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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | ISO | RGD:1307001 | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PGLS mRNA] | CTD | PMID:31150632 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PGLS mRNA | CTD | PMID:22206623 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PGLS mRNA | CTD | PMID:19465110 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1307001 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PGLS mRNA | CTD | PMID:32109520 | 2-butoxyethanol | decreases expression | EXP | | 6480464 | n-butoxyethanol results in decreased expression of PGLS mRNA | CTD | PMID:19812364 | 4,4'-sulfonyldiphenol | increases expression | ISO | RGD:1315936 | 6480464 | bis4-hydroxyphenylsulfone results in increased expression of PGLS mRNA | CTD | PMID:31121516 | acetamide | decreases expression | ISO | RGD:1307001 | 6480464 | acetamide results in decreased expression of PGLS mRNA | CTD | PMID:31881176 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of PGLS mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases methylation | ISO | RGD:1315936 | 6480464 | Aflatoxin B1 results in decreased methylation of PGLS intron | CTD | PMID:30157460 | bis(2-ethylhexyl) phthalate | decreases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in decreased expression of PGLS mRNA | CTD | PMID:19850644 | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | PPARA protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of PGLS mRNA] | CTD | PMID:19850644 | bisphenol A | increases expression | ISO | RGD:1315936 | 6480464 | bisphenol A results in increased expression of PGLS mRNA | CTD | PMID:25047013 | bisphenol A | decreases expression | ISO | RGD:1307001 | 6480464 | bisphenol A results in decreased expression of PGLS mRNA | CTD | PMID:25181051 | bisphenol F | increases expression | ISO | RGD:1315936 | 6480464 | bisphenol F results in increased expression of PGLS mRNA | CTD | PMID:31121516 | butan-1-ol | multiple interactions | ISO | RGD:1315936 | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of PGLS mRNA | CTD | PMID:29432896 | cadmium atom | increases expression | ISO | RGD:1315936 | 6480464 | Cadmium results in increased expression of PGLS mRNA | CTD | PMID:24376830 | cadmium dichloride | decreases methylation | ISO | RGD:1307001 | 6480464 | Cadmium Chloride results in decreased methylation of PGLS promoter | CTD | PMID:22457795 | cadmium dichloride | increases expression | ISO | RGD:1315936 | 6480464 | Cadmium Chloride results in increased expression of PGLS protein | CTD | PMID:24527689 | chlorpyrifos | decreases expression | ISO | RGD:1307001 | 6480464 | Chlorpyrifos results in decreased expression of PGLS mRNA | CTD | PMID:18668222 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PGLS gene | CTD | PMID:20938992 | cisplatin | increases expression | ISO | RGD:1315936 | 6480464 | Cisplatin results in increased expression of PGLS mRNA | CTD | PMID:27594783 | clofibrate | decreases expression | EXP | | 6480464 | Clofibrate results in decreased expression of PGLS mRNA | CTD | PMID:17585979 | crocidolite asbestos | increases expression | ISO | RGD:1315936 | 6480464 | Asbestos, Crocidolite results in increased expression of PGLS mRNA | CTD | PMID:29523930 | crocidolite asbestos | increases expression | EXP | | 6480464 | Asbestos, Crocidolite results in increased expression of PGLS mRNA | CTD | PMID:29279043 | cyclosporin A | increases expression | ISO | RGD:1315936 | 6480464 | Cyclosporine results in increased expression of PGLS mRNA | CTD | PMID:20106945, PMID:22147139 | dibutyl phthalate | decreases expression | ISO | RGD:1307001 | 6480464 | Dibutyl Phthalate results in decreased expression of PGLS mRNA | CTD | PMID:21266533 | dioxygen | increases expression | EXP | | 6480464 | Oxygen deficiency results in increased expression of PGLS mRNA | CTD | PMID:24205000 | doxorubicin | decreases expression | ISO | RGD:1315936 | 6480464 | Doxorubicin results in decreased expression of PGLS mRNA | CTD | PMID:29803840 | enzyme inhibitor | multiple interactions | ISO | RGD:1315936 | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PGLS protein | CTD | PMID:23301498 | ethanol | increases expression | ISO | RGD:1315936 | 6480464 | Ethanol results in increased expression of PGLS protein | CTD | PMID:20621659 | ethanol | multiple interactions | ISO | RGD:1315936 | 6480464 | [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of PGLS mRNA | CTD | PMID:29432896 | folic acid | multiple interactions | EXP | | 6480464 | [1 more ... | CTD | PMID:20938992, PMID:22206623 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of PGLS mRNA | CTD | PMID:25629700 | hyaluronic acid | multiple interactions | ISO | RGD:1307001 | 6480464 | Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of PGLS protein] | CTD | PMID:23178681 | hydrogen peroxide | affects expression | ISO | RGD:1315936 | 6480464 | Hydrogen Peroxide affects the expression of PGLS mRNA | CTD | PMID:20044591 | hydrogen peroxide | multiple interactions | ISO | RGD:1307001 | 6480464 | Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of PGLS protein] | CTD | PMID:23178681 | hydrogen peroxide | decreases expression | ISO | RGD:1307001 | 6480464 | Hydrogen Peroxide results in decreased expression of PGLS protein | CTD | PMID:23178681 | hydroquinone | affects expression | ISO | RGD:1315936 | 6480464 | hydroquinone affects the expression of PGLS protein | CTD | PMID:17181942 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PGLS gene | CTD | PMID:20938992 | methylmercury chloride | decreases expression | ISO | RGD:1315936 | 6480464 | methylmercuric chloride results in decreased expression of PGLS mRNA | CTD | PMID:28001369 | N-nitrosomorpholine | increases expression | ISO | RGD:1307001 | 6480464 | N-nitrosomorpholine results in increased expression of PGLS protein | CTD | PMID:19716841 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of PGLS mRNA | CTD | PMID:23811191 | piroxicam | increases expression | ISO | RGD:1315936 | 6480464 | Piroxicam results in increased expression of PGLS mRNA | CTD | PMID:21858171 | sodium fluoride | decreases expression | EXP | | 6480464 | Sodium Fluoride results in decreased expression of PGLS protein | CTD | PMID:28918527 | T-2 toxin | affects expression | ISO | RGD:1307001 | 6480464 | T-2 Toxin affects the expression of PGLS protein | CTD | PMID:26141394 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:1315936 | 6480464 | tert-Butylhydroperoxide results in decreased expression of PGLS mRNA | CTD | PMID:15336504 | tetrachloromethane | affects expression | EXP | | 6480464 | Carbon Tetrachloride affects the expression of PGLS mRNA | CTD | PMID:17484886 | tetrachloromethane | decreases expression | ISO | RGD:1307001 | 6480464 | Carbon Tetrachloride results in decreased expression of PGLS mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | ISO | RGD:1307001 | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PGLS mRNA] | CTD | PMID:31150632 | thapsigargin | decreases expression | EXP | | 6480464 | Thapsigargin results in decreased expression of PGLS protein | CTD | PMID:24648495 | thimerosal | decreases expression | ISO | RGD:1315936 | 6480464 | Thimerosal results in decreased expression of PGLS mRNA | CTD | PMID:27188386 | thioacetamide | decreases expression | ISO | RGD:1307001 | 6480464 | Thioacetamide results in decreased expression of PGLS mRNA | CTD | PMID:23411599 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of PGLS mRNA | CTD | PMID:19448997 | tungsten | increases expression | EXP | | 6480464 | Tungsten results in increased expression of PGLS mRNA | CTD | PMID:30912803 | tunicamycin | increases expression | ISO | RGD:1315936 | 6480464 | Tunicamycin results in increased expression of PGLS mRNA | CTD | PMID:29453283 | valproic acid | increases methylation | ISO | RGD:1315936 | 6480464 | Valproic Acid results in increased methylation of PGLS gene | CTD | PMID:29154799 | valproic acid | decreases expression | ISO | RGD:1315936 | 6480464 | Valproic Acid results in decreased expression of PGLS mRNA | CTD | PMID:28001369, PMID:29154799 | |