
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	176,136,341 - 176,137,318 (-)	NCBI		GRCr8
mRatBN7.2	2	173,838,518 - 173,839,495 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	173,838,518 - 173,839,495 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	180,982,788 - 180,983,765 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	179,005,149 - 179,006,126 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	173,605,147 - 173,606,124 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	187,741,770 - 187,748,445 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	187,741,770 - 187,742,747 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	207,144,494 - 207,150,926 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	180,482,313 - 180,483,290 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	180,432,418 - 180,433,396 (-)	NCBI
Celera	2	167,783,260 - 167,784,237 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

Bglap
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955545	2,381,156 - 2,381,978 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955545	2,381,091 - 2,382,114 (+)	NCBI	ChiLan1.0	ChiLan1.0

BGLAP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	93,602,088 - 93,605,108 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	93,333,985 - 93,337,006 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	131,583,789 - 131,586,459 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	135,413,871 - 135,416,432 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	135,413,871 - 135,416,432 (+)	Ensembl	panpan1.1		panPan2

BGLAP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	41,630,092 - 41,630,976 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	41,630,098 - 41,665,791 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	41,117,871 - 41,118,763 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	41,494,521 - 41,495,418 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	41,494,525 - 41,516,608 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	41,275,834 - 41,276,717 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	41,329,023 - 41,329,894 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	41,613,117 - 41,614,007 (-)	NCBI		UU_Cfam_GSD_1.0

Bglap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	26,449,368 - 26,451,906 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	5,481,355 - 5,482,155 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	5,480,023 - 5,482,288 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

Bglap
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624885	1,527,538 - 1,528,109 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624885	1,526,625 - 1,528,235 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	16		18
Low	20	19	42
Below cutoff		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007976754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000000127 ⟹ ENSCSAP00000015925

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	20	7,623,883 - 7,624,812 (-)	Ensembl

RefSeq Acc Id:

XM_007976754 ⟹ XP_007974945

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	20	7,623,716 - 7,626,353 (-)	NCBI
Vero_WHO_p1.0	NW_023666038	6,916,245 - 6,918,859 (-)	NCBI

Sequence:

show sequence

GTTGCAGTGAGCCGAGATGGTGCCATTGTACTCCTGCCTGGGCGACAGAGCAAGACTCCGTCTC
AAAAAAAAAAGAATCGCGGGCACTTTGTTTCTCTTGCTTCTTCCACTTCATTCTTCTTCTGCCA
GGGCAGCCAAAGGCAGGATGGGTGCTTCCTGGATCCACCAGAGGGGGAAAGGGGTTTGGTGTGG
ATGGGGGCAGAACTTTTCCCTAGTGAGGGCTTTGGTGAGGTCTGCCAGAGGCACACTGGGGACA
TAGGCAAGCATCAGGTGGCCCCCACTTCCCCCATCCCATAAACAGCACTCAGCTCAGTCTCCCT
CTGCCCACTTTGTTACCATGGAGCTGTGGCATTCAAGCATTCAAATGCCCTGCTCCTGTCAGGC
CTGCCCCGTTGGGTGCTTTGTTTACTTGTCAGGTTGGGCAGATGGTCTCAAGCCCTGGTGGGTG
GGTGGGTGGGTGAGTGACACAGGTTAGACAGGGGAAGGTCCCAGGACACCTCTTTCCTCTCTAG
GCTGACCTGAGGCAGTGGAGGCTCTCAGGTGTGGGATGGGGTTTTCAGGCTGGGATGTTCTGTA
CCATAGAGGACAGGCCTTCCTATCGCTTACAGGAACACTACAGGAGGGCAGGTCCCTCCCCAGG
GTGGTTAACACTGTGGAGGCTGCAGGGTCAGAAGGAGAATCGGGGGGACCGGGAGGGCAGAGGC
ACACTCCATCTCCATGCTCCTCAGGCCCTGCCTCTCTGCCTGCTAAGGGCACGGGGAAGGGGTT
CCCCACCTCAGTGAGTGCCTGCCTCCCTGCCCTGTGCCTGTGTACCTGGCAGTCACAGCCACCT
AGTGTGTCCCAGAGACCAACCAGTTGACCTCATCTGCCCAGCCCCACCTCCACTGGCTTTGGCT
CTTGGTCTTGTGCCGCCCGACCCTTTCTCCTGTCCGGATGTGCAGGGCCTGAGCCATCGAGCTG
CGCCCACAGCAGACTGCCTTTGGTGTCTCACCGGGTGAACGAGGGCATTGCGAGGCATCCCCTC
CCTGGGTTTGGCTCCTGCCTACGGGGCTGACAGTAGAAATCACAGGCTGTGAGAGAGCTGGAGC
CCAGCTCTGCTTGAACCTATTTTAGGTCTCTGACCCCTGCTTCCTCTTTAGAATCTCCTTAGAG
CTCAGCCAGTGCTCAACTTGAGGCTGGGGGTCTCTGAAGAAGAGTGAGTCGGGGCTGAGGGGTC
TCAGGCTGCCCCCTGAGGAAGGGGCCAGAGGCAGTGTCAAGAGCCAGGCAGTCTGATTGTGGCT
CACCCTCCATCACTCCCAGTGGCCCCTGGCCTGGCAGCCGCAGCTCCCAACCACAGTATCCTTT
GGGGTTTGGCCTACGGAGCTGGGGCGGATGACCCTCAAATAGCCCTGGCAGATTCCCCCTAGAC
CCGCCTGTACCATGGTCAGGCATGCCCCTCCTCATCGCCGGGACACAGCCCAGAGGGTATAAAC
AGTGCTGGAGGCTGGCGGGGCAGGCCAGCTGAGTCCTGAGCAGGAGCCCAACACAGCCACCGAG
ACGCCATGAGAGCCCTCACACTGCTCGCCTTGCTGGCCCTGGCCACACTTTGCATCACTGGCCA
GGCAGGTGCGAAACCCAGCGGTGCAGAGTCCAGCAAAGGTGCAGCCTTTGTGTCCAAGCAGGAG
GGCAGCGAGGTGGTGAAGAGACCCAGGCGCTACCTGTATCAATGGCTGGGAGCCCCAGCCCCCT
ACCCAGATCCCCTGGAGCCCAAGAGGGAGGTGTGTGAGCTCAATCCGGACTGTGACGAGCTGGC
TGACCACATCGGCTTCCAGGAGGCCTATCGGCGCTTCTACGGCCCGGTCTAGGGTGTTGCTCCG
CTGGCCTGGCCGGCAAACCCAGTTCTGCTCCTCTCCAGGCCCCCTTCTTTCCCCTTGCCCTTGC
CCTTGCCCTTGCCCTGACCTCCCAGCCCTATGGATGTGGGGTCCCCATCATCCAGCTGCTCCCA
AATAAACTCCAAAAGAGGAATCCGTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007974945	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000015925
	ENSCSAP00000015925.1

RefSeq Acc Id:	XP_007974945 ⟸ XM_007976754
- UniProtKB:	A0A0D9S4Y6 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000015925 ⟸ ENSCSAT00000000127

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000002112	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000000127.1	UniProtKB/TrEMBL
InterPro	GLA-like_dom_SF	UniProtKB/TrEMBL
	GLA_domain	UniProtKB/TrEMBL
	Osteocalcin	UniProtKB/TrEMBL
	Osteocalcin/MGP	UniProtKB/TrEMBL
KEGG Report	csab:103223843	UniProtKB/TrEMBL
NCBI Gene	BGLAP	ENTREZGENE
PANTHER	OSTEOCALCIN	UniProtKB/TrEMBL
	PTHR14235	UniProtKB/TrEMBL
PRINTS	GLABONE	UniProtKB/TrEMBL
PROSITE	GLA_1	UniProtKB/TrEMBL
	GLA_2	UniProtKB/TrEMBL
SMART	GLA	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57630	UniProtKB/TrEMBL
UniProt	A0A0D9S4Y6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-08-09	BGLAP	bone gamma-carboxyglutamate protein	LOC103223843	bone gamma-carboxyglutamate protein	Symbol and/or name change	5135510	APPROVED
2020-12-08	LOC103223843	bone gamma-carboxyglutamate protein	BGLAP	bone gamma-carboxyglutamate protein	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)