Rad21l (RAD21-like (S. pombe)) - Rat Genome Database

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Gene: Rad21l (RAD21-like (S. pombe)) Mus musculus
Analyze
Symbol: Rad21l
Name: RAD21-like (S. pombe)
RGD ID: 1625905
MGI Page MGI
Description: Predicted to enable chromatin binding activity. Acts upstream of or within several processes, including double-strand break repair via homologous recombination; homologous chromosome segregation; and seminiferous tubule development. Located in lateral element. Part of meiotic cohesin complex. Is expressed in brain; gonad; and metanephros. Orthologous to human RAD21L1 (RAD21 cohesin complex component like 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: double-strand-break repair protein rad21-like protein 1; Gm14160; MeiRAD21; MeiRAD21L; Rad21l1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392151,486,286 - 151,512,542 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2151,487,324 - 151,510,453 (-)EnsemblGRCm39 Ensembl
GRCm382151,644,366 - 151,670,622 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2151,645,404 - 151,668,533 (-)EnsemblGRCm38mm10GRCm38
MGSCv372151,471,140 - 151,494,269 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362151,336,845 - 151,359,974 (-)NCBIMGSCv36mm8
Celera2157,462,516 - 157,485,682 (-)NCBICelera
Cytogenetic Map2G3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21242291   PMID:21274006   PMID:21527826   PMID:21677750   PMID:21743440   PMID:21873635   PMID:22164254   PMID:22415368   PMID:22711701   PMID:24194600   PMID:24413433   PMID:24589552  
PMID:24797475   PMID:25795304   PMID:26232174   PMID:26742488   PMID:27172213   PMID:27626380   PMID:27665783   PMID:27792785   PMID:27796301   PMID:28050734   PMID:28239026   PMID:30853435  
PMID:35648791  


Genomics

Comparative Map Data
Rad21l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392151,486,286 - 151,512,542 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2151,487,324 - 151,510,453 (-)EnsemblGRCm39 Ensembl
GRCm382151,644,366 - 151,670,622 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2151,645,404 - 151,668,533 (-)EnsemblGRCm38mm10GRCm38
MGSCv372151,471,140 - 151,494,269 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362151,336,845 - 151,359,974 (-)NCBIMGSCv36mm8
Celera2157,462,516 - 157,485,682 (-)NCBICelera
Cytogenetic Map2G3NCBI
RAD21L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38201,226,044 - 1,255,876 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl201,226,044 - 1,296,421 (+)EnsemblGRCh38hg38GRCh38
GRCh37201,206,688 - 1,236,520 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36201,154,700 - 1,183,101 (+)NCBINCBI36Build 36hg18NCBI36
Celera201,303,090 - 1,331,471 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef201,161,202 - 1,187,291 (+)NCBIHuRef
CHM1_1201,206,765 - 1,235,147 (+)NCBICHM1_1
T2T-CHM13v2.0201,273,334 - 1,303,183 (+)NCBIT2T-CHM13v2.0
Rad21l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23140,160,128 - 140,188,324 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3140,160,118 - 140,188,298 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.03147,163,335 - 147,191,008 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3147,163,838 - 147,188,929 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03153,516,755 - 153,544,210 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3138,919,326 - 138,946,960 (-)NCBICelera
Cytogenetic Map3q41NCBI
Rad21l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955596457,835 - 486,046 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955596455,932 - 485,853 (+)NCBIChiLan1.0ChiLan1.0
RAD21L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1201,153,378 - 1,179,801 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl201,153,384 - 1,231,383 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0201,385,935 - 1,413,301 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
RAD21L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12419,741,398 - 19,771,675 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2419,699,792 - 19,771,679 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2419,395,679 - 19,425,941 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02420,431,965 - 20,462,227 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2420,387,160 - 20,462,205 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12419,709,731 - 19,739,954 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02419,815,102 - 19,845,324 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02420,246,438 - 20,276,321 (-)NCBIUU_Cfam_GSD_1.0
Rad21l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640168,981,343 - 169,006,392 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648517,413,006 - 17,435,951 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493648517,413,006 - 17,435,951 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAD21L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11734,035,526 - 34,064,215 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21738,591,104 - 38,611,242 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAD21L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1255,299,061 - 55,335,200 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl255,307,711 - 55,333,874 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660871,712,827 - 1,741,923 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rad21l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247412,485,471 - 2,542,500 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247412,486,612 - 2,542,452 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:256
Count of miRNA genes:118
Interacting mature miRNAs:127
Transcripts:ENSMUST00000096439, ENSMUST00000180195
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
4141033Wg2d_mweight gain in high growth mice 2d (mouse)Not determined143773445160303008Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143773445165665019Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
13504830Bacsq1_mbaculum shape QTL 1 (mouse)2145716184161016184Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000096439   ⟹   ENSMUSP00000094174
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2151,487,324 - 151,510,453 (-)Ensembl
GRCm38.p6 Ensembl2151,645,404 - 151,668,533 (-)Ensembl
RefSeq Acc Id: ENSMUST00000180195   ⟹   ENSMUSP00000136918
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2151,487,324 - 151,510,453 (-)Ensembl
GRCm38.p6 Ensembl2151,645,404 - 151,668,533 (-)Ensembl
RefSeq Acc Id: NM_001276400   ⟹   NP_001263329
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392151,487,324 - 151,510,453 (-)NCBI
GRCm382151,645,404 - 151,668,533 (-)NCBI
Celera2157,462,516 - 157,485,682 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006500042   ⟹   XP_006500105
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392151,486,286 - 151,512,542 (-)NCBI
GRCm382151,644,366 - 151,670,622 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006500043   ⟹   XP_006500106
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392151,486,286 - 151,512,542 (-)NCBI
GRCm382151,644,366 - 151,670,622 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006500044   ⟹   XP_006500107
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392151,486,286 - 151,512,542 (-)NCBI
GRCm382151,644,366 - 151,670,622 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001263329   ⟸   NM_001276400
- UniProtKB: F6KST0 (UniProtKB/Swiss-Prot),   A2AU37 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006500107   ⟸   XM_006500044
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006500105   ⟸   XM_006500042
- Peptide Label: isoform X1
- UniProtKB: F6KST0 (UniProtKB/Swiss-Prot),   A2AU37 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006500106   ⟸   XM_006500043
- Peptide Label: isoform X1
- UniProtKB: F6KST0 (UniProtKB/Swiss-Prot),   A2AU37 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000094174   ⟸   ENSMUST00000096439
RefSeq Acc Id: ENSMUSP00000136918   ⟸   ENSMUST00000180195
Protein Domains
Rad21/Rec8-like protein C-terminal eukaryotic   Rad21/Rec8-like protein N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A2AU37-F1-model_v2 AlphaFold A2AU37 1-552 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3652039 AgrOrtholog
Ensembl Genes ENSMUSG00000074704 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000094174.4 UniProtKB/TrEMBL
  ENSMUSP00000136918 ENTREZGENE
  ENSMUSP00000136918.2 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000096439.4 UniProtKB/TrEMBL
  ENSMUST00000180195 ENTREZGENE
  ENSMUST00000180195.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.580 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Rad21/Rec8-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rad21/Rec8_C_eu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rad21_Rec8_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ScpA-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:668929 UniProtKB/Swiss-Prot
MGD MGI:3652039 ENTREZGENE
NCBI Gene 668929 ENTREZGENE
PANTHER DOUBLE-STRAND-BREAK REPAIR PROTEIN RAD21-LIKE PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12585 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Rad21_Rec8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rad21_Rec8_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rad21l PhenoGen
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2AU37 ENTREZGENE
  F6KST0 ENTREZGENE
  R4GML2_MOUSE UniProtKB/TrEMBL
  RD21L_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary E5RTP6 UniProtKB/Swiss-Prot
  F6KST0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Rad21l  RAD21-like (S. pombe)  Gm14160  predicted gene 14160  Symbol and/or name change 5135510 APPROVED