MEF2A (myocyte enhancer factor 2A) - Rat Genome Database

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Gene: MEF2A (myocyte enhancer factor 2A) Chlorocebus sabaeus
Analyze
Symbol: MEF2A
Name: myocyte enhancer factor 2A
RGD ID: 18345619
Description: ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN cellular response to glucose stimulus (ortholog); dendrite morphogenesis (ortholog); positive regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH chromosome 15q26-qter deletion syndrome (ortholog); Coronary Artery Disease, Autosomal Dominant 1 (ortholog); dilated cardiomyopathy (ortholog); FOUND IN chromatin (inferred); cytosol (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: myocyte-specific enhancer factor 2A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12918,150,315 - 18,312,975 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2918,150,854 - 18,309,247 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605928,253,312 - 28,416,154 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MEF2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12918,150,315 - 18,312,975 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2918,150,854 - 18,309,247 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605928,253,312 - 28,416,154 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MEF2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381599,565,417 - 99,716,488 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1599,565,417 - 99,716,488 (+)EnsemblGRCh38hg38GRCh38
GRCh3715100,105,622 - 100,256,693 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361597,956,185 - 98,071,524 (+)NCBINCBI36Build 36hg18NCBI36
Build 341597,956,184 - 98,071,524NCBI
Celera1576,525,015 - 76,675,549 (+)NCBICelera
Cytogenetic Map15q26.3NCBI
HuRef1576,235,794 - 76,386,442 (+)NCBIHuRef
CHM1_11599,947,526 - 100,097,943 (+)NCBICHM1_1
T2T-CHM13v2.01597,329,154 - 97,480,250 (+)NCBIT2T-CHM13v2.0
Mef2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39766,880,911 - 67,026,435 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl766,880,911 - 67,022,606 (-)EnsemblGRCm39 Ensembl
GRCm38767,231,163 - 67,376,456 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl767,231,163 - 67,372,858 (-)EnsemblGRCm38mm10GRCm38
MGSCv37774,378,710 - 74,517,744 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36767,112,774 - 67,251,808 (-)NCBIMGSCv36mm8
Celera764,692,674 - 64,806,488 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map736.72NCBI
Mef2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81130,258,083 - 130,392,819 (-)NCBIGRCr8
mRatBN7.21120,847,874 - 120,982,488 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1120,850,080 - 120,981,948 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1128,846,933 - 128,978,666 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01136,017,035 - 136,148,765 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01128,821,335 - 128,953,169 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01128,207,715 - 128,341,681 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1128,209,971 - 128,341,263 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01129,273,893 - 129,407,071 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11122,128,377 - 122,183,406 (-)NCBI
Celera1113,052,879 - 113,157,227 (-)NCBICelera
Cytogenetic Map1q22NCBI
Mef2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541626,953,798 - 27,051,171 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541626,926,753 - 27,051,171 (+)NCBIChiLan1.0ChiLan1.0
MEF2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21689,108,247 - 89,258,902 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11592,805,248 - 92,955,775 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01578,246,439 - 78,396,720 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11597,428,808 - 97,579,092 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1597,428,744 - 97,579,092 (+)Ensemblpanpan1.1panPan2
MEF2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1341,012,103 - 41,177,588 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl341,015,713 - 41,179,448 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha343,686,343 - 43,878,500 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0341,389,861 - 41,582,392 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl341,397,662 - 41,582,402 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1340,922,313 - 41,112,375 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0341,153,499 - 41,343,252 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0341,373,135 - 41,563,186 (-)NCBIUU_Cfam_GSD_1.0
Mef2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640142,352,128 - 142,499,799 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364833,834,700 - 3,919,766 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364833,837,891 - 3,982,334 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEF2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1138,341,158 - 138,511,314 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11138,398,270 - 138,508,639 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21154,615,130 - 154,689,503 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Mef2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247684,704,799 - 4,796,719 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247684,701,734 - 4,852,833 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 35 17 60
Low 1 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000015022   ⟹   ENSCSAP00000012975
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2918,150,854 - 18,309,247 (+)Ensembl
RefSeq Acc Id: XM_007990551   ⟹   XP_007988742
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12918,150,323 - 18,312,975 (+)NCBI
Vero_WHO_p1.0NW_02366605928,253,312 - 28,416,154 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007990552   ⟹   XP_007988743
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12918,150,329 - 18,312,975 (+)NCBI
Vero_WHO_p1.0NW_02366605928,253,312 - 28,416,154 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007990553   ⟹   XP_007988744
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12918,150,341 - 18,312,975 (+)NCBI
Vero_WHO_p1.0NW_02366605928,253,312 - 28,416,154 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007990554   ⟹   XP_007988745
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12918,150,338 - 18,312,975 (+)NCBI
Vero_WHO_p1.0NW_02366605928,253,394 - 28,416,154 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007990556   ⟹   XP_007988747
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12918,150,341 - 18,312,975 (+)NCBI
Vero_WHO_p1.0NW_02366605928,253,394 - 28,416,154 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007990557   ⟹   XP_007988748
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12918,150,353 - 18,312,975 (+)NCBI
Vero_WHO_p1.0NW_02366605928,253,312 - 28,416,154 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_007988742   ⟸   XM_007990551
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007988743   ⟸   XM_007990552
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007988745   ⟸   XM_007990554
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007988744   ⟸   XM_007990553
- Peptide Label: isoform X6
- UniProtKB: A0A0D9RWI6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007988747   ⟸   XM_007990556
- Peptide Label: isoform X4
RefSeq Acc Id: XP_007988748   ⟸   XM_007990557
- Peptide Label: isoform X5
RefSeq Acc Id: ENSCSAP00000012975   ⟸   ENSCSAT00000015022


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000016929 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015022.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1810.10 UniProtKB/TrEMBL
InterPro HJURP_C UniProtKB/TrEMBL
  MADS_MEF2-like UniProtKB/TrEMBL
  TF_MADSbox UniProtKB/TrEMBL
  TF_MADSbox_sf UniProtKB/TrEMBL
NCBI Gene MEF2A ENTREZGENE
PANTHER MYOCYTE-SPECIFIC ENHANCER FACTOR 2A UniProtKB/TrEMBL
  SERUM RESPONSE FACTOR HOMOLOG UniProtKB/TrEMBL
Pfam HJURP_C UniProtKB/TrEMBL
  SRF-TF UniProtKB/TrEMBL
PRINTS MADSDOMAIN UniProtKB/TrEMBL
PROSITE MADS_BOX_1 UniProtKB/TrEMBL
  MADS_BOX_2 UniProtKB/TrEMBL
SMART MADS UniProtKB/TrEMBL
Superfamily-SCOP SSF55455 UniProtKB/TrEMBL
UniProt A0A0D9RWI6 ENTREZGENE, UniProtKB/TrEMBL