Fbxw14 (F-box and WD-40 domain protein 14) - Rat Genome Database
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Gene: Fbxw14 (F-box and WD-40 domain protein 14) Mus musculus
Analyze
No known orthologs.
Symbol: Fbxw14
Name: F-box and WD-40 domain protein 14
RGD ID: 1624040
MGI Page MGI
Description: Orthologous to human FBXW12 (F-box and WD repeat domain containing 12); INTERACTS WITH bisphenol A; genistein; pirinixic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AU045528; E330009N23Rik; F-box only protein 12; F-box protein 12; Fbx12; Fbxo1; Fbxo12; MGC117492
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399109,099,857 - 109,116,797 (-)NCBIGRCm39mm39
GRCm389109,270,789 - 109,287,729 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9109,270,790 - 109,287,676 (-)EnsemblGRCm38mm10GRCm38
MGSCv379109,173,639 - 109,190,190 (-)NCBIGRCm37mm9NCBIm37
MGSCv369109,128,531 - 109,145,082 (-)NCBImm8
Cytogenetic Map9F2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:10531037   PMID:10725249   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15520277   PMID:16141072   PMID:16141073   PMID:21267068  


Genomics


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse
13515058Adip20d_madiposity 20d (mouse)9108915010118915010Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:672
Count of miRNA genes:429
Interacting mature miRNAs:485
Transcripts:ENSMUST00000066901, ENSMUST00000112041, ENSMUST00000119470
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001311159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_015793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006512182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC122308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF176528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK087709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT025696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000112041   ⟹   ENSMUSP00000107672
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9109,271,126 - 109,287,671 (-)Ensembl
RefSeq Acc Id: ENSMUST00000198048   ⟹   ENSMUSP00000143127
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9109,270,790 - 109,276,126 (-)Ensembl
RefSeq Acc Id: ENSMUST00000198844   ⟹   ENSMUSP00000143404
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9109,270,836 - 109,287,676 (-)Ensembl
RefSeq Acc Id: ENSMUST00000198928   ⟹   ENSMUSP00000142991
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9109,285,270 - 109,287,082 (-)Ensembl
RefSeq Acc Id: NM_001311159   ⟹   NP_001298088
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399109,100,191 - 109,116,744 (-)NCBI
GRCm389109,271,123 - 109,287,676 (-)NCBI
Sequence:
RefSeq Acc Id: NM_015793   ⟹   NP_056608
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399109,100,193 - 109,116,744 (-)NCBI
GRCm389109,271,125 - 109,287,676 (-)NCBI
MGSCv379109,173,639 - 109,190,190 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006512182   ⟹   XP_006512245
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399109,099,857 - 109,116,797 (-)NCBI
GRCm389109,270,789 - 109,287,729 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017313455   ⟹   XP_017168944
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399109,102,611 - 109,116,797 (-)NCBI
GRCm389109,273,543 - 109,287,729 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017313456   ⟹   XP_017168945
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399109,102,611 - 109,116,797 (-)NCBI
GRCm389109,273,543 - 109,287,729 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017313457   ⟹   XP_017168946
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399109,102,611 - 109,116,797 (-)NCBI
GRCm389109,273,543 - 109,287,729 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_056608   ⟸   NM_015793
- Peptide Label: isoform 1
- UniProtKB: Q8C2Y5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006512245   ⟸   XM_006512182
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: NP_001298088   ⟸   NM_001311159
- Peptide Label: isoform 2
- UniProtKB: Q4FZL9 (UniProtKB/TrEMBL),   Q8C2Y5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017168944   ⟸   XM_017313455
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017168946   ⟸   XM_017313457
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017168945   ⟸   XM_017313456
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000142991   ⟸   ENSMUST00000198928
RefSeq Acc Id: ENSMUSP00000143404   ⟸   ENSMUST00000198844
RefSeq Acc Id: ENSMUSP00000143127   ⟸   ENSMUST00000198048
RefSeq Acc Id: ENSMUSP00000107672   ⟸   ENSMUST00000112041
Protein Domains
F-box


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1354703 AgrOrtholog
Ensembl Genes ENSMUSG00000105589 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000107672 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000142991 UniProtKB/TrEMBL
  ENSMUSP00000143127 UniProtKB/TrEMBL
  ENSMUSP00000143404 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000112041 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000198048 UniProtKB/TrEMBL
  ENSMUST00000198844 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000198928 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro F-box_dom_cyclin-like UniProtKB/TrEMBL
  F-box_dom_like UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report mmu:50757 UniProtKB/TrEMBL
MGD MGI:1354703 ENTREZGENE
NCBI Gene 50757 ENTREZGENE
Pfam F-box-like UniProtKB/TrEMBL
PhenoGen Fbxw14 PhenoGen
PROSITE FBOX UniProtKB/TrEMBL
SMART FBOX UniProtKB/TrEMBL
Superfamily-SCOP F-box_dom_Skp2-like UniProtKB/TrEMBL
  WD40_like UniProtKB/TrEMBL
UniProt A0A0G2JF22_MOUSE UniProtKB/TrEMBL
  A0A0G2JFD3_MOUSE UniProtKB/TrEMBL
  B7ZN94_MOUSE UniProtKB/TrEMBL
  B9EHJ2_MOUSE UniProtKB/TrEMBL
  Q3UXB1_MOUSE UniProtKB/TrEMBL
  Q4FZL9 ENTREZGENE, UniProtKB/TrEMBL
  Q8C2Y5 ENTREZGENE, UniProtKB/TrEMBL
  Q9QZN2_MOUSE UniProtKB/TrEMBL