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Gene: Fbxw7 (F-box and WD-40 domain protein 7) Mus musculus
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Symbol: Fbxw7
Name: F-box and WD-40 domain protein 7
Description: Predicted to have several functions, including cyclin binding activity; phosphothreonine residue binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding activity; and positive regulation of proteolysis involved in cellular protein catabolic process. Localizes to several cellular components, including the Golgi apparatus; nucleolus; and perinuclear region of cytoplasm. Is expressed in brain; early conceptus; and genitourinary system. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7); PARTICIPATES IN Notch signaling pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110001A17Rik; AGO; Cdc4; F-box and WD-40 domain protein 7, archipelago homolog; F-box and WD-40 domain-containing protein 7; f-box only protein 30; F-box protein FBW7; F-box protein Fbxw6; F-box-WD40 repeat protein 6; F-box/WD repeat-containing protein 7; Fbw7; Fbwd6; Fbx30; Fbxo30; Fbxw6; SEL-10
Orthologs:
Homo sapiens (human) : FBXW7 (F-box and WD repeat domain containing 7)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Fbxw7 (F-box and WD repeat domain containing 7)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fbxw7 (F-box and WD repeat domain containing 7)
Pan paniscus (bonobo/pygmy chimpanzee) : FBXW7 (F-box and WD repeat domain containing 7)
Canis lupus familiaris (dog) : FBXW7 (F-box and WD repeat domain containing 7)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fbxw7 (F-box and WD repeat domain containing 7)
Sus scrofa (pig) : FBXW7 (F-box and WD repeat domain containing 7)
Chlorocebus sabaeus (green monkey) : FBXW7 (F-box and WD repeat domain containing 7)
Heterocephalus glaber (naked mole-rat) : Fbxw7 (F-box and WD repeat domain containing 7)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl384,815,268 - 84,979,198 (+)Ensembl
GRCm38384,814,990 - 84,979,198 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37384,619,499 - 84,783,120 (+)NCBIGRCm37mm9NCBIm37
MGSCv36385,038,138 - 85,063,561 (+)NCBImm8
Celera384,827,347 - 84,997,996 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map337.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Fbxw7
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1624041
Created: 2007-05-02
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.