VPS8 (VPS8 subunit of CORVET complex) - Rat Genome Database

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Gene: VPS8 (VPS8 subunit of CORVET complex) Chlorocebus sabaeus
Analyze
Symbol: VPS8
Name: VPS8 subunit of CORVET complex
RGD ID: 18343595
Description: INVOLVED IN endosomal vesicle fusion (inferred); protein targeting to vacuole (inferred); ASSOCIATED WITH Contracture (ortholog); Currarino syndrome (ortholog); genetic disease (ortholog); FOUND IN CORVET complex (inferred); early endosome (inferred); HOPS complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: vacuolar protein sorting-associated protein 8 homolog; VPS8, CORVET complex subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1154,368,144 - 4,607,691 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl154,367,706 - 4,607,656 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606313,129,642 - 13,374,062 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
VPS8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1154,368,144 - 4,607,691 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl154,367,706 - 4,607,656 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606313,129,642 - 13,374,062 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
VPS8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383184,812,166 - 185,052,614 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3184,812,143 - 185,052,614 (+)EnsemblGRCh38hg38GRCh38
GRCh373184,529,954 - 184,770,402 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363186,012,625 - 186,253,096 (+)NCBINCBI36Build 36hg18NCBI36
Celera3182,976,573 - 183,217,415 (+)NCBICelera
Cytogenetic Map3q27.2NCBI
HuRef3181,939,950 - 182,180,425 (+)NCBIHuRef
CHM1_13184,492,807 - 184,733,266 (+)NCBICHM1_1
T2T-CHM13v2.03187,627,968 - 187,868,623 (+)NCBIT2T-CHM13v2.0
Vps8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391621,241,859 - 21,463,431 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1621,241,868 - 21,463,430 (+)EnsemblGRCm39 Ensembl
GRCm381621,423,118 - 21,644,681 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1621,423,118 - 21,644,680 (+)EnsemblGRCm38mm10GRCm38
MGSCv371621,423,191 - 21,644,753 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361621,337,101 - 21,558,663 (+)NCBIMGSCv36mm8
Celera1621,989,997 - 22,212,312 (+)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1612.69NCBI
Vps8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,906,702 - 93,140,844 (-)NCBIGRCr8
mRatBN7.21179,402,236 - 79,634,234 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1179,402,239 - 79,634,133 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01183,104,912 - 83,323,606 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1183,105,064 - 83,300,409 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01186,184,133 - 86,400,369 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,635,546 - 81,866,781 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11181,693,489 - 81,956,899 (-)NCBI
Celera1178,253,172 - 78,478,852 (-)NCBICelera
Cytogenetic Map11q23NCBI
Vps8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542022,504,440 - 22,715,094 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542022,504,076 - 22,715,094 (-)NCBIChiLan1.0ChiLan1.0
VPS8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22182,666,542 - 182,928,965 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13182,671,258 - 182,933,681 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03181,850,827 - 182,089,846 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13190,329,884 - 190,567,701 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3190,329,567 - 190,567,700 (+)Ensemblpanpan1.1panPan2
VPS8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13417,632,749 - 17,889,607 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3417,632,208 - 17,889,036 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3421,718,439 - 21,975,304 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03417,541,151 - 17,798,080 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3417,541,174 - 17,798,080 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13417,577,616 - 17,834,488 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03417,573,242 - 17,830,270 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03417,802,258 - 18,060,093 (+)NCBIUU_Cfam_GSD_1.0
Vps8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602118,751,043 - 118,999,613 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365784,840,636 - 5,091,474 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365784,842,899 - 5,091,439 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VPS8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13122,693,760 - 122,950,420 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113122,693,681 - 122,953,625 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213132,225,073 - 132,278,113 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Vps8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473071,545,939 - 71,767,178 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473071,544,572 - 71,782,622 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 31 5 53
Low 5 15 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000012053   ⟹   ENSCSAP00000010102
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl154,367,706 - 4,607,656 (-)Ensembl
RefSeq Acc Id: XM_007971868   ⟹   XP_007970059
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1154,368,144 - 4,607,691 (-)NCBI
Vero_WHO_p1.0NW_02366606313,129,642 - 13,374,062 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007971870   ⟹   XP_007970061
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1154,368,144 - 4,597,874 (-)NCBI
Vero_WHO_p1.0NW_02366606313,129,642 - 13,364,555 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007971871   ⟹   XP_007970062
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1154,368,144 - 4,607,691 (-)NCBI
Vero_WHO_p1.0NW_02366606313,129,643 - 13,373,987 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037988488   ⟹   XP_037844416
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366606313,129,643 - 13,333,461 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007970059 (Get FASTA)   NCBI Sequence Viewer  
  XP_007970061 (Get FASTA)   NCBI Sequence Viewer  
  XP_007970062 (Get FASTA)   NCBI Sequence Viewer  
  XP_037844416 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000010102.1
Reference Protein Sequences
RefSeq Acc Id: XP_007970062   ⟸   XM_007971871
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RNB3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007970059   ⟸   XM_007971868
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RNB3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007970061   ⟸   XM_007971870
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RNB3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000010102   ⟸   ENSCSAT00000012053
RefSeq Acc Id: XP_037844416   ⟸   XM_037988488
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RNB3 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013962 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000012053.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro Vps41/Vps8 UniProtKB/TrEMBL
  Vps8_central_dom UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene VPS8 ENTREZGENE
PANTHER VACUOLAR PROTEIN SORTING VPS41 UniProtKB/TrEMBL
  VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG UniProtKB/TrEMBL
Pfam Vps8 UniProtKB/TrEMBL
PROSITE WD_REPEATS_2 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART RING UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF50978 UniProtKB/TrEMBL
UniProt A0A0D9RNB3 ENTREZGENE, UniProtKB/TrEMBL