Zrsr2-ps1 (zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2, pseudogene 1) - Rat Genome Database

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Gene: Zrsr2-ps1 (zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2, pseudogene 1) Mus musculus
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Symbol: Zrsr2-ps1
Name: zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2, pseudogene 1
RGD ID: 1624059
MGI Page MGI
Description: Predicted to enable identical protein binding activity and pre-mRNA 3'-splice site binding activity. Involved in mRNA splicing, via spliceosome. Part of U12-type spliceosomal complex. Is expressed in several structures, including early conceptus; liver; nervous system; reproductive system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia and myelodysplastic syndrome. Orthologous to human ZRSR2P1 (ZRSR2 pseudogene 1) and ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2).
Type: pseudo (Ensembl: transcribed_processed_pseudogene)
RefSeq Status: VALIDATED
Previously known as: 35kD; CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1; D11Ncv; D11Ncvs75; Ir; Irlgs2; S; SP2; U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1, related sequence 1; U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 35 kDa, related sequence 1; U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), related sequence 1; U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1; U2(RNU2) small nuclear RNA auxiliary factor 1-like 1; U2af1-; U2af1-rs1; U2afb; U2afbp-rs; Zrsr1
RGD Orthologs
Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391122,922,019 - 22,926,500 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1122,923,228 - 22,924,514 (+)EnsemblGRCm39 Ensembl
GRCm381122,972,005 - 22,976,496 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1122,972,005 - 22,976,496 (+)EnsemblGRCm38mm10GRCm38
MGSCv371122,872,029 - 22,874,908 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361122,872,037 - 22,874,908 (+)NCBIMGSCv36mm8
Celera1125,107,666 - 25,110,540 (+)NCBICelera
Cytogenetic Map11A3.2NCBI
cM Map1114.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7729597   PMID:7774561   PMID:7849406   PMID:7870588   PMID:7894162   PMID:7896102   PMID:7956352   PMID:8136831   PMID:8284201   PMID:8661059   PMID:8661130   PMID:9001233  
PMID:9070927   PMID:9170106   PMID:9584126   PMID:9678333   PMID:9927192   PMID:10349636   PMID:10395797   PMID:10679248   PMID:11042159   PMID:11076861   PMID:11210191   PMID:11217851  
PMID:11463825   PMID:11514337   PMID:11668390   PMID:12466851   PMID:12477932   PMID:12627233   PMID:14673161   PMID:15163367   PMID:16033648   PMID:16141072   PMID:16141073   PMID:16403808  
PMID:16575173   PMID:16987518   PMID:17121465   PMID:17291163   PMID:17371845   PMID:18039842   PMID:19052635   PMID:21267068   PMID:21873635   PMID:29617656   PMID:29875017   PMID:31331069  
PMID:32527007   PMID:33691379  


Genomics

Comparative Map Data
Zrsr2-ps1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391122,922,019 - 22,926,500 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1122,923,228 - 22,924,514 (+)EnsemblGRCm39 Ensembl
GRCm381122,972,005 - 22,976,496 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1122,972,005 - 22,976,496 (+)EnsemblGRCm38mm10GRCm38
MGSCv371122,872,029 - 22,874,908 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361122,872,037 - 22,874,908 (+)NCBIMGSCv36mm8
Celera1125,107,666 - 25,110,540 (+)NCBICelera
Cytogenetic Map11A3.2NCBI
cM Map1114.24NCBI
Zrsr2-ps1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814101,173,861 - 101,179,999 (+)NCBIGRCr8
mRatBN7.21496,972,651 - 96,978,364 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1496,972,580 - 96,978,891 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.014107,750,162 - 107,751,895 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14107,750,162 - 107,751,892 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014107,826,181 - 107,827,914 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414103,657,880 - 103,659,613 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1495,955,831 - 95,957,564 (+)NCBICelera
Cytogenetic Map14q22NCBI

Variants

.
Variants in Zrsr2-ps1
134 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:510
Count of miRNA genes:368
Interacting mature miRNAs:412
Transcripts:ENSMUST00000049506
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse
1357518Tgyl1_mtriglyceride level 1 (mouse)Not determined11688027733916219Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
1300990Bits3_mbitterness sensitivity 3 (mouse)Not determined11837212142372260Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
1302171Pgia28_mproteoglycan induced arthritis 28 (mouse)Not determined11890609742906218Mouse
4141047Nilac1_mnicotine induced locomotor activity 1 (mouse)Not determined11901178043011942Mouse
13524844Ppiq9_mprepulse inhibition QTL 9 (mouse)11904999735077325Mouse
13463472Mcvq15_mmean corpuscular volume QTL 15 (mouse)111095123244951464Mouse
13463479Mchq19_mmean corpuscular hemoglobin QTL 19 (mouse)111095123244951464Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
10412216Eae44_mexperimental allergic encephalomyelitis susceptibility 44 (mouse)Not determined111226863739950840Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse

Markers in Region
Zrsr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381122,973,357 - 22,974,040UniSTSGRCm38
MGSCv371122,872,328 - 22,872,563UniSTSGRCm37
MGSCv371122,872,517 - 22,873,176UniSTSGRCm37
Celera1125,108,989 - 25,109,672UniSTS
Cytogenetic Map11A3.2UniSTS
RH137461  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381122,973,276 - 22,973,468UniSTSGRCm38
MGSCv371122,873,276 - 22,873,468UniSTSGRCm37
Celera1125,108,908 - 25,109,100UniSTS
Cytogenetic Map11A3.2UniSTS
PMC303337P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381122,972,328 - 22,972,563UniSTSGRCm38
MGSCv371122,872,328 - 22,872,563UniSTSGRCm37
Celera1125,107,965 - 25,108,200UniSTS
Cytogenetic Map11A3.2UniSTS
PMC303337P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381122,973,892 - 22,974,115UniSTSGRCm38
MGSCv371122,873,892 - 22,874,115UniSTSGRCm37
Celera1125,109,524 - 25,109,747UniSTS
Cytogenetic Map11A3.2UniSTS
PMC303337P4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381122,973,766 - 22,974,478UniSTSGRCm38
MGSCv371122,873,766 - 22,874,478UniSTSGRCm37
Celera1125,109,398 - 25,110,110UniSTS
Cytogenetic Map11A3.2UniSTS
PMC87265P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381122,972,036 - 22,972,328UniSTSGRCm38
MGSCv371122,872,036 - 22,872,328UniSTSGRCm37
Celera1125,107,673 - 25,107,965UniSTS
Cytogenetic Map11A3.2UniSTS
PMC87265P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381122,974,690 - 22,974,852UniSTSGRCm38
MGSCv371122,874,690 - 22,874,852UniSTSGRCm37
Celera1125,110,322 - 25,110,484UniSTS
Cytogenetic Map11A3.2UniSTS
Murr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A3.2UniSTS
cM Map1112.0UniSTS
Murr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A3.2UniSTS
cM Map1112.0UniSTS
U2af1-rs1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381122,972,040 - 22,972,328UniSTSGRCm38
MGSCv371122,872,040 - 22,872,328UniSTSGRCm37
Celera1125,107,677 - 25,107,965UniSTS
Cytogenetic Map11A3.2UniSTS
cM Map1112.0UniSTS
Zrsr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381122,972,328 - 22,972,563UniSTSGRCm38
MGSCv371122,872,328 - 22,872,563UniSTSGRCm37
Celera1125,107,965 - 25,108,200UniSTS
Cytogenetic Map11A3.2UniSTS
Zrsr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381122,972,517 - 22,973,176UniSTSGRCm38
MGSCv371122,872,517 - 22,873,176UniSTSGRCm37
Celera1125,108,154 - 25,108,813UniSTS
Cytogenetic Map11A3.2UniSTS
Zrsr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A3.2UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000049506   ⟹   ENSMUSP00000062025
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1122,922,005 - 22,926,496 (+)Ensembl
GRCm38.p6 Ensembl1122,972,005 - 22,976,496 (+)Ensembl
RefSeq Acc Id: ENSMUST00000229075
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1122,923,228 - 22,924,514 (+)Ensembl
GRCm38.p6 Ensembl1122,973,228 - 22,974,514 (+)Ensembl
RefSeq Acc Id: ENSMUST00000230879
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1122,923,215 - 22,926,496 (+)Ensembl
GRCm38.p6 Ensembl1122,973,215 - 22,976,496 (+)Ensembl
RefSeq Acc Id: NR_175920
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391122,922,019 - 22,926,500 (+)NCBI
RefSeq Acc Id: ENSMUSP00000062025   ⟸   ENSMUST00000049506
Protein Domains
C3H1-type   RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64707-F1-model_v2 AlphaFold Q64707 1-428 view protein structure

Promoters
RGD ID:6822520
Promoter ID:MM_KWN:6649
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_011663
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361122,872,026 - 22,873,927 (+)MPROMDB
RGD ID:8674090
Promoter ID:EPDNEW_M15076
Type:initiation region
Name:Zrsr1_1
Description:Mus musculus zinc finger , RNA binding motif and serine/argininerich 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381122,972,037 - 22,972,097EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98885 AgrOrtholog
Ensembl Genes ENSMUSG00000044068 Ensembl
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  U2AF_small UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_CCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98885 ENTREZGENE
NCBI Gene 22183 ENTREZGENE
PANTHER PTHR12620 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35 KDA SUBUNIT-RELATED PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-CCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Zrsr2-ps1 PhenoGen
PRINTS U2AUXFACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_C3H1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C3H1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q3TN32_MOUSE UniProtKB/TrEMBL
  Q64707 ENTREZGENE
  Q793C9_MOUSE UniProtKB/TrEMBL
  Q8BST8_MOUSE UniProtKB/TrEMBL
  U2AFL_MOUSE UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-02-13 Zrsr2-ps1  zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2, pseudogene 1  Zrsr1  zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1  Symbol and/or name updated 27372883 PROVISIONAL