GFM1 (G elongation factor mitochondrial 1) - Rat Genome Database

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Gene: GFM1 (G elongation factor mitochondrial 1) Chlorocebus sabaeus
Analyze
Symbol: GFM1
Name: G elongation factor mitochondrial 1
RGD ID: 18357960
Description: ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); translation elongation factor activity (inferred); INVOLVED IN mitochondrial translational elongation (inferred); translation (inferred); translational elongation (inferred); ASSOCIATED WITH combined oxidative phosphorylation deficiency (ortholog); combined oxidative phosphorylation deficiency 1 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: elongation factor G, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11532,153,650 - 32,198,393 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1532,150,607 - 32,198,396 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660414,716,825 - 4,761,563 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
mitochondrion  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GFM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11532,153,650 - 32,198,393 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1532,150,607 - 32,198,396 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660414,716,825 - 4,761,563 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
GFM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383158,644,527 - 158,695,581 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3158,644,527 - 158,695,581 (+)EnsemblGRCh38hg38GRCh38
GRCh373158,362,316 - 158,413,370 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363159,845,011 - 159,893,055 (+)NCBINCBI36Build 36hg18NCBI36
Celera3156,784,902 - 156,832,946 (+)NCBICelera
Cytogenetic Map3q25.32NCBI
HuRef3155,758,163 - 155,806,206 (+)NCBIHuRef
CHM1_13158,325,291 - 158,373,337 (+)NCBICHM1_1
T2T-CHM13v2.03161,418,448 - 161,469,504 (+)NCBIT2T-CHM13v2.0
Gfm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39367,337,448 - 67,382,401 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl367,337,429 - 67,383,862 (+)EnsemblGRCm39 Ensembl
GRCm38367,430,115 - 67,475,068 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl367,430,096 - 67,476,529 (+)EnsemblGRCm38mm10GRCm38
MGSCv37367,234,037 - 67,278,990 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36367,518,044 - 67,562,997 (+)NCBIMGSCv36mm8
Celera367,556,209 - 67,601,175 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map330.96NCBI
Gfm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82154,010,601 - 154,055,523 (+)NCBIGRCr8
mRatBN7.22151,700,573 - 151,745,477 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2151,700,564 - 151,745,471 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2158,817,201 - 158,861,971 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02156,867,699 - 156,912,472 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02151,500,450 - 151,545,218 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02164,601,575 - 164,646,478 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2164,601,586 - 164,646,439 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02183,950,902 - 183,995,881 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42157,283,046 - 157,327,969 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12157,233,008 - 157,277,932 (+)NCBI
Celera2146,070,110 - 146,114,990 (+)NCBICelera
Cytogenetic Map2q32NCBI
Gfm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554489,390,576 - 9,433,404 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554489,390,576 - 9,432,919 (+)NCBIChiLan1.0ChiLan1.0
GFM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22156,583,431 - 156,634,795 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13156,588,163 - 156,639,527 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03155,670,432 - 155,721,404 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13163,721,473 - 163,769,454 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3163,721,479 - 163,769,454 (+)Ensemblpanpan1.1panPan2
GFM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12351,940,307 - 51,983,196 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2351,940,071 - 51,982,636 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2351,749,477 - 51,792,992 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02352,580,688 - 52,624,233 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2352,580,668 - 52,624,232 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12352,161,073 - 52,204,519 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02352,213,985 - 52,257,486 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02352,499,435 - 52,542,963 (+)NCBIUU_Cfam_GSD_1.0
Gfm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560284,441,526 - 84,489,184 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365195,244,591 - 5,292,439 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365195,245,202 - 5,292,426 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GFM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1398,411,179 - 98,458,525 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11398,411,132 - 98,456,496 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213106,704,037 - 106,749,956 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Gfm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473036,354,255 - 36,400,195 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473036,354,334 - 36,400,999 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 53
Low 20 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000010251   ⟹   ENSCSAP00000008346
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1532,150,607 - 32,198,396 (-)Ensembl
RefSeq Acc Id: XM_008008572   ⟹   XP_008006763
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11532,153,650 - 32,198,393 (-)NCBI
Vero_WHO_p1.0NW_0236660414,716,825 - 4,761,563 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038002667   ⟹   XP_037858595
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660414,716,825 - 4,761,469 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008006763 (Get FASTA)   NCBI Sequence Viewer  
  XP_037858595 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000008346.1
Reference Protein Sequences
RefSeq Acc Id: XP_008006763   ⟸   XM_008008572
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RIA7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000008346   ⟸   ENSCSAT00000010251
RefSeq Acc Id: XP_037858595   ⟸   XM_038002667
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RIA7 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000012162 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000010251.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.230.10 UniProtKB/TrEMBL
  3.30.70.240 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  Elongation Factor G (Translational Gtpase), domain 3 UniProtKB/TrEMBL
  Translation factors UniProtKB/TrEMBL
InterPro EFG_II UniProtKB/TrEMBL
  EFG_III UniProtKB/TrEMBL
  EFG_III/V UniProtKB/TrEMBL
  EFG_IV UniProtKB/TrEMBL
  EFG_V UniProtKB/TrEMBL
  EFG_V-like UniProtKB/TrEMBL
  EFTu-like_2 UniProtKB/TrEMBL
  G_TR_CS UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  TF_GTP-bd_dom UniProtKB/TrEMBL
  Transl_B-barrel_sf UniProtKB/TrEMBL
  Transl_elong_EFG/EF2 UniProtKB/TrEMBL
  Transl_elong_EFG/EF2_IV UniProtKB/TrEMBL
KEGG Report csab:103241412 UniProtKB/TrEMBL
NCBI Gene GFM1 ENTREZGENE
PANTHER ELONGATION FACTOR G, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR43636 UniProtKB/TrEMBL
Pfam EFG_C UniProtKB/TrEMBL
  EFG_II UniProtKB/TrEMBL
  EFG_IV UniProtKB/TrEMBL
  GTP_EFTU UniProtKB/TrEMBL
  GTP_EFTU_D2 UniProtKB/TrEMBL
PRINTS ELONGATNFCT UniProtKB/TrEMBL
PROSITE G_TR_1 UniProtKB/TrEMBL
  G_TR_2 UniProtKB/TrEMBL
SMART EFG_C UniProtKB/TrEMBL
  EFG_IV UniProtKB/TrEMBL
Superfamily-SCOP SSF50447 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  SSF54211 UniProtKB/TrEMBL
  SSF54980 UniProtKB/TrEMBL
UniProt A0A0D9RIA7 ENTREZGENE, UniProtKB/TrEMBL