Cox14 (cytochrome c oxidase assembly protein 14) - Rat Genome Database

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Gene: Cox14 (cytochrome c oxidase assembly protein 14) Mus musculus
Analyze
Symbol: Cox14
Name: cytochrome c oxidase assembly protein 14
RGD ID: 1623995
MGI Page MGI
Description: Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 10. Orthologous to human COX14 (cytochrome c oxidase assembly factor COX14).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2310016M24Rik; AA959804; cytochrome c oxidase assembly protein C12orf62 homolog; cytochrome c oxidase assembly protein COX14; hypothetical protein LOC66379; MGC106475; uncharacterized protein C12orf62 homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391599,623,499 - 99,626,017 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1599,623,528 - 99,627,413 (+)EnsemblGRCm39 Ensembl
GRCm381599,725,618 - 99,728,136 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,725,647 - 99,729,532 (+)EnsemblGRCm38mm10GRCm38
MGSCv371599,556,049 - 99,558,567 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361599,553,681 - 99,556,148 (+)NCBIMGSCv36mm8
Celera15101,881,390 - 101,883,690 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15489334   PMID:15747579   PMID:16141072  
PMID:16141073   PMID:16602821   PMID:18614015   PMID:18799693   PMID:21267068   PMID:21677750   PMID:21873635   PMID:39134548  


Genomics

Comparative Map Data
Cox14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391599,623,499 - 99,626,017 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1599,623,528 - 99,627,413 (+)EnsemblGRCm39 Ensembl
GRCm381599,725,618 - 99,728,136 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,725,647 - 99,729,532 (+)EnsemblGRCm38mm10GRCm38
MGSCv371599,556,049 - 99,558,567 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361599,553,681 - 99,556,148 (+)NCBIMGSCv36mm8
Celera15101,881,390 - 101,883,690 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.13NCBI
COX14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381250,112,236 - 50,120,453 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1250,112,082 - 50,120,457 (+)EnsemblGRCh38hg38GRCh38
GRCh371250,506,019 - 50,514,236 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361248,792,167 - 48,800,501 (+)NCBINCBI36Build 36hg18NCBI36
Celera1249,301,386 - 49,309,712 (+)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1247,539,086 - 47,547,544 (+)NCBIHuRef
CHM1_11250,471,914 - 50,480,383 (+)NCBICHM1_1
T2T-CHM13v2.01250,075,318 - 50,083,543 (+)NCBIT2T-CHM13v2.0
Cox14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87132,731,069 - 132,733,159 (+)NCBIGRCr8
mRatBN7.27130,852,226 - 130,854,316 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx7132,655,936 - 132,658,032 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07134,881,517 - 134,883,613 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07134,794,042 - 134,796,138 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07141,378,537 - 141,380,960 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7141,380,322 - 141,380,495 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,883,197 - 115,885,604 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47138,451,395 - 138,469,295 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7127,333,532 - 127,335,955 (+)NCBICelera
Cytogenetic Map7q36NCBI
LOC102015156
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955547676,342 - 690,777 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955547690,167 - 690,777 (+)NCBIChiLan1.0ChiLan1.0
LOC100981933
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21044,068,910 - 44,069,327 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11244,065,672 - 44,066,089 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01238,635,386 - 38,643,804 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11239,532,786 - 39,541,104 (-)NCBIpanpan1.1PanPan1.1panPan2
COX14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1274,609,156 - 4,614,325 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl274,609,385 - 4,609,558 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2741,643,854 - 41,649,021 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0274,658,277 - 4,663,449 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1274,622,964 - 4,628,327 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,612,647 - 4,617,820 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02742,038,888 - 42,044,052 (+)NCBIUU_Cfam_GSD_1.0
LOC101956167
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494565,388,046 - 65,393,682 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365127,776,329 - 7,776,502 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365127,776,321 - 7,776,784 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110260660
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl516,021,272 - 16,021,445 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1516,016,419 - 16,021,676 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103238297
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11146,339,901 - 46,349,088 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1146,348,669 - 46,348,839 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037199,770,581 - 199,780,333 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101701927
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248162,197,701 - 2,202,800 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248162,197,701 - 2,202,931 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cox14
72 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:128
Count of miRNA genes:116
Interacting mature miRNAs:127
Transcripts:ENSMUST00000023761
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
11528547Sluc34_msusceptibility to lung cancer 34 (mouse)1597884933102896555Mouse
1301918Skull22_mskull morphology 22 (mouse)Not determined1585901546104073951Mouse
14928306Manh79_mmandible shape 79 (mouse)1578847557104073951Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578601103102901704Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78601103102901704Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
11530038Sluc34b_msusceptibility to lung cancer 34b (mouse)1585896437104073951Mouse
11530037Sluc34a_msusceptibility to lung cancer 34a (mouse)1585896437104073951Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567270698101270847Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1578897881104073951Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579163411104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580884933104073951Mouse
14700689Carg5_mCandida albicans resistance gene 5 (mouse)1597697881103008427Mouse
4141581Dshv1_mdorsal hippocampal volume 1 (mouse)Not determined92788640103425899Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined79908940104073951Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580313634104073951Mouse
4141511Gdcr1_mglycerolphosphate dehydrogenase regulator 1 (mouse)Not determined82615474104073951Mouse
1357614Bmca_mbile mucin accumulation (mouse)Not determined1585896437104073951Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580884933104073951Mouse

Markers in Region
22.MMHAP28FLH1.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381599,724,579 - 99,724,760UniSTSGRCm38
MGSCv371599,555,010 - 99,555,191UniSTSGRCm37
Celera15101,880,351 - 101,880,532UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map15F1-F3UniSTS
Whitehead_YAC15 UniSTS
AA959804  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381599,727,815 - 99,727,977UniSTSGRCm38
MGSCv371599,558,246 - 99,558,408UniSTSGRCm37
Celera15101,883,369 - 101,883,531UniSTS
Cytogenetic Map15F1UniSTS
Whitehead/MRC_RH15882.96UniSTS
Gpd1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381599,724,065 - 99,724,976UniSTSGRCm38
MGSCv371599,554,496 - 99,555,407UniSTSGRCm37
Celera15101,879,837 - 101,880,748UniSTS
Cytogenetic Map15F1-F3UniSTS
Cytogenetic Map15F1UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000023761   ⟹   ENSMUSP00000023761
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1599,623,528 - 99,627,413 (+)Ensembl
GRCm38.p6 Ensembl1599,725,647 - 99,729,532 (+)Ensembl
Ensembl Acc Id: ENSMUST00000238530
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1599,623,558 - 99,625,451 (+)Ensembl
GRCm38.p6 Ensembl1599,725,677 - 99,727,570 (+)Ensembl
RefSeq Acc Id: NM_183256   ⟹   NP_899079
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391599,623,499 - 99,626,017 (+)NCBI
GRCm381599,725,618 - 99,728,136 (+)ENTREZGENE
MGSCv371599,556,049 - 99,558,567 (+)RGD
Celera15101,881,390 - 101,883,690 (+)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_899079   ⟸   NM_183256
- UniProtKB: Q8BH51 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000023761   ⟸   ENSMUST00000023761

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BH51-F1-model_v2 AlphaFold Q8BH51 1-57 view protein structure

Promoters
RGD ID:6825581
Promoter ID:MM_KWN:19702
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_183256
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361599,555,091 - 99,556,332 (+)MPROMDB
RGD ID:8685010
Promoter ID:EPDNEW_M20536
Type:initiation region
Name:Cox14_1
Description:Mus musculus cytochrome c oxidase assembly protein 14 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20537  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381599,725,675 - 99,725,735EPDNEW
RGD ID:8685012
Promoter ID:EPDNEW_M20537
Type:initiation region
Name:Cox14_2
Description:Mus musculus cytochrome c oxidase assembly protein 14 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20536  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381599,725,803 - 99,725,863EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913629 AgrOrtholog
Ensembl Genes ENSMUSG00000023020 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000023761 ENTREZGENE
  ENSMUST00000023761.4 UniProtKB/Swiss-Prot
InterPro COX14 UniProtKB/Swiss-Prot
KEGG Report mmu:66379 UniProtKB/Swiss-Prot
MGD MGI:1913629 ENTREZGENE
NCBI Gene 66379 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX14 UniProtKB/Swiss-Prot
  PTHR36684 UniProtKB/Swiss-Prot
Pfam COX14 UniProtKB/Swiss-Prot
PhenoGen Cox14 PhenoGen
UniProt COX14_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-27 Cox14  cytochrome c oxidase assembly protein 14  2310016M24Rik  RIKEN cDNA 2310016M24 gene  Symbol and/or name change 5135510 APPROVED