Fbxw7 (F-box and WD-40 domain protein 7) - Rat Genome Database

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Gene: Fbxw7 (F-box and WD-40 domain protein 7) Mus musculus
Analyze
Symbol: Fbxw7
Name: F-box and WD-40 domain protein 7
RGD ID: 1624041
MGI Page MGI
Description: Predicted to enable several functions, including cyclin binding activity; phosphothreonine residue binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of osteoclast development; and positive regulation of proteolysis involved in protein catabolic process. Acts upstream of or within several processes, including Notch signaling pathway; protein destabilization; and vasculogenesis. Located in several cellular components, including Golgi apparatus; nucleolus; and perinuclear region of cytoplasm. Is expressed in central nervous system; early conceptus; genitourinary system; and skeletal muscle tissue. Human ortholog(s) of this gene implicated in developmental delay, hypotonia, and impaired language. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110001A17Rik; A; AGO; Cdc4; F-box and WD-40 domain protein 7, archipelago homolog; F-box and WD-40 domain-containing protein 7; f-box only protein 30; F-box protein FBW7; F-box protein Fbxw6; F-box-WD40 repeat protein 6; F-box/WD repeat-containing protein 7; Fbw7; Fbwd6; Fbx30; Fbxo3; Fbxo30; Fbxw6; SEL-; SEL-10
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39384,721,901 - 84,886,505 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl384,722,575 - 84,886,505 (+)EnsemblGRCm39 Ensembl
GRCm38384,814,990 - 84,979,198 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl384,815,268 - 84,979,198 (+)EnsemblGRCm38mm10GRCm38
MGSCv37384,619,499 - 84,783,120 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36385,038,138 - 85,063,561 (+)NCBIMGSCv36mm8
Celera384,827,347 - 84,997,996 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map337.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood vessel morphology  (IAGP)
abnormal brain development  (IAGP)
abnormal brain vasculature morphology  (IAGP)
abnormal cerebellar foliation  (IAGP)
abnormal cerebellum development  (IAGP)
abnormal cerebellum fissure morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal cortical intermediate zone morphology  (IAGP)
abnormal cortical plate morphology  (IAGP)
abnormal embryonic/fetal subventricular zone morphology  (IAGP)
abnormal epididymis morphology  (IAGP)
abnormal erythrocyte cell number  (IAGP)
abnormal heart development  (IAGP)
abnormal hematopoietic stem cell physiology  (IAGP)
abnormal male germ cell physiology  (IAGP)
abnormal neural tube closure  (IAGP)
abnormal neuron apoptosis  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal seminiferous tubule epithelium morphology  (IAGP)
abnormal Sertoli cell barrier morphology  (IAGP)
abnormal Sertoli cell morphology  (IAGP)
abnormal somite border morphology  (IAGP)
abnormal somite development  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal tectum morphology  (IAGP)
abnormal testis development  (IAGP)
abnormal vascular development  (IAGP)
abnormal vasculogenesis  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
arrest of spermatogenesis  (IAGP)
arrested T cell differentiation  (IAGP)
bile duct hyperplasia  (IAGP)
cerebellum vermis hypoplasia  (IAGP)
cleft palate  (IAGP)
decreased angiogenesis  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased epididymis weight  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased litter size  (IAGP)
decreased male germ cell number  (IAGP)
decreased neuronal precursor cell number  (IAGP)
decreased Purkinje cell number  (IAGP)
decreased Purkinje cell size  (IAGP)
decreased Sertoli cell number  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased testis weight  (IAGP)
decreased tumor latency  (IAGP)
dilated bile duct  (IAGP)
disorganized yolk sac vascular plexus  (IAGP)
ectopic Sertoli cells  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged thymus  (IAGP)
eyelids open at birth  (IAGP)
impaired lung alveolus development  (IAGP)
increased cholangiocarcinoma incidence  (IAGP)
increased double-positive T cell number  (IAGP)
increased lymphoma incidence  (IAGP)
increased male germ cell apoptosis  (IAGP)
increased T cell apoptosis  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
intracranial hemorrhage  (IAGP)
lethality, complete penetrance  (IAGP)
male infertility  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
oligozoospermia  (IAGP)
open neural tube  (IAGP)
pale yolk sac  (IAGP)
pallor  (IAGP)
pericardial edema  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
reduced male fertility  (IAGP)
respiratory failure  (IAGP)
seminiferous tubule degeneration  (IAGP)
small cerebellum  (IAGP)
small epididymis  (IAGP)
small testis  (IAGP)
testicular atrophy  (IAGP)
testis degeneration  (IAGP)
thalamus hypoplasia  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
thymus hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Loss of Fbxw7 expression is a predictor of recurrence in colorectal liver metastasis. Kawashita Y, etal., J Hepatobiliary Pancreat Sci. 2017 Oct;24(10):576-583. doi: 10.1002/jhbp.500. Epub 2017 Oct 12.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10531037   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11425854   PMID:11461910   PMID:11735228   PMID:12354302   PMID:12466851  
PMID:12477932   PMID:14610273   PMID:14672936   PMID:14739463   PMID:14766969   PMID:15520277   PMID:15592418   PMID:15618518   PMID:15782199   PMID:16061623   PMID:16141072   PMID:16141073  
PMID:16964442   PMID:16989775   PMID:17141158   PMID:17967808   PMID:17984302   PMID:18077674   PMID:18287559   PMID:18367647   PMID:18474632   PMID:18625840   PMID:18641686   PMID:18787170  
PMID:18799693   PMID:18948752   PMID:19421138   PMID:19562935   PMID:20059953   PMID:20208556   PMID:20534483   PMID:20638938   PMID:20815813   PMID:20826802   PMID:20935640   PMID:21070969  
PMID:21076392   PMID:21092141   PMID:21123947   PMID:21147854   PMID:21205095   PMID:21267068   PMID:21282377   PMID:21349854   PMID:21368833   PMID:21368834   PMID:21503901   PMID:21642990  
PMID:21677750   PMID:21827743   PMID:21873635   PMID:21911492   PMID:21953459   PMID:22117044   PMID:22348067   PMID:22405651   PMID:22473991   PMID:22513362   PMID:22608923   PMID:22665065  
PMID:22708077   PMID:22710480   PMID:22797700   PMID:22848434   PMID:22897623   PMID:22912667   PMID:23109421   PMID:23454868   PMID:23507969   PMID:23518349   PMID:23518350   PMID:23575666  
PMID:23676439   PMID:23776410   PMID:23785053   PMID:23791182   PMID:23820376   PMID:23858059   PMID:23873023   PMID:23955342   PMID:24357321   PMID:24446488   PMID:24457827   PMID:24647000  
PMID:24752894   PMID:24820417   PMID:24879440   PMID:24884509   PMID:24952961   PMID:24958101   PMID:25105579   PMID:25437563   PMID:25555218   PMID:25579381   PMID:25670854   PMID:25716680  
PMID:25720964   PMID:25918410   PMID:26206584   PMID:26575021   PMID:26774286   PMID:27152455   PMID:27238018   PMID:27594513   PMID:27764699   PMID:27773673   PMID:27798604   PMID:27922003  
PMID:28036276   PMID:28287082   PMID:28422719   PMID:28581198   PMID:28752701   PMID:29069604   PMID:29074464   PMID:29149593   PMID:29282223   PMID:29346117   PMID:29386660   PMID:29472293  
PMID:29475832   PMID:29550488   PMID:29633504   PMID:30275535   PMID:30700911   PMID:30783098   PMID:30830867   PMID:30854564   PMID:30936475   PMID:31017010   PMID:31150734   PMID:31246581  
PMID:31278268   PMID:31341888   PMID:31423512   PMID:31445163   PMID:31685994   PMID:31748650   PMID:31772025   PMID:31883011   PMID:32005754   PMID:32152552   PMID:32267917   PMID:32371478  
PMID:32380038   PMID:32853822   PMID:32900488   PMID:32931083   PMID:33070870   PMID:33086033   PMID:33234509   PMID:33260160   PMID:33369138   PMID:33537812   PMID:33821962   PMID:34321999  
PMID:34351636   PMID:34475389   PMID:34518642   PMID:34636321   PMID:34998785   PMID:35058228   PMID:35069531   PMID:35165395   PMID:35225231   PMID:35440636   PMID:35651754   PMID:36104351  
PMID:36481094   PMID:36924565   PMID:37589076   PMID:37773720   PMID:37843504   PMID:37914694   PMID:38281999   PMID:38485719   PMID:38834586  


Genomics

Comparative Map Data
Fbxw7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39384,721,901 - 84,886,505 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl384,722,575 - 84,886,505 (+)EnsemblGRCm39 Ensembl
GRCm38384,814,990 - 84,979,198 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl384,815,268 - 84,979,198 (+)EnsemblGRCm38mm10GRCm38
MGSCv37384,619,499 - 84,783,120 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36385,038,138 - 85,063,561 (+)NCBIMGSCv36mm8
Celera384,827,347 - 84,997,996 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map337.7NCBI
FBXW7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384152,320,544 - 152,536,092 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4152,320,544 - 152,536,092 (-)EnsemblGRCh38hg38GRCh38
GRCh374153,241,696 - 153,457,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364153,461,860 - 153,675,622 (-)NCBINCBI36Build 36hg18NCBI36
Build 344153,601,099 - 153,690,635NCBI
Celera4150,566,189 - 150,779,958 (-)NCBICelera
Cytogenetic Map4q31.3NCBI
HuRef4148,968,491 - 149,182,492 (-)NCBIHuRef
CHM1_14153,220,162 - 153,434,185 (-)NCBICHM1_1
T2T-CHM13v2.04155,643,699 - 155,859,255 (-)NCBIT2T-CHM13v2.0
Fbxw7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82172,447,738 - 172,609,591 (+)NCBIGRCr8
mRatBN7.22170,149,706 - 170,311,536 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2170,149,694 - 170,309,941 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02184,230,191 - 184,309,805 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2184,231,260 - 184,309,664 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02203,633,724 - 203,708,120 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42176,675,226 - 176,750,737 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2164,144,641 - 164,303,043 (+)NCBICelera
Cytogenetic Map2q34NCBI
Fbxw7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554716,848,101 - 6,955,881 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554716,852,459 - 7,026,590 (-)NCBIChiLan1.0ChiLan1.0
FBXW7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23150,206,219 - 150,420,227 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14150,563,293 - 150,777,771 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04144,660,676 - 144,874,404 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14156,312,274 - 156,527,649 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4156,312,274 - 156,402,351 (-)Ensemblpanpan1.1panPan2
FBXW7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11550,187,579 - 50,417,188 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1550,189,240 - 50,417,195 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1550,529,850 - 50,761,421 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01550,869,433 - 51,101,086 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1550,870,969 - 50,964,288 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11550,130,239 - 50,363,954 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01550,231,872 - 50,463,188 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01550,542,860 - 50,774,097 (-)NCBIUU_Cfam_GSD_1.0
Fbxw7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530140,081,138 - 40,271,734 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366892,259,477 - 2,344,764 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366892,261,163 - 2,449,951 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXW7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl876,482,844 - 76,699,348 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1876,482,027 - 76,699,354 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FBXW7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1798,894,261 - 99,105,955 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl798,892,504 - 99,106,084 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603778,541,091 - 78,756,369 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxw7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248583,775,795 - 3,873,336 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248583,778,842 - 3,974,351 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fbxw7
4286 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2764
Count of miRNA genes:568
Interacting mature miRNAs:704
Transcripts:ENSMUST00000029727, ENSMUST00000107675, ENSMUST00000107678, ENSMUST00000107679, ENSMUST00000151410
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
1357585Manln3_mmandible length 3 (mouse)Not determined35262550986625745Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
13464139Nhdlq17_mnon-HDL QTL 17 (mouse)35292318386923183Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
1301917Tshp4_mtooth shape 4 (mouse)Not determined35262550986625745Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1300593Skull4_mskull morphology 4 (mouse)Not determined35262550986625745Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35890730792907307Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse

Markers in Region
RH136531  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38384,829,068 - 84,829,279UniSTSGRCm38
MGSCv37384,632,990 - 84,633,201UniSTSGRCm37
Celera384,840,811 - 84,841,022UniSTS
Cytogenetic Map3E3.3UniSTS
Fbxw7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38384,952,215 - 84,952,589UniSTSGRCm38
MGSCv37384,756,137 - 84,756,511UniSTSGRCm37
Celera384,971,029 - 84,971,403UniSTS
Cytogenetic Map3E3.3UniSTS
cM Map344.0UniSTS
13.mHAa9g1.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38384,846,177 - 84,846,277UniSTSGRCm38
MGSCv37384,650,099 - 84,650,199UniSTSGRCm37
Celera384,865,173 - 84,865,273UniSTS
Cytogenetic Map3E3.3UniSTS
Whitehead_YAC3 UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001177773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001177774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_080428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB221593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC102136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC158583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF391192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF427101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH011252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK032174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC065380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC131648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000029727   ⟹   ENSMUSP00000029727
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl384,859,453 - 84,884,952 (+)Ensembl
GRCm38.p6 Ensembl384,952,146 - 84,977,645 (+)Ensembl
RefSeq Acc Id: ENSMUST00000107675   ⟹   ENSMUSP00000103302
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl384,832,787 - 84,886,504 (+)Ensembl
GRCm38.p6 Ensembl384,925,480 - 84,979,197 (+)Ensembl
RefSeq Acc Id: ENSMUST00000107678   ⟹   ENSMUSP00000103305
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl384,771,452 - 84,886,505 (+)Ensembl
GRCm38.p6 Ensembl384,864,145 - 84,979,198 (+)Ensembl
RefSeq Acc Id: ENSMUST00000107679   ⟹   ENSMUSP00000103306
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl384,722,575 - 84,886,505 (+)Ensembl
GRCm38.p6 Ensembl384,815,268 - 84,979,198 (+)Ensembl
RefSeq Acc Id: ENSMUST00000151410
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl384,722,785 - 84,884,989 (+)Ensembl
GRCm38.p6 Ensembl384,815,478 - 84,977,682 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212597
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl384,723,073 - 84,810,811 (+)Ensembl
GRCm38.p6 Ensembl384,815,766 - 84,903,504 (+)Ensembl
RefSeq Acc Id: NM_001177773   ⟹   NP_001171244
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39384,722,884 - 84,886,505 (+)NCBI
GRCm38384,815,577 - 84,979,198 (+)NCBI
MGSCv37384,619,499 - 84,783,120 (+)RGD
Celera384,827,347 - 84,997,996 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001177774   ⟹   NP_001171245
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39384,771,452 - 84,886,505 (+)NCBI
GRCm38384,864,145 - 84,979,198 (+)NCBI
MGSCv37384,619,499 - 84,783,120 (+)RGD
Celera384,827,347 - 84,997,996 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_080428   ⟹   NP_536353
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39384,859,518 - 84,886,505 (+)NCBI
GRCm38384,952,211 - 84,979,198 (+)NCBI
MGSCv37384,619,499 - 84,783,120 (+)RGD
Celera384,827,347 - 84,997,996 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006501656   ⟹   XP_006501719
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39384,722,297 - 84,886,505 (+)NCBI
GRCm38384,814,990 - 84,979,198 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006501657   ⟹   XP_006501720
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39384,721,901 - 84,886,505 (+)NCBI
GRCm38384,815,538 - 84,979,198 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006501658   ⟹   XP_006501721
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39384,832,509 - 84,886,505 (+)NCBI
GRCm38384,925,372 - 84,979,198 (+)NCBI
Sequence:
RefSeq Acc Id: NP_536353   ⟸   NM_080428
- Peptide Label: isoform 2
- UniProtKB: Q8VBV4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001171244   ⟸   NM_001177773
- Peptide Label: isoform 1
- UniProtKB: Q8VBV4 (UniProtKB/Swiss-Prot),   Q8CCS5 (UniProtKB/Swiss-Prot),   A2RRI5 (UniProtKB/Swiss-Prot),   Q8VHP4 (UniProtKB/Swiss-Prot),   D3YUA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001171245   ⟸   NM_001177774
- Peptide Label: isoform 1
- UniProtKB: Q8VBV4 (UniProtKB/Swiss-Prot),   Q8CCS5 (UniProtKB/Swiss-Prot),   A2RRI5 (UniProtKB/Swiss-Prot),   Q8VHP4 (UniProtKB/Swiss-Prot),   D3YUA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006501719   ⟸   XM_006501656
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006501720   ⟸   XM_006501657
- Peptide Label: isoform X1
- UniProtKB: Q8VBV4 (UniProtKB/Swiss-Prot),   Q8CCS5 (UniProtKB/Swiss-Prot),   A2RRI5 (UniProtKB/Swiss-Prot),   Q8VHP4 (UniProtKB/Swiss-Prot),   D3YUA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006501721   ⟸   XM_006501658
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000029727   ⟸   ENSMUST00000029727
RefSeq Acc Id: ENSMUSP00000103302   ⟸   ENSMUST00000107675
RefSeq Acc Id: ENSMUSP00000103306   ⟸   ENSMUST00000107679
RefSeq Acc Id: ENSMUSP00000103305   ⟸   ENSMUST00000107678
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VBV4-F1-model_v2 AlphaFold Q8VBV4 1-710 view protein structure

Promoters
RGD ID:6833770
Promoter ID:MM_KWN:34734
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   Brain,   ES_Cell,   Kidney,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000054322
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36384,755,966 - 84,756,466 (+)MPROMDB
RGD ID:6881002
Promoter ID:EPDNEW_M3952
Type:multiple initiation site
Name:Fbxw7_1
Description:Mus musculus F-box and WD-40 domain protein 7 , transcript variant3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3954  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38384,833,687 - 84,833,747EPDNEW
RGD ID:6881006
Promoter ID:EPDNEW_M3954
Type:multiple initiation site
Name:Fbxw7_2
Description:Mus musculus F-box and WD-40 domain protein 7 , transcript variant3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3952  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38384,952,286 - 84,952,346EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1354695 AgrOrtholog
Ensembl Genes ENSMUSG00000028086 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000029727 ENTREZGENE
  ENSMUST00000029727.8 UniProtKB/Swiss-Prot
  ENSMUST00000107675 ENTREZGENE
  ENSMUST00000107675.8 UniProtKB/TrEMBL
  ENSMUST00000107678 ENTREZGENE
  ENSMUST00000107678.8 UniProtKB/Swiss-Prot
  ENSMUST00000107679 ENTREZGENE
  ENSMUST00000107679.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1280.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro F-box-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F-box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G-protein_beta_WD-40_rep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:50754 UniProtKB/Swiss-Prot
MGD MGI:1354695 ENTREZGENE
NCBI Gene 50754 ENTREZGENE
PANTHER EPITHELIAL CELL-TRANSFORMING SEQUENCE 2 ONCOGENE-LIKE UniProtKB/TrEMBL
  F-BOX DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  F-BOX/WD REPEAT-CONTAINING PROTEIN 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHOSPHOLIPASE A-2-ACTIVATING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam F-box-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fbxw7 PhenoGen
PRINTS GPROTEINBRPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2RRI5 ENTREZGENE
  D3YUA5 ENTREZGENE
  D3YUA8 ENTREZGENE, UniProtKB/TrEMBL
  FBXW7_MOUSE UniProtKB/Swiss-Prot
  Q0VGT7_MOUSE UniProtKB/TrEMBL
  Q8CCS5 ENTREZGENE
  Q8VBV4 ENTREZGENE
  Q8VHP4 ENTREZGENE
UniProt Secondary A2RRI5 UniProtKB/Swiss-Prot
  D3YUA5 UniProtKB/Swiss-Prot
  Q8CCS5 UniProtKB/Swiss-Prot
  Q8VHP4 UniProtKB/Swiss-Prot