KIF23-AS1 (KIF23 and PAQR5 antisense RNA 1)

Gene: KIF23-AS1 (KIF23 and PAQR5 antisense RNA 1) Homo sapiens

Analyze

Symbol:

KIF23-AS1

Name:

KIF23 and PAQR5 antisense RNA 1

RGD ID:

16562209

HGNC Page

HGNC:27075

Description:

ASSOCIATED WITH genetic disease; INTERACTS WITH aristolochic acid A; sodium arsenite

Type:

ncrna (Ensembl: lncRNA)

RefSeq Status:

VALIDATED

Previously known as:

AC027237.3; AC027237.5; LOC145694; novel transcript, antisense to PAQR5; uncharacterized LOC145694

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38.p14 Ensembl - Human Genome Assembly GRCh38 Ensembl

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	69,396,904 - 69,415,029 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	69,396,904 - 69,415,029 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	69,689,243 - 69,707,368 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Cytogenetic Map	15	q23	NCBI
CHM1_1	15	69,807,232 - 69,825,357 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	67,218,981 - 67,237,106 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

aristolochic acid A (EXP)

sodium arsenite (EXP)

References

Additional References at PubMed

PMID:14702039	PMID:15146197

Genomics

Variants

Variants in KIF23-AS1
6 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
NM_001367805.3(KIF23):c.11+62_11+82dup	duplication	not provided [RCV001637797]	Chr15:69414535..69414536 [GRCh38] Chr15:69706874..69706875 [GRCh37] Chr15:15q23	benign
GRCh38/hg38 15q22.2-26.3(chr15:59828460-101920998)x3	copy number gain	See cases [RCV000142915]	Chr15:59828460..101920998 [GRCh38] Chr15:60120659..102461201 [GRCh37] Chr15:57907951..100278724 [NCBI36] Chr15:15q22.2-26.3	pathogenic
NM_001104554.1(PAQR5):c.88_39158dup	duplication	Large for gestational age [RCV000161776]	Chr15:69403910..69442980 [GRCh38] Chr15:69696249..69735319 [GRCh37] Chr15:15q23	not provided
GRCh38/hg38 15q23-24.1(chr15:68830574-73823337)x1	copy number loss	See cases [RCV000050780]	Chr15:68830574..73823337 [GRCh38] Chr15:69122913..74115678 [GRCh37] Chr15:66909967..71902731 [NCBI36] Chr15:15q23-24.1	pathogenic
NM_001367805.3(KIF23):c.-29C>T	single nucleotide variant	not provided [RCV002261517]	Chr15:69414437 [GRCh38] Chr15:69706776 [GRCh37] Chr15:15q23	uncertain significance
NM_001367805.3(KIF23):c.11+8C>A	single nucleotide variant	not provided [RCV002825572]	Chr15:69414484 [GRCh38] Chr15:69706823 [GRCh37] Chr15:15q23	uncertain significance
NM_017705.4(PAQR5):c.520G>A (p.Glu174Lys)	single nucleotide variant	Inborn genetic diseases [RCV002916190]	Chr15:69397475 [GRCh38] Chr15:69689814 [GRCh37] Chr15:15q23	uncertain significance
NM_017705.4(PAQR5):c.605A>G (p.Tyr202Cys)	single nucleotide variant	Inborn genetic diseases [RCV003179381]	Chr15:69397560 [GRCh38] Chr15:69689899 [GRCh37] Chr15:15q23	uncertain significance
NM_017705.4(PAQR5):c.610C>G (p.Leu204Val)	single nucleotide variant	Inborn genetic diseases [RCV003208232]	Chr15:69399974 [GRCh38] Chr15:69692313 [GRCh37] Chr15:15q23	uncertain significance
NM_001367805.3(KIF23):c.11+17C>G	single nucleotide variant	not provided [RCV003694603]	Chr15:69414493 [GRCh38] Chr15:69706832 [GRCh37] Chr15:15q23	likely benign

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	561
Count of miRNA genes:	275
Interacting mature miRNAs:	299
Transcripts:	ENST00000558107, ENST00000558617, ENST00000560539
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

visual system

adipose tissue

appendage

entire extraembryonic component

High

Medium

109

111

Low

1184

1200

1011

130

180

2056

458

979

292

1114

1309

433

1399

Below cutoff

1207

997

632

412

866

305

1858

1243

2612

124

228

297

107

747

968

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NR_132969	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_132970	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_132971	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC027237	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK056793	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX097197	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CN360125	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DB499817	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DB570961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENST00000558107

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	69,403,845 - 69,414,220 (-)	Ensembl

RefSeq Acc Id:

ENST00000558617

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	69,396,904 - 69,415,029 (-)	Ensembl

RefSeq Acc Id:

ENST00000560539

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	69,396,904 - 69,415,029 (-)	Ensembl

RefSeq Acc Id:

ENST00000659608

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	69,403,284 - 69,414,211 (-)	Ensembl

RefSeq Acc Id:

ENST00000663170

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	69,402,453 - 69,414,193 (-)	Ensembl

RefSeq Acc Id:

ENST00000669669

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	69,396,955 - 69,402,087 (-)	Ensembl

RefSeq Acc Id:

NR_132969

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	15	69,403,282 - 69,415,029 (-)	NCBI
T2T-CHM13v2.0	15	67,225,359 - 67,237,106 (-)	NCBI

Sequence:

show sequence

AACTGGCCTGTGTAAGCGGATGGGCTCGGCCTCAAGGACAGGGTGCTCGGCTGAAAAAAAAGCT
AGCGGCGATCACCGGTGCCAGGGCTCTCCAGAAACGGAGCCCATCTAACCAATGCCCAGCACAC
TCGCTCTGCTCCACACACGAGACCACCTCCGACCCGCACTAAGTTGGCCAACTGCACTCTGGAG
GCGGCGGCAGCCAGCGAGGGAGAAGGGAAAGGCTGTCCCGGGACCCCGAGGAGGACTGCCCCGC
CCCCGGGAACCGGGTGCGGCGTAAAACAACCCCGGCTCCGGGCCGACCCTTCCTGGCCCCTTGG
AGGCCCAGGCGGGGCGGCGGGGGGCGACGCGGCAGGGGTCTCCGCGCCCAGGCTCCCGCGGAGC
GGCCACACGTGGAGGTTCCCACTTTGGGGTCGCGGCCGCAGCAGCACCGGGCGGGATGCTGTCC
GCGCTGCCCGCGTACGGCCGCGGCCTGAGTGGAGACGCCTGCCCCCAGCCCCGAGGCCTCGGCC
CCCGTCCGCCCTCTCTCCCTGCTCGGCGGCCTCGTACTCACGCTGACTTCATGGCAGCAGGCTC
CACGCCGCCCAAACGCGCATGCGGGACGGCTGGCTGGCGAAGACTGCGGGACGTTAGGACCGGC
AGCAAGAACTAGAACTTCGCGGCTAAGGCGCGGTGCTCTGCGAAGCCGGCGGCGACGCTAAGAG
CCCAGGTGAGCTCCCGCCTGGCGCATTTCAAACGGGCCAATCAGCGCCCGTCCGCAGGGAGAGG
CAGGACCTCCGCGGAAGTGACTTCGCTGCCGGAAGTGGCGCTTGTCTCCTAGGCGACCGACGCT
GAAAGGGCCGCGGAGTCGCGTGTCAGGGCTGGAGGGAGATCTTGAGGTCCTCCCAGTGACTGAC
CTGGCTCATTCTCCGAAAGTGGTTGACAGGCCACTACGAGAGCTCTTGAGAGAAGCTTTGTGAC
ATGAAATTCATCAAATGAAGCAAGATTCATTTTTAAAGAATAATACAAAGCTCCAGAGTAATAT
GCTTAATCCAAATGTTTAAATAGAATTTAAAACCACATTTTAAGTAAATTTAAAATTAATGAAA
TATCAATAGTTTGCCTTAACAAGGACTTGCTTGAACCATATTCTCCTTTTAAAATCACACACAC
AGAATCAGTGTACATTTAGAGAAATTTCCCCAGCTGAATAACATTTTTGACATGAATTCATTCA
AAAGACACCAACCATTATGAATATTTTAGGCCATGATAAGCTGTAACCACCTCCGGCTTATGGT
GGTTAGGATGTTGCAGCTTAATGTTGACATCTGGCATGAAAAGCTTATGGTCTGAGTCATGTTT
CTTTTTTATGTAATTCTGGCTTGGGAATCCGATACAGAGCAGCTGAGAAATAAATTATGTTGCT
GAGGCTGAAGATGATGCACAGAAGTATGGCTCCAGCTATCTGAGAGAAAGAGAAGGGCTTGGAG
GTGGCCAGGAGCCATTCCTTCCTCAGAGTCTTGTCCAGAAGTATGGCTTCCATCTGCATGTGCG
TGGCCAGGATCACACACACGTGAAACAGCTGGTGACTGTGACCTATGGCAAACACAAAAGGCCG
TCAAGATCAGCAATGAAAAGGAATGAGTACTGATACATGCTATGGCATTCATGCTAAAAATGAT
GCTAAGTGAAAGAAACCAGACAGGAGACCACATATTATATAAAATCTCCAGAATATGCAAATCC
ATAAAGACAGAGAGTAGATTAGAGGCTGCCTCAAGCAGGGGGTGAGAATAGGTATTAACAGTGC
ATGGGTCTGATGGAGGGGATGAAAATGTTCTAAAACTGATGTATGGTGAATTTACTGAAAATAT
CATTAAATTGTATACTTGACAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NR_132970

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	15	69,396,904 - 69,415,029 (-)	NCBI
T2T-CHM13v2.0	15	67,218,981 - 67,237,106 (-)	NCBI

Sequence:

show sequence

AACTGGCCTGTGTAAGCGGATGGGCTCGGCCTCAAGGACAGGGTGCTCGGCTGAAAAAAAAGCT
AGCGGCGATCACCGGTGCCAGGGCTCTCCAGAAACGGAGCCCATCTAACCAATGCCCAGCACAC
TCGCTCTGCTCCACACACGAGACCACCTCCGACCCGCACTAAGTTGGCCAACTGCACTCTGGAG
GCGGCGGCAGCCAGCGAGGGAGAAGGGAAAGGCTGTCCCGGGACCCCGAGGAGGACTGCCCCGC
CCCCGGGAACCGGGTGCGGCGTAAAACAACCCCGGCTCCGGGCCGACCCTTCCTGGCCCCTTGG
AGGCCCAGGCGGGGCGGCGGGGGGCGACGCGGCAGGGGTCTCCGCGCCCAGGCTCCCGCGGAGC
GGCCACACGTGGAGGTTCCCACTTTGGGGTCGCGGCCGCAGCAGCACCGGGCGGGATGCTGTCC
GCGCTGCCCGCGTACGGCCGCGGCCTGAGTGGAGACGCCTGCCCCCAGCCCCGAGGCCTCGGCC
CCCGTCCGCCCTCTCTCCCTGCTCGGCGGCCTCGTACTCACGCTGACTTCATGGCAGCAGGCTC
CACGCCGCCCAAACGCGCATGCGGGACGGCTGGCTGGCGAAGACTGCGGGACGTTAGGACCGGC
AGCAAGAACTAGAACTTCGCGGCTAAGGCGCGGTGCTCTGCGAAGCCGGCGGCGACGCTAAGAG
CCCAGGTGAGCTCCCGCCTGGCGCATTTCAAACGGGCCAATCAGCGCCCGTCCGCAGGGAGAGG
CAGGACCTCCGCGGAAGTGACTTCGCTGCCGGAAGTGGCGCTTGTCTCCTAGGCGACCGACGCT
GAAAGGGCCGCGGAGTCGCGTGTCAGGGCTGGAGGGAGATCTTGAGATCACTTCAAACTTAAGT
GAGCTCAGGTTCATCTGGAGGATGACTCGGCCTCTGTTCTCTCGTCCCACCTGACGAGAAATAC
CCACAGGTGTGGAGGGGCTGGCCCCCTTCACCTGGGTCTCGACTCCTGTTTTGTTCTGCGGTTC
CCATTGCAGTGCTGTGACCCCCCAGAAGCTCAGGAAAACAACTGACTTCCTGGTGTTGCCAACA
GGCAGAGAGGAGATGCAGCCAGTCCTTACCCTGTAGAAGATGGGGAGGGAGTCCCAGGTGTACG
GATAAGCAAAGGCGAGGACACGAATCACCTTACAGAGTCTGGGCTTCTGGATTTCAAGAAACCT
AAATCAGGGAAGGAAAGTGGGGAGGAAATGGAATGAAAAGAGTCTCAGCAAATTGCATACGCAC
ATGCATGCACACCGAGGGCCTGGTCATCAACAGAGGACAAGCATTTTTCTACAAGCTCCTGTGG
CCAGCAGCTTCTCCACCAGCCTCGTCCATTCCTCCCACCCCAATGGAAGTGACAAAACTTCAGA
TGCAAAAAGATCTCCAGGGACACCATCTCCTGACCATGGGAAGCAGTGGTGTCCAGACTAAGCC
AGAAAGGAGGCGCTGGGCAGAAACCCTTCAAGGGCCAAGTTATGTAACTGCCAAAGAACCTTTT
AAAACTCTAGTTGCTACAGGGACAGGGAACGGGTAGGGGGAATCGGGGGATCCACTGCCACAGA
CTCTTGGGGGGCACACTCTGCAGAGGCTGAGATGCACCCATCTAGTTGGAGCCCAGGTATTATC
ATGCAGGAGACCTGGGTTCAAGTAGGTGTTTGACCCTTGGAGAGCTTTCTGGAATATTTATACC
ACACACAGGGATACTTGGCTTGGGAAAACTAAATAAACGTGAAGTCTTTCAAAAAAAAAAAAAA
A

hide sequence

RefSeq Acc Id:

NR_132971

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	15	69,396,904 - 69,415,029 (-)	NCBI
T2T-CHM13v2.0	15	67,218,981 - 67,237,106 (-)	NCBI

Sequence:

show sequence

AACTGGCCTGTGTAAGCGGATGGGCTCGGCCTCAAGGACAGGGTGCTCGGCTGAAAAAAAAGCT
AGCGGCGATCACCGGTGCCAGGGCTCTCCAGAAACGGAGCCCATCTAACCAATGCCCAGCACAC
TCGCTCTGCTCCACACACGAGACCACCTCCGACCCGCACTAAGTTGGCCAACTGCACTCTGGAG
GCGGCGGCAGCCAGCGAGGGAGAAGGGAAAGGCTGTCCCGGGACCCCGAGGAGGACTGCCCCGC
CCCCGGGAACCGGGTGCGGCGTAAAACAACCCCGGCTCCGGGCCGACCCTTCCTGGCCCCTTGG
AGGCCCAGGCGGGGCGGCGGGGGGCGACGCGGCAGGGGTCTCCGCGCCCAGGCTCCCGCGGAGC
GGCCACACGTGGAGGTTCCCACTTTGGGGTCGCGGCCGCAGCAGCACCGGGCGGGATGCTGTCC
GCGCTGCCCGCGTACGGCCGCGGCCTGAGTGGAGACGCCTGCCCCCAGCCCCGAGGCCTCGGCC
CCCGTCCGCCCTCTCTCCCTGCTCGGCGGCCTCGTACTCACGCTGACTTCATGGCAGCAGGCTC
CACGCCGCCCAAACGCGCATGCGGGACGGCTGGCTGGCGAAGACTGCGGGACGTTAGGACCGGC
AGCAAGAACTAGAACTTCGCGGCTAAGGCGCGGTGCTCTGCGAAGCCGGCGGCGACGCTAAGAG
CCCAGGTGAGCTCCCGCCTGGCGCATTTCAAACGGGCCAATCAGCGCCCGTCCGCAGGGAGAGG
CAGGACCTCCGCGGAAGTGACTTCGCTGCCGGAAGTGGCGCTTGTCTCCTAGGCGACCGACGCT
GAAAGGGCCGCGGAGTCGCGTGTCAGGGCTGGAGGGAGATCTTGAGTCTCTCGTCCCACCTGAC
GAGAAATACCCACAGGTGTGGAGGGGCTGGCCCCCTTCACCTGGGTCTCGACTCCTGTTTTGTT
CTGCGGTTCCCATTGCAGTGCTGTGACCCCCCAGAAGCTCAGGAAAACAACTGACTTCCTGGTG
TTGCCAACAGGCAGAGAGGAGATGCAGCCAGTCCTTACCCTGTAGAAGATGGGGAGGGAGTCCC
AGGTGTACGGATAAGCAAAGGCGAGGACACGAATCACCTTACAGAGTCTGGGCTTCTGGATTTC
AAGAAACCTAAATCAGGGAAGGAAAGTGGGGAGGAAATGGAATGAAAAGAGTCTCAGCAAATTG
CATACGCACATGCATGCACACCGAGGGCCTGGTCATCAACAGAGGACAAGCATTTTTCTACAAG
CTCCTGTGGCCAGCAGCTTCTCCACCAGCCTCGTCCATTCCTCCCACCCCAATGGAAGTGACAA
AACTTCAGATGCAAAAAGATCTCCAGGGACACCATCTCCTGACCATGGGAAGCAGTGGTGTCCA
GACTAAGCCAGAAAGGAGGCGCTGGGCAGAAACCCTTCAAGGGCCAAGTTATGTAACTGCCAAA
GAACCTTTTAAAACTCTAGTTGCTACAGGGACAGGGAACGGGTAGGGGGAATCGGGGGATCCAC
TGCCACAGACTCTTGGGGGGCACACTCTGCAGAGGCTGAGATGCACCCATCTAGTTGGAGCCCA
GGTATTATCATGCAGGAGACCTGGGTTCAAGTAGGTGTTTGACCCTTGGAGAGCTTTCTGGAAT
ATTTATACCACACACAGGGATACTTGGCTTGGGAAAACTAAATAAACGTGAAGTCTTTCAAAAA
AAAAAAAAAA

hide sequence

Additional Information

External Database Links

Database	Acc Id	Source(s)
COSMIC	KIF23-AS1	COSMIC
Ensembl Genes	ENSG00000259426	Ensembl, ENTREZGENE
Ensembl Transcript	ENST00000558617	ENTREZGENE
	ENST00000560539	ENTREZGENE
GTEx	ENSG00000259426	GTEx
HGNC ID	HGNC:27075	ENTREZGENE
Human Proteome Map	KIF23-AS1	Human Proteome Map
NCBI Gene	LOC145694	ENTREZGENE
RNAcentral	URS00008E397F	RNACentral
	URS00008E3A12	RNACentral
	URS00008E3A4F	RNACentral

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-01-11	KIF23-AS1	KIF23 and PAQR5 antisense RNA 1	AC027237.3	novel transcript, antisense to PAQR5	Symbol and/or name change	19259463	PROVISIONAL
2020-08-20	AC027237.3	novel transcript, antisense to PAQR5	AC027237.5	novel transcript, antisense to PAQR5	Symbol and/or name change	19259462	PROVISIONAL
2020-06-25	AC027237.5	novel transcript, antisense to PAQR5	LOC145694	uncharacterized LOC145694	Symbol and/or name change	19259462	PROVISIONAL
2020-06-18	LOC145694	uncharacterized LOC145694	AC027237.5	novel transcript, antisense to PAQR5	Symbol and/or name change	5135510	APPROVED
2020-02-07	AC027237.5	novel transcript, antisense to PAQR5	AC027237.3	novel transcript, antisense to PAQR5	Symbol and/or name change	19259462	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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