Apela (apelin receptor early endogenous ligand) - Rat Genome Database
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Gene: Apela (apelin receptor early endogenous ligand) Mus musculus
Analyze
Symbol: Apela
Name: apelin receptor early endogenous ligand
RGD ID: 1624719
MGI Page MGI
Description: Predicted to have hormone activity. Involved in SMAD protein signal transduction; circulatory system development; and positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis. Localizes to extracellular space. Is expressed in several structures, including embryo ectoderm; embryo endoderm; gut; heart; and metanephros. Used to study pre-eclampsia. Orthologous to human APELA (apelin receptor early endogenous ligand); INTERACTS WITH 4,4'-sulfonyldiphenol; bisphenol A; bisphenol F.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E; Ela; Elabela; End; Ende; ENSMUSG00000074303; Gm10664
RGD Orthologs
Human
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39865,481,069 - 65,489,988 (-)NCBIGRCm39mm39
GRCm38865,028,417 - 65,037,336 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl865,028,417 - 65,037,336 (-)EnsemblGRCm38mm10GRCm38
MGSCv37867,552,316 - 67,561,235 (-)NCBIGRCm37mm9NCBIm37
Celera867,592,177 - 67,600,984 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:14610273   PMID:16141072   PMID:16141073   PMID:17967808   PMID:19468303   PMID:20153842  
PMID:22008794   PMID:23390484   PMID:24407481   PMID:26611206   PMID:28663440   PMID:28817612   PMID:28854362   PMID:28890073   PMID:30959515   PMID:31338035   PMID:32174138  


Genomics

Comparative Map Data
Apela
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39865,481,069 - 65,489,988 (-)NCBIGRCm39mm39
GRCm38865,028,417 - 65,037,336 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl865,028,417 - 65,037,336 (-)EnsemblGRCm38mm10GRCm38
MGSCv37867,552,316 - 67,561,235 (-)NCBIGRCm37mm9NCBIm37
Celera867,592,177 - 67,600,984 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
APELA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4164,877,178 - 164,898,965 (+)EnsemblGRCh38hg38GRCh38
GRCh384164,877,023 - 164,899,063 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374165,798,156 - 165,818,676 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera4163,130,354 - 163,150,890 (+)NCBI
Cytogenetic Map4q32.3NCBI
HuRef4161,551,632 - 161,572,198 (+)NCBIHuRef
CHM1_14165,774,708 - 165,795,266 (+)NCBICHM1_1
Apela
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540340,257,467 - 40,266,275 (-)NCBIChiLan1.0ChiLan1.0
APELA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14169,176,909 - 169,197,001 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4169,176,910 - 169,195,553 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04157,125,485 - 157,145,999 (+)NCBIMhudiblu_PPA_v0panPan3
APELA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11560,967,944 - 60,990,955 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Apela
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936555969,902 - 978,736 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APELA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1853,703,735 - 53,736,989 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2856,863,643 - 56,896,787 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APELA
(Chlorocebus sabaeus - African green monkey)		 No map positions available.
Apela
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475811,944,563 - 11,954,027 (-)NCBI

Position Markers
Gm10664  
Mouse AssemblyChrPosition (strand)SourceJBrowse
cM Map8 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83383736267837502Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000124790   ⟹   ENSMUSP00000139425
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl865,028,420 - 65,037,172 (-)Ensembl
RefSeq Acc Id: ENSMUST00000142822   ⟹   ENSMUSP00000140510
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl865,028,417 - 65,037,336 (-)Ensembl
RefSeq Acc Id: NM_001297554   ⟹   NP_001284483
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39865,481,069 - 65,489,988 (-)NCBI
GRCm38865,028,417 - 65,037,336 (-)NCBI
Celera867,592,177 - 67,600,984 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242247   ⟹   XP_011240549
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39865,481,069 - 65,489,882 (-)NCBI
GRCm38865,028,417 - 65,037,230 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001284483 (Get FASTA)   NCBI Sequence Viewer  
  XP_011240549 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAE20426 (Get FASTA)   NCBI Sequence Viewer  
  P0DMC4 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001284483   ⟸   NM_001297554
- Peptide Label: precursor
- UniProtKB: P0DMC4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011240549   ⟸   XM_011242247
- Peptide Label: isoform X1
- UniProtKB: P0DMC4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000139425   ⟸   ENSMUST00000124790
RefSeq Acc Id: ENSMUSP00000140510   ⟸   ENSMUST00000142822

Promoters
RGD ID:8667175
Promoter ID:EPDNEW_M11619
Type:multiple initiation site
Name:Apela_1
Description:Mus musculus apelin receptor early endogenous ligand , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38865,037,157 - 65,037,217EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3642370 AgrOrtholog
Ensembl Genes ENSMUSG00000079042 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000139425 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000140510 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000124790 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000142822 ENTREZGENE, UniProtKB/Swiss-Prot
KEGG Report mmu:100038489 UniProtKB/Swiss-Prot
MGD MGI:3642370 ENTREZGENE
NCBI Gene 100038489 ENTREZGENE
PhenoGen Apela PhenoGen
UniProt ELA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3V438_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-02-12 Apela  apelin receptor early endogenous ligand  Gm10664  predicted gene 10664  Symbol and/or name change 5135510 APPROVED