H2AFV (H2A histone family member V)

Gene: H2AFV (H2A histone family member V) Chlorocebus sabaeus

Analyze

Symbol:

H2AFV (Ensembl: H2AZ2)

Name:

H2A histone family member V (Ensembl:H2A.Z variant histone 2)

RGD ID:

18367849

Description:

ENCODES a protein that exhibits molecular adaptor activity (ortholog); ASSOCIATED WITH pleomorphic xanthoastrocytoma (ortholog); FOUND IN nucleosome (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

histone H2A.V

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	H2AZ2 (H2A.Z variant histone 2)	NCBI	Ortholog
Mus musculus (house mouse):	H2az2 (H2A.Z histone variant 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	H2az2 (H2A.Z variant histone 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	LOC102016130 (histone H2A.V)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100974682 (histone H2A.V)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	H2AZ2 (H2A.Z variant histone 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101962450 (histone H2A.V)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	H2AZ2 (H2A.Z variant histone 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	LOC101713540 (histone H2A.V)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	13,829,359 - 13,843,069 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	13,829,330 - 13,842,796 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666062	8,693,291 - 8,708,095 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

pleomorphic xanthoastrocytoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

chromosome (IEA)

nucleosome (IEA,ISO)

nucleus (IEA)

Molecular Function

DNA binding (IEA)

molecular adaptor activity (ISO)

protein heterodimerization activity (IEA)

structural constituent of chromatin (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

H2AFV
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	13,829,359 - 13,843,069 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	13,829,330 - 13,842,796 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666062	8,693,291 - 8,708,095 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

H2AZ2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	44,826,889 - 44,848,126 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	44,826,791 - 44,848,087 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	44,866,488 - 44,887,725 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	44,833,013 - 44,854,250 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	7	44,965,339 - 44,986,571 (-)	NCBI		Celera
Cytogenetic Map	7	p13	NCBI
HuRef	7	44,751,981 - 44,773,197 (-)	NCBI		HuRef
CHM1_1	7	44,870,854 - 44,892,091 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	44,987,408 - 45,008,612 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	44,905,993 - 44,927,227 (-)	NCBI

H2az2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	6,377,226 - 6,394,511 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	6,377,229 - 6,394,443 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	6,427,226 - 6,444,511 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	6,427,229 - 6,444,443 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	6,327,229 - 6,344,446 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	6,328,022 - 6,344,442 (-)	NCBI		MGSCv36	mm8
Celera	11	6,913,952 - 6,931,156 (-)	NCBI		Celera
Cytogenetic Map	11	A1	NCBI
cM Map	11	4.01	NCBI

H2az2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	85,507,228 - 85,526,166 (-)	NCBI		GRCr8
mRatBN7.2	14	81,293,304 - 81,312,209 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	81,293,299 - 81,312,144 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	85,694,227 - 85,713,500 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	86,934,027 - 86,953,299 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	83,383,623 - 83,402,893 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	86,687,782 - 86,706,639 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	86,687,782 - 86,706,626 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	80,320,991 - 80,339,905 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	87,180,334 - 87,199,178 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	14	80,174,623 - 80,193,467 (-)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

LOC102016130
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955456	7,364,329 - 7,374,786 (+)	NCBI	ChiLan1.0	ChiLan1.0

LOC100974682
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	49,740,061 - 49,761,434 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	98,064,798 - 98,086,171 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	45,543,839 - 45,561,970 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	45,609,163 - 45,630,674 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	45,612,565 - 45,630,680 (-)	Ensembl	panpan1.1		panPan2

H2AZ2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Dog10K_Boxer_Tasha	16	2,489,540 - 2,499,243 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	14,361,814 - 14,371,488 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	14,340,143 - 14,375,051 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.0	16	13,994,852 - 14,003,640 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	13,974,384 - 13,984,112 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101962450
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	100,490,319 - 100,503,178 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936478	19,702,914 - 19,714,897 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936478	19,702,914 - 19,714,898 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

H2AZ2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	50,533,429 - 50,552,392 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	50,533,382 - 50,548,341 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	55,305,989 - 55,314,885 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC101713540
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	7,430,065 - 7,440,973 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	7,429,941 - 7,440,973 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	36	20	60
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007981414	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007981415	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007981416	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007981417	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000013789 ⟹ ENSCSAP00000011779

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	21	13,829,330 - 13,842,796 (+)	Ensembl

RefSeq Acc Id:

XM_007981415 ⟹ XP_007979606

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	21	13,829,359 - 13,843,069 (+)	NCBI
Vero_WHO_p1.0	NW_023666062	8,693,296 - 8,708,095 (-)	NCBI

Sequence:

show sequence

AAGCGGGCATTGGCCGCAGCAGCGCGAGGCGGGCACGGGGTATTGTCCGGCTCCGGCGGCGGCG
GTCGGTGCTGCGAGAGCGGCGGCGGCGGCGCAGGTCGTCAGCGGGCGGGCGCGCGGCCGAGCGG
AGGCAGAGTCGGCGCCGAGAACATGGCTGGAGGCAAAGCTGGAAAGGACAGTGGGAAGGCCAAG
GCTAAGGCAGTATCTCGCTCACAGAGAGCTGGGCTACAGTTTCCTGTGGGCCGCATCCACAGAC
ACTTGAAGACTCGCACCACAAGCCATGGAAGGGTGGGTGCCACTGCTGCCGTGTACAGTGCTGC
GATTCTGGAGTACCTCACTGCAGAGGTGCTGGAGCTGGCAGGTAATGCTTCTAAGGATCTCAAA
GTAAAGCGTATCACTCCGCGTCACTTGCAGCTTGCAATCCGTGGTGATGAAGAGTTGGATTCTC
TTATCAAGGCTACCATAGCTGGGGGTGGTGTGATCCCTCACATCCACAAATCTCTGATTGGAAA
GAAGGGACAGCAGAAAACTGCTTAGAGGGATGCTTTAACCAACCCTCTTCCTCCCTGTCGTTGT
ACTGTAACTGGGACAGAAGAAATAATGGGGATATGTGGAATTTTTAACAACAGTTAAATGGAAA
AGCATAGACAATTACTGTAGACATGATAAAAGAAACATTTGTACGTTCTTAGACTCGAAGTTTG
ATAAAAGTACCTTTTCATGTGGTGACAGTTGTGTGTTGATTGGCTAGGTTTCTCCCGCGTGTTT
TATACAAAAATGGAATTGATAAACCATTTTTTACAAAATTAA

hide sequence

RefSeq Acc Id:

XM_007981417 ⟹ XP_007979608

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	21	13,829,360 - 13,843,069 (+)	NCBI
Vero_WHO_p1.0	NW_023666062	8,693,291 - 8,708,095 (-)	NCBI

Sequence:

show sequence

AGCGGGCATTGGCCGCAGCAGCGCGAGGCGGGCACGGGGTATTGTCCGGCTCCGGCGGCGGCGG
TCGGTGCTGCGAGAGCGGCGGCGGCGGCGCAGGTCGTCAGCGGGCGGGCGCGCGGCCGAGCGGA
GGCAGAGTCGGCGCCGAGAACATGGCTGGAGGCAAAGCTGGAAAGGACAGTGGGAAGGCCAAGG
CTAAGGCAGTATCTCGCTCACAGAGAGCTGGGCTACAGGTGCTGGAGCTGGCAGGTAATGCTTC
TAAGGATCTCAAAGTAAAGCGTATCACTCCGCGTCACTTGCAGCTTGCAATCCGTGGTGATGAA
GAGTTGGATTCTCTTATCAAGGCTACCATAGCTGGGGGTGGTGTGATCCCTCACATCCACAAAT
CTCTGATTGGAAAGAAGGGACAGCAGAAAACTGCTTAGAGGGATGCTTTAACCAACCCTCTTCC
TCCCTGTCGTTGTACTGTAACTGGGACAGAAGAAATAATGGGGATATGTGGAATTTTTAACAAC
AGTTAAATGGAAAAGCATAGACAATTACTGTAGACATGATAAAAGAAACATTTGTACGTTCTTA
GACTCGAAGTTTGATAAAAGTACCTTTTCATGTGGTGACAGTTGTGTGTTGATTGGCTAGGTTT
CTCCCGCGTGTTTTATACAAAAATGGAATTGATAAACCATTTTTTACAAAATTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007979606	(Get FASTA)	NCBI Sequence Viewer
	XP_007979608	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000011779
	ENSCSAP00000011779.1
	ENSCSAP00000017985.1

RefSeq Acc Id:	XP_007979606 ⟸ XM_007981415
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9RT40 (UniProtKB/TrEMBL), A0A0D9SAU6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_007979608 ⟸ XM_007981417
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSCSAP00000011779 ⟸ ENSCSAT00000013789

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000015697	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSCSAG00000018443	UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000013789.1	UniProtKB/TrEMBL
	ENSCSAT00000018533.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.20.10	UniProtKB/TrEMBL
InterPro	Histone-fold	UniProtKB/TrEMBL
	Histone_H2A	UniProtKB/TrEMBL
	Histone_H2A/H2B/H3	UniProtKB/TrEMBL
	Histone_H2A_C	UniProtKB/TrEMBL
	Histone_H2A_CS	UniProtKB/TrEMBL
NCBI Gene	H2AFV	ENTREZGENE
PANTHER	HISTONE H2A.V	UniProtKB/TrEMBL
	HISTONE H2A.Z	UniProtKB/TrEMBL
	PTHR23430	UniProtKB/TrEMBL
Pfam	Histone	UniProtKB/TrEMBL
	Histone_H2A_C	UniProtKB/TrEMBL
PRINTS	HISTONEH2A	UniProtKB/TrEMBL
PROSITE	HISTONE_H2A	UniProtKB/TrEMBL
SMART	H2A	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47113	UniProtKB/TrEMBL
UniProt	A0A0D9RT40	ENTREZGENE, UniProtKB/TrEMBL
	A0A0D9SAU6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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