REM2 (RRAD and GEM like GTPase 2) - Rat Genome Database

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Gene: REM2 (RRAD and GEM like GTPase 2) Chlorocebus sabaeus
Analyze
Symbol: REM2
Name: RRAD and GEM like GTPase 2
RGD ID: 18368622
Description: ENCODES a protein that exhibits GTP binding (ortholog); GTPase activity (ortholog); ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); genetic disease (ortholog); lysinuric protein intolerance (ortholog); FOUND IN plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: GTP-binding protein REM 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,249,170 - 23,254,732 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,250,334 - 23,253,988 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605923,168,745 - 23,173,245 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
REM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,249,170 - 23,254,732 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,250,334 - 23,253,988 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605923,168,745 - 23,173,245 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
REM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381422,883,222 - 22,887,678 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1422,883,222 - 22,887,678 (+)EnsemblGRCh38hg38GRCh38
GRCh371423,352,431 - 23,356,887 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,422,272 - 22,426,729 (+)NCBINCBI36Build 36hg18NCBI36
Build 341422,422,280 - 22,426,729NCBI
Celera143,215,328 - 3,219,787 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,469,552 - 3,474,011 (+)NCBIHuRef
CHM1_11423,351,095 - 23,355,552 (+)NCBICHM1_1
T2T-CHM13v2.01417,081,280 - 17,085,738 (+)NCBIT2T-CHM13v2.0
Rem2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391454,713,676 - 54,717,889 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1454,713,557 - 54,717,888 (+)EnsemblGRCm39 Ensembl
GRCm381454,476,100 - 54,480,434 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,476,100 - 54,480,431 (+)EnsemblGRCm38mm10GRCm38
MGSCv371455,094,937 - 55,099,271 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361453,430,305 - 53,434,639 (+)NCBIMGSCv36mm8
Celera1452,269,483 - 52,273,799 (+)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1427.8NCBI
Rem2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81531,903,972 - 31,908,451 (+)NCBIGRCr8
mRatBN7.21527,933,950 - 27,938,429 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1527,933,950 - 27,938,429 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1529,773,309 - 29,777,787 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01530,920,530 - 30,925,008 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,170,864 - 29,175,344 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,121,273 - 33,125,752 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,121,273 - 33,125,752 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,006,429 - 37,010,908 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41532,539,996 - 32,544,475 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11532,555,820 - 32,559,500 (+)NCBI
Celera1527,516,641 - 27,521,120 (+)NCBICelera
Cytogenetic Map15p13NCBI
Rem2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540937,402,212 - 37,408,312 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540937,403,758 - 37,408,312 (-)NCBIChiLan1.0ChiLan1.0
REM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21524,312,623 - 24,319,212 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11423,529,111 - 23,533,681 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0143,700,397 - 3,704,897 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11421,800,155 - 21,804,692 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1421,800,155 - 21,804,692 (+)Ensemblpanpan1.1panPan2
REM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,215,023 - 3,223,470 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,208,269 - 3,382,311 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,163,373 - 3,171,150 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.083,322,753 - 3,330,535 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,315,969 - 3,330,486 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,014,093 - 3,021,870 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,075,874 - 3,083,649 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,337,852 - 3,345,634 (+)NCBIUU_Cfam_GSD_1.0
Rem2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864034,971,438 - 34,976,785 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367221,410,731 - 1,416,991 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367221,412,068 - 1,416,967 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
REM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl776,143,726 - 76,150,147 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1776,141,015 - 76,149,162 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Rem2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248209,635,552 - 9,640,482 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248209,635,971 - 9,640,321 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 10
Low 21 15 50
Below cutoff 15 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000014314   ⟹   ENSCSAP00000012290
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2923,250,334 - 23,253,988 (+)Ensembl
RefSeq Acc Id: XM_007990787   ⟹   XP_007988978
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12923,249,170 - 23,254,732 (+)NCBI
Vero_WHO_p1.0NW_02366605923,168,745 - 23,173,238 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037987559   ⟹   XP_037843487
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605923,168,747 - 23,173,245 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007988978 (Get FASTA)   NCBI Sequence Viewer  
  XP_037843487 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000012290.1
Reference Protein Sequences
RefSeq Acc Id: XP_007988978   ⟸   XM_007990787
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RUK1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000012290   ⟸   ENSCSAT00000014314
RefSeq Acc Id: XP_037843487   ⟸   XM_037987559
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000016222 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000014314.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Sigma_54_int_dom_ATP-bd_1 UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
KEGG Report csab:103231448 UniProtKB/TrEMBL
NCBI Gene REM2 ENTREZGENE
PANTHER GTP-BINDING PROTEIN REM 2 UniProtKB/TrEMBL
  RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  SIGMA54_INTERACT_1 UniProtKB/TrEMBL
SMART RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0D9RUK1 ENTREZGENE, UniProtKB/TrEMBL