Pgls (6-phosphogluconolactonase) - Rat Genome Database
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Gene: Pgls (6-phosphogluconolactonase) Mus musculus
Analyze
Symbol: Pgls
Name: 6-phosphogluconolactonase
RGD ID: 1625472
MGI Page MGI
Description: Predicted to have 6-phosphogluconolactonase activity and monosaccharide binding activity. Predicted to be involved in pentose-phosphate shunt, oxidative branch. Predicted to localize to cytoplasm. Is expressed in cerebellum; hemolymphoid system; and thymus primordium. Orthologous to human PGLS (6-phosphogluconolactonase); PARTICIPATES IN pentose phosphate pathway; pentose phosphate pathway - oxidative phase; ribose 5-phosphate isomerase deficiency pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110030K05Rik; 6PGL; AI447866; Plgs
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,044,828 - 72,048,911 (+)NCBIGRCm39mm39
GRCm38871,592,184 - 71,596,267 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,592,176 - 71,601,092 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,116,083 - 74,120,166 (+)NCBIGRCm37mm9NCBIm37
MGSCv36874,521,173 - 74,525,256 (+)NCBImm8
Celera874,106,490 - 74,110,576 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
osteoporosis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14681479   PMID:15018818   PMID:15489334   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:21267068   PMID:21677750   PMID:21873635   PMID:28245920   PMID:30457570   PMID:30713523   PMID:31779658  


Genomics

Comparative Map Data
Pgls
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,044,828 - 72,048,911 (+)NCBIGRCm39mm39
GRCm38871,592,184 - 71,596,267 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,592,176 - 71,601,092 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,116,083 - 74,120,166 (+)NCBIGRCm37mm9NCBIm37
MGSCv36874,521,173 - 74,525,256 (+)NCBImm8
Celera874,106,490 - 74,110,576 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
PGLS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1917,511,636 - 17,521,288 (+)EnsemblGRCh38hg38GRCh38
GRCh381917,511,649 - 17,521,291 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371917,622,278 - 17,632,097 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,483,432 - 17,493,097 (+)NCBINCBI36hg18NCBI36
Build 341917,483,431 - 17,493,095NCBI
Celera1917,524,049 - 17,533,713 (+)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1917,187,513 - 17,197,177 (+)NCBIHuRef
CHM1_11917,621,814 - 17,631,479 (+)NCBICHM1_1
Pgls
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01620,020,444 - 20,025,930 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,020,444 - 20,025,930 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,880,872 - 19,886,358 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,791,241 - 18,796,727 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11618,792,185 - 18,796,720 (+)NCBI
Celera1618,504,223 - 18,509,709 (+)NCBICelera
Cytogenetic Map16p14NCBI
Pgls
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955524793,239 - 801,107 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955524797,439 - 801,070 (-)NCBIChiLan1.0ChiLan1.0
PGLS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11917,971,544 - 17,980,431 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1917,971,544 - 17,980,431 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01916,998,851 - 17,008,558 (+)NCBIMhudiblu_PPA_v0panPan3
PGLS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2045,294,008 - 45,301,038 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12045,293,970 - 45,301,074 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pgls
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365963,414,003 - 3,422,467 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PGLS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl260,164,259 - 60,197,648 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1260,186,690 - 60,198,037 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,778,632 - 59,787,018 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PGLS
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1615,997,865 - 16,006,137 (+)NCBI
ChlSab1.1 Ensembl615,997,806 - 16,006,805 (+)Ensembl
Pgls
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624908522,698 - 526,526 (-)NCBI

Position Markers
AI447866  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38871,600,765 - 71,601,019UniSTSGRCm38
MGSCv37874,124,664 - 74,124,918UniSTSGRCm37
Celera874,115,073 - 74,115,327UniSTS
Cytogenetic Map8C1UniSTS
Cytogenetic Map8B3.3UniSTS
Whitehead/MRC_RH8765.18UniSTS
Pgls  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C1UniSTS
cM Map8 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:989
Count of miRNA genes:526
Interacting mature miRNAs:621
Transcripts:ENSMUST00000034264, ENSMUST00000123240, ENSMUST00000127626, ENSMUST00000138742, ENSMUST00000143441
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034264   ⟹   ENSMUSP00000034264
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,592,176 - 71,596,269 (+)Ensembl
RefSeq Acc Id: ENSMUST00000123240
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,592,211 - 71,595,665 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127626   ⟹   ENSMUSP00000122042
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,592,184 - 71,601,092 (+)Ensembl
RefSeq Acc Id: ENSMUST00000138742   ⟹   ENSMUSP00000120113
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,592,237 - 71,595,111 (+)Ensembl
RefSeq Acc Id: ENSMUST00000143441   ⟹   ENSMUSP00000116524
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,592,291 - 71,596,269 (+)Ensembl
RefSeq Acc Id: NM_001294269   ⟹   NP_001281198
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39872,044,828 - 72,048,911 (+)NCBI
GRCm38871,592,184 - 71,596,267 (+)NCBI
Celera874,106,490 - 74,110,576 (+)NCBI
Sequence:
RefSeq Acc Id: NM_025396   ⟹   NP_079672
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39872,044,828 - 72,048,911 (+)NCBI
GRCm38871,592,184 - 71,596,267 (+)NCBI
MGSCv37874,116,083 - 74,120,166 (+)RGD
Celera874,106,490 - 74,110,576 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_079672   ⟸   NM_025396
- Peptide Label: isoform 1
- UniProtKB: Q9CQ60 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001281198   ⟸   NM_001294269
- Peptide Label: isoform 2
- UniProtKB: Q9CQ60 (UniProtKB/Swiss-Prot),   D3Z4X1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000120113   ⟸   ENSMUST00000138742
RefSeq Acc Id: ENSMUSP00000116524   ⟸   ENSMUST00000143441
RefSeq Acc Id: ENSMUSP00000034264   ⟸   ENSMUST00000034264
RefSeq Acc Id: ENSMUSP00000122042   ⟸   ENSMUST00000127626
Protein Domains
Glucosamine_iso

Promoters
RGD ID:8667415
Promoter ID:EPDNEW_M11739
Type:initiation region
Name:Pgls_1
Description:Mus musculus 6-phosphogluconolactonase , transcript variant 1,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38871,592,207 - 71,592,267EPDNEW
RGD ID:6843601
Promoter ID:MM_KWN:54801
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000085618,   OTTMUST00000085619,   OTTMUST00000085620,   OTTMUST00000085621,   OTTMUST00000085622
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36874,115,116 - 74,117,942 (+)MPROMDB
RGD ID:6848332
Promoter ID:MM_ACW:47904
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4
Transcripts:PGLSANDBCNP1.MSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36874,119,749 - 74,120,249 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913421 AgrOrtholog
Ensembl Genes ENSMUSG00000031807 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034264 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000116524 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000120113 UniProtKB/TrEMBL
  ENSMUSP00000122042 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034264 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000127626 UniProtKB/TrEMBL
  ENSMUST00000138742 UniProtKB/TrEMBL
  ENSMUST00000143441 ENTREZGENE, UniProtKB/TrEMBL
InterPro 6-phosphogluconolactonase_DevB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glc/Gal-6P_isomerase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NagB/RpiA_transferase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGLS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:66171 UniProtKB/Swiss-Prot
MGD MGI:1913421 ENTREZGENE
NCBI Gene 66171 ENTREZGENE
PANTHER PTHR11054 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glucosamine_iso UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pgls PhenoGen
Superfamily-SCOP SSF100950 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs pgl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.282284 ENTREZGENE
  Mm.402679 ENTREZGENE
UniProt 6PGL_MOUSE UniProtKB/Swiss-Prot
  D3Z4X1 ENTREZGENE, UniProtKB/TrEMBL
  F6X8L5_MOUSE UniProtKB/TrEMBL
  Q8CBG6_MOUSE UniProtKB/TrEMBL
  Q9CQ60 ENTREZGENE
UniProt Secondary Q3TA62 UniProtKB/Swiss-Prot